Bioactive peptides, networks and systems biology

BioEssays

Volumn 31, Issue 3, 2009, Pages 300-314

  Boonen, Kurt ^a   Creemers, John W ^a   Schoofs, Liliane ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Department of Biology   (Belgium)

Author keywords

Neuropeptides; Peptidomics; Signalling network; Systems biology

Indexed keywords

GLUCAGON; NEUROPEPTIDE; SOMATOSTATIN;

CELL DIFFERENTIATION; CELL INTERACTION; CELL METABOLISM; GENE DUPLICATION; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMMUNICATION; HUMANS; PEPTIDES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 65249144584     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.200800055     Document Type: Review

References (192)

1. Schwyzer, R., ACTH: a short introductory review. Ann N Y Acad Sci 1977. 28: 3-26.
2. Strand, F. L., Neuropeptides. Cambridge, The MITT Press, 1999.
3. Fricker, L. D., Neuropeptide-processing enzymes: applications for drugs discovery. AAPS J 2005. 7: 449-455.
4. Nemere, I. and Hintze, K., Novel hormone receptors. J Cell Biochem 2008. 103: 401-407.
5. Fuxe, K., Li, X. M., Tanganelli, S., Hedlund, P., O'Connor, W. T., et al. Receptor-receptor interactions and their relevance for receptor diversity. Focus on neuropeptide/dopamine interactions. Ann N Y Acad Sci 1995. 757: 365-376.
6. Mentlein, R., Cell-surface peptidases. Int Rev Cytol 2004. 235: 165-213.
7. Konkoy, C. S. and Davis, T. P., Ectoenzymes as sites of peptide regulation. Trends Pharmacol Sci 1996. 17: 288-294.
8. Hallberg, M. and Nyberg, F., Neuropeptide conversion to bioactive fragments - an important pathway in neuromodulation. Curr Protein Pept Sci 2003. 4: 31-44.
9. Klavdieva, M. M., The history of neuropeptides I/IV. Front Neuroendocrinol 1995. 16: 293-321; 1996. 17: 126-153, 155-179, 247-280.
10. Sanger, F. and Thompson, E. O., Amino acid sequence in the glycyl chain of insulin. I. Identification of lower peptides from partial hydrolysates. Biochem J 1953. 53: 353-366.
11. Sanger, F. and Thompson, E. O., Amino acid sequence in the glycyl chain of insulin. II. Identification of lower peptides from partial hydrolysates. Biochem J 1953. 53: 366-374.
12. Du Vigneaud, V., Ressler, C. and Trippett, S., The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. J Biol Chem 1953. 205: 949-957.
13. Popenoe, E. A. and Du Vigneaud, V., Degradative studies on vasopressin and performic acid-oxidized vasopressin. J Biol Chem 1953. 205: 133-143.
14. De Wied, D., The neuropeptide story. Front Neuroendocrinol 1997. 18: 101-113.
15. Kastin, A. J., Miller, L. H., Sandman, C. A., Schally, A. V. and Plotnikoff, N. P., CNS and pituitary effects of hypothalamic peptides and MSH. Essays Neurochem Neuropharmacol 1977. 1: 139-176.
16. Von Bohlen und Halbach, O., The renin-angiotensin system in the mammalian central nervous system. Curr. Protein Pept Sci 2005. 6: 355-371.
17. Chai, S. Y., Fernando, R., Peck, G., Ye, S. Y., Mendelsohn, F. A., et al. The angiotensin IV/AT4 receptor. Cell Mol Life Sci 2004. 61: 2728-2737.
18. Prado, C. L., Pugh-Bernard, A. E., Elghazi, L., Sosa-Pineda, B. and Sussel, L., Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 2004. 101: 2924-2949.
19. Ahrén, B., Wierup, N. and Sundler, F., Neuropeptides and the regulation of islet function. Diabetes 2006. 55: 98-107.
20. Raile, K., Klammt, J., Garten, A., Laue, S., Blüher, M., et al. Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells. Regul Pept 2006. 135: 30-38.
21. Vasir, B., Reitz, P., Xu, G., Sharma, A., Bonner-Weir, S., et al. Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia 2000. 43: 763-772.
22. Denef, C., Paracrine interactions in the anterior pituitary. Clin Endocrinol Metab 1986. 15: 1-32.
23. Houben, H. and Denef, C., Bioactive peptides in anterior pituitary cells. Peptides 1994. 15: 547-582.
24. Schwartz, J., Intercellular communication in the anterior pituitary. Endocr Rev 2000. 21: 488-513.
25. Dardenne, M. and Savino, W., Control of thymus physiology by peptidic hormones and neuropeptides. Immunol Today 1994. 115: 518-523.
