Expression of the beacon gene in the rat pancreatic islets: Opposite effects of beacon (47-73) protein (ubiquitin-like protein 5) on insulin secretion in vivo and insulin release by isolated islets

Pancreas

Volumn 29, Issue 2, 2004, Pages 99-103

  Nowak, Krzysztof W ^a   Ruciński, Marcin ^b   Kaczmarek, Przemysław ^a   Szkudelski, Tomasz ^a   Malendowicz, Ludwik K ^b  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Beacon; Beacon mRNA; Glucose; Immunocytochemistry; Insulin; Pancreatic islets; Rat

Indexed keywords

GENE PRODUCT; INSULIN; MESSENGER RNA; PROTEIN BEACON[47-73]; UBIQUITIN LIKE PROTEIN 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BEACON GENE; CELL ISOLATION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE FUNCTION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; INJECTIONS, SUBCUTANEOUS; INSULIN; ISLETS OF LANGERHANS; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UBIQUITINS;

EID: 3242775614     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200408000-00003     Document Type: Article

References (21)

1. Shafrir E, Gutman A. Psammomys obesus of the Jerusalem colony: a model for nutritionally induced, non-insulin-dependent diabetes. J Basic Clin Phys Pharm. 1993;4:83-99.
2. Barnett M, Collier GR, Collier FM, et al. A cross-sectional and short-term longitudinal characterization of NIDDM in Psammomys obesus. Diabetologia. 1994;37:671-676.
3. Collier GR, McMillan JS, Windmill K, et al. Beacon: a novel gene involved in the regulation of energy balance. Diabetes. 2000;49:1766-1771.
4. Walder KR, Fahey RP, Morton GJ, et al. Characterization of obesity phenotypes in Psammomys obesus (Israeli sand rats). Int J Exp Diabetes Res. 2000;1:177-184.
5. Walder K, Ziv E, Kalman R, et al. Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes. Int J Obes. 2002;26:605-609.
6. Walder K, Segal D, Jowett J, et al. Obesity and diabetes gene discovery approaches. Curr Pharm Des. 2003;9:1357-1372.
7. Walder K, McMillan JS, Civitarese A, et al. Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obsesus (Israeli sand rats). Int J Obes. 2001;25:1281-1285.
8. Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 1967;16:35-39.
9. Friedman JS, Koop BF, Raymond V, et al. Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes. Genomics. 2001;71:252-255.
10. Dittmar GAG, Wilkinson CRM, Finley D. Role of a ubiquitin-like modification in polarized morphogenesis. Science. 2002;295:2442-2446.
11. Jentsch S, Pyrowolakis G. Ubiquitin and its kin: how close are the family ties? Trends Cell Biol. 2000;10:335-342.
12. Adeghate T, Ponery AS, Pallot DJ, et al. Distribution of vasoactive intestinal polypeptide, neuropeptide-Y and substance-P and their effects on insulin secretion from the in vitro pancreas of normal and diabetic rats. Peptides. 2001;22:99-107.
13. Sainsbury A, Rohner-Jeanrenaud F, Cusin I, et al. Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary- adrenal axis, and vagal mediation of hyperinsulinaemia. Diabetologia. 1997;40:1269-1277.
14. Nowak KW, Maćkowiak P, Świtońska MM, et al. Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci. 2000;66: 449-454.
15. Świtońska MM, Kaczmarek P, Malendowicz LK, et al. Orexins and adipoinsular axis function in the rat. Regul Pept. 2002;104:69-73.
16. Colombo M, Gregersen S, Xiao J, et al. Effect of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets. Pancreas. 2003;27:161-166.
17. Gomori A, Ishihara A, Ito M, et al. Chronic intracerebroventricular infusion of MCH causes obesity in mice. Am J Physiol Endocrinol Metab. 2002;284:E583-E588.
18. Reimer MK, Pacini G, Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology. 2003;144:916-921.
19. Tassone F, Broglio F, Destefanis S, et al. Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity. J Clin Endocrinol Metab. 2003;88:5478-5483.
20. Manabe T, Okada Y, Sawai H, et al. Effect of galanin on plasma glucose, insulin and pancreatic glucagon in dogs. J Int Med Res. 2003;31:126-132.
21. Nowak KW, Maćkowiak P, Nogowski L, et al. Acute leptin action on insulin blood level and insulin receptor in the rat. Life Sci. 1998;63:1347-1352.