메뉴 건너뛰기




Volumn 302, Issue 2, 2009, Pages 193-202

The sweeter side of ACE2: Physiological evidence for a role in diabetes

Author keywords

Angiotensin converting enzyme 2; Beta cell dysfunction; Diabetes; Glucose homeostasis; Renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MLN 4760; ORAL ANTIDIABETIC AGENT; UNCLASSIFIED DRUG;

EID: 62949127898     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.09.020     Document Type: Review
Times cited : (170)

References (157)
  • 1
    • 24044536393 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials
    • Abuissa H., Jones P.G., Marso S.P., and O'Keefe J.J.H. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials. J. Am. Coll. Cardiol. 46 (2005) 821-826
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 821-826
    • Abuissa, H.1    Jones, P.G.2    Marso, S.P.3    O'Keefe, J.J.H.4
  • 3
    • 0032511601 scopus 로고    scopus 로고
    • Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group
    • Anonymous. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group. BMJ 317 (1998) 713-720
    • (1998) BMJ , vol.317 , pp. 713-720
  • 4
    • 0034700790 scopus 로고    scopus 로고
    • Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators
    • Anonymous. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators. Lancet 355 (2000) 253-259
    • (2000) Lancet , vol.355 , pp. 253-259
  • 5
    • 0033859538 scopus 로고    scopus 로고
    • Type 2 diabetes in children and adolescents. American Diabetes Association
    • Anonymous. Type 2 diabetes in children and adolescents. American Diabetes Association. Diabetes Care 23 (2000) 1442-1443
    • (2000) Diabetes Care , vol.23 , pp. 1442-1443
  • 7
    • 0028366072 scopus 로고
    • Changes in islet blood flow in rats with NIDDM
    • Atef N., Portha B., and Pénicaud L. Changes in islet blood flow in rats with NIDDM. Diabetologia 37 (1994) 677-680
    • (1994) Diabetologia , vol.37 , pp. 677-680
    • Atef, N.1    Portha, B.2    Pénicaud, L.3
  • 8
    • 0035074165 scopus 로고    scopus 로고
    • Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
    • Bader M., Peters J., Baltatu O., Müller D.N., and Luft F.C. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. J. Mol. Med. 79 (2001) 76-102
    • (2001) J. Mol. Med. , vol.79 , pp. 76-102
    • Bader, M.1    Peters, J.2    Baltatu, O.3    Müller, D.N.4    Luft, F.C.5
  • 9
    • 0033964491 scopus 로고    scopus 로고
    • The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy
    • Baltatu O., Silva Jr. J.A., Ganten D., and Bader M. The brain renin-angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy. Hypertension 35 1 Pt 2 (2000) 409-412
    • (2000) Hypertension , vol.35 , Issue.1 PART 2 , pp. 409-412
    • Baltatu, O.1    Silva Jr., J.A.2    Ganten, D.3    Bader, M.4
  • 10
    • 0025954408 scopus 로고
    • Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow
    • Baron A.D., Laakso M., Brechtel G., and Edelman S.V. Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow. J. Clin. Endocrinol. Metab. 73 (1991) 637-643
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 637-643
    • Baron, A.D.1    Laakso, M.2    Brechtel, G.3    Edelman, S.V.4
  • 12
    • 33750861042 scopus 로고    scopus 로고
    • Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase
    • Beard K.M., Lu H., Ho K., and Fantus I.G. Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase. Diabetes 55 (2006) 2678-2687
    • (2006) Diabetes , vol.55 , pp. 2678-2687
    • Beard, K.M.1    Lu, H.2    Ho, K.3    Fantus, I.G.4
  • 15
    • 0029926375 scopus 로고    scopus 로고
    • Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide
    • Brosnihan K.B., Li P., and Ferrario C.M. Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension 27 (1996) 523-528
    • (1996) Hypertension , vol.27 , pp. 523-528
    • Brosnihan, K.B.1    Li, P.2    Ferrario, C.M.3
  • 16
    • 0035239910 scopus 로고    scopus 로고
    • The renin-angiotensin system in the endocrine pancreas
    • Carlsson P.-O. The renin-angiotensin system in the endocrine pancreas. JOP 2 (2001) 26-32
    • (2001) JOP , vol.2 , pp. 26-32
    • Carlsson, P.-O.1
  • 18
    • 0031911742 scopus 로고    scopus 로고
    • Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats
    • Carlsson P.O., Berne C., and Jansson L. Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats. Diabetologia 41 (1998) 127-133
    • (1998) Diabetologia , vol.41 , pp. 127-133
    • Carlsson, P.O.1    Berne, C.2    Jansson, L.3
  • 19
    • 0030952821 scopus 로고    scopus 로고
    • Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats
    • Carlsson P.O., Jansson L., Ostenson C.G., and Kallskog O. Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats. Diabetes 46 (1997) 947-952
    • (1997) Diabetes , vol.46 , pp. 947-952
    • Carlsson, P.O.1    Jansson, L.2    Ostenson, C.G.3    Kallskog, O.4
  • 21
    • 1542375103 scopus 로고    scopus 로고
    • Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?