26. Gnessi, L., Fabbri, A. and Spera, G., Gonadal peptides as mediators of development and functional control of the testis: an integrated system with hormones and local environment. Endocr Rev 1997. 18: 541-609.
27. Glasgow, E., Kusano, K., Chin, H., Mezey, E., Young, W. S. III, et al. Single cell reverse transcription-polymerase chain reaction analysis of rat supraoptic magnocellular neurons: neuropeptide phenotypes and high voltage-gated calcium channel subtypes. Endocrinology 1999. 140: 5391-5401.
28. Seuntjens, E., Hauspie, A., Roudbaraki, M., Vankelecom, H. and Denef, C., Combined expression of different hormone genes in single cells of normal rat and mouse pituitary. Arch Physiol Biochem 2002. 110: 12-15.
29. Boonen, K., Landuyt, B., Baggerman, G., Husson, S. J., Huybrechts, J., et al. Peptidomics: the integrated approach of MS, hyphenated techniques and bioinformatics for neuropeptide analysis. J Sep Sci 2008. 31: 427-445.
30. Che, F. Y., Yan, L., Li, H., Mzhavia, N., Devi, L. A., et al. Identification of peptides from brain and pituitary of Cpe(fat)/ Cpe(fat) mice. Proc Natl Acad Sci USA 2002. 98: 9971-9976.
31. Sigafoos, J., Chestnut, W. G., Merrill, B. M., Taylor, L. C., Diliberto, E. J. Jr., et al. Novel peptides from adrenomedullary chromaffin vesicles. J Anat 1993. 183: 253-264.
32. Hökfelt, T., Millhorn, D., Seroogy, K., Tsuruo, Y., Ceccatelli, S., et al. Coexistence of peptides with classical neurotransmitters. Experientia 1987. 43: 768-780.
33. Merighi, A., Costorage and coexistence of neuropeptides in the mammalian CNS. Prog Neurobiol 2002. 66: 161-190.
34. Barabási, A. L. and Oltvai, Z. N., Network biology: understanding the cell's functional organization. Nat Rev Genet 2004. 5: 101-113.
35. Almaas, E., Biological impacts and context of network theory. J Exp Biol 2007. 210: 1548-1558.
36. Cusick, M. E., Klitgord, N., Vidal, M. and Hill, D. E., Interactome: gateway into systems biology. Hum Mol Genet 2005. 14: R171-R181.
37. Wolf, Y. I., Karev, G. and Koonin, E. V., Scale-free networks in biology: new insights into the fundamentals of evolution? Bioessays 2002. 24: 105-109.
38. Arkin, A. and Ross, J., Computational functions in biochemical reaction networks. Biophys J 1994. 67: 560-578.
39. Alon, U., An introduction to systems biology: design principles of biological circuits. Chapman & Hall/CRC, Boca Raton, 2007.
40. Alon, U., Network motifs: theory and experimental approaches. Nat Rev Genet 2007. 8: 450-461.
41. Ma'ayan, A., Jenkins, S. L., Neves, S., Hasseldine, A., Grace, E., et al. Formation of regulatory patterns during signal propagation in a mammalian cellular network. Science 2005. 309: 1078-1083.
42. Itzkovitz, S., Levitt, R., Kashtan, N., Milo, R., Itzkovitz, M., et al. Coarse-graining and self-dissimilarity of complex networks. Phys Rev E Stat Nonlin Soft Matter Phys 2005. 71: 016127.
43. Hertz, J., Krogh, A. and Palmer, R. G., Introduction to the theory of neural computation. Boulder, Colorado, Perseus Books, 1991.
44. Bray, D., Protein molecules as computational elements in living cells. Nature 1995. 376: 307-312.
45. Bhalla, U. S. and Iyengar, R., Emergent properties of networks of biological signaling pathways. Science 1999. 283: 381-387.
46. Levchenko, A., Dynamical and integrative cell signaling: challenges for the new biology. Biotechnol Bioeng 2003. 84: 773-782.
47. Chen, R. E. and Thorner, J., Systems biology approaches in cell signaling research. Genome Biol 2005. 6: 235.
48. Komarova, N. L., Zou, X., Nie, Q. and Bardwell, L., A theoretical framework for specificity in cell signaling. Mol Syst Biol 2005. 1: 0023.
49. Tyson, J. J., Chen, K. C. and Novak, B., Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signalling pathways in the cell. Curr Opin Cell Biol 2003. 15: 221-231.
50. Asthagiri, A. R. and Lauffenburger, D. A., Bioengineering models of cell signaling. Annu Rev Biomed Eng 2000. 2: 31-53.
51. Ma'ayan, A., Blitzer, R. D. and Iyengar, R., Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct 2005. 34: 319-349.
