Molecular mechanisms of resistance: Free energy calculations of mutation effects on inhibitor binding to HIV-1 protease

Protein Science

Volumn 7, Issue 8, 1998, Pages 1750-1756

  Rick, Steven W ^a   Topol, Igor A ^a   Erickson, John W ^a   Burt, Stanley K ^a  

^a SAIC FREDERICK INC   (United States)

Author keywords

Cavities; Drug resistance; Free energy calculations; HIV protease; Mutations

Indexed keywords

INDINAVIR; KYNOSTATIN 272; PROTEINASE; PROTEINASE INHIBITOR; SAQUINAVIR;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CHEMICAL STRUCTURE; COMPUTER PROGRAM; DRUG BINDING; ENZYME ACTIVITY; ENZYME INHIBITOR COMPLEX; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEINASE INHIBITION; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

EID: 0032469463     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070809     Document Type: Article

References (5)

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