메뉴 건너뛰기




Volumn 10, Issue 22, 2004, Pages 7520-7528

Differential radiosensitization in DNA mismatch repair-proficient and -deficient human colon cancer xenografts with 5-iodo-2-pyrimidinone-2′- deoxyribose

Author keywords

[No Author keywords available]

Indexed keywords

5 IODO 2 PYRIMIDINONE 2' DEOXYRIBOSE; CELL DNA; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

EID: 9344235474     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-1144     Document Type: Article
Times cited : (29)

References (46)
  • 1
    • 0028337391 scopus 로고
    • An in vivo comparison of oral 5-iodo-2′-deoxyuridine and 5-iodo-2-pyrimidinone-2′-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116
    • Kinsella TJ, Kunugi KA, Vielhuber KA, et al. An in vivo comparison of oral 5-iodo-2′-deoxyuridine and 5-iodo-2-pyrimidinone-2′-deoxyribose toxicity, pharmacokinetics, and DNA incorporation in athymic mouse tissues and the human colon cancer xenograft, HCT-116. Cancer Res 1994;54:2695-700.
    • (1994) Cancer Res , vol.54 , pp. 2695-2700
    • Kinsella, T.J.1    Kunugi, K.A.2    Vielhuber, K.A.3
  • 2
    • 0001002341 scopus 로고    scopus 로고
    • An approach to the radiosensitization of human tumors
    • Kinsella TJ. An approach to the radiosensitization of human tumors. Cancer J Sci Am 1996;2:184.
    • (1996) Cancer J Sci Am , vol.2 , pp. 184
    • Kinsella, T.J.1
  • 3
    • 0031931512 scopus 로고    scopus 로고
    • Preclinical evaluation of 5-iodo-2-pyrimidinone-2′-deoxyribose as a prodrug for 5-iodo-2′-deoxyuridine-mediated radiosensitization in mouse and human tissues
    • Kinsella TJ, Kunugi KA, Vielhuber KA, et al. Preclinical evaluation of 5-iodo-2-pyrimidinone-2′-deoxyribose as a prodrug for 5-iodo-2′- deoxyuridine-mediated radiosensitization in mouse and human tissues. Clin Cancer Res 1998;4:99-109.
    • (1998) Clin Cancer Res , vol.4 , pp. 99-109
    • Kinsella, T.J.1    Kunugi, K.A.2    Vielhuber, K.A.3
  • 4
    • 0034050958 scopus 로고    scopus 로고
    • Preclinical toxicity and efficacy study of a 14-day schedule of oral 5-iodo-2-pyrimidinone-2′-deoxyribose as a prodrug for 5-iodo-2′- deoxyuridine radiosensitization in U251 human glioblastoma xenografts
    • Kinsella TJ, Vielhuber KA, Kunugi KA, et al. Preclinical toxicity and efficacy study of a 14-day schedule of oral 5-iodo-2-pyrimidinone-2′- deoxyribose as a prodrug for 5-iodo-2′-deoxyuridine radiosensitization in U251 human glioblastoma xenografts. Clin Cancer Res 2000;6:1468-75.
    • (2000) Clin Cancer Res , vol.6 , pp. 1468-1475
    • Kinsella, T.J.1    Vielhuber, K.A.2    Kunugi, K.A.3
  • 5
    • 0033813259 scopus 로고    scopus 로고
    • Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2′-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: Implications for phase I study design
    • Kinsella TJ, Schupp JE, Davis TW, et al. Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2′- deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design. Clin Cancer Res 2000;6:3670-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 3670-3679
    • Kinsella, T.J.1    Schupp, J.E.2    Davis, T.W.3
  • 6
    • 0026762436 scopus 로고
    • Conversion of 5-iodo-2-pyrimidinone-2′-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design
    • Chang CN, Doong SL, Cheng YC, Conversion of 5-iodo-2-pyrimidinone- 2′-deoxyribose to 5-iodo-deoxyuridine by aldehyde oxidase. Implication in hepatotropic drug design. Biochem Pharmacol 1992;43:2269-73.