52. Salers, P., Ouafik, L. H., Giraud, P., Dutour, A., Maltese, J. Y., et al. Evidence for pyroglutamyl peptidase I and prolyl endopeptidase activities in the rat insulinoma cell line RINm 5F: lack of relationship with TRH metabolism. Mol Cell Biochem 1991. 106: 15-24.
53. Grondin, G., Hooper, N. M. and LeBel, D., Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells. J Histochem Cytochem 1999. 47: 489-498.
54. Takahashi, M., Fukuda, K., Shimada, K., Barnes, K., Turner, A. J., et al. Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells. Biochem J 1995. 311: 657-665.
55. Zraika, S., Hull, R. L., Udayasankar, J., Clark, A., Utzschneider, K.M., et al. Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis. Diabetes 2007. 56: 304-310.
56. Mackin, R. B. and Noe, B. D., Characterization of an islet carboxypeptidase B involved in prohormone processing. Endocrinology 1987. 120: 457-468.
57. Guest, P. C., Ravazzola, M., Davidson, H. W., Orci, L. and Hutton, J. C., Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology 1991. 129: 734-740.
58. Fontés, G., Lajoix, A. D., Bergeron, F., Cadel, S., Prat, A., et al. Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B. Endocrinology 2005. 146: 702-712.
59. Mentzel, S., Dijkman, H. B., Van Son, J. P., Koene, R. A. and Assmann, K. J., Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice. J Histochem Cytochem 1996. 44: 445-461.
60. Conlon, J. M. and Larhammar, D., The evolution of neuroendocrine peptides. Gen Comp Endocrinol 2005. 142: 53-59.
61. Holmgren, S. and Jensen, J., Evolution of vertebrate neuropeptides. Brain Res Bull 2001. 55: 723-735.
62. Darlison, M. G. and Richter, D., Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends Neurosci 1999. 22: 81-88.
63. Davidson E. H. and Erwin, D. H., Gene regulatory networks and the evolution of animal body plans. Science 2006. 311: 796-800.
64. Yarden Y Sliwkowski, M. X., Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001. 2: 127-137.
65. Ogawa, K., Abe, K., Kurosawa, N., Kurohmaru, M. and Sugino, H., Expression of alpha, beta A and beta B subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett 1993. 319: 217-220.
66. Verspohl, E. J., Ammon, H. P. and Wahl, M. A., Activin A: its effects on rat pancreatic islets and the mechanism of action involved. Life Sci 1993. 53: 1069-1078.
67. Shibata, H., Yasuda, H., Sekine, N., Mine, T., Totsuka, Y., et al. Activin A increases intracellular free calcium concentrations in rat pancreatic islets. FEBS Lett 1993. 329: 194-198.
68. Shibata, H., Kanzaki, M., Takeuchi, T., Miyazaki, J. and Kojima, I., Two distinct signaling pathways activated by activin A in glucoseresponsive pancreatic beta-cell lines. J Mol Endocrinol 1996. 16: 249-258.
69. Totsuka, Y., Tabuchi, M., Kojima, I., Shibai, H. and Ogata, E., A novel action of activin A: stimulation of insulin secretion in rat pancreatic islets. Biochem Biophys Res Commun 1988. 156: 335-339.
70. Shiozaki, S., Tajima, T., Zhang, Y. Q., Furukawa, M., Nakazato, Y., et al. Impaired differentiation of endocrine and exocrine cells of the pancreas in transgenic mouse expressing the truncated type II activin receptor. Biochim Biophys Acta 1999. 1450: 1-11.
71. Graf, R., Immunocytochemical detection of anti-ACTH reactivity in pancreatic islet cells of normal and steroid diabetic rats. Histochemistry 1981. 73: 233-238.
72. Borelli, M. I., Morano, M. I., Estivariz, F. E. and Gagliardino, J. J., Glucose-induced secretion of ACTH-like products by rat pancreatic islets. Arch Int Physiol Biochim Biophys 1994. 102: 17-20.
73. Al-Majed, H. T., Jones, P.M., Persaud, S. J., Sugden, D., Huang, G. C., et al. ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans. J Endocrinol 2004. 180: 155-166.
74. Borelli, M. I., Estivariz, F. E. and Gagliardino, J. J., Evidence for the paracrine action of islet-derived corticotropin-like peptides on the regulation of insulin release. Metabolism 1996. 45: 565-570.
75. Martínez, A., Weaver, C., Lopez, J., Bhathena, S. J., Elsasser, T., et al. Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology 1996. 137: 2626-2632.
76. Martinez, A., Kapas, S., Miller, M. J., Ward, Y. and Cuttitta, F., Coexpression of receptors for adrenomedullin, calcitonin gene-related peptide, and amylin in pancreatic beta-cells. Endocrinology 2000. 141: 406-411.
77. Mulder, H., Ahren, B., Karlsson, S. and Sundler, F., Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion. Regul Pept 1996. 62: 107-112.
78. Fehmann, H. C., McGregor, G., Wever, V., Eissele, R., Goke, R., et al. The effects of two FMRFamide related peptides (A-18-F-amide and F-8-F-amide; 'morphine modulating peptides') on the endocrine and exocrine rat pancreas. Neuropeptides 1990. 17: 87-92.
79. Kim, H. S., Yumkham, S., Lee, H. Y., Cho, J. H., Kim, M. H., et al. C-terminal part of AgRP stimulates insulin secretion through calcium release in pancreatic beta Rin5mf cells. Neuropeptides 2005. 39: 385-393.
80. Leung, P. S., The physiology of a local renin-angiotensin system in the pancreas. J Physiol 2007. 580: 31-37.
81. Brasier, A. R., Philippe, J., Campbell, D. J. and Habener, J. F., Novel expression of the angiotensinogen gene in a rat pancreatic islet cell line. Transcriptional regulation by glucocorticoids. Trans Assoc Am Physicians 1986. 99: 13-19.
82. Ghiani, B. U. and Masini, M. A., Angiotensin II binding sites in the rat pancreas and their modulation after sodium loading and depletion. Comp Biochem Physiol A Physiol 1995. 111: 439-444.
83. Leung, K. K. and Leung, P. S., Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line. JOP 2008. 9: 290-299.
84. Sorhede Winzell, M., Magnusson, C. and Ahren, B., The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Regul Pept 2005. 131: 12-17.
85. Lindop, G. B., Mallon, E. A. and MacIntyre, G., Atrial natriuretic peptide in the heart and pancreas. Histol Histopathol 1986. 1: 147-154.
86. Verspohl, E. J., Kühn, M. and Ammon, H. P., RIN m5F (rat insulinoma) cells possess receptors for atrial natriuretic peptide (ANP) and a functioning cGMP system. Horm Metab Res 1988. 20: 700-701.
87. Verspohl, E. J. and Bernemann, I. K., Atrial natriuretic peptide (ANP)-induced inhibition of glucagon secretion: mechanism of action in isolated rat pancreatic islets. Peptides 1996. 17: 1023-1029.
88. Nowak, K. W., Rucinski, M., Kaczmarek, P., Szkudelski, T., Malendowicz, L. K., et al. Expression of the beacon gene in the rat pancreatic islets: opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets. 2004. 29: 99-103.
89. Powell, A. M., Voyles, N. R., Wilkins, S. D., Zalenski, C. M., Timmers, K. I., et al. Developmental patterns for pancreatic opioids in the rat. Pancreas 1989. 4: 694-701.
90. Cetin, Y., Immunohistochemistry of beta-neoendorphin and dynorphin in the endocrine pancreas of rat and man. Histochemistry 1985. 83: 369-373.
91. Khawaja, X. Z., Green, I. C., Thorpe, J. R. and Titheradge, M. A., The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat. Comparison with brain. Biochem J 1990. 267: 233-240.
92. Ahrén, B., Effects of beta-endorphin, met-enkephalin, and dynorphin A on basal and stimulated insulin secretion in the mouse. Int J Pancreatol 1989. 5: 165-178.
93. Yang, C., Lee, B., Chen, T. H. and Hsu, W. H., Mechanisms of bradykinin-induced insulin secretion in clonal beta cell line RINm5F. J Pharmacol Exp Ther 1997. 282: 1247-1252.
94. Moura, A. S., Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations. Braz J Med Biol Res 2000. 33: 1089-1092.
95. Yang, C., Chao, J. and Hsu, W. H., The effect of bradykinin on secretion of insulin, glucagon, and somatostatin from the perfused rat pancreas. Metabolism 1997. 46: 1113-1115.
96. Alwmark, A., Stavinoha, M. W., Cooper, C. W., Greeley G. H., Jr. and Thompson, J. C., Calcitonin inhibition of insulin release from isolated rat pancreatic islets. Diabetes 1986. 35: 58-60.
97. Ahrén, B. and Sundler, F., Localization of calcitonin gene-related peptide and islet amyloid polypeptide in the rat and mouse pancreas. Cell Tissue Res 1992. 269: 315-322.
98. Ahrén, B., Wierup, N. and Sundler, F., Neuropeptides and the regulation of islet function. Diabetes 2006. 55: 98-107.
99. Pettersson, M. and Ahrén, B., Insulin and glucagon secretion in rats: effects of calcitonin gene-related peptide. Regul Pept 1988. 23: 37-50.
100. Lewis, C. E., Clark, A., Ashcroft, S. J., Cooper, G. J. and Morris, J. F., Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cells. Mol Cell Endocrinol 1988. 57: 41-49.
