-
1
-
-
42049089502
-
DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture
-
Kastan M.B. DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture. Mol Cancer Res 6 (2008) 517-524
-
(2008)
Mol Cancer Res
, vol.6
, pp. 517-524
-
-
Kastan, M.B.1
-
2
-
-
36749022214
-
The DNA damage response: ten years after
-
Harper J.W., and Elledge S.J. The DNA damage response: ten years after. Mol Cell 28 (2007) 739-745
-
(2007)
Mol Cell
, vol.28
, pp. 739-745
-
-
Harper, J.W.1
Elledge, S.J.2
-
3
-
-
39749166975
-
DNA repair pathways as targets for cancer therapy
-
Helleday T., Petermann E., Lundin C., Hodgson B., and Sharma R.A. DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8 (2008) 193-204
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 193-204
-
-
Helleday, T.1
Petermann, E.2
Lundin, C.3
Hodgson, B.4
Sharma, R.A.5
-
4
-
-
63449100206
-
Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers
-
Kinsella T.J. Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers. Clin Cancer Res (2009)
-
(2009)
Clin Cancer Res
-
-
Kinsella, T.J.1
-
5
-
-
0038557114
-
Who's on first in the cellular response to DNA damage?
-
Cline S.D., and Hanawalt P.C. Who's on first in the cellular response to DNA damage?. Nat Rev Mol Cell Biol 4 (2003) 361-372
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 361-372
-
-
Cline, S.D.1
Hanawalt, P.C.2
-
6
-
-
0037323776
-
The complex matter of DNA double-strand break detection
-
Bradbury J.M., and Jackson S.P. The complex matter of DNA double-strand break detection. Biochem Soc Trans 31 (2003) 40-44
-
(2003)
Biochem Soc Trans
, vol.31
, pp. 40-44
-
-
Bradbury, J.M.1
Jackson, S.P.2
-
7
-
-
33646748283
-
A systems approach to mapping DNA damage response pathways
-
Workman C.T., Mak H.C., McCuine S., Tagne J.B., Agarwal M., Ozier O., et al. A systems approach to mapping DNA damage response pathways. Science 312 (2006) 1054-1059
-
(2006)
Science
, vol.312
, pp. 1054-1059
-
-
Workman, C.T.1
Mak, H.C.2
McCuine, S.3
Tagne, J.B.4
Agarwal, M.5
Ozier, O.6
-
8
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald III E.R., Hurov K.E., Luo J., et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316 (2007) 1160-1166
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
-
10
-
-
0036255776
-
The Li-Fraumeni syndrome
-
Chompret A. The Li-Fraumeni syndrome. Biochimie 84 (2002) 75-82
-
(2002)
Biochimie
, vol.84
, pp. 75-82
-
-
Chompret, A.1
-
11
-
-
33646187811
-
The multifaceted mismatch-repair system
-
Jiricny J. The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol 7 (2006) 335-346
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 335-346
-
-
Jiricny, J.1
-
12
-
-
33749037721
-
Clinical management of BRCA1 and BRCA2 mutation carriers
-
Domchek S.M., and Weber B.L. Clinical management of BRCA1 and BRCA2 mutation carriers. Oncogene 25 (2006) 5825-5831
-
(2006)
Oncogene
, vol.25
, pp. 5825-5831
-
-
Domchek, S.M.1
Weber, B.L.2
-
13
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat Med 10 (2004) 789-799
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
14
-
-
33744481750
-
Molecular pathogenesis of Fanconi anemia: recent progress
-
Taniguchi T., and D'Andrea A.D. Molecular pathogenesis of Fanconi anemia: recent progress. Blood 107 (2006) 4223-4233
-
(2006)
Blood
, vol.107
, pp. 4223-4233
-
-
Taniguchi, T.1
D'Andrea, A.D.2
-
15
-
-
21744452376
-
Cancer in xeroderma pigmentosum and related disorders of DNA repair
-
Cleaver J.E. Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 5 (2005) 564-573
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 564-573
-
-
Cleaver, J.E.1
-
16
-
-
0141757494
-
Regulation and mechanisms of mammalian double-strand break repair
-
Valerie K., and Povirk L.F. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22 (2003) 5792-5812
-
(2003)
Oncogene
, vol.22
, pp. 5792-5812
-
-
Valerie, K.1
Povirk, L.F.2
-
17
-
-
34250900982
-
Base-excision repair of oxidative DNA damage
-
David S.S., O'Shea V.L., and Kundu S. Base-excision repair of oxidative DNA damage. Nature 447 (2007) 941-950
-
(2007)
Nature
, vol.447
, pp. 941-950
-
-
David, S.S.1
O'Shea, V.L.2
Kundu, S.3
-
18
-
-
33745083977
-
Base excision repair fidelity in normal and cancer cells
-
Chan K.K., Zhang Q.M., and Dianov G.L. Base excision repair fidelity in normal and cancer cells. Mutagenesis 21 (2006) 173-178
-
(2006)
Mutagenesis
, vol.21
, pp. 173-178
-
-
Chan, K.K.1
Zhang, Q.M.2
Dianov, G.L.3
-
19
-
-
18944390248
-
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
-