    • (1992) Biochem Pharmacol , vol.43 , pp. 2269-2273
    • Chang, C.N.1    Doong, S.L.2    Cheng, Y.C.3
  • 7
    • 0021205578 scopus 로고
    • The use of halogenated thymidine analogs as clinical radiosensitizers: Rationale, current status, and future prospects: Non-hypoxic cell sensitizers
    • Kinsella TJ, Mitchell JB, Russo A, Morstyn G, Glatstein E. The use of halogenated thymidine analogs as clinical radiosensitizers: rationale, current status, and future prospects: non-hypoxic cell sensitizers. Int J Radiat Oncol Biol Phys 1984;10:1399-406.
    • (1984) Int J Radiat Oncol Biol Phys , vol.10 , pp. 1399-1406
    • Kinsella, T.J.1    Mitchell, J.B.2    Russo, A.3    Morstyn, G.4    Glatstein, E.5
  • 8
    • 0023946021 scopus 로고
    • Pharmacology and phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme
    • Kinsella TJ, Collins J, Rowland J, et al. Pharmacology and phase I/II study of continuous intravenous infusions of iododeoxyuridine and hyperfractionated radiotherapy in patients with glioblastoma multiforme. J Clin Oncol 1988;6:871-9.
    • (1988) J Clin Oncol , vol.6 , pp. 871-879
    • Kinsella, T.J.1    Collins, J.2    Rowland, J.3
  • 9
    • 0024541879 scopus 로고
    • A phase I study of intraarterial iododeoxyuridine in patients with colorectal liver metastases
    • Chang AE, Collins JM, Speth PA, et al. A phase I study of intraarterial iododeoxyuridine in patients with colorectal liver metastases. J Clin Oncol 1989;7:662-8.
    • (1989) J Clin Oncol , vol.7 , pp. 662-668
    • Chang, A.E.1    Collins, J.M.2    Speth, P.A.3
  • 10
    • 0025979284 scopus 로고
    • Primary treatment of large and massive adult sarcomas with iododeoxyuridine and aggressive hyperfractionated irradiation
    • Goffman T, Tochner Z, Glatstein E. Primary treatment of large and massive adult sarcomas with iododeoxyuridine and aggressive hyperfractionated irradiation. Cancer (Phila.) 1991;67:572-6.
    • (1991) Cancer (Phila) , vol.67 , pp. 572-576
    • Goffman, T.1    Tochner, Z.2    Glatstein, E.3
  • 11
    • 0027490744 scopus 로고
    • Iododeoxyuridine (IUdR) combined with radiation in the treatment of malignant glioma: A comparison of short versus long intravenous dose schedules (RTOG 86-12)
    • Urtasun RC, Cosmatos D, DelRowe J, et al. Iododeoxyuridine (IUdR) combined with radiation in the treatment of malignant glioma: a comparison of short versus long intravenous dose schedules (RTOG 86-12). Int J Radiat Oncol Biol Phys 1993;27:207-14.
    • (1993) Int J Radiat Oncol Biol Phys , vol.27 , pp. 207-214
    • Urtasun, R.C.1    Cosmatos, D.2    DelRowe, J.3
  • 12
    • 0028019247 scopus 로고
    • Treatment of locally advanced cancer of the head and neck with 5′-iododeoxyuridine and hyperfractionated radiation therapy: Measurement of cell labeling and thymidine replacement
    • Epstein AH, Lebovics RS, Goffman T, et al. Treatment of locally advanced cancer of the head and neck with 5′-iododeoxyuridine and hyperfractionated radiation therapy: measurement of cell labeling and thymidine replacement. J Natl Cancer Inst (Bethesda) 1994;86:1775-80.
    • (1994) J Natl Cancer Inst (Bethesda) , vol.86 , pp. 1775-1780
    • Epstein, A.H.1    Lebovics, R.S.2    Goffman, T.3
  • 13
    • 0031745291 scopus 로고    scopus 로고
    • Intravenous delivery of 5′-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: Results of a pilot study
    • Epstein AH, Lebovics RS, Van Waes C, et al. Intravenous delivery of 5′-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: results of a pilot study. Laryngoscope 1998;108:1090-4.
    • (1998) Laryngoscope , vol.108 , pp. 1090-1094
    • Epstein, A.H.1    Lebovics, R.S.2    Van Waes, C.3
  • 14
    • 0032418892 scopus 로고    scopus 로고
    • Preoperative idoxuridine and radiation for large soft tissue sarcomas: Clinical results with five-year follow-up
    • Sondak VK, Robertson JM, Sussman JJ, et al. Preoperative idoxuridine and radiation for large soft tissue sarcomas: clinical results with five-year follow-up. Ann Surg Oncol 1998;5:106-12.