    • Clark A., and Nilsson M.R. Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?. Diabetologia 47 (2004) 157-169
    • (2004) Diabetologia , vol.47 , pp. 157-169
    • Clark, A.1    Nilsson, M.R.2
  • 23
    • 0014336473 scopus 로고
    • Dynamics of insulin secretion by the perfused rat pancreas
    • Curry D., Bennett L., and Grodsky G.M. Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 83 (1968) 572-584
    • (1968) Endocrinology , vol.83 , pp. 572-584
    • Curry, D.1    Bennett, L.2    Grodsky, G.M.3
  • 27
    • 0037381607 scopus 로고    scopus 로고
    • Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes
    • Dalla Vestra M., Masiero A., Roiter A.M., Saller A., Crepaldi G., and Fioretto P. Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes. Diabetes 52 (2003) 1031-1035
    • (2003) Diabetes , vol.52 , pp. 1031-1035
    • Dalla Vestra, M.1    Masiero, A.2    Roiter, A.M.3    Saller, A.4    Crepaldi, G.5    Fioretto, P.6
  • 29
    • 0029905875 scopus 로고    scopus 로고
    • Is there an internal cardiac renin-angiotensin system?
    • Danser A.H.J., and Schalekamp M.A.D.H. Is there an internal cardiac renin-angiotensin system?. Heart 76 (1996) 28-32
    • (1996) Heart , vol.76 , pp. 28-32
    • Danser, A.H.J.1    Schalekamp, M.A.D.H.2
  • 32
    • 0041828484 scopus 로고    scopus 로고
    • Inflammatory mediators and islet ß-cell failure: a link between type 1 and type 2 diabetes
    • Donath M.Y., Størling J., Maedler K., and Mandrup-Poulsen T. Inflammatory mediators and islet ß-cell failure: a link between type 1 and type 2 diabetes. J. Mol. Med. 81 (2003) 455-470
    • (2003) J. Mol. Med. , vol.81 , pp. 455-470
    • Donath, M.Y.1    Størling, J.2    Maedler, K.3    Mandrup-Poulsen, T.4
  • 35
    • 0028010788 scopus 로고
    • Tissue angiotensin system in cardiovascular medicine. A paradigm shift?