Jagtap P., and Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat Rev Drug Discov 4 (2005) 421-440
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 421-440
-
-
Jagtap, P.1
Szabo, C.2
-
20
-
-
0742305875
-
Repairing DNA-methylation damage
-
Sedgwick B. Repairing DNA-methylation damage. Nat Rev Mol Cell Biol 5 (2004) 148-157
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 148-157
-
-
Sedgwick, B.1
-
22
-
-
35548985406
-
A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading
-
Kesseler K.J., Kaufmann W.K., Reardon J.T., Elston T.C., and Sancar A. A mathematical model for human nucleotide excision repair: damage recognition by random order assembly and kinetic proofreading. J Theor Biol 249 (2007) 361-375
-
(2007)
J Theor Biol
, vol.249
, pp. 361-375
-
-
Kesseler, K.J.1
Kaufmann, W.K.2
Reardon, J.T.3
Elston, T.C.4
Sancar, A.5
-
24
-
-
0037445248
-
Role of DNA mismatch repair defects in the pathogenesis of human cancer
-
Peltomaki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 21 (2003) 1174-1179
-
(2003)
J Clin Oncol
, vol.21
, pp. 1174-1179
-
-
Peltomaki, P.1
-
25
-
-
33645322935
-
Signalling cell cycle arrest and cell death through the MMR System
-
O'Brien V., and Brown R. Signalling cell cycle arrest and cell death through the MMR System. Carcinogenesis 27 (2006) 682-692
-
(2006)
Carcinogenesis
, vol.27
, pp. 682-692
-
-
O'Brien, V.1
Brown, R.2
-
26
-
-
34250844984
-
A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells
-
Zeng X., and Kinsella T.J. A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Autophagy 3 (2007) 368-370
-
(2007)
Autophagy
, vol.3
, pp. 368-370
-
-
Zeng, X.1
Kinsella, T.J.2
-
27
-
-
55449088400
-
Recruitment of mismatch repair proteins to the site of DNA damage in human cells
-
Hong Z., Jiang J., Hashiguchi K., Hoshi M., Lan L., and Yasui A. Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J Cell Sci 121 (2008) 3146-3154
-
(2008)
J Cell Sci
, vol.121
, pp. 3146-3154
-
-
Hong, Z.1
Jiang, J.2
Hashiguchi, K.3
Hoshi, M.4
Lan, L.5
Yasui, A.6
-
28
-
-
0035687887
-
Mechanisms of tolerance to DNA damaging therapeutic drugs
-
Karran P. Mechanisms of tolerance to DNA damaging therapeutic drugs. Carcinogenesis 22 (2001) 1931-1937
-
(2001)
Carcinogenesis
, vol.22
, pp. 1931-1937
-
-
Karran, P.1
-
29
-
-
64849083398
-
-
National Cancer Institute Accessed October 22, 2008
-
National Cancer Institute. Integrative Cancer Biology Program. http://icbp.nci.nih.gov Accessed October 22, 2008
-
Integrative Cancer Biology Program
-
-
-
30
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt H.C., Aslanian A.S., Lees J.A., and Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11 (2007) 175-189
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
31
-
-
34548324267
-
The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials
-
Marchetti S., and Schellens J.H. The impact of FDA and EMEA guidelines on drug development in relation to Phase 0 trials. Br J Cancer 97 (2007) 577-581
-
(2007)
Br J Cancer
, vol.97
, pp. 577-581
-
-
Marchetti, S.1
Schellens, J.H.2
-
32
-
-
52449092892
-
Oncologic phase 0 trials incorporating clinical pharmacodynamics: from concept to patient
-
Doroshow J.H., and Parchment R.E. Oncologic phase 0 trials incorporating clinical pharmacodynamics: from concept to patient. Clin Cancer Res 14 (2008) 3658-3663
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3658-3663
-
-
Doroshow, J.H.1
Parchment, R.E.2
-
33
-
-
52449091099
-
Designing phase 0 cancer clinical trials
-
Murgo A.J., Kummar S., Rubinstein L., Gutierrez M., Collins J., Kinders R., et al. Designing phase 0 cancer clinical trials. Clin Cancer Res 14 (2008) 3675-3682
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3675-3682
-
-
Murgo, A.J.1
Kummar, S.2
Rubinstein, L.3
Gutierrez, M.4
Collins, J.5
Kinders, R.6
-
34
-
-
52449128056
-
The development of phase I cancer trial methodologies: the use of pharmacokinetic and pharmacodynamic end points sets the scene for phase 0 cancer clinical trials
-
Calvert A.H., and Plummer R. The development of phase I cancer trial methodologies: the use of pharmacokinetic and pharmacodynamic end points sets the scene for phase 0 cancer clinical trials. Clin Cancer Res 14 (2008) 3664-3669
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3664-3669
-
-
Calvert, A.H.1
Plummer, R.2
-
35
-
-
31044446360
-
PARP inhibitors for cancer therapy
-
Curtin N.J. PARP inhibitors for cancer therapy. Expert Rev Mol Med 7 (2005) 1-20
-
(2005)
Expert Rev Mol Med