    • (1998) Ann Surg Oncol , vol.5 , pp. 106-112
    • Sondak, V.K.1    Robertson, J.M.2    Sussman, J.J.3
  • 15
    • 0037445248 scopus 로고    scopus 로고
    • Role of DNA mismatch repair defects in the pathogenesis of human cancer
    • Peltomaki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003;21:1174-9.
    • (2003) J Clin Oncol , vol.21 , pp. 1174-1179
    • Peltomaki, P.1
  • 16
    • 0032907596 scopus 로고    scopus 로고
    • Involvement of the DNA mismatch repair system in antineoplastic drug resistance
    • Lage H, Dietel M, Involvement of the DNA mismatch repair system in antineoplastic drug resistance. J Cancer Res Clin Oncol 1999;125:156-65.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 156-165
    • Lage, H.1    Dietel, M.2
  • 17
    • 0142123326 scopus 로고    scopus 로고
    • Mismatch repair and response to DNA-damaging antitumour therapies
    • Bignami M, Casorelli I, Karran P. Mismatch repair and response to DNA-damaging antitumour therapies. Eur J Cancer 2003;39:2142-9.
    • (2003) Eur J Cancer , vol.39 , pp. 2142-2149
    • Bignami, M.1    Casorelli, I.2    Karran, P.3
  • 18
    • 0027292234 scopus 로고
    • An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
    • Kat A, Thilly WG, Fang WH, et al. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci USA 1993;90:6424-8.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6424-6428
    • Kat, A.1    Thilly, W.G.2    Fang, W.H.3
  • 19
    • 0030834332 scopus 로고    scopus 로고
    • Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft
    • Friedman HS, Johnson SP, Dong Q, et al. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft. Cancer Res 1997;57:2933-6.
    • (1997) Cancer Res , vol.57 , pp. 2933-2936
    • Friedman, H.S.1    Johnson, S.P.2    Dong, Q.3
  • 20
    • 0029822592 scopus 로고    scopus 로고
    • Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
    • Swann PF, Waters TR, Moulton DC, et al. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science (Wash DC) 1996;273:1109-11.
    • (1996) Science (Wash DC) , vol.273 , pp. 1109-1111
    • Swann, P.F.1    Waters, T.R.2    Moulton, D.C.3
  • 21
    • 0642374238 scopus 로고    scopus 로고
    • A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage
    • Meyers M, Hwang A, Wagner MW, et al. A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage. Oncogene 2003;22:7376-88.
    • (2003) Oncogene , vol.22 , pp. 7376-7388
    • Meyers, M.1    Hwang, A.2    Wagner, M.W.3
  • 22
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003;349:247-57.
    • (2003) N Engl J Med , vol.349 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 23
    • 0029812676 scopus 로고    scopus 로고
    • Cisplatin and Adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line
    • Drummond JT, Anthoney A, Brown R, Modrich P. Cisplatin and Adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem 1996;271:19645-8.
    • (1996) J Biol Chem , vol.271 , pp. 19645-19648
    • Drummond, J.T.1    Anthoney, A.2    Brown, R.3    Modrich, P.4
  • 24
    • 0029904811 scopus 로고    scopus 로고
    • The role of DNA mismatch repair in platinum drug resistance
    • Fink D, Nebel S, Aebi S, et al. The role of DNA mismatch repair in platinum drug resistance. Cancer Res 1996;56:4881-6.
    • (1996) Cancer Res , vol.56 , pp. 4881-4886
    • Fink, D.1    Nebel, S.2    Aebi, S.3
  • 25
    • 8944230189 scopus 로고    scopus 로고
    • Loss of DNA mismatch repair in acquired resistance to cisplatin
    • Aebi S, Kurdi-Haidar B, Gordon R, et al. Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res 1996;56:3087-90.
    • (1996) Cancer Res , vol.56 , pp. 3087-3090
    • Aebi, S.1    Kurdi-Haidar, B.2    Gordon, R.3
  • 26
    • 2642706705 scopus 로고    scopus 로고
    • Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation
    • Davis TW, Wilson-Van Patten C, Meyers M, et al. Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res 1998;58:767-78.