101. Shimizu, K., Kato, Y., Shiratori, K., Ding, Y., Song, Y., et al. Evidence for the existence of CCK-producing cells in rat pancreatic islets. Endocrinology 1998. 139: 389-396.
102. Shimizu, K., Shiratori, K., Sakayori, N., Kobayashi, M. and Hayashi, N., Expression of cholecystokinin in the pancreas during development. Pancreas 1999. 19: 98-104.
103. Morisset, J., Julien, S. and Lainé, J., Localization of cholecystokinin receptor subtypes in the endocine pancreas. J Histochem Cytochem 2003. 51: 1501-1513.
104. Karlsson, S., Sundler, F. and Ahrén, B., CCK receptor subtype in insulin-producing cells: a combined functional and in situ hybridization study in rat islets and a rat insulinoma cell line. Regul Pept 1998. 78: 95-103.
105. 2+, Rb+ fluxes, of cAMP and cGMP for the CCK8-modulated insulin release. Regul Pept 1987. 17: 229-241.
106. Jensen, P. B., Kristensen, P., Clausen, J. T., Judge, M. E., Hastrup, S., et al. The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans. FEBS Lett 1999. 447: 139-143.
107. Wierup, N., Kuhar, M., Nilsson, B. O., Mulder, H., Ekblad, E., et al. Cocaine- and amphetamine-regulated transcript (CART) is expressed in several islet cell types during rat development. J Histochem Cytochem 2004. 52: 169-177.
108. Wierup, N., Richards, W. G., Bannon, A. W., Kuhar, M. J., Ahrén, B., et al. CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul Pept 2005. 129: 203-211.
109. Petrusz, P., Merchenthaler, I., Maderdrut, J. L., Vigh, S. and Schally, A. V., Corticotropin-releasing factor (CRF)-like immunoreactivity in the vertebrate endocrine pancreas. Proc Natl Acad Sci USA 1983. 80: 1721-1725.
110. 2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides 2006. 27: 1814-1819.
111. Moltz, J. H. and Fawcett, C. P., Corticotropin-releasing factor: its action on the islets of Langerhans. Endocr Res 1985. 11: 87-93.
112. Papotti, M., Tarabra, E., Allia, E., Bozzalla-Cassione, F., Broglio, F., et al. Presence of cortistatin in the human pancreas. J Endocrinol Invest 2003. 26: C15-18.
113. Josefsen, K., Buschard, K., Sørensen, L. R., Wøllike, M., Ekman, R., et al. Glucose stimulation of pancreatic beta-cell lines induces expression and secretion of dynorphin. Endocrinology 1998. 139: 4329-4336.
114. Green, I. C., Perrin, D., Penman, E., Yaseen, A., Ray, K., et al. Effect of dynorphin on insulin and somatostatin secretion calcium uptake, and c-AMP levels in isolated rat islets of Langerhans. Diabetes 1983. 32: 685-690.
115. Kugelmeier, P., Nett, P. C., Züllig, R., Lehmann, R., Weber, M., et al. Expression and hypoxic regulation of the endothelin system in endocrine cells of human and rat pancreatic islets. JOP 2008. 2: 133-149.
116. Brock, B., Gregersen, S., Kristensen, K., Thomsen, J. L., Buschard, K., et al. The insulinotropic effect of endothelin-1 is mediated by glucagon release from the islet alpha cells. Diabetologia 1999. 42: 1302-1307.
117. De Carlo, E., Milanesi, A., Martini, C., Maffei, P., Sicolo, N., et al. Endothelin-1 and endothelin-3 stimulate insulin release by isolated rat pancreatic islets. J Endocrinol Invest 2000. 23: 240-245.
118. Verspohl, E. J., Berger, U. and Ammon, H. P., The significance of mu-and delta-receptors in rat pancreatic islets for the opioid-mediated insulin release. Biochim Biophys Acta 1986. 888: 217-224.
119. Green, I. C., Ray, K. and Perrin, D., Opioid peptide effects on insulin release and c-AMP in islets of Langerhans. Horm Metab Res 1983. 15: 124-128.
120. Salazar, R. and Zühlke, H., Expression of the insulin gene is regulated by opioid peptides. Biomed Biochim Acta 1990. 49: 1165-1170.
121. Rodríguez-Gallardo, J., Silvestre, R. A. and Marco, J., Inhibitory effect of enterostatin on the beta cell response to digestive insulinotropic peptides. Int J Obes Relat Metab Disord 1999. 23: 787-792.
122. Wang, Z. L., Kulkarni, R. N., Wang, R. M., Smith, D. M., Ghatei, M. A., et al. Possible evidence for endogenous production of a novel galanin-like peptide. J Clin Invest 1997. 100: 189-196.
