Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells

Journal of Histochemistry and Cytochemistry

Volumn 47, Issue 4, 1999, Pages 489-497

  Grondin, Gilles ^a   Hooper, Nigel M ^b   LeBel, Denis ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Dipeptidyl peptidase IV; Endocrine pancreas; Glucagon; Membrane dipeptidase; Pancreatic polypeptide; PP cells; Secretion granule; cells

Indexed keywords

DIPEPTIDASE; DIPEPTIDYL PEPTIDASE IV; GLUCAGON; PANCREAS ENZYME; PANCREAS HORMONE; PANCREAS POLYPEPTIDE;

ANIMAL TISSUE; ARTICLE; ENDOTHELIUM CELL; ENZYME LOCALIZATION; ENZYME SUBSTRATE; IMMUNOCYTOCHEMISTRY; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SECRETORY GRANULE; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0032927798     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549904700407     Document Type: Article

References (30)

1. Arvan P, Kuliawat R, Prabakaran D, Zavacki AM, Elahi D, Wang S, Pilkey D (1991) Protein discharge from immature secretory granules displays both regulated and constitutive characteristics. J Biol Chem 266:14171-14174
2. Baldissera FG (1994) Differential processing of regulatory peptide precursors in pancreas and gut: studies of proglucagon and prosomatostatin processing. Danish Med Bull 41:79-92
3. Bendayan M (1984) Concentration of amylase along its secretory pathway in the pancreatic acinar cell as revealed by high resolution immunocytochemistry. Histochem J 16:85-108
4. Dickinson CJ, Takeuchi T, Guo Y-J, Stadler BT, Yamada T (1993) Expression and processing of prohormones in nonendocrine cells. Am J Physiol 264:G553-560
5. Dittié AS, Thomas L, Thomas G, Tooze SA (1997) Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation. EMBO J 16:4859-4870
6. Drucker DJ, Shi Q, Crivici A, Sumner-Smith M, Tavares W, Hill M, Deforest L, Cooper S, Brubaker PL (1997) Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV. Nature Biotechnol 15:673-677
7. Frohman L, Downs T, Heimer E, Felix A (1989) Dipeptidyl peptidase-IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma. J Clin Invest 83:1533-1540
8. Halban PA, Irminger JC (1994) Sorting and processing of secretory proteins. Biochem J 299:1-18
9. Hook VYH, Azaryan AV, Hwang S-R, Tezapsidis N (1994) Proteases and the emerging role of protease inhibitors in prohormone processing. FASEB J 8:1269-1278
10. Hooper NM, Cook S, Lainé J, LeBel D (1997a) Identification of membrane dipeptidase as a major glycosyl-phosphatidylinositol-anchored protein of the pancreatic zymogen granule membrane, and evidence for its release by phospholipase A. Biochem J 324:151-157
11. Hooper NM, Karran EH, Turner AJ (1997b) Membrane protein secretases. Biochem J 321:265-279
12. Howell S, Brewis IA, Hooper NM, Kenny AJ, Turner AJ (1993) Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Lett 317:109-112
13. Keynan S, Hooper NM, Turner AJ (1996) Molecular and functional aspects of membrane dipeptidase. In Hooper NM, ed. Zinc Metalloproteases in Health and Disease. London, Taylor & Francis, 285-309
14. Kieffer TJ, Mcintosh CHS, Pederson RA (1995) Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136:3585-3596
15. LeBel D, Grondin G, Cook S, Hooper NM (1998) Membrane dipeptidase in the pig exocrine pancreas: ultrastructural localization and secretion. J Histochem Cytochem 46:841-846
16. Like AA, Orci L (1972) Embryogenesis of the human pancreatic islets: a light and electron microscopic study. Diabetes 21:511-534
17. Littlewood M, Hooper NM, Turner AJ (1989) Ectoenzymes of the kidney microvillar membrane. Affinity purification, characterization and localization of the phospholipase C-solubilized form of renal dipeptidase. Biochem J 257:361-367
18. Loh YP, Beinfeld MC, Birch NP (1993) Proteolytic processing of prohormones and proneuropeptides. In Loh YP, ed. Mechanisms of Intracellular Trafficking and Processing of Proproteins. Boca Raton, FL, CRC Press, 179-224
19. Macnair DC, Kenny AJ (1979) Proteins of the kidney microvillar membrane. The amphipathic form of dipeptidyl peptidase IV. Biochem J 179:379-395
20. Medeiros MS, Turner AJ (1996) Metabolism and functions of neuropeptide Y. Neurochem Res 21:1125-1132
21. Mentlain R, Gallwitz B, Schmidt W (1993) Dipeptidyl peptidase-IV hydrolyses gastric inhibitory peptide (GIP), glucagon-like peptide-1(7-36) amide, peptide histidine methionine (PHM) and is responsible for their degradation in human serum. Eur J Biochem 214:829-835
22. Mentlein R, Dahms P, Grandt D, Kruger R (1993) Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV. Regul Pept 49:133-134
23. Orci L, Ravazzola M, Anderson RGW (1987) The condensing vacuole of exocrine cells is more acidic than the mature secretory vesicle. Nature 326:77-79
24. Paquette J, Leblond FA, Beattie M, LeBel D (1986) Reducing conditions induce a total degradation of the major zymogen granule membrane protein in both its membranous and its soluble form. Immunochemical quantitation of the two forms. Biochem Cell Biol 64:456-462
25. Poulsen MD, Hansen GH, Dabelsteen E, Hoyer PE, Norén O, Sjöström H (1993) Dipeptidyl peptidase IV is sorted to the secretory granules in pancreatic islet A-cells. J Histochem Cytochem 41:81-88
26. Proost P, De Meester I, Schols D, Struyf S, Lambeir AM, Wuyts A, Opdenakker G, De Clercq E, Scharpe S, Van Damme J (1998) Ammo-terminal truncation of chemokines by CD26/dipeptidylpeptidase IV - conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. J Biol Chem 273:7222-7227
27. Ravazzola M, Benoit R, Ling N, Guillemain R, Orci L (1983) Immunocytochemical localization of prosomatostatin fragments in maturing and mature secretory granules of pancreatic and gastrointestinal D cells. Proc Natl Acad Sci USA 80:215-218
28. Rombout JH, Abad ME, Binkhorst FM, Taverne-Thiele JJ (1987) Coexistence of pancreatic polypeptide (PP)-and glucagon-immunoreactivity in pancreatic endocrine cells of mouse. Histochemistry 87:1-6
29. Trugnan G, Aït-Slimane T, David F, Baricault L, Berbar T, Lenoir C, Sapin C (1997) Dipeptidyl peptidase IV (DPP-IV/CD26): biochemistry and control of cell-surface expression. In Kenny AJ, Boustead CM, eds. Cell-surface Peptidases in Health and Disease. Oxford, BIOS Scientific Publishers, 203-217
30. Vanhoof G, Goossens F, De Meester I, Hendriks D, Scharpe S (1995) Proline motifs in peptides and their biological processing. FASEB J 9:736-744