Control of cell death pathways by HTLV-1 proteins

Frontiers in Bioscience

Volumn 14, Issue 9, 2009, Pages 3338-3351

  Saggioro, Daniela ^a   Silic Benussi, Micol ^b   Biasiotto, Roberta ^b   D'Agostino, Donna M ^a,b   Ciminale, Vincenzo ^a,b  

^a VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Apoptosis; HTLV 1; Mitochondria; p12; p13; Review; Tax

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

VIRUS PROTEIN;

CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; HOMEOSTASIS; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW; T CELL LEUKEMIA;

CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; HOMEOSTASIS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; VIRAL PROTEINS;

EID: 63849254161     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2735/3456     Document Type: Article

References (137)

1. M. D. Lairmore. & G. Franchini: Human T-cell leukemia virus types 1 and 2. In: Fields Virology, Fifth Edition. Eds: Knipe D. M., Howley P. M., Lippincott Williams and Wilkins, Philadelphia (2007)
2. Grassmann R, M. Aboud, K. T. Jeang: Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 24, 5976-5985(2005) (Pubitemid 43086115)
3. Kubota R, S. S. Soldan, R. Martin, S. Jacobson: Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient. J Neurovirol 8, 53-57(2002) (Pubitemid 34196415)
4. Taylor G P, M. Matsuoka: Natural history of adult T-cell leukemia/lymphoma and approaches to therapy. Oncogene 24, 6047-6057(2005) (Pubitemid 43086122)
5. Hanahan D, R. A. Weinberg: The hallmarks of cancer. Cell 100, 57-70(2000) (Pubitemid 30046295)
6. Meier P, K. H. Vousden: Lucifer's labyrinth-ten years of path finding in cell death. Mol Cell 28, 746-754(2007) (Pubitemid 350225737)
7. Jana S, J. Paliwal: Apoptosis: potential therapeutic targets for new drug discovery. Curr Med Chem 14, 2369-2379(2007) (Pubitemid 47618045)
8. Krammer P H, R. Arnold, I. N. Lavrik: Life and death in peripheral T cells. Nat Rev Immunol 7, 532-542(2007) (Pubitemid 46987784)
9. Brenner D, P. H. Krammer, R. Arnold: Concepts of activated T cell death. Crit Rev Oncol Hematol 66, 52-64(2008)
10. Scaffidi C, S. Fulda, A. Srinivasan, C. Friesen, F. Li, K. J. Tomaselli, K. M. Debatin, P. H. Krammer, M. E. Peter: Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17, 1675-1687(1998) (Pubitemid 28119121)
11. Rasola A, P. Bernardi: The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis 12, 815-833(2007) (Pubitemid 46653292)
12. Valitutti S, S. Muller, M. Cella, E. Padovan, A. Lanzavecchia: Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151(1995)
13. Lanzavecchia A, F. Sallusto: Progressive differentiation and selection of the fittest in the immune response. Nat Rev Immunol 2, 982-987(2002) (Pubitemid 37323221)
14. Macallan D C, B. Asquith, A. J. Irvine, D. L. Wallace, A. Worth, H. Ghattas, Y. Zhang, G. E. Griffin, D. F. Tough, P. C. Beverley: Measurement and modeling of human T cell kinetics. Eur J Immunol 33, 2316-2326(2003) (Pubitemid 37010049)
15. Rathmell J C, C. B. Thompson: Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 109 Suppl, S97-107 (2002) (Pubitemid 34457855)
16. Schluns K S, L. Lefrancois: Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3, 269-279(2003) (Pubitemid 37328680)
17. Overbaugh J, C. R. Bangham: Selection forces and constraints on retroviral sequence variation. Science 292, 1106-1109(2001) (Pubitemid 32440922)