123. McDermott, A. M. and Sharp, G. W., Gi2 and Gi3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell. Diabetes 1995. 44: 453-459.
124. Baggio, L. L. and Drucker, D. J., Biology of incretins: GLP-1 and GIP. Gastroenterology 2007. 132: 2131-2157.
125. Suzuki, S., Kawai, K., Ohashi, S., Watanabe, Y. and Yamashita, K., Interaction of glucagon-like peptide-1(7-36) amide and gastric inhibitory polypeptide or cholecystokinin on insulin and glucagon secretion from the isolated perfused rat pancreas. Metabolism 1992. 41: 359-363.
126. Wang, T. C., Bonner-Weir, S., Oates, P. S., Chulak, M., Simon, B., et al. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest 1993. 92: 1349-1356.
127. Brand, S. J. and Wang, T. C., Gastrin gene expression and regulation in rat islet cell lines. J Biol Chem 1988. 263: 16597-16603.
128. Rooman, I. and Bouwens, L., Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 2004. 47: 259-265.
129. Wahl, M. A., Landsbeck, E. A., Ammon, H. P. and Verspohl, E. J., Gastrin-releasing peptide: binding and functional studies in mouse pancreatic islets. Pancreas 1992. 7: 345-351.
130. Kloss, H., Wahl, M. A., Neye, H. and Verspohl, E. J., Modulation of gastrin-releasing peptide (GRP) receptors in insulin secreting cells. Cell Biochem Funct 1999. 17: 229-236.
131. Date, Y., Nakazato, M., Hashiguchi, S., Dezaki, K., Mondal, M. S., et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002. 51: 124-129.
132. Kageyama, H., Funahashi, H., Hirayama, M., Takenoya, F., Kita, T., et al. Morphological analysis of ghrelin and its receptor distribution in the rat pancreas. Regul Pept 2005. 126: 67-71.
133. Adeghate, E. and Ponery, A. S., Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. J Neuroendocrinol 2002. 14: 555-560.
134. Colombo, M., Gregersen, S., Xiao, J. and Hermansen, K., Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets. Pancreas 2003. 27: 161-166.
135. 2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 2004. 53: 3142-3151.
136. Bosman, F. T., Van Assche, C., Nieuwenhuyzen Kruseman, A. C., Jackson, S. and Lowry, P. J., Growth hormone releasing factor (GRF) immunoreactivity in human and rat gastrointestinal tract and pancreas. J Histochem Cytochem 1984. 32: 1139-1144.
137. Green, I. C., Southern, C. and Ray, K., Mechanism of action of growth-hormone-releasing hormone in stimulating insulin secretion in vitro from isolated rat islets and dispersed islet cells. Horm Res 1990. 33: 199-204.
138. Nakazato, M., Yamaguchi, H., Date, Y., Miyazato, M., Kangawa, K., et al. Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylin. Endocrinology 1998. 139: 5247-5254.
139. Hauge-Evans, A. C., Richardson, C. C., Milne, H. M., Christie, M. R., Persaud, S. J., et al. A role for kisspeptin in islet function. Diabetologia 2006. 49: 2131-2135.
140. Silvestre, R. A., Egido, E. M., Hernández, R. and Marco, J., Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol 2008. 196: 283-290.
141. Kieffer, T. J., Heller, R. S. and Habener, J. F., Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun 1996. 224: 522-527.
142. Fehmann, H. C., Bode, H. P., Ebert, T., Karl, A. and Göke, B., Interaction of GLP-I and leptin at rat pancreatic B-cells: effects on insulin secretion and signal transduction. Horm Metab Res 1997. 29: 572-576.
143. Fehmann, H. C., Peiser, C., Bode, H. P., Stamm, M., Staats, P., et al. Leptin: a potent inhibitor of insulin secretion. Peptides 1997. 18: 1267-1273.
144. Seppälä, M., Wahlström, T. and Leppäluoto, J., Luteinizing hormonereleasing factor (LRF)-like immunoreactivity in rat pancreatic islet cells. Life Sci 1979. 25: 1489-1496.
145. Klier, M., Schusdziarra, V. and Pfeiffer, E. F., Effect of luteinizing hormone-releasing hormone upon insulin release from rat islets in vitro. FEBS Lett 1980. 121: 363-364.
146. Pissios, P., Ozcan, U., Kokkotou, E., Okada, T., Liew, C. W., et al. Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes 2007. 56: 311-319.
147. Tadayyon, M., Welters, H. J., Haynes, A. C., Cluderay, J. E. and Hervieu, G., Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines. Biochem Biophys Res Commun 2000. 275: 709-712.
148. Kawai, K., Mukai, H., Chiba, Y., Ohmori, H., Suzuki, S., et al. Effects of neuromedin B on insulin and glucagon release from the isolated perfused rat pancreas. Endocrinol Jpn 1989. 36: 587-594.
