Function-blocking antithrombospondin-1 monoclonal antibodies

Journal of Thrombosis and Haemostasis

Volumn 4, Issue 2, 2006, Pages 459-468

  Annis, D S ^a   Murphy Ullrich, J E ^b   Mosher, Deane F ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Monoclonal antibody; Thrombospondin; Transforming growth factor

Indexed keywords

CALCIUM; EPIDERMAL GROWTH FACTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 133; MONOCLONAL ANTIBODY 5G11; MONOCLONAL ANTIBODY A4.1; MONOCLONAL ANTIBODY A6.1; MONOCLONAL ANTIBODY C6.7; MONOCLONAL ANTIBODY D4.6; MONOCLONAL ANTIBODY ESTS10; MONOCLONAL ANTIBODY ESTS12; MONOCLONAL ANTIBODY HB8432; MONOCLONAL ANTIBODY P10; MONOCLONAL ANTIBODY P12; MONOCLONAL ANTIBODY TSP127.6; PROPERDIN; PROTEIN ANTIBODY; THROMBOSPONDIN 1; THROMBOSPONDIN 2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN; THROMBOSPONDIN;

AMINO TERMINAL SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; CALCIUM BINDING; CONTROLLED STUDY; EPITOPE MAPPING; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; SCIENTIFIC LITERATURE; SEQUENCE HOMOLOGY; SPECIES COMPARISON; STEREOSPECIFICITY; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE; RAT; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; EPITOPE MAPPING; HUMANS; MICE; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS; THROMBOSPONDIN 1; THROMBOSPONDINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 33645578672     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2006.01723.x     Document Type: Article

References (57)

