Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12I protein

Journal of Virology

Volumn 75, Issue 13, 2001, Pages 6086-6094

  Johnson, J M ^a   Nicot, C ^a   Fullen, J ^a   Ciminale, V ^a   Casareto, L ^a   Mulloy, J C ^a   Jacobson, S ^a   Franchini, G ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; HLA A2 ANTIGEN; HLA B7 ANTIGEN; HLA C ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS PROTEIN;

ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; VIRUS INTERFERENCE;

BETA 2-MICROGLOBULIN; BIOLOGICAL TRANSPORT; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A2 ANTIGEN; HLA-B7 ANTIGEN; HLA-C ANTIGENS; HUMANS; MULTIENZYME COMPLEXES; ONCOGENE PROTEINS, VIRAL; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANSCRIPTION FACTORS;

EID: 0034978742     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.13.6086-6094.2001     Document Type: Article

References (56)

1. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain
2. Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains
3. Cutting edge: Adenovirus E19 has two mechanisms for affecting class I MHC expression
4. Degradation of proteins retained in the endoplasmic reticulum
5. Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: Novel mRNAs and proteins produced by HTLV-I
6. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
7. HIV-1 Nef protein protects infected primary, cells against killing by cytotoxic T lymphocytes
8. I reduces viral infectivity in vivo
9. The HTLV-I orf I protein is recognized by serum antibodies from naturally infected humans and experimentally infected rabbits
10. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro
11. Lactacystin, proteasome function, and cell fate
12. Structure, function and regulation of the coated vesicle V-ATPase
13. + ATPase
14. Antibodies to human T-lymphotropic virus type I in patients with tropical spastic paraparesis
15. A new technique for the assay of infectivity of human adenovirus 5 DNA
16. Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera
17. Down-regulation of major histocompatibility complex class 1 molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
18. Isolation of an HTLV-I-like retrovirus from patients with tropical spastic paraparesis
19. MHC gene control of the natural killer system at the level of the target and the host
20. Importance of the Nef gene for maintenance of high virus loads and for development of AIDS
21. Protein isoforms encoded by the pX region of the human T-cell leukemia/lymphotropic virus type I
22. In vitro infection of human macrophages by human T-cell leukemia/lymphotropic virus type 1 (HTLV-1)
23. I and the vacuolar H+ATPase 16 kDa subunit protein
24. II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments
25. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
26. Interactions between HIV-1 Nef and Vacuolar ATPase facilitate the internalization of CD4
27. The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane
28. Cell lines producing human T-cell lymphoma virus show altered HLA expression
29. Calreticulin: One protein, one gene, many functions
30. c chains and affects their expression on the cell surface
31. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
32. Folding and assembly of major histocompatibility complex class 1 heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide
33. I protein enhances STAT5 activation and decreases the IL-2 requirement for proliferation of primary human PBMC
34. HTLV-1 associated myelopathy, a new clinical entity
35. 2+ store, with functional properties distinct from those of the endoplasmic reticulum
36. Evidence for the chronic in vivo production of human T cell leukemia virus type 1 Rof and Tof proteins from cytotoxic T lymphocytes directed against viral peptides
37. Viral strategies of immune evasion
38. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
39. Primary structure of the Aequorea victoria green-fluorescent protein
40. Calnexin retains unassembled major histocompatibility complex class I free heavy chains in the endoplasmic reticulum
41. Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes
42. Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes
43. HTLV-I and HTLV-III antibodies and tropical spastic paraparesis
44. Surfing the Sec61 channel: Bidirectional protein translocation across the ER membrane
45. Human T-cell leukemia virus type I transactivator induces class I major histocompatibility antigen expression in glial cells
46. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11
47. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
48. Altered HLA antigens expressed on T and B lymphocytes of adult T-cell leukemia/lymphoma patients and their relatives
49. The cytosolic tail of class 1 MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products
50. Viral subversion of the immune system
51. I protein greatly influences its stability
52. Altered expression of class 1 HLA antigen on peripheral mononuclear cells in patients with adult T-cell leukemia: Inverse relationship with natural killer susceptibility
53. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
54. Sec61-mediated transfer of membrane protein from the endoplasmic reticulum to the proteasome for destruction
55. Antigen processing and presentation by the class I major histocompatibility complex
56. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease