Epidermal growth factor-like repeats of thrombospondins activate phospholipase Cγ and increase epithelial cell migration through indirect epidermal growth factor receptor activation

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6389-6402

  Liu, Anguo ^a   Garg, Pallavi ^a   Yang, Shiqi ^a   Gong, Ping ^a   Pallero, Manuel A ^b   Annis, Douglas S ^c   Liu, Yuanyuan ^c   Passaniti, Antonino ^a   Mann, Dean ^a   Mosher, Deane F ^c   Murphy Ullrich, Joanne E ^b   Goldblum, Simeon E ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; BIOLOGICAL RESPONSE; CELL MIGRATION; CELLULAR RESPONSE; ECTODOMAIN; EPIDERMAL GROWTH FACTOR RECEPTORS; EPIDERMAL GROWTH FACTOR-LIKE REPEAT; EPIDERMAL GROWTH FACTORS; EPITHELIAL CELL MIGRATION; FLANKING SEQUENCE; HOST CELLS; LIGAND BINDING; MATRIX METALLOPROTEASE; MULTIDOMAIN PROTEINS; PHOSPHOLIPASE C; RECEPTOR INTERACTION; RECOMBINANT PROTEIN; SIGNALING PATHWAYS; THROMBOSPONDIN; TIME-DEPENDENT;

AMINO ACIDS; BIOACTIVITY; CELL MEMBRANES; CYTOLOGY; LIGANDS; PEPTIDES;

PHOSPHORYLATION;

EPIDERMAL GROWTH FACTOR RECEPTOR; GELATINASE B; PHOSPHOLIPASE C GAMMA; THROMBOSPONDIN 1; TYROSINE; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEIN; THROMBOSPONDIN;

ARTICLE; BINDING AFFINITY; CELL MIGRATION; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RECEPTOR BINDING; TANDEM REPEAT; CELL MOTION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE;

AMINO ACID MOTIFS; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASE 9; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THROMBOSPONDINS; TIME FACTORS;

EID: 65249162907     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809198200     Document Type: Article

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