Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 6, 1999, Pages 1255-1262

  Lee, Hong Kee ^a   Chui, Wai Keung ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antifolates; Combinatorial synthesis; Dihydrofolate reductase; Enzyme inhibitors

Indexed keywords

DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; TETRAHYDROFOLIC ACID DERIVATIVE; TRIAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; NONHUMAN; PILOT STUDY; RAT; THIN LAYER CHROMATOGRAPHY;

ANIMALS; DRUG EVALUATION, PRECLINICAL; FOLIC ACID ANTAGONISTS; LIVER; MALE; RATS; RATS, WISTAR; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES;

EID: 0032973501     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00051-6     Document Type: Article

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