Drug-resistant molecular mechanism of CRF01Æ HIV-1 protease due to V82F mutation

Journal of Computer-Aided Molecular Design

Volumn 23, Issue 5, 2009, Pages 261-272

  Liu, Xiaoqing ^a   Xiu, Zhilong ^a   Hao, Ce ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

CRF01_AE HIV 1 protease; Inhibitor; Molecular dynamics simulation; Mutation; Resistance

Indexed keywords

BINDING ENERGY; DISEASES; DRUG THERAPY; VIRUSES;

CRF01_AE HIV-1 PROTEASE; DYNAMICS SIMULATION; HIV-1 PROTEASE; HUMAN IMMUNODEFICIENCY VIRUS; INHIBITOR; MOLECULAR DYNAMIC SIMULATION; MOLECULAR MECHANISM; MUTATION; RESISTANCE; SUBSITES;

MOLECULAR DYNAMICS;

ISOQUINOLINE DERIVATIVE; LOPINAVIR; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG MECHANISM; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS RESISTANCE;

EID: 65049090021     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-008-9256-x     Document Type: Article

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