    • Dzau V.J., and Re R. Tissue angiotensin system in cardiovascular medicine. A paradigm shift?. Circulation 89 (1994) 493-498
    • (1994) Circulation , vol.89 , pp. 493-498
    • Dzau, V.J.1    Re, R.2
  • 36
    • 0034525646 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus in UK children-an emerging problem
    • Ehtisham S., Barrett T.G., and Shaw N.J. Type 2 diabetes mellitus in UK children-an emerging problem. Diabet. Med. 17 (2000) 867-871
    • (2000) Diabet. Med. , vol.17 , pp. 867-871
    • Ehtisham, S.1    Barrett, T.G.2    Shaw, N.J.3
  • 37
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    • Evans J.L., Goldfine I.D., Maddux B.A., and Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23 (2002) 599-622
    • (2002) Endocr. Rev. , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 38
    • 62949121839 scopus 로고    scopus 로고
    • ACE2 over-expression in the subfornical organ prevents the angiotensin-II-mediated pressor and drinking responses and is associated with AT1 receptor down-regulation
    • Feng Y., Yue X., Xia H., Bindom S.M., Hickman P., Filipeanu C., Wu G., and Lazartigues E. ACE2 over-expression in the subfornical organ prevents the angiotensin-II-mediated pressor and drinking responses and is associated with AT1 receptor down-regulation. Circ. Res. 102 (2008) 628-629
    • (2008) Circ. Res. , vol.102 , pp. 628-629
    • Feng, Y.1    Yue, X.2    Xia, H.3    Bindom, S.M.4    Hickman, P.5    Filipeanu, C.6    Wu, G.7    Lazartigues, E.8
  • 39
    • 0035092904 scopus 로고    scopus 로고
    • Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo
    • Fernandes L., Fortes Z.B., Nigro D., Tostes R.C.A., Santos R.A.S., and Catelli de Carvalho M.H. Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo. Hypertension 37 (2001) 703-709
    • (2001) Hypertension , vol.37 , pp. 703-709
    • Fernandes, L.1    Fortes, Z.B.2    Nigro, D.3    Tostes, R.C.A.4    Santos, R.A.S.5    Catelli de Carvalho, M.H.6
  • 40
    • 44649103333 scopus 로고    scopus 로고
    • Genomic and proteomic approaches for targeting angiotensin converting enzyme2 for cardiovascular diseases
    • Ferreira A.J., and Raizada M.K. Genomic and proteomic approaches for targeting angiotensin converting enzyme2 for cardiovascular diseases. Curr. Opin. Cardiol. 23 (2008) 364-369
    • (2008) Curr. Opin. Cardiol. , vol.23 , pp. 364-369
    • Ferreira, A.J.1    Raizada, M.K.2
  • 41
    • 0030667938 scopus 로고    scopus 로고
    • Angiotensin II affects basal, pulsatile, and glucose-stimulated insulin secretion in humans
    • Fliser D., Schaefer F., Schmid D., Veldhuis J.D., and Ritz E. Angiotensin II affects basal, pulsatile, and glucose-stimulated insulin secretion in humans. Hypertension 30 (1997) 1156-1161
    • (1997) Hypertension , vol.30 , pp. 1156-1161
    • Fliser, D.1    Schaefer, F.2    Schmid, D.3    Veldhuis, J.D.4    Ritz, E.5
  • 42
    • 0031739041 scopus 로고    scopus 로고
    • Relationship between insulin sensitivity and maximal forearm blood flow in young men
    • Fossum E., Hoieggen A., Moan A., Rostrup M., Nordby G., and Kjeldsen S.E. Relationship between insulin sensitivity and maximal forearm blood flow in young men. Hypertension 32 (1998) 838-843
    • (1998) Hypertension , vol.32 , pp. 838-843
    • Fossum, E.1    Hoieggen, A.2    Moan, A.3    Rostrup, M.4    Nordby, G.5    Kjeldsen, S.E.6
  • 43
    • 33646397829 scopus 로고    scopus 로고
    • Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats
    • Frisbee J.C. Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats. Am. J. Physiol. Heart Circ. Physiol. 290 (2006) H2066-H2074
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290
    • Frisbee, J.C.1
  • 48
    • 0036314864 scopus 로고    scopus 로고
    • Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?