18. Asquith B, Y. Zhang, A. J. Mosley, C. M. de Lara, D. L. Wallace, A. Worth, L. Kaftantzi, K. Meekings, G. E. Griffin, Y. Tanaka, D. F. Tough, P. C. Beverley, G. P. Taylor, D. C. Macallan, C. R. Bangham: In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A 104, 8035-8040(2007) (Pubitemid 47185871)
19. Sibon D, A. S. Gabet, M. Zandecki, C. Pinatel, J. Thete, M. H. Delfau-Larue, S. Rabaaoui, A. Gessain, O. Gout, S. Jacobson, F. Mortreux, E. Wattel: HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest 116, 974-983(2006)
20. Harhaj E W, L. Good, G. Xiao, S. C. Sun: Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 18, 1341-1349(1999) (Pubitemid 29094886)
21. Ruckes T, D. Saul, J. Van Snick, O. Hermine, R. Grassmann: Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. Blood 98, 1150-1159(2001)
22. Pise-Masison C A, M. Radonovich, R. Mahieux, P. Chatterjee, C. Whiteford, J. Duvall, C. Guillerm, A. Gessain, J. N. Brady: Transcription profile of cells infected with human T-cell leukemia virus type I compared with activated lymphocytes. Cancer Res 62, 3562-3571(2002) (Pubitemid 34651409)
23. Akl H, B. M. Badran, N. E. Zein, F. Bex, C. Sotiriou, K. E. Willard-Gallo, A. Burny, P. Martiat: HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation. Leukemia 21, 788-796(2007) (Pubitemid 46444564)
24. Kfoury Y, R. Nasr, O. Hermine, H. de The, A. Bazarbachi: Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway. Cell Death Differ 12 Suppl 1, 871-877(2005) (Pubitemid 41030603)
25. Yoshida, M.: Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol 19, 475-496(2001) (Pubitemid 32368043)
26. Grassmann R, C. Dengler, I. Muller-Fleckenstein, B. Fleckenstein, K. McGuire, M. C. Dokhelar, J. G. Sodroski, W. A. Haseltine: Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci U S A 86, 3351-3355(1989) (Pubitemid 19129609)
27. Robek M D, L. Ratner: Immortalization of CD4 (+) and CD8 (+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J Virol 73, 4856-4865(1999) (Pubitemid 29246746)
28. Hasegawa H, H. Sawa, M. J. Lewis, Y. Orba, N. Sheehy, Y. Yamamoto, T. Ichinohe, Y. Tsunetsugu-Yokota, H. Katano, H. Takahashi, J. Matsuda, T. Sata, T. Kurata, K. Nagashima, W. W. Hall: Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12, 466-472(2006)
29. Franchini G, C. Nicot, J. M. Johnson: Seizing of T cells by human T-cell leukemia/lymphoma virus type 1. Adv Cancer Res 89, 69-132(2003) (Pubitemid 41184280)
30. Neuveut C, K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, K. T. Jeang: Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol 18, 3620-3632(1998) (Pubitemid 28240535)
31. Haller K, Y. Wu, E. Derow, I. Schmitt, K. T. Jeang, R. Grassmann: Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. Mol Cell Biol 22, 3327-3338(2002) (Pubitemid 34453974)
32. Suzuki, T, S. Kitao, H. Matsushime, M. Yoshida: HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4. EMBO J 15, 1607-1614(1996)
33. Wu K, M. E. Bottazzi, C. de la Fuente, L. Deng, S. D. Gitlin, A. Maddukuri, S. Dadgar, H. Li, A. Vertes, A. Pumfery, F. Kashanchi: Protein profile of tax-associated complexes. J Biol Chem 279, 495-508(2004) (Pubitemid 38044851)
34. Lemoine F J, S. J. Marriott: Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene 21, 7230-7234(2002) (Pubitemid 35305610)
35. Yamada T, S. Yamaoka, T. Goto, M. Nakai, Y. Tsujimoto, M. Hatanaka: The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J Virol 68, 3374-3379(1994) (Pubitemid 24129788)