, vol.7
, pp. 1-20
-
-
Curtin, N.J.1
-
36
-
-
33745876586
-
Inhibition of poly(ADP-ribose) polymerase in cancer
-
Plummer E.R. Inhibition of poly(ADP-ribose) polymerase in cancer. Curr Opin Pharmacol 6 (2006) 364-368
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 364-368
-
-
Plummer, E.R.1
-
37
-
-
33947380240
-
Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
-
Ratnam K., and Low J.A. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin Cancer Res 13 (2007) 1383-1388
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1383-1388
-
-
Ratnam, K.1
Low, J.A.2
-
38
-
-
34548072788
-
The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity
-
Miknyoczki S., Chang H., Grobelny J., Pritchard S., Worrell C., McGann N., et al. The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity. Mol Cancer Ther 6 (2007) 2290-2302
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2290-2302
-
-
Miknyoczki, S.1
Chang, H.2
Grobelny, J.3
Pritchard, S.4
Worrell, C.5
McGann, N.6
-
39
-
-
49249119415
-
A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair
-
Ashworth A. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J Clin Oncol 26 (2008) 3785-3790
-
(2008)
J Clin Oncol
, vol.26
, pp. 3785-3790
-
-
Ashworth, A.1
-
40
-
-
35148894301
-
First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM)
-
(abstr 8013)
-
Plummer R., Lorigan P., Evans J., Steven N., Middleton M., Wilson R., et al. First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM). J Clin Oncol 24 (2006) 456s (abstr 8013)
-
(2006)
J Clin Oncol
, vol.24
-
-
Plummer, R.1
Lorigan, P.2
Evans, J.3
Steven, N.4
Middleton, M.5
Wilson, R.6
-
41
-
-
25444497278
-
The concept of synthetic lethality in the context of anticancer therapy
-
Kaelin Jr. W.G. The concept of synthetic lethality in the context of anticancer therapy. Nat Rev Cancer 5 (2005) 689-698
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 689-698
-
-
Kaelin Jr., W.G.1
-
42
-
-
0030667434
-
Integrating genetic approaches into the discovery of anticancer drugs
-
Hartwell L.H., Szankasi P., Roberts C.J., Murray A.W., and Friend S.H. Integrating genetic approaches into the discovery of anticancer drugs. Science 278 (1997) 1064-1068
-
(1997)
Science
, vol.278
, pp. 1064-1068
-
-
Hartwell, L.H.1
Szankasi, P.2
Roberts, C.J.3
Murray, A.W.4
Friend, S.H.5
-
43
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H., McCabe N., Lord C.J., Tutt A.N., Johnson D.A., Richardson T.B., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434 (2005) 917-921
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.4
Johnson, D.A.5
Richardson, T.B.6
-
44
-
-
51649117107
-
6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
-
6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26 (2008) 4189-4199
-
(2008)
J Clin Oncol
, vol.26
, pp. 4189-4199
-
-
Hegi, M.E.1
Liu, L.2
Herman, J.G.3
Stupp, R.4
Wick, W.5
Weller, M.6
-
45
-
-
4043143034
-
Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway
-
Liu L., and Gerson S.L. Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway. Curr Opin Investig Drugs 5 (2004) 623-627
-
(2004)
Curr Opin Investig Drugs
, vol.5
, pp. 623-627
-
-
Liu, L.1
Gerson, S.L.2
-
46
-
-
0034326784
-
Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
-
Plumb J.A., Strathdee G., Sludden J., Kaye S.B., and Brown R. Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 60 (2000) 6039-6044
-
(2000)
Cancer Res
, vol.60
, pp. 6039-6044
-
-
Plumb, J.A.1
Strathdee, G.2
Sludden, J.3
Kaye, S.B.4
Brown, R.5
-
47
-
-
0034798687
-
Targeting DNA mismatch repair for radiosensitization
-
Berry S.E., and Kinsella T.J. Targeting DNA mismatch repair for radiosensitization. Semin Radiat Oncol 11 (2001) 300-315
-
(2001)
Semin Radiat Oncol
, vol.11
, pp. 300-315
-
-
Berry, S.E.1
Kinsella, T.J.2
-
48
-
-
9344235474
-
Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2'-deoxyribose
-
Seo Y., Yan T., Schupp J.E., Colussi V., Taylor K.L., and Kinsella T.J. Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2'-deoxyribose. Clin Cancer Res 10 (2004) 7520-7528
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7520-7528
-
-
Seo, Y.1
Yan, T.2
Schupp, J.E.3
Colussi, V.4
Taylor, K.L.5
Kinsella, T.J.6
-
49
-
-
48249092713
-
DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy
-
Ashwell S., and Zabludoff S. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy. Clin Cancer Res 14 (2008) 4032-4037
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4032-4037
-
-
Ashwell, S.1
Zabludoff, S.2
|