Function and targeting of G-quadruplexes

Current Opinion in Molecular Therapeutics

Volumn 11, Issue 2, 2009, Pages 146-155

  Wong, Han Min ^a   Payet, Linda ^a   Huppert, Julian Leon ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Drug target; G guadruplet; Gene expression; Transcriptional regulation; Translational control

Indexed keywords

3,4 TETRAMETHYLPYRIDINIUMPORPHYRAZINE; 3,4 TETRAMETHYLPYRIDINIUMPORPHYRAZINE ZINC; 5,10,15,20 [TETRA(N METHYL 3 PYRIDYL)] 26,28 DISELENASAPPHYRIN CHLORIDE; ACRIDINE DERIVATIVE; AGRO 100; ANTHRAQUINONE DERIVATIVE; ANTICOAGULANT AGENT; ANTINEOPLASTIC AGENT; ARC 183; AS 1411; CX 3543; DOUBLE STRANDED RNA; GUANINE QUADRUPLEX; HELICASE; HYPOXIA INDUCIBLE FACTOR 1; OXAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR A; PORPHYRIN DERIVATIVE; QUARFLOXIN; QUINOLONE DERIVATIVE; SINGLE STRANDED RNA; TELOMERASE; TELOMESTATIN; TETRA(4 N METHYLPYRIDYL)PORPHINE; UNCLASSIFIED DRUG; VASCULOTROPIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ACUTE GRANULOCYTIC LEUKEMIA; BIOLOGICAL ACTIVITY; CANCER CELL; CANCER CELL DESTRUCTION; CANCER THERAPY; CELL SURVIVAL; CLINICAL TRIAL; DNA HELIX; DNA RNA HYBRIDIZATION; DRUG DESIGN; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG WITHDRAWAL; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN GENOME; KIDNEY CANCER; MOLECULAR INTERACTION; NEOPLASM; ONCOGENE C MYC; ONCOGENE H RAS; REVIEW; RNA TRANSCRIPTION; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; TELOMERE; THERMOSTABILITY; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE; HUMANS; MODELS, MOLECULAR; MODELS, THEORETICAL; NEOPLASMS;

EID: 63849156605     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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