36. Chlichlia K, G. Moldenhauer, P. T. Daniel, M. Busslinger, L. Gazzolo, V. Schirrmacher, K. Khazaie: Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis. Oncogene 10, 269-277(1995)
37. Fujita M, H. Shiku: Differences in sensitivity to induction of apoptosis among rat fibroblast cells transformed by HTLV-I tax gene or cellular nuclear oncogenes. Oncogene 11, 15-20(1995)
38. Chen X, V. Zachar, M. Zdravkovic, M. Guo, P. Ebbesen, X. Liu: Role of the Fas/Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type I Tax transactivator. J Gen Virol 78, 3277-3285(1997) (Pubitemid 27511318)
39. Hall A P, J. Irvine, K. Blyth, E. R. Cameron, D. E. Onions, M. E. Campbell: Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. J Pathol 186, 209-214(1998) (Pubitemid 28467832)
40. Nicot C, R. Harrod: Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 Tax protein. Mol Cell Biol 20, 8580-8589(2000)
41. Kao S Y, F. J. Lemoine, S. J. Mariott: HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents. Oncogene 19, 2240-2248(2000) (Pubitemid 30307190)
42. Brauweiler A, J. E. Garrus, J. C. Reed, J. K. Nyborg: Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. Virology 231, 135-140(1997) (Pubitemid 27238771)
43. Copeland K F, A. G. Haaksma, J. Goudsmit, P. H. Krammer, J. L. Heeney: Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax. AIDS Res Hum Retroviruses 10, 1259-1268(1994) (Pubitemid 24349702)
44. Kishi S, S. Saijyo, M. Arai, S. Karasawa, S. Ueda, M. Kannagi, Y. Iwakura, M. Fujii, S. Yonehara: Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy. J Exp Med 186, 57-64(1997) (Pubitemid 27304847)
45. Arai M, M. Kannagi, M. Matsuoka, T. Sato, N. Yamamoto, M. Fujii: Expression of FAP-1 (Fasassociated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients. AIDS Res Hum Retroviruses 14, 261-267(1998) (Pubitemid 28084021)
46. Mulloy J C, T. Kislyakova, A. Cereseto, L. Casareto, A. LoMonico, J. Fullen, M. V. Lorenzi, A. Cara, C. Nicot, C. Giam, G. Franchini: Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain. J Virol 72, 8852-8860(1998) (Pubitemid 28471829)
47. Iwanaga Y, T. Tsukahara, T. Ohashi, Y. Tanaka, M. Arai, M. Nakamura, K. Ohtani, Y. Koya, M. Kannagi, N. Yamamoto, M. Fujii: Human T-cell leukemia virus type 1 tax protein abrogates interleukin-2 dependence in a mouse T-cell line. J Virol 73, 1271-1277(1999) (Pubitemid 29036781)
48. Kawakami A, T. Nakashima, H. Sakai, S. Urayama, S. Yamasaki, A. Hida, M. Tsuboi, H. Nakamura, H. Ida, K. Migita, Y. Kawabe, K. Eguchi: Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation. Blood 94, 3847-3854(1999)
49. Saggioro D, S. Barp, L. Chieco-Bianchi: Block of a mitochondrial-mediated apoptotic pathway in Taxexpressing murine fibroblasts. Exp Cell Res 269, 245-55(2001) (Pubitemid 32907166)
50. Mesnard J M, C. Devaux: Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. Virology 257, 277-284(1999) (Pubitemid 29393394)
51. de la Fuente C, L. Wang, D. Wang, L. Deng, K. Wu, H. Li, L. D. Stein, T. Denny, F. Coffman, K. Kehn, S. Baylor, A. Maddukuri, A. Pumfery, F. Kashanchi: Paradoxical effects of a stress signal on pro-and anti-apoptotic machinery in HTLV-1 Tax expressing cells. Mol Cell Biochem 245, 99-113(2003) (Pubitemid 36416826)
52. Tsukasaki K, S. Tanosaki, S. DeVos, W. K. Hofmann, W. Wachsman, A. F. Gombart, J. Krebs, A. Jauch, C. R. Bartram, K. Nagai, M. Tomonaga, J. W. Said, H. P. Koeffler: Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays. Int J Cancer 109, 875-881(2004) (Pubitemid 38500744)
