Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 tax protein

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8580-8589

  Nicot, C ^a   Harrod, R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P300; TAX PROTEIN; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIRUS INFECTION;

AMINO ACID CHLOROMETHYL KETONES; APOPTOSIS; BASE SEQUENCE; BINDING SITES; CASPASES; CELL NUCLEUS; CYSTEINE PROTEINASE INHIBITORS; GENE PRODUCTS, TAX; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NF-KAPPA B; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANS-ACTIVATORS;

EID: 0033756230     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8580-8589.2000     Document Type: Article

References (61)

1. Compensatory apoptosis in response to SV40 large T antigen expression in the liver
2. Activate NF-kappa B or die?
3. Control of apoptosis by Rel/NF-kappaB transcription factors
4. Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB-binding protein and p300
5. A node between proliferation, apoptosis, and growth arrest
6. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
7. Induction of apoptosis by the transcription factor c-Jun
8. The p53 pathway and apoptosis
9. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
10. Role of CBP/p300 in nuclear receptor signaling
11. Immediate effects of reversible HTLV-I Tax function: T-cell activation and apoptosis
12. ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death
13. The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein
14. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
15. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
16. Anchoring of CREB-binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation
17. Conjunction dysfunction: CBP/p300 in human disease
18. Tumors derived from HTLV-I Tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression
19. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
20. p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex
21. An exposed KID-like domain in human T-cell lymphotropic virus type-1 Tax is responsible for the recruitment of coactivators CBP/p300
22. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor
23. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
24. Nuclear fusion of signaling pathways
25. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
26. Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation
27. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
28. Human T cell leukemia virus-I (HTLV-I) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular prooxidant state
29. Twist is a potential oncogene that inhibits apoptosis
30. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C.elegans cell death gene ced-3
31. Activation of Bcl2 expression in human endothelial cells chronically expressing the human T-cell lymphotropic virus type-I
32. HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300
33. Bcl-X(L) is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples
34. Cytoplasmic forms of human T-cell leukemia virus type 1 Tax induce NF-κB activation
35. Establishment of HTLV-I-infected cell lines from French, Guianese and West Indian patients and isolation of a proviral clone producing viral particles
36. HTLV-I induced myeloneuropathy in WKAH rats: Apoptosis and local activation of the HTLV-I pX and TNF-alpha genes implicated in the pathogenesis
37. HTLV-I associated myelopathy, a new clinical entity
38. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
39. Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse
40. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
41. E2F1 has both oncogenic and tumor-suppressive properties in a transgenic model
42. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
43. Apoptotic response to growth factor deprivation involves cooperative interactions between c-Fos and p300
44. p53-Mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300
45. Dysregulation of apoptosis in cancer
46. Mechanisms of apoptosis avoidance in cancer
47. Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein
48. Transcriptional activation by NF-kappaB requires multiple coactivators
49. Identification of HTLV-I Tax trans-activator mutants exhibiting novel transcriptional phenotypes
50. Persistent activation of NF-kappaB by the Tax transforming protein of HTLV-1: Hijacking cellular IkappaB kinases
51. Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site
52. Apoptosis in the pathogenesis and treatment of disease
53. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat
54. Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control
55. Binding of p53 to the KIX domain of CREB binding protein
56. Transcriptional cross talk between NF-κB and p53
57. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha
58. The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein
59. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
60. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
61. Function for p300 and not CBP in the apoptotic response to DNA damage