Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein

Molecular and Cellular Biology

Volumn 22, Issue 10, 2002, Pages 3327-3338

  Haller, Kerstin ^a   Wu, Yalin ^a   Derow, Elisabeth ^a   Schmitt, Iris ^a   Jeang, Kuan Teh ^a   Grassmann, Ralph ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; GROWTH FACTOR; HOLOENZYME; ONCOPROTEIN; PROTEIN P21; RETINOBLASTOMA PROTEIN; TAX PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA; LYMPHOCYTE TRANSFORMATION; MITOGENICITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RETINOBLASTOMA; T LYMPHOCYTE ACTIVATION; TRANSGENIC MOUSE;

CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; FIBROBLASTS; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LYMPHOCYTES; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA PROTEIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1; MUS MUSCULUS; RNA VIRUSES;

EID: 0036242244     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.10.3327-3338.2002     Document Type: Article

References (52)

1. Proliferative response of Tax 1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway
2. Expression of cell-cycle regulatory genes in HTLV-1 infected T-cell lines: Possible involvement of Tax1 in the altered expression of cyclin D2, p181nk4 and p21Waf1/Cip1/Sid1
3. A pair of selectable herpesvirus vectors for simultaneous gene expression in human lymphoid cells
4. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma
5. Repression of bax gene expression by the HTLV-1 Tax protein: Implications for suppression of apoptosis in virally infected cells
6. Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets
7. Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with tropical spastic paraparesis/HTLV-1 associated myelopathy
8. p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T-cells
9. Limiting amounts of p27Kip1 correlates with constitutive activation of cyclin E-CDK2 complex in HTLV-1-transformed T-cells
10. Identification of CDK4 sequences involved in cyclin D1 and p16 binding
11. wafl in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2
12. High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis
13. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by herpesvirus saimiri vector
14. Selectable recombinant herpesvirus saimiri is capable of persisting in a human T-cell line
15. Role of human T-cell leukemia virus type I X region proteins in immortalization of primary human lymphocytes in culture
16. Viral transformation of human T-lymphocytes
17. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
18. Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells
19. Abundant tax protein expression in CD4+T cells infected with human T-cell lymphotropic virus type I (HTLV-1) is prevented by cytotoxic T lymphocytes
20. High frequency of viral protein expression in human T cell lymphotropic virus type 1-infected peripheral blood mononuclear cells
21. Direct trans-activation of the human cyclin D2 gene by the oncogenc product Tax of human T-cell leukemia virus type I
22. How viral oncogenes make the cell cycle
23. HTLV-I transactivator protein, tax, is a trans-repressor of the human beta-polymerase gene
24. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
25. Virus-encoded cyclin
26. New functional activities for the p21 family of CDK inhibitors
27. Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16 INK4A-negative T-cell line
28. Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4A
29. A family of human cdc2-related protein kinases
30. CDK4 expression and activity are required for cytokine responsiveness in T cells
31. Principles of CDK regulation
32. Cyclin-dependent kinases: Engines, clocks, and microprocessors
33. Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain
34. Human T-cell leukemia virus type 1 Tax and cell cycle progression: Role of cyclin D-cdk and p110Rb
35. Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I
36. Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-κB pathway and is dependent on p53 phosphorylation
37. Creation of chimeric junctions, deletions, and insertions by PCR
38. Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the Tax-CBP/p300 interaction
39. A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes
40. Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309
41. Transcriptional up-regulation of the cyclin D2 gene and acquisition of new cyclin-dependent kinase partners in human T-cell leukemia virus type 1-infected cells
42. 1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein
43. HTLV-1 Tax is a zinc-binding protein: Role of zinc in Tax structure and function
44. Mutational analysis of human T-cell leukemia virus type I Tax: Regions necessary for function determined with 47 mutant proteins
45. G1 phase progression: Cycling on cue
46. D-type cyclins
47. Identification of HTLV-1 tax trans-activator mutants exhibiting novel transcriptional phenotypes
48. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4
49. Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms
50. Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins
51. Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53
52. HTLV-1 oncoprotein tax and cellular transcription factors