1. Adams JC. Thrombospondins: Multifunctional regulators of cell interactions. Annu Rev Cell Dev Biol 2001; 17: 25-51.
2. Mosher DF, Huwiler KG, Misenheimer TM, Annis DS. Expression of recombinant matrix components using baculoviruses. Methods Cell Biol 2002; 69: 69-81.
3. Calzada MJ, Annis DS, Zeng B, Marcinkiewicz C, Banas B, Lawler J, Mosher DF, Roberts DD. Identification of novel beta-1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1. J Biol Chem 2004; 279: 41734-43.
4. Kvansakul M, Adams JC, Hohenester E. Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats. Embo J 2004; 23: 1223-33.
5. Carlson CB, Bernstein AD, Annis DS, Misenheimer TM, Hannah BL, Mosher DF, Keck JL. Structure of the calcium-rich signature domain of human thrombospondin-2. Nat Struct Mol Biol 2005; 12: 910-14.
6. Clezardin P, McGregor JL, Lyon M, Clemetson KJ, Huppert J. Characterization of two murine monoclonal antibodies (P10, P12) directed against different determinants on human blood platelet thrombospondin. Eur J Biochem 1986; 154: 95-102.
7. Legrand C, Dubernard V, Kieffer N, Nurden AT. Use of a monoclonal antibody to measure the surface expression of thrombospondin following platelet activation. Eur J Biochem 1988; 171: 393-99.
8. Lawler J, Derick LH, Connolly JE, Chen J-H, Chao FC. The structure of human platelet thrombospondin. J Biol Chem 1985; 260: 3762-72.
9. Adams JC, Lawler J. Diverse mechanisms for cell attachment to platelet thrombospondin. J Cell Sci 1993; 104: 1061-71.
10. Jaffe EA, Ruggiero JT, Leung LK, Doyle MJ, McKeown-Longo PJ, Mosher DF. Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc Natl Acad Sci USA 1983; 80: 998-1002.
11. Dixit VM, Galvin NJ, O'Rourke KM, Frazier WA. Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J Biol Chem 1986; 261: 1962-68.
12. Dixit VM, Haverstick DM, O'Rourke KM, Hennessy SW, Grant GA, Santoro S, Frazier WA. A monoclonal antibody against human thrombospondin inhibits platelet aggregation. Proc Natl Acad Sci USA 1985; 82: 3472-76.
13. Prater CA, Plotkin J, Jaye D, Frazier WA. The properdin-like Type I repeats of human thrombospondin contain a cell attachment site. J Cell Biol 1991; 112: 1031-40.
14. Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor- β secreted by endothelial cells by a novel mechanism. J Cell Biol 1993; 122: 923-32.
15. Murphy-Ullrich JE, Schultz-Cherry S, Höök M. Transforming growth factor- β complexes with thrombospondin. Mol Biol Cell 1992; 3: 181 -88.
16. Misenheimer TM, Hahr AJ, Harms AC, Annis DS, Mosher DF. Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. J Biol Chem 2001; 276: 45882-87.
17. Huwiler KG, Vestling MM, Annis DS, Mosher DF. Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. Biochemistry 2002; 41: 14329-39.
18. Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J. C-mannosylation and O-fucosylation of the thrombospondin type 1 module. J Biol Chem 2001; 276: 6485-98.
19. Calzada MJ, Zhou L, Sipes JM, Zhang J, Krutzsch HC, Iruela-Arispe ML, Annis DS, Mosher DF, Roberts DD. Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo. Circ Res 2004; 94: 462-70.
20. Sottile J, Selegue J, Mosher DF. Synthesis of truncated amino-terminal trimers of thrombospondin. Biochemistry 1991; 30: 6556-62.
21. Panetti TS, Kudryk BJ, Mosher DF. Interaction of recombinant procollagen and properdin modules of thrombospondin-1 with heparin and fibrinogen/ fibrin. J Biol Chem 1999; 274: 430-37.
22. Chen H, Strickland DK, Mosher DF. Metabolism of thrombospondin 2. Binding and degradation by 3T3 cells and glycosaminoglycan-variant Chinese hamster ovary cells. J Biol Chem 1996; 271: 15993-99.
23. Chen H, Sottile J, O'Rourke KM, Dixit VM, Mosher DF. Properties of recombinant mouse thrombospondin 2 expressed in Spodoptera cells. J Biol Chem 1994; 269: 32226-32.
24. Murphy-Ullrich JE, Mosher DF. Localization of thrombospondin in clots formed in situ. Blood 1985; 66: 1098-104.
25. Hannah BL, Misenheimer TM, Pranghofer MM, Mosher DF. A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding. J Biol Chem 2004; 279: 51915-22.
26. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation 2001; 104: 2641-44.
27. Legrand C, Thibert V, Dubernard V, Bégault B, Lawler J. Molecular requirements for the interaction of thrombospondin with thrombin-activated human platelets: Modulation of platelet aggregation. Blood 1992; 79: 1995-2003.
28. Galvin NJ, Dixit VM, O'Rourke KM, Santoro SA, Grant GA, Frazier WA. Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing. J Cell Biol 1985; 101: 1434-41.
29. Misenheimer TM, Huwiler KG, Annis DS, Mosher DF. Physical characterization of the procollagen module of human thrombospondin 1 expressed in insect cells. J Biol Chem 2000; 275: 40938-45.
30. Calzada MJ, Roberts DD. Novel integrin antagonists derived from thrombospondins. Curr Pharm Des 2005; 11: 849-66.
