Presence of cortistatin in the human pancreas

Journal of Endocrinological Investigation

Volumn 26, Issue 8, 2003, Pages

  Papotti, M ^a   Tarabra, E ^a   Allia E ^a   Bozzalla Cassione, F ^a   Broglio, F ^a   Deghenghi, R ^a   Ghigo, E ^a   Muccioli, Giampiero ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Cortistatin; Endocrine pancreas; Ghrelin; Immunohistochemistry; RT PCR; Somatostatin

Indexed keywords

ANTIBODY; CORTISTATIN; GHRELIN; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; INSULIN; MESSENGER RNA; PEPTIDE; RNA; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 5; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ARTICLE; AUTOCRINE EFFECT; BRAIN CORTEX; CONTROLLED STUDY; EXOCRINE GLAND; HORMONAL REGULATION; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INHIBITION KINETICS; INSULIN RELEASE; NORMAL HUMAN; PANCREAS; PANCREAS ISLET; PANCREAS ISLET CELL; PARACRINE SIGNALING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLEEP INDUCTION; STOMACH ACID SECRETION; TISSUE LEVEL;

EID: 17444442311     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347348     Document Type: Article

References (22)

1. de Lecea L, del Rio JA, Criado JR, et al. Cortistatin is expressed in a distinct subset of cortical interneurons. J Neurosci 1997, 17: 5868-80.
2. Fukusumi S, Kitada C, Takekawa S, et al. Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun 1997, 232: 157-63.
3. Ejeskar K, Abel F, Sjoberg R, Backstrom J, Kogner P, Martinsson T. Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3_p36.2, but absence of mutations in primary tumors. Cytogenet Cell Genet 2000, 89: 62-6.
4. Spier AD, de Lecea L. Cortistatin: A member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Rev 2000, 33: 228-41.
5. Deghenghi R, Papotti M, Ghigo E, Muccioli G. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. J Endocrinol Invest 2001, 24: RC1-3.
6. Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity. Eur J Pharmacol 2002, 440: 235-54.
7. Broglio F, Arvat E, Benso A, et al. Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. J Clin Endocrinol Metab 2002, 87: 3783-90.
8. Broglio F, van Koetsveld P, Benso A, et al. Ghrelin secretion is inhibited by either somatostatin or cortistatin in human. J Clin Endocrinol Metab 2002, 87: 4829-32.
9. Deghenghi R, Avallone R, Torsello A, Muccioli G, Ghigo E, Locatelli V. Growth hormone-inhibiting activity of cortistatin in the rat. J Endocrinol Invest 2001, 24: RC31-3.
10. Dalm J, van Hagen PM, van Koetsveld PM, et al. Cortistatin rather then somatostatin as potential endogenous ligand for somatostatin receptors in the human immune system. J Clin Endocrinol Metab 2003, 88: 270-6.
11. Broglio F, Arvat E, Benso A, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 2001, 86: 5083-6.
12. Volante M, Allìa E, Gugliotta P, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002, 87: 1300-08.
13. Ukkola O. Ghrelin and insulin metabolism. Eur J Clin Invest 2003, 33: 183-5.
14. Reubi JC, Kappeler A, Waser B, Schonbrunn A, Laissue J. Immunohistochemical localization of somatostatin receptor sst2A in human pancreatic islets. J Clin Endocrinol Metab 1998, 83: 3746-9.
15. Papotti M, Bongiovanni M, Volante M, et al. Expression of somatostatin receptor types 1-5 in 81 cases of gastro-intestinal and pancreatic (GEP) endocrine tumors. A correlative immunohistochemical and RT-PCR analysis. Virchows Arch 2002, 440: 461-75.
16. Papotti M, Cassoni P, Volante M, Deghenghi R, Muccioli G, Ghigo E. Ghrelin-producing endocrine tumors of the stomach and intestine. J Clin Endocrinol Metab 2001, 86: 5052-9.
17. Sanchez-Alavez M, Gomez-Chavarin M, Navarro L, et al. Cortistatin modulates memory processes in rats. Brain Res 2000, 858: 78-83.
18. de Lecea L, Sutcliffe JR. Peptides, sleep and cortistatin. Mol Psychiatry 1996, 1: 349-51.
19. Patel YC. Somatostatin and its receptor family. Front Neuroendocrinol 1999, 20: 157-98.
20. Kojima M, Hosoda H, Kangawa K. Purification and distribution of ghrelin: The natural endogenous ligand for the growth hormone secretagogue receptor. Horm Res 2001, 56: 93-7.
21. Arosio M, Ronchi CL, Gebbia C, Cappiello V, Beck-Peccoz P, Peracchi M. Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. J Clin Endocrinol Metab 2003, 88: 701-4.
22. Lucidi P, Murdolo G, Di Loreto C, et al. Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia. Diabetes 2002, 51: 2911-4.