Syntheses of 2,4,6-trisubstituted pyrimidine derivatives as a new class of antifilarial topoisomerase II inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 47-50

  Katiyar, Sanjay Babu ^a   Bansal, Iti ^a   Saxena, J K ^a   Chauhan, P M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Antifilarial; Pyrimidine; Topoisomerase II

Indexed keywords

ANTIFILARIAL AGENT; GYRASE INHIBITOR; NALIDIXIC ACID; NOVOBIOCIN; PYRIMIDINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FILARIA; IN VITRO STUDY; NONHUMAN; PARASITE; SETARIA CERVI; STANDARDIZATION;

ANIMALS; DNA TOPOISOMERASES, TYPE II; FILARICIDES; PYRIMIDINES; SETARIA NEMATODE; STRUCTURE-ACTIVITY RELATIONSHIP;

SETARIA CERVI;

EID: 9644287864     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.046     Document Type: Article

References (15)

1. P.M.S. Chauhan Drug of the Future 25 2000 481
2. J.K. Saxena, A.K. Srivastava, P.K. Murthy, R.K. Chatterjee, S. Ghatak, and R.D. Walter Tropenmed. Parasitol. 35 1984 174
3. U. Pandya, J.K. Saxena, S.M. Kaul, P.K. Murthy, R.K. Chatterjee, R.P. Tripathi, A.P. Bhaduri, and O.P. Shukla J. Helminthol. 71 1997 325
4. S. Bhattacharya, D. Katiyar, P. Bajpai, R.P. Tripathi, and J.K. Saxena Parasitol. Res. 92 2004 177
5. D. Katiyar, V.K. Tiwari, R.P. Tripathi, V.M. Reddy, S.M. Bhattacharya, and J.K. Saxena Arzreimittelforschung 53 2003 857
6. S.K. Srivastava, A. Agarwal, P.M.S. Chauhan, S.K. Agarwal, A.P. Bhaduri, S.N. Singh, N. Fatima, and R.K. Chatterjee J. Med. Chem. 42 1999 1667
7. S.K. Srivastava, P.M.S. Chauhan, A.P. Bhaduri, N. Fatima, and R.K. Chatterjee J. Med. Chem. 43 2000 2275
8. K.T. Potts, M.J. Cipullo, P. Ralli, and G. Theodoridis J. Org. Chem. 47 1982 3027
9. H. Junjappa, H. Ila, and C.V. Asokan Tetrahedron 1990 5423
10. W.D. Rudorf, A. Schierhorn, and M. Augustin Tetrahedron 35 1979 551
11. S.M.S. Chauhan, and H. Junjappa Tetrahedron 32 1976 1779
12. S.M.S. Chauhan, and H. Junjappa Synthesis 1974 880
13. K.T. Potts, M.J. Cipullo, P. Ralli, and G. Theodoridis J. Org. Chem. 47 1983 3027
14. U. Pandya, J.K. Saxena, S.M. Kaul, P.K. Murthy, R.K. Chatterjee, R.P. Tripathi, A.P. Bhaduri, and O.P. Shukla Med. Sci. Res. 27 1999 103
15. 5S: C 69.70, H 5.61, N 16.94. Found: C 69.35, H 5.76, N 16.83