53. Pomerantz J L, D. Baltimore: Two pathways to NF-kappaB. Mol Cell 10, 693-695(2002)
54. Claudio E, K. Brown, U. Siebenlist: NF-kappaB guides the survival and differentiation of developing lymphocytes. Cell Death Differ 13, 697-701(2006)
55. Ballard D W, E. Bohnlein, J. W. Lowenthal, Y. Wano, B. R. Franza, W. C. Greene: HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science 241, 1652-1655(1988)
56. Mori N, M. Fujii, S. Ikeda, Y. Yamada, M. Tomonaga, D. W. Ballard, N. Yamamoto: Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood 93, 2360-8(1999) (Pubitemid 29153640)
57. Mori N, M. Fujii, M. Hinz, K. Nakayama, Y. Yamada, S. Ikeda, Y. Yamasaki, F. Kashanchi, Y. Tanaka, M. Tomonaga, N. Yamamoto: Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2-independent growth of T cells. Int J Cancer 99, 378-385(2002) (Pubitemid 34495852)
58. Hironaka N, K. Mochida, N. Mori, M. Maeda, N. Yamamoto, S. Yamaoka: Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia 6, 266-278(2004) (Pubitemid 38657083)
59. Yamaoka S, G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, A. Israel: Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93, 1231-1240(1998) (Pubitemid 28307427)
60. Harhaj E. W, S. C. Sun: IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem 274, 22911-22914(1999)
61. Chu Z L, Y. A. Shin, J. M. Yang, J. A. DiDonato, D. W. Ballard: IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. J Biol Chem 274, 15297-15300(1999)
62. Xiao G, E. W. Harhaj, S. C. Sun: Domain-specific interaction with the I kappa B kinase (IKK) regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J Biol Chem 275, 34060-34067(2000)
63. Xiao G, M. E. Cvijic, A. Fong, E. W. Harhaj, M. T. Uhlik, M. Waterfield, S. C. Sun: Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 20, 6805-6815(2001) (Pubitemid 33134210)
64. Kitajima I, T. Shinohara, J. Bilakovics, D. A. Brown, X. Xu, M. Nerenberg: Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B. Science 258, 1792-1795(1992) (Pubitemid 23087346)
65. Sanda T, K. Asamitsu, H. Ogura, S. Iida, A. Utsunomiya, R. Ueda, T. Okamoto: Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia 20, 590-598(2006)
66. Mori N, Y. Yamada, S. Ikeda, Y. Yamasaki, K. Tsukasaki, Y. Tanaka, M. Tomonaga, N. Yamamoto, M. Fujii: Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100, 1828-1834(2002) (Pubitemid 34925163)
67. Waldele K, K. Silbermann, G. Schneider, T. Ruckes, B. R. Cullen, R. Grassmann: Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Blood 107, 4491-4499(2006) (Pubitemid 43801377)
68. Pichler K, T. Kattan, J. Gentzsch, A. K. Kress, G. P. Taylor, C. R. Bangham, R. Grassmann: Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T-cells by the viral Tax oncoprotein. Blood 111, 4741-4751(2008)
69. Mayr B, M. Montminy: Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2, 599-609(2001) (Pubitemid 33674011)
70. Cha-Molstad H, D. M. Keller, G. S. Yochum, S. Impey, R. H. Goodman: Cell-type-specific binding of the transcription factor CREB to the cAMP-response element. Proc Natl Acad Sci U S A 101, 13572-13577(2004) (Pubitemid 39238444)
71. Chrivia J C, R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, R. H. Goodman: Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-369(1993)