    • (1998) Cancer Res , vol.58 , pp. 767-778
    • Davis, T.W.1    Wilson-Van Patten, C.2    Meyers, M.3
  • 27
    • 0035890422 scopus 로고    scopus 로고
    • Loss of DNA mismatch repair imparts defective cdc2 signaling and G arrest responses without altering survival after ionizing radiation
    • Yan T, Schupp JE, Hwang HS, et al. Loss of DNA mismatch repair imparts defective cdc2 signaling and G arrest responses without altering survival after ionizing radiation. Cancer Res 2001;61:8290-7.
    • (2001) Cancer Res , vol.61 , pp. 8290-8297
    • Yan, T.1    Schupp, J.E.2    Hwang, H.S.3
  • 28
    • 15444348851 scopus 로고    scopus 로고
    • Role of DNA mismatch repair in the cytotoxicity of ionizing radiation
    • Fritzell JA, Narayanan L, Baker SM, et al. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Res 1997;57:5143-7.
    • (1997) Cancer Res , vol.57 , pp. 5143-5147
    • Fritzell, J.A.1    Narayanan, L.2    Baker, S.M.3
  • 29
    • 0038297562 scopus 로고    scopus 로고
    • The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase
    • Franchitto A, Pichierri P, Piergentili R, et al. The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 2003;22:2110-20.
    • (2003) Oncogene , vol.22 , pp. 2110-2120
    • Franchitto, A.1    Pichierri, P.2    Piergentili, R.3
  • 30
    • 0032578544 scopus 로고    scopus 로고
    • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation
    • DeWeese TL, Shipman JM, Larrier NA, et al. Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. Proc Natl Acad Sci USA 1998;95:11915-20.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11915-11920
    • DeWeese, T.L.1    Shipman, J.M.2    Larrier, N.A.3
  • 31
    • 0034282743 scopus 로고    scopus 로고
    • Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways
    • Zeng M, Narayanan L, Xu XS, et al. Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways. Cancer Res 2000;60:4889-93.
    • (2000) Cancer Res , vol.60 , pp. 4889-4893
    • Zeng, M.1    Narayanan, L.2    Xu, X.S.3
  • 32
    • 0033561529 scopus 로고    scopus 로고
    • The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells
    • Berry SE, Garces C, Hwang HS, et al. The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Cancer Res 1999;59:1840-5.
    • (1999) Cancer Res , vol.59 , pp. 1840-1845
    • Berry, S.E.1    Garces, C.2    Hwang, H.S.3
  • 33
    • 0034667429 scopus 로고    scopus 로고
    • Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine
    • Berry SE, Davis TW, Schupp JE, et al. Selective radiosensitization of drug-resistant MutS homologue-2 (MSH2) mismatch repair-deficient cells by halogenated thymidine (dThd) analogues: Msh2 mediates dThd analogue DNA levels and the differential cytotoxicity and cell cycle effects of the dThd analogues and 6-thioguanine. Cancer Res 2000;60:5773-80.
    • (2000) Cancer Res , vol.60 , pp. 5773-5780
    • Berry, S.E.1    Davis, T.W.2    Schupp, J.E.3
  • 34
    • 0034798687 scopus 로고    scopus 로고
    • Targeting DNA mismatch repair for radiosensitization
    • Berry SE, Kinsella TJ. Targeting DNA mismatch repair for radiosensitization. Semin Radiat Oncol 2001;11:300-15.
    • (2001) Semin Radiat Oncol , vol.11 , pp. 300-315
    • Berry, S.E.1    Kinsella, T.J.2
  • 35
    • 0141481273 scopus 로고    scopus 로고
    • Role of MutSalpha in the recognition of iododeoxyuridine in DNA
    • Berry SE, Loh T, Yan T, Kinsella TJ. Role of MutSalpha in the recognition of iododeoxyuridine in DNA. Cancer Res 2003;63:5490-5.
    • (2003) Cancer Res , vol.63 , pp. 5490-5495
    • Berry, S.E.1    Loh, T.2    Yan, T.3    Kinsella, T.J.4
  • 36
    • 0025327622 scopus 로고
    • Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine
    • Fornace AJ Jr, Dobson PP, Kinsella TJ. Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine. Int J Radiat Oncol Biol Phys 1990;18:873-8.
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 873-878
    • Fornace Jr., A.J.1    Dobson, P.P.2    Kinsella, T.J.3
  • 37
    • 0025128324 scopus 로고
    • The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells
    • Lawrence TS, Davis MA, Maybaum J, Stetson PL, Ensminger WD. The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells. Radiat Res 1990;123:192-8.
