Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

Journal of Medicinal Chemistry

Volumn 42, Issue 21, 1999, Pages 4300-4312

  Chowdhury, Shafinaz F ^a   Villamor, Victor Bernier ^b   Guerrero, Ramon Hurtado ^b   Leal, Isabel ^b   Brun, Reto ^c   Croft, Simon L ^d   Goodman, Jonathan M ^e   Maes, Louis ^f   Ruiz Perez, Luis M ^b   Pacanowska, Dolores Gonzalez ^b   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f TIBOTEC BVBA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 BENZYLPYRIMIDINE DERIVATIVE; ANTIPROTOZOAL AGENT; DIHYDROFOLATE REDUCTASE INHIBITOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; LEISHMANIASIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMIASIS;

ANIMALS; DRUG DESIGN; FOLIC ACID ANTAGONISTS; HUMANS; LEISHMANIA INFANTUM; LEISHMANIA MAJOR; MACROPHAGES, PERITONEAL; MICE; MODELS, MOLECULAR; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS, AFRICAN;

EID: 0032749527     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981130+     Document Type: Article

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