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Volumn 13, Issue 11, 2007, Pages 1151-1156
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Molecular dynamics studies on HIV-1 protease: A comparison of the flap motions between wild type protease and the M46I/G51D double mutant
a
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Author keywords
Flap motions; Gromacs 3.2; HIV 1 drug resistant mutants; HIV 1 protease; Molecular dynamics simulations
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Indexed keywords
ASPARTIC ACID;
GLYCINE;
HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE;
HUMAN IMMUNODEFICIENCY VIRUS PROTEIN;
ISOLEUCINE;
METHIONINE;
MUTANT PROTEIN;
PROTEINASE;
UNCLASSIFIED DRUG;
ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;
RECOMBINANT PROTEIN;
ARTICLE;
COMPARATIVE STUDY;
ENZYME ACTIVE SITE;
ENZYME ANALYSIS;
ENZYME BINDING;
ENZYME CONFORMATION;
ENZYME STABILITY;
ENZYME STRUCTURE;
ENZYME SUBSTRATE COMPLEX;
FLAP MOTION;
MOLECULAR DYNAMICS;
MUTANT;
PRIORITY JOURNAL;
SOLVATION;
STEREOSPECIFICITY;
VIRUS RESISTANCE;
WILD TYPE;
AMINO ACID SUBSTITUTION;
ANTIBIOTIC RESISTANCE;
CHEMICAL STRUCTURE;
CHEMISTRY;
COMPUTER SIMULATION;
ENZYMOLOGY;
HUMAN;
HUMAN IMMUNODEFICIENCY VIRUS 1;
METABOLISM;
MUTATION;
PROTEIN CONFORMATION;
HUMAN IMMUNODEFICIENCY VIRUS 1;
AMINO ACID SUBSTITUTION;
ANTI-HIV AGENTS;
COMPUTER SIMULATION;
DRUG RESISTANCE, VIRAL;
ENZYME STABILITY;
HIV PROTEASE;
HIV-1;
HUMANS;
MODELS, MOLECULAR;
MUTATION;
PROTEIN CONFORMATION;
RECOMBINANT PROTEINS;
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EID: 34848820304
PISSN: 16102940
EISSN: 09485023
Source Type: Journal
DOI: 10.1007/s00894-007-0242-3 Document Type: Article |
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Times cited : (12)
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References (26)
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