72. Parker D, K. Ferreri, T. Nakajima, V. J. LaMorte, R. Evans, S. C. Koerber, C. Hoeger, M. R. Montminy: Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism. Mol Cell Biol 16, 694-703(1996)
73. Zhang X, D. T. Odom, S. H. Koo, M. D. Conkright, G. Canettieri, J. Best, H. Chen, R. Jenner, E. Herbolsheimer, E. Jacobsen, S. Kadam, J. R. Ecker, B. Emerson, J. B. Hogenesch, T. Unterman, R. A. Young, M. Montminy: Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A 102, 4459-4464(2005) (Pubitemid 40397134)
74. Jean D, M. Harbison, D. J. McConkey, Z. Ronai, M. Bar-Eli: CREB and its associated proteins act as survival factors for human melanoma cells. J Biol Chem 273, 24884-24890(1998) (Pubitemid 28454995)
75. Ciani E, S. Guidi, G. Della Valle, G. Perini, R. Bartesaghi, A. Contestabile: Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation. J Biol Chem 277, 49896-49902(2002) (Pubitemid 36014438)
76. Mantamadiotis T, T. Lemberger, S. C. Bleckmann, H. Kern, O. Kretz, A. Martin Villalba, F. Tronche, C. Kellendonk, D. Gau, J. Kapfhammer, C. Otto, W. Schmid, G. Schutz: Disruption of CREB function in brain leads to neurodegeneration. Nat Genet 31, 47-54(2002)
77. Shankar D B, K. M. Sakamoto: The role of cyclic-AMP binding protein (CREB) in leukemia cell proliferation and acute leukemias. Leuk Lymphoma 45, 265-270(2004) (Pubitemid 38181427)
78. Shankar D B, J. C. Cheng, K. Kinjo, N. Federman, T. B. Moore, A. Gill, N. P. Rao, E. M. Landaw, K. M. Sakamoto: The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia. Cancer Cell 7, 351-362(2005) (Pubitemid 40544652)
79. Shankar D B, J. C. Cheng, K. M. Sakamoto: Role of cyclic AMP response element binding protein in human leukemias. Cancer 104, 1819-1824(2005) (Pubitemid 41513163)
80. Cheng J C, K. Kinjo, D. R. Judelson, J. Chang, W. S. Wu, I. Schmid, D. B. Shankar, N. Kasahara, R. Stripecke, R. Bhatia, E. M. Landaw, K. M. Sakamoto: CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood 111, 1182-1192(2008) (Pubitemid 351213399)
81. Saggioro D, L. Acquasaliente, L. Daprai, L. Chieco-Bianchi: Inhibition of apoptosis by human T-lymphotropic virus type-1 tax protein. Ann N y Acad Sci 1010, 591-597(2003) (Pubitemid 38265052)
82. Trevisan R, L. Daprai, L. Acquasaliente, V. Ciminale, L. Chieco-Bianchi, D. Saggioro: Relevance of CREB phosphorylation in the anti-apoptotic function of human T-lymphotropic virus type 1 tax protein in serum-deprived murine fibroblasts. Exp Cell Res 299, 57-67(2004) (Pubitemid 39078381)
83. Trevisan R, L. Daprai, L. Paloschi, N. Vajente, L. Chieco-Bianchi, D. Saggioro: Antiapoptotic effect of human T-cell leukemia virus type 1 tax protein correlates with its creb transcriptional activity. Exp Cell Res 312, 1390-1400(2006)
84. Kim y M, J. A. Ramirez, J. E. Mick, H. A. Giebler, J. P. Yan, J. K. Nyborg: Molecular characterization of the tax-containing HTLV-1 enhancer complex reveals a prominent role for CREB phosphorylation in tax transactivation. J Biol Chem 282, 18750-18757(2007) (Pubitemid 47100135)
85. Wilson J B, J. L. Bell, A. J. Levine: Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. EMBO J 15, 3117-3126(1996) (Pubitemid 26187759)
86. Wilson B E, E. Mochon, L. M. Boxer: Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol 16, 5546-5556(1996) (Pubitemid 26315074)
87. Mori N, M. Fujii, G. Cheng, S. Ikeda, Y. Yamasaki, Y. Yamada, M. Tomonaga, N. Yamamoto: Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways. Virus Genes 22, 279-287(2001) (Pubitemid 32587634)