    • Gerich J.E. Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?. Diabetes 51 (2002) S117-S121
    • (2002) Diabetes , vol.51
    • Gerich, J.E.1
  • 49
    • 7244240604 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats
    • Gironacci M.M., Valera M.S., Yujnovsky I., and Pena C. Angiotensin-(1-7) inhibitory mechanism of norepinephrine release in hypertensive rats. Hypertension 44 (2004) 783-787
    • (2004) Hypertension , vol.44 , pp. 783-787
    • Gironacci, M.M.1    Valera, M.S.2    Yujnovsky, I.3    Pena, C.4
  • 50
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • Grankvist K., Marklund S., and Taljedal I. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem. J. 199 (1981) 393-398
    • (1981) Biochem. J. , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.2    Taljedal, I.3
  • 51
    • 0034732256 scopus 로고    scopus 로고
    • Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study
    • Gress T.W., Nieto F.J., Shahar E., Wofford M.R., and Brancati F.L. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study. N. Engl. J. Med. 342 (2000) 905-912
    • (2000) N. Engl. J. Med. , vol.342 , pp. 905-912
    • Gress, T.W.1    Nieto, F.J.2    Shahar, E.3    Wofford, M.R.4    Brancati, F.L.5
  • 52
    • 0028365310 scopus 로고
    • Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
    • Griendling K.K., Minieri C.A., Ollerenshaw J.D., and Alexander R.W. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ. Res. 74 (1994) 1141-1148
    • (1994) Circ. Res. , vol.74 , pp. 1141-1148
    • Griendling, K.K.1    Minieri, C.A.2    Ollerenshaw, J.D.3    Alexander, R.W.4
  • 56
    • 0242569193 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence
    • Guy J.L., Jackson R.M., Acharya K.R., Sturrock E.D., Hooper N.M., and Turner A.J. Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence. Biochemistry 42 (2003) 13185-13192
    • (2003) Biochemistry , vol.42 , pp. 13185-13192
    • Guy, J.L.1    Jackson, R.M.2    Acharya, K.R.3    Sturrock, E.D.4    Hooper, N.M.5    Turner, A.J.6
  • 57
    • 15744379018 scopus 로고    scopus 로고
    • Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
    • Harmon J.S., Stein R., and Robertson R.P. Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells. J. Biol. Chem. 280 (2005) 11107-11113
    • (2005) J. Biol. Chem. , vol.280 , pp. 11107-11113
    • Harmon, J.S.1    Stein, R.2    Robertson, R.P.3
  • 59
    • 36749034164 scopus 로고    scopus 로고
    • Ultrastructural islet study of early fibrosis in the Ren2 model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell
    • Hayden M., Karuparthi P., Habibi J., Waseker C., Lastra G., Marnrique C., Stas S., and Sowers J. Ultrastructural islet study of early fibrosis in the Ren2 model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell. JOP 8 (2007) 725-738
    • (2007) JOP , vol.8 , pp. 725-738
    • Hayden, M.1    Karuparthi, P.2    Habibi, J.3    Waseker, C.4    Lastra, G.5    Marnrique, C.6    Stas, S.7    Sowers, J.8
  • 60
    • 0036632466 scopus 로고    scopus 로고
    • Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus
    • Hayden M., and Tyagi S. Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus. JOP 3 (2002) 86-108
    • (2002) JOP , vol.3 , pp. 86-108
    • Hayden, M.1    Tyagi, S.2
  • 61
    • 0035154879 scopus 로고    scopus 로고
    • Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells
    • Heitsch H., Brovkovych S., Malinski T., and Wiemer G. Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells. Hypertension 37 (2001) 72-76
    • (2001) Hypertension , vol.37 , pp. 72-76
    • Heitsch, H.1    Brovkovych, S.2    Malinski, T.3    Wiemer, G.4
  • 63
    • 34547410910 scopus 로고    scopus 로고
    • Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental billiary fibrosis
    • Herath C., Warner F.J., Lubel J., Dean R.J., Jia Z., Lew R.A., Smith A.I., Burrell L.M., and Angus P.W. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental billiary fibrosis. J. Hepatol. 47 (2007) 387-395
    • (2007) J. Hepatol. , vol.47 , pp. 387-395