    • (1990) Radiat Res , vol.123 , pp. 192-198
    • Lawrence, T.S.1    Davis, M.A.2    Maybaum, J.3    Stetson, P.L.4    Ensminger, W.D.5
  • 38
    • 0025325880 scopus 로고
    • The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure
    • Lawrence TS, Davis MA, Maybaum J, Stetson PL, Ensminger WD. The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure. Int J Radiat Oncol Biol Phys 1990;18:1393-8.
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 1393-1398
    • Lawrence, T.S.1    Davis, M.A.2    Maybaum, J.3    Stetson, P.L.4    Ensminger, W.D.5
  • 39
    • 0026633463 scopus 로고
    • Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. I. Radiosensitization of human colon cancer cells by iododeoxyuridine
    • Miller EM, Fowler JF, Kinsella TJ, Linear-quadratic analysis of radiosensitization by halogenated pyrimidines. I. Radiosensitization of human colon cancer cells by iododeoxyuridine Radiat Res 1992;131:81-9.
    • (1992) Radiat Res , vol.131 , pp. 81-89
    • Miller, E.M.1    Fowler, J.F.2    Kinsella, T.J.3
  • 40
    • 0023222079 scopus 로고
    • Technique for detection of DNA nucleobases by reversed-phase high-performance liquid chromatography optimized for quantitative determination of thymidine substitution by iododeoxyuridine
    • Belanger K, Collins JM, Klecker RW Jr. Technique for detection of DNA nucleobases by reversed-phase high-performance liquid chromatography optimized for quantitative determination of thymidine substitution by iododeoxyuridine. J Chromatogr 1987;417:57-63.
    • (1987) J Chromatogr , vol.417 , pp. 57-63
    • Belanger, K.1    Collins, J.M.2    Klecker Jr., R.W.3
  • 41
    • 0028348423 scopus 로고
    • Kinetics of cell labeling and thymidine replacement after continuous infusion of halogenated pyrimidines in vivo
    • Rodriguez R, Ritter MA, Fowler JF, Kinsella TJ. Kinetics of cell labeling and thymidine replacement after continuous infusion of halogenated pyrimidines in vivo. Int J Radiat Oncol Biol Phys 1994;29:105-13.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 105-113
    • Rodriguez, R.1    Ritter, M.A.2    Fowler, J.F.3    Kinsella, T.J.4
  • 42
    • 0032920567 scopus 로고    scopus 로고
    • Bromodeoxyuridine alternating with radiation for advanced uterine cervix cancer: A phase 1 and drug incorporation study
    • Eisbruch A, Robertson JM, Johnston CM, et al. Bromodeoxyuridine alternating with radiation for advanced uterine cervix cancer: a phase 1 and drug incorporation study. J Clin Oncol 1999;17:31-40.
    • (1999) J Clin Oncol , vol.17 , pp. 31-40
    • Eisbruch, A.1    Robertson, J.M.2    Johnston, C.M.3
  • 43
    • 0029143992 scopus 로고
    • Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint
    • Hawn MT, Umar A, Carethers JM, et al. Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint. Cancer Res 1995;55:3721-5.
    • (1995) Cancer Res , vol.55 , pp. 3721-3725
    • Hawn, M.T.1    Umar, A.2    Carethers, J.M.3
  • 44
    • 0030741503 scopus 로고    scopus 로고
    • hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
    • Brown R, Hirst GL, Gallagher WM, et al. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents. Oncogene 1997;15:45-52.
    • (1997) Oncogene , vol.15 , pp. 45-52
    • Brown, R.1    Hirst, G.L.2    Gallagher, W.M.3
  • 45
    • 0037442698 scopus 로고    scopus 로고
    • Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization
    • Taverna P, Hwang HS, Schupp JE, et al. Inhibition of base excision repair potentiates iododeoxyuridine-induced cytotoxicity and radiosensitization. Cancer Res 2003;63:838-46.
    • (2003) Cancer Res , vol.63 , pp. 838-846
    • Taverna, P.1    Hwang, H.S.2    Schupp, J.E.3
  • 46
    • 7044278257 scopus 로고    scopus 로고
    • The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity
    • Cortellino S, Turner D, Masciullo V, et al. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci USA 2003;100:15071-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15071-15076
    • Cortellino, S.1    Turner, D.2    Masciullo, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.