88. Datta S R, A. Brunet, M. E. Greenberg: Cellular survival: a play in three Akts. Genes Dev 13, 2905-2927(1999)
89. Fresno Vara J A, E. Casado, J. de Castro, P. Cejas, C. Belda-Iniesta, M. Gonzalez-Baron: PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30, 193-204(2004)
90. Peloponese J M Jr, K. T. Jeang: Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein. J Biol Chem 281, 8927-8938(2006)
91. Jeong S J, C. A. Pise-Masison, M. F. Radonovich, H. U. Park, J. N. Brady: Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene 24, 6719-6728(2005) (Pubitemid 41486802)
92. Ikezoe T, C. Nishioka, K. Bandobashi, Y. Yang, Y. Kuwayama, Y. Adachi, T. Takeuchi, H. P. Koeffler, H. Taguchi: Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells. Leuk Res 31, 673-682(2007) (Pubitemid 46560001)
93. Jeong S J, A. Dasgupta, K. J. Jung, J. H. Um, A. Burke, H. U. Park, J. N. Brady: PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 370, 264-272(2008) (Pubitemid 350199679)
94. Fridman J S, S. W. Lowe: Control of apoptosis by p53. Oncogene 22, 9030-9040(2003) (Pubitemid 38121703)
95. Rodier F, J. Campisi, D. Bhaumik: Two faces of p53: aging and tumor suppression. Nucleic Acids Res 35, 7475-7484(2007)
96. Reid R L, P. F. Lindholm, A. Mireskandari, J. Dittmer, J. N. Brady: Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Oncogene 8, 3029-3036(1993) (Pubitemid 23312907)
97. Takemoto S, R. Trovato, A. Cereseto, C. Nicot, T. Kislyakova, L. Casareto, T. Waldmann, G. Torelli, G. Franchini: p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14 (ARF)-MDM2 loop in ex vivo and cultured adult T-cell leukemia/lymphoma cells. Blood 95, 3939-3944(2000) (Pubitemid 30412871)
98. Pise-Masison C A, K. S. Choi, M. Radonovich, J. Dittmer, S. J. Kim, J. N. Brady: Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 Tax protein. J Virol 72, 1165-1170(1998) (Pubitemid 28116899)
99. Ariumi Y, A. Kaida, J. Y. Lin, M. Hirota, O. Masui, S. Yamaoka, Y. Taya, K. Shimotohno: HTLV-1 tax oncoprotein represses the p53-mediated transactivation function through coactivator CBP sequestration. Oncogene 19, 1491-1499(2000) (Pubitemid 30175670)
100. Pise-Masison C A, R. Mahieux, H. Jiang, M. Ashcroft, M. Radonovich, J. Duvall, C. Guillerm, J. N. Brady: Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation. Mol Cell Biol 20, 3377-3386(2000) (Pubitemid 30243883)
101. Jeong S J, M. Radonovich, J. N. Brady, C. A. Pise-Masison: HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity. Blood 104, 1490-1497(2004) (Pubitemid 39166529)
102. Datta A, M. Bellon, U. Sinha-Datta, A. Bazarbachi, Y. Lepelletier, D. Canioni, T. A. Waldmann, O. Hermine, C. Nicot: Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood 108, 1021-1029(2006) (Pubitemid 44154640)
103. Kehn K, L. Fuente Cde, K. Strouss, R. Berro, H. Jiang, J. Brady, R. Mahieux, A. Pumfery, M. E. Bottazzi, F. Kashanchi: The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene 24, 525-540(2005) (Pubitemid 40188558)
104. Krueger A, S. C. Fas, M. Giaisi, M. Bleumink, A. Merling, C. Stumpf, S. Baumann, D. Holtkotte, V. Bosch, P. H. Krammer, M. Li-Weber: HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP). Blood 107, 3933-3939(2006) (Pubitemid 43726799)
105. Nicot C, R. L. Harrod, V. Ciminale, G. Franchini: Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene 24, 6026-6034(2005) (Pubitemid 43086120)