    • Herath, C.1    Warner, F.J.2    Lubel, J.3    Dean, R.J.4    Jia, Z.5    Lew, R.A.6    Smith, A.I.7    Burrell, L.M.8    Angus, P.W.9
  • 66
    • 42649139218 scopus 로고    scopus 로고
    • The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice
    • Imai Y., Kuba K., and Penninger J.M. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp. Physiol. 93 (2008) 543-548
    • (2008) Exp. Physiol. , vol.93 , pp. 543-548
    • Imai, Y.1    Kuba, K.2    Penninger, J.M.3
  • 68
    • 0024461317 scopus 로고
    • Pancreatic and islet blood flow in the regenerating pancreas after a partial pancreatectomy in adult rats
    • Jansson L., and Sandler S. Pancreatic and islet blood flow in the regenerating pancreas after a partial pancreatectomy in adult rats. Surgery 106 (1981) 861-866
    • (1981) Surgery , vol.106 , pp. 861-866
    • Jansson, L.1    Sandler, S.2
  • 70
    • 0035903192 scopus 로고    scopus 로고
    • Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
    • Kaneto H., Xu G., Song K.-H., Suzuma K., Bonner-Weir S., Sharma A., and Weir G.C. Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J. Biol. Chem. 276 (2001) 31099-31104
    • (2001) J. Biol. Chem. , vol.276 , pp. 31099-31104
    • Kaneto, H.1    Xu, G.2    Song, K.-H.3    Suzuma, K.4    Bonner-Weir, S.5    Sharma, A.6    Weir, G.C.7
  • 71
    • 0031752685 scopus 로고    scopus 로고
    • Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections
    • King H., Aubert R.E., and Herman W.H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21 (1998) 1414-1431
    • (1998) Diabetes Care , vol.21 , pp. 1414-1431
    • King, H.1    Aubert, R.E.2    Herman, W.H.3
  • 72
    • 0032040381 scopus 로고    scopus 로고
    • Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway
    • Kishi K., Muromoto N., Nakaya Y., Miyata I., Hagi A., Hayashi H., and Ebina Y. Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway. Diabetes 47 (1998) 550-558
    • (1998) Diabetes , vol.47 , pp. 550-558
    • Kishi, K.1    Muromoto, N.2    Nakaya, Y.3    Miyata, I.4    Hagi, A.5    Hayashi, H.6    Ebina, Y.7
  • 74
    • 0025292440 scopus 로고
    • Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
    • Laakso M., Edelman S.V., Brechtel G., and Baron A.D. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J. Clin. Invest. 85 (1990) 1844-1852
    • (1990) J. Clin. Invest. , vol.85 , pp. 1844-1852
    • Laakso, M.1    Edelman, S.V.2    Brechtel, G.3    Baron, A.D.4
  • 75
  • 76
    • 24044444558 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    • Lambert D.W., Yarski M., Warner F.J., Thornhill P., Parkin E.T., Smith A.I., Hooper N.M., and Turner A.J. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J. Biol. Chem. 280 (2005) 30113-30119
    • (2005) J. Biol. Chem. , vol.280 , pp. 30113-30119
    • Lambert, D.W.1    Yarski, M.2    Warner, F.J.3    Thornhill, P.4    Parkin, E.T.5    Smith, A.I.6    Hooper, N.M.7    Turner, A.J.8
  • 77
    • 0029950077 scopus 로고    scopus 로고
    • The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects
    • Langheinrich M., Ae Lee M., Böhm M., Pinto Y.M., Ganten D., and Paul M. The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects. Am. J. Hypertens. 9 (1996) 506-512
    • (1996) Am. J. Hypertens. , vol.9 , pp. 506-512
    • Langheinrich, M.1    Ae Lee, M.2    Böhm, M.3    Pinto, Y.M.4    Ganten, D.5    Paul, M.6
  • 78
    • 1542374750 scopus 로고    scopus 로고
    • Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
    • Lau T., Carlsson P.O., and Leung P.S. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia 47 (2004) 240-248
    • (2004) Diabetologia , vol.47 , pp. 240-248
    • Lau, T.1    Carlsson, P.O.2    Leung, P.S.3
  • 79
    • 0037901037 scopus 로고    scopus 로고
    • Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system
    • Lavoie J.L., and Sigmund C.D. Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system. Endocrinology 144 (2003) 2179-2183
    • (2003) Endocrinology , vol.144 , pp. 2179-2183
    • Lavoie, J.L.1    Sigmund, C.D.2
  • 80
    • 0031967888 scopus 로고    scopus 로고
    • Immunohistochemical localization of angiotensin II in the mouse pancreas
