Time-dependent inhibition of isoprenylcysteine carboxyl methyltransferase by indole-based small molecules

Biochemistry

Volumn 46, Issue 2, 2007, Pages 554-560

  Baron, Rudi A ^a,b   Peterson, Yuri K ^a   Otto, James C ^a   Rudolph, Johannes ^a   Casey, Patrick J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ACTIVE INHIBITORS; ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE (ICMT); METHYLATION; PRENYLATED PROTEINS;

CATALYSIS; DISSOCIATION; DRUG PRODUCTS; HYDROPHOBICITY; NITROGEN COMPOUNDS; PROTEINS; REACTION KINETICS;

ENZYME INHIBITION;

ACETAMIDE DERIVATIVE; BENZENE DERIVATIVE; CYSMETHYNIL; CYSTEINE DERIVATIVE; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; INDOLE DERIVATIVE; METHYL GROUP; NITROGEN; PRENYLAMINE; PRENYLCYSTEINE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; STRUCTURE ACTIVITY RELATION;

ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; INDOLES; KINETICS; PROTEIN ISOPRENYLATION; PROTEIN METHYLTRANSFERASES; RECOMBINANT PROTEINS;

EID: 33846236895     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060344n     Document Type: Article

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