106. Albrecht B, M. D. Lairmore: Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol Mol Biol Rev 66, 396-406(2002) (Pubitemid 35001136)
107. Derse D, J. Mikovits, F. Ruscetti: X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 237, 123-128(1997) (Pubitemid 27464847)
108. Robek M D, F. H. Wong, L. Ratner: Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes. J Virol 72, 4458-4462(1998) (Pubitemid 28188757)
109. Collins N D, G. C. Newbound, B. Albrecht, J. L. Beard, L. Ratner, M. D. Lairmore: Selective ablation of human T-cell lymphotropic virus type 1 p12I reduces viral infectivity in vivo. Blood 91, 4701-4707(1998) (Pubitemid 28270320)
110. Hiraragi H, S. J. Kim, A. J. Phipps, M. Silic-Benussi, V. Ciminale, L. Ratner, P. L. Green, M. D. Lairmore: Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13 (II) is required for viral infectivity in vivo. J Virol 80, 3469-3476(2006)
111. D'Agostino D. M, M. Silic-Benussi, H. Hiraragi, M. D. Lairmore, V. Ciminale: The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth. Cell Death Differ 12 Suppl 1, 905-915(2005) (Pubitemid 41030605)
112. D'Agostino D M, L. Zotti, T. Ferro, G. Franchini, L. Chieco-Bianchi, V. Ciminale: The p13II protein of HTLV type 1: comparison with mitochondrial proteins coded by other human viruses. AIDS Res Hum Retroviruses 16, 1765-1770(2000)
113. Koralnik I J, J. Fullen, G. Franchini: The p12I, p13II, and p30II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J Virol 67, 2360-2366(1993) (Pubitemid 23088414)
114. Ciminale V, L. Zotti, D. M. D'Agostino, T. Ferro, L. Casareto, G. Franchini, P. Bernardi, L. Chieco-Bianchi: Mitochondrial targeting of the p13II protein coded by the x-II ORF of human T-cell leukemia/lymphotropic virus type I (HTLV-I). Oncogene 18, 4505-4514(1999) (Pubitemid 29396658)
115. Silic-Benussi M, I. Cavallari, T. Zorzan, E. Rossi, H. Hiraragi, A. Rosato, K. Horie, D. Saggioro, M. D. Lairmore, L. Willems, L. Chieco-Bianchi, D. M. D'Agostino, V. Ciminale: Suppression of tumor growth and cell proliferation by p13II, a mitochondrial protein of human T cell leukemia virus type 1. Proc Natl Acad Sci U S A 101, 6629-6634(2004) (Pubitemid 38586025)
116. Hiraragi H, B. Michael, A. Nair, M. Silic-Benussi, V. Ciminale, M. Lairmore: Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13II sensitizes Jurkat T cells to Ras-mediated apoptosis. J Virol 79, 9449-9457(2005) (Pubitemid 41022289)
117. Lefebvre L, A. Vanderplasschen, V. Ciminale, H. Heremans, O. Dangoisse, J. C. Jauniaux, J. F. Toussaint, V. Zelnik, A. Burny, R. Kettmann, L. Willems: Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13 (II) accessory proteins interact with farnesyl pyrophosphate synthetase. J Virol 76, 1400-1414(2002) (Pubitemid 34066441)
118. Yi M, D. Weaver, G. Hajnoczky: Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol 167, 661-672(2004) (Pubitemid 39565147)
119. Pizzo P, T. Pozzan: Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics. Trends Cell Biol 17, 511-517(2007) (Pubitemid 47562768)
120. Bernardi, P, A. Rasola: Calcium and cell death: the mitochondrial connection. Subcell Biochem 45, 481-506(2007)
121. D'Agostino D M, L. Ranzato, G. Arrigoni, I. Cavallari, F. Belleudi, M. R. Torrisi, M. Silic-Benussi, T. Ferro, V. Petronilli, O. Marin, L. Chieco-Bianchi, P. Bernardi, V. Ciminale: Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. Critical role of arginine residues. J Biol Chem 277, 34424-34433(2002)