    • Leung P., Chan H., and Wong P. Immunohistochemical localization of angiotensin II in the mouse pancreas. Histochem. J. 30 (1998) 21-25
    • (1998) Histochem. J. , vol.30 , pp. 21-25
    • Leung, P.1    Chan, H.2    Wong, P.3
  • 81
    • 33947526470 scopus 로고    scopus 로고
    • The physiology of a local renin-angiotensin system in the pancreas
    • Leung P.S. The physiology of a local renin-angiotensin system in the pancreas. J. Physiol. 580 (2007) 31-37
    • (2007) J. Physiol. , vol.580 , pp. 31-37
    • Leung, P.S.1
  • 82
    • 0032898010 scopus 로고    scopus 로고
    • Expression and localization of the renin-angiotensin system in the rat pancreas
    • Leung P.S., Chan W.P., Wong T.P., and Sernia C. Expression and localization of the renin-angiotensin system in the rat pancreas. J. Endocrinol. 160 (1999) 13-19
    • (1999) J. Endocrinol. , vol.160 , pp. 13-19
    • Leung, P.S.1    Chan, W.P.2    Wong, T.P.3    Sernia, C.4
  • 84
    • 0030765388 scopus 로고    scopus 로고
    • Potentiation of the hypotensive effect of bradykinin by short-term infusion of angiotensin-(1-7) in normotensive and hypertensive rats
    • Lima C.V., Paula R.D., Resende F.L., Khosla M.C., and Santos R.A.S. Potentiation of the hypotensive effect of bradykinin by short-term infusion of angiotensin-(1-7) in normotensive and hypertensive rats. Hypertension 30 (1997) 542-548
    • (1997) Hypertension , vol.30 , pp. 542-548
    • Lima, C.V.1    Paula, R.D.2    Resende, F.L.3    Khosla, M.C.4    Santos, R.A.S.5
  • 85
    • 33644596657 scopus 로고    scopus 로고
    • The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets
    • Lupi R., Guerra S.D., Bugliani M., Boggi U., Mosca F., Torri S., Prato S.D., and Marchetti P. The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. Eur. J. Endocrinol. 154 (2006) 355-361
    • (2006) Eur. J. Endocrinol. , vol.154 , pp. 355-361
    • Lupi, R.1    Guerra, S.D.2    Bugliani, M.3    Boggi, U.4    Mosca, F.5    Torri, S.6    Prato, S.D.7    Marchetti, P.8
  • 86
    • 0033600762 scopus 로고    scopus 로고
    • Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells
    • Maechler P., Jornot L., and Wollheim C.B. Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J. Biol. Chem. 274 (1999) 27905-27913
    • (1999) J. Biol. Chem. , vol.274 , pp. 27905-27913
    • Maechler, P.1    Jornot, L.2    Wollheim, C.B.3
  • 87
    • 29244448292 scopus 로고    scopus 로고
    • The diabetogenic potential of thiazide-type and beta blocker combinations in patients with hypertension
    • Mason J.M., Dickenson H.O., Nicholson D.J., Campbel F., Ford G., and Williams B. The diabetogenic potential of thiazide-type and beta blocker combinations in patients with hypertension. J. Hypertens. 23 (2005) 1777-1781
    • (2005) J. Hypertens. , vol.23 , pp. 1777-1781
    • Mason, J.M.1    Dickenson, H.O.2    Nicholson, D.J.3    Campbel, F.4    Ford, G.5    Williams, B.6
  • 89
    • 0032710966 scopus 로고    scopus 로고
    • Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria
    • Meyer T.W., Bennett P.H., and Nelson R.G. Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria. Diabetologia 42 (1999) 1341-1344
    • (1999) Diabetologia , vol.42 , pp. 1341-1344
    • Meyer, T.W.1    Bennett, P.H.2    Nelson, R.G.3
  • 95
    • 85084950572 scopus 로고    scopus 로고
    • Development of diabetes is retarded by ACE inhibition in hypertensive patients: a sub-analysis of the Captopril Prevention Project
    • Niklason A., Hedner T., Kiskanen L., and Lanke J. Development of diabetes is retarded by ACE inhibition in hypertensive patients: a sub-analysis of the Captopril Prevention Project. J. Hypertens. 38 (2004) E28-E32
    • (2004) J. Hypertens. , vol.38
    • Niklason, A.1    Hedner, T.2    Kiskanen, L.3    Lanke, J.4
  • 97
    • 0344069509 scopus 로고    scopus 로고
    • Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo
    • Oliveira M.A., Bruno Fortes Z.B., Santos R.A., Kosla M.C., and De Carvalho M.H. Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo. Peptides 20 (1999) 1