31. Schultz-Cherry S, Chen H, Mosher DF, Misenheimer TM, Krutzsch HC, Roberts DD, Murphy-Ullrich JE. Regulation of transforming growth factor β activation by discrete sequences of thrombospondin 1. J Biol Chem 1995; 270: 7304-10.
32. Ribeiro SM, Poczatek M, Schultz-Cherry S, Villain M, Murphy-Ullrich JE. The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor- β. J Biol Chem 1999; 274: 13586-93.
33. Murphy-Ullrich JE, Poczatek M. Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology. Cytokine Growth Factor Rev 2000; 11: 59-69.
34. Young GD, Murphy-Ullrich JE. The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem 2004; 279: 47633-42.
35. Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH. Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol 2002; 159: 373-82.
36. Wiltscheck R, Kammerer RA, Dames SA, Schulthess T, Blommers MJ, Engel J, Alexandrescu AT. Heteronuclear NMR assignments and secondary structure of the coiled coil trimerization domain from cartilage matrix protein in oxidized and reduced forms. Protein Sci 1997; 6: 1734-45.
37. Hohenester E, Tisi D, Talts JF, Timpl R. The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin. Mol Cell 1999; 4: 783-92.
38. Harris LJ, Larson SB, Hasel KW, Day J, Greenwood A, McPherson A. The three-dimensional structure of an intact monoclonal antibody for canine lymphoma. Nature 1992; 360: 369-72.
39. Harris LJ, Skaletsky E, McPherson A. Crystallographic structure of an intact IgG1 monoclonal antibody. J Mol Biol 1998; 275: 861-72.
40. Sandin S, Ofverstedt LG, Wikstrom AC, Wrange O, Skoglund U. Structure and flexibility of individual immunoglobulin G molecules in solution. Structure (Camb) 2004;12: 409-15.
41. Adams JC, Lawler J. Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1. Mol Biol Cell 1994; 5: 423-37.
42. Roberts DD, Sherwood JA, Ginsburg V. Platelet thrombospondin mediates attachment and spreading of human melanoma cells. J Cell Biol 1987; 104: 131-39.
43. Yabkowitz R, Mansfield PJ, Ryan US, Suchard SJ. Thrombospondin mediates migration and potentiates platelet-derived growth factor-dependent migration of calf pulmonary artery smooth muscle cells. J Cell Physiol 1993; 157: 24-32.
44. Nesselroth SM, Willis AI, Fuse S, Olson ET, Lawler J, Sumpio BE, Gahtan V. The C-terminal domain of thrombospondin-1 induces vascular smooth muscle cell chemotaxis. J Vasc Surg 2001; 33: 595-600.
45. Mansfield PJ, Suchard SJ. Thrombospondin promotes chemotaxis and haptotaxis of human peripheral blood monocytes. J Immunol 1994; 153: 4219-29.
46. Harpel JG, Schultz-Cherry S, Murphy-Ullrich JE, Rifkin DB. Tamoxifen and estrogen effects on TGF-beta formation: Role of thrombospondin-1, alphavbeta3, and integrin-associated protein. Biochem Biophys Res Commun 2001; 284: 11-4.
47. Chen D, Asahara T, Krasinski K, Witzenbichler B, Yang J, Magner M, Kearney M, Frazier WA, Isner JM, Andres V. Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery. Circulation 1999; 100: 849-54.
48. Clezardin P, Serre C-M, Trzeciak M-C, Drouin J, Delmas PD. Thrombospondin binds to the surface of human osteosarcoma cells and mediates platelet-osteosarcoma cell interaction. Cancer Res 1991; 51: 2621-27.
49. Tolsma SS, Volpert OV, Good DJ, Frazier WA, Polverini PJ, Bouck N. Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. J Cell Biol 1993; 122: 497-511.
50. Good DJ, Polverini PJ, Rastinejad F, Le Beau MM, Lemons RS, Frazier WA, Bouck NP. A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc Natl Acad Sci USA 1990; 87: 6624-28.
51. Taraboletti G, Belotti D, Borsotti P, Vergani V, Rusnati M, Presta M, Glavazzi R. The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor. Cell Growth Differ 1997; 8: 471-79.
52. Osterhout DJ, Frazier WA, Higgins D. Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems. Dev Biol 1992; 150: 256-65.
53. Galvin NJ, Vance PM, Dixit VM, Fink B, Frazier WA. Interaction of human thrombospondin with types I-V collagen: Direct binding and electron microscopy. J Cell Biol 1987; 104: 1413-22.
54. Suchard SJ, Burton MJ, Dixit VM, Boxer LA. Human neutrophil adherence to thrombospondin occurs through a CD11/CD18-independent mechanism. J Immunol 1991; 146: 3945-52.
55. Sherwood JA, Roberts DD, Spitalnik SL, Lawler JW, Miller LH, Howard RJ. Falciparum malaria parasitized erythrocytes bind to a carboxy-terminal thrombospondin fragment and not the amino-terminal heparin-binding region. Mol Biochem Parasitol 1990; 40: 173-81.
56. Majluf-Cruz A, Manns JM, Uknis AB, Yang X, Colman RW, Harris RB, Frazier W, Lawler J, DeLa Cadena RA. Residues F16-G33 and A784-N823 within platelet thrombospondin-1 play a major role in binding human neutrophils: Evaluation by two novel binding assays. J Lab Clin Med 2000; 136: 292-302.
57. Hotchkiss KA, Chesterman CN, Hogg PJ. Catalysis of disulfide isomerization in thrombospondin 1 by protein disulfide isomerase. Biochemistry 1996; 35: 9761-67.