149. Nakamura, T., Otsuki, M., Okabayashi, Y., Fujii, M., Tani, S., et al. Effects of neuromedin B and neuromedin C on insulin release from isolated perfused rat pancreas. Nippon Naibunpi Gakkai Zasshi 1989. 65: 695-703.
150. Kaczmarek, P., Malendowicz, L. K., Pruszynska-Oszmalek, E., Wojciechowicz, T., Szczepankiewicz, D., et al. Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets. Int J Mol Med 2006. 18: 951-955.
151. Jamal, H., Jones, P. M., Byrne, J., Suda, K., Ghatei, M. A., et al. Peptide contents of neuropeptide Y, vasoactive intestinal polypeptide, and beta-calcitonin gene-related peptide and their messenger ribonucleic acids after dexamethasone treatment in the isolated rat islets of Langerhans. Endocrinology 1991. 129: 3372-3380.
152. Teitelman, G., Alpert, S., Polak, J. M., Martinez, A. and Hanahan, D., Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. Development 1993. 118: 1031-1039.
153. Cho, Y. R. and Kim, C. W., Neuropeptide Y promotes beta-cell replication via extracellular signal-regulated kinase activation. Biochem Biophys Res Commun 2004. 314: 773-780.
154. Moltz, J. H. and McDonald, J. K., Neuropeptide Y: direct and indirect action on insulin secretion in the rat. Peptides 1985. 6: 1155-1159.
155. Berelowitz, M. and Frohman, L. A., Immunoreactive neurotensin in the pancreas of genetically obese and diabetic mice. A longitudinal study. Diabetes 1983. 32: 51-54.
156. Coppola, T., Béraud-Dufour, S., Antoine, A., Vincent, J. P. and Mazella, J., Neurotensin protects pancreatic beta cells from apoptosis. Int J Biochem Cell Biol 2008. 40: 2296-2302.
157. Dolais-Kitabgi, J., Kitabgi, P., Brazeau, P. and Freychet, P., Effect of neurotensin on insulin, glucagon, and somatostatin release from isolated pancreatic islets. Endocrinology 1979. 105: 256-260.
158. Ouedraogo, R., Näslund, E. and Kirchgessner, A. L., Glucose regulates the release of orexin-A from the endocrine pancreas. Diabetes 2003. 52: 111-117.
159. Nowak, K. W., Strowski, M. Z., Switonska, M. M., Kaczmarek, P., Singh, V., et al. Evidence that orexins A and B stimulate insulin secretion from rat pancreatic islets via both receptor subtypes. Int J Mol Med 2005. 15: 969-972.
160. Göncz, E., Strowski, M. Z., Grötzinger, C., Nowak, K. W., Kaczmarek, P., et al. Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway. Endocrinology 2008. 149: 1618-1826.
161. Johansson, O., Hilliges, M., Olsson, A., Ostenson, C. G., Morris, M., et al. Oxytocin in pancreatic islets - immunohistochemical localization in normal and non-insulin-dependent diabetic rats. Acta Physiol Scand 1991. 141: 143-144.
162. Lee, B., Yang, C., Chen, T. H., al-Azawi, N. and Hsu, W. H., Effect of AVP and oxytocin on insulin release: involvement of V1b receptors. Am J Physiol 1995. 269: E1095-1100.
163. Lee, B., Chen, T. H. and Hsu, W. H., Oxytocin-stimulated insulin release in a clonal beta-cell line RINm5F: involvement of phospholipase C-dependent and!independent pathways. Zhongguo Yao Li Xue Bao 1996. 17: 390-394.
164. Yada, T., Sakurada, M., Ishihara, H., Nakata, M., Shioda, S., et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats. J Physiol 1997. 505: 319-328.
165. 2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors. Regul Pept 2004. 123: 147-153.
166. Meuris, S., Verloes, A. and Robyn, C., Immunocytochemical localization of prolactin-like immunoreactivity in rat pancreatic islets. Endocrinology 1983. 112: 2221-2223.
167. Sorenson, R. L. and Stout, L. E., Prolactin receptors and JAK2 in islets of Langerhans: an immunohistochemical analysis. Endocrinology 1995. 136: 4092-4098.
168. Amaral, M. E., Ueno, M., Carvalheira, J. B., Carneiro, E. M., Velloso, L. A., et al. Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway. Horm Metab Res 2003. 35: 282-289.
169. Tian, Y. and Laychock, S. G., Prolactin regulates adenylyl cyclase and insulin secretion in rat pancreatic islets. Mol Cell Endocrinol 2003. 204: 75-84.
