A systems approach to mapping DNA damage response pathways

Science

Volumn 312, Issue 5776, 2006, Pages 1054-1059

  Workman, Christopher T ^a   Mak, H Craig ^a   McCuine, Scott ^a   Tagne, Jean Bosco ^b   Agarwal, Maya ^a   Ozier, Owen ^b   Begley, Thomas J ^c   Samson, Leona D ^d   Ideker, Trey ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES; MUTAGENESIS; PATTERN RECOGNITION; PHOTOMAPPING; SIGNALING; TOXICITY;

CASUAL PATHWAY MODELS; DAMAGE RELATED TRANSCRIPTION FACTORS; ENVIRONMENTAL TOXICITY; RESPONSE PATHWAYS;

DNA;

MESYLIC ACID METHYL ESTER; TRANSCRIPTION FACTOR;

DNA; MUTAGENICITY; PHENOTYPE; TOXICITY;

ARTICLE; DNA DAMAGE; DNA INTEGRATION; ECOTOXICITY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; YEAST;

DNA DAMAGE; DNA REPAIR; DNA, FUNGAL; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; METHYL METHANESULFONATE; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SACCHAROMYCES; SIGNAL TRANSDUCTION; SYSTEMS THEORY; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 33646748283     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1122088     Document Type: Article

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31. We acknowledge funding from the National Institute of Environmental Health Sciences (NIEHS), the National Cancer Institute (NCI), and the David and Lucille Packard Foundation. L.D.S. is the Ellison American Cancer Society Research Professor. We thank R. Young, D. Odom, T. I. Lee, M. Daly, and B. Ren for assistance with ChIP-chip analysis and J. Kadonaga, W. McGinnis, and G. Kassavetis for consultations on the binding motif predictions. Microarray data have been deposited in the ArrayExpress database (accession numbers E-TABM-92 and E-TABM-93).