Computational simulations of HIV-1 proteases-multi-drug resistance due to nonactive site mutation L90M

Journal of the American Chemical Society

Volumn 128, Issue 24, 2006, Pages 7887-7895

  Ode, Hirotaka ^a   Neya, Saburo ^a   Hata, Masayuki ^a   Sugiura, Wataru ^a,b   Hoshino, Tyuji ^a,c  

^a CHIBA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATION THEORY; COMPUTER SIMULATION; DRUG DOSAGE; MUTAGENESIS;

ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS); COMPUTATIONAL SIMULATIONS; DRUG RESISTANCE; MUTATION RATE;

PROTEINS;

LEUCINE; LOPINAVIR; METHIONINE; MUTANT PROTEIN; NELFINAVIR; PROTEINASE; PROTEINASE INHIBITOR; SAQUINAVIR; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; ARTICLE; COMPUTER SIMULATION; CONFORMATIONAL TRANSITION; DRUG STRUCTURE; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; LIFE CYCLE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MULTIDRUG RESISTANCE; MUTATION; MUTATION RATE; NON ACTIVE SITE MUTATION;

BASE SEQUENCE; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; KINETICS; LEUCINE; METHIONINE; MODELS, MOLECULAR; MUTATION;

EID: 33745407153     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja060682b     Document Type: Article

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