170. Minn, A. H., Patterson, N. B., Pack, S., Hoffmann, S. C., Gavrilova, O., et al. Resistin is expressed in pancreatic islets. Biochem Biophys Res Commun 2003. 310: 641-645.
171. Brown, J. E., Onyango, D. J. and Dunmore, S. J., Resistin downregulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells. FEBS Lett 2007. 581: 3273-3276.
172. Rufener, C., Amherdt, M., Baetens, D., Yanaihara, N. and Orci, L., Immunofluorescent localization of secretin in pancreatic monolayer culture. Histochemistry 1976. 47: 171-173.
173. Otsuki, M., Sakamoto, C., Ohki, A., Yuu, H., Morita, S., et al. Effects of porcine secretin on exocrine and endocrine function in the isolated perfused rat pancreas. Am J Physiol 1981. 241: G43-48.
174. De Giorgio, R., Sternini, C., Anderson, K., Brecha, N. C. and Go, V. L., Tissue distribution and innervation pattern of peptide immunoreactivities in the rat pancreas. Peptides 1992. 13: 91-98.
175. McGregor, G. P., Hartel, R., Haberberger, R., Kummer, W. and Voigt, K., Preprotachykinin-A gene expression occurs transiently in the developing rat endocrine pancreas and can be regulated in RINm5F cells. Endocrinology 1995. 136: 2538-2546.
176. Persson-Sjögren, S., Lejon, K., Holmberg, D. and Forsgren, S., Expression of the NK-1 receptor on islet cells and invading immune cells in the non-obese diabetic mouse. J Autoimmun 2005. 24: 269-279.
177. Fu, X. W. and Sun, A. M., Stimulative effect of substance P on insulin secretion from isolated rat islets under normobaric oxygen incubation. Zhongguo Yao Li Xue Bao 1989. 10: 69-73.
178. Fu, X. W., Shen, X. M., Su, Q. F. and Zhang, J. R., Effects of substance P on electric activity of mouse pancreatic islet cells in vitro. Zhongguo Yao Li Xue Bao 1991. 12: 328-330.
179. Martino, E., Lernmark, A., Seo, H., Steiner, D. F. and Refetoff, S., High concentration of thyrotropin-releasing hormone in pancreatic islets. Proc Natl Acad Sci USA 1978. 75: 4265-4267.
180. Yamada, M., Shibusawa, N., Hashida, T., Ozawa, A., Monden, T., et al. Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting
181. Najvirtová, M., Bacová, Z., Mátéffyová, A. and Strbák, V., A role of thyrotropin-releasing hormone in insulin secretion by isolated rat pancreatic islets. Pflugers Arch 2005. 449: 547-552.
182. Nielsen, J. H., Mechanisms of pancreatic beta-cell growth and regeneration: studies on rat insulinoma cells. Exp Clin Endocrinol 1989. 93: 277-285.
183. Fragner, P., Quette, J. and Aratan-Spire, S., Thyroid status and the regulation of thyrotropin-releasing hormone synthesis in rat pancreatic islets: comparison with insulin regulation. Biochem Biophys Res Commun 1998. 247: 564-568.
184. Li, C., Chen, P., Vaughan, J., Blount, A., Chen, A., et al. Urocortin III is expressed in pancreatic beta-cells and stimulates insulin and glucagon secretion. Endocrinology 2003. 144: 3216-3224.
185. 2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells. Peptides 2006. 27: 1814-1819.
186. 2+ influx in rat pancreatic beta-cells. Diabetes 1999. 48: 1741-1746.
187. Silvestre, R. A., Rodríguez-Gallardo, J., Egido, E. M. and Marco, J., Inhibition of insulin release by urotensin II - a study on the perfused rat pancreas. Horm Metab Res 2001. 33: 379-381.
188. Inagaki, N., Kuromi, H. and Seino, S., PACAP/VIP receptors in pancreatic beta-cells: their roles in insulin secretion. Ann N Y Acad Sci 1996. 805: 44-51.
189. Emami, S., Regnauld, K., Ferrand, N., Astesano, A., Pessah, M., et al. Stimulatory transducing systems in pancreatic islet cells. Ann N Y Acad Sci 1998. 865: 118-131.
190. Kato, I., Suzuki, Y., Akabane, A., Yonekura, H., Tanaka, O., et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem 1994. 269: 21223-21228.
191. Sánchez-Franco, F., Cacicedo, L., Vasallo, J. L., Blazquez, J. L., Muñoz Barragan, L., Arginine-vasopressin immunoreactive material in the gastrointestinal tract. Histochemistry 1986. 85: 419-422.
192. Khalaf, L. J. and Taylor, K. W., Pertussis toxin reverses the inhibition of insulin secretion caused by [Arg8]vasopressin in rat pancreatic islets. FEBS Lett 1988. 231: 148-150.