122. Rustin P: Mitochondria, from cell death to proliferation. Nat Genet 30, 352-353(2002)
123. Giorgio M, M. Trinei, E. Migliaccio, P. G. Pelicci: Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 8, 722-728(2007) (Pubitemid 47312827)
124. Ding W, B. Albrecht, R. Luo, W. Zhang, J. R. Stanley, G. C. Newbound, M. D. Lairmore: Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12 (I): association with calreticulin and calnexin. J Virol 75, 7672-7682(2001) (Pubitemid 32738025)
125. Johnson J M, C. Nicot, J. Fullen, V. Ciminale, L. Casareto, J. C. Mulloy, S. Jacobson, G. Franchini: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12 (I) protein. J Virol 75, 6086-6094(2001) (Pubitemid 32553139)
126. Franchini G, J. C. Mulloy, I. J. Koralnik, A. lo Monico, J. J. Sparkowski, T. Andresson, D. J. Goldstein, R. Schlegel: The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase. J Virol 67, 7701-7704(1993) (Pubitemid 23343909)
127. Mulloy J C, R. W. Crownley, J. Fullen, W. J. Leonard, G. Franchini: The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface. J Virol 70, 3599-3605(1996)
128. Nicot C, J. C. Mulloy, M. G. Ferrari, J. M. Johnson, K. Fu, R. Fukumoto, R. Trovato, J. Fullen, W. J. Leonard, G. Franchini: HTLV-1 p12 (I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells. Blood 98, 823-829(2001)
129. Albrecht B, N. D. Collins, M. T. Burniston, J. W. Nisbet, L. Ratner, P. L. Green, M. D. Lairmore: Human T-lymphotropic virus type 1 open reading frame I p12 (I) is required for efficient viral infectivity in primary lymphocytes. J Virol 74, 9828-9835(2000)
130. Banerjee P, G. Feuer, E. Barker: Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and-2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cellmediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. J Virol 81, 9707-9717(2007) (Pubitemid 350067675)
131. Ding W, B. Albrecht, R. E. Kelley, N. Muthusamy, S. J. Kim, R. A. Altschuld, M. D. Lairmore: Human T-cell lymphotropic virus type 1 p12 (I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells. J Virol 76, 10374-10382(2002)
132. Albrecht B, C. D. D'Souza, W. Ding, S. Tridandapani, K. M. Coggeshall, M. D. Lairmore: Activation of nuclear factor of activated T cells by human T-lymphotropic virus type 1 accessory protein p12 (I). J Virol 76, 3493-3501(2002) (Pubitemid 34224550)
133. Kim S J, W. Ding, B. Albrecht, P. L. Green, M. D. Lairmore: A conserved calcineurin-binding motif in human T lymphotropic virus type 1 p12I functions to modulate nuclear factor of activated T cell activation. J Biol Chem 278, 15550-15557(2003) (Pubitemid 36799662)
134. Nair A, B. Michael, H. Hiraragi, S. Fernandez, G. Feuer, K. Boris-Lawrie, M. Lairmore: Human T lymphotropic virus type 1 accessory protein p12I modulates
135. Los M, K. Khazaie, K. Schulze-Osthoff, P. A. Baeuerle, V. Schirrmacher, K. Chlichlia: Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state. J Immunol 161, 3050-3055(1998) (Pubitemid 28425731)
136. Sasada T, H. Nakamura, H. Masutani, S. Ueda, H. Sono, A. Takabayashi, J. Yodoi: Thioredoxin-mediated redox control of human T cell lymphotropic virus type I (HTLV-I) gene expression. Mol Immunol 38, 723-732(2002) (Pubitemid 34158875)
137. Masutani H, S. Ueda, J. Yodoi: The thioredoxin system in retroviral infection and apoptosis. Cell Death Differ 12 Suppl 1, 991-998(2005) (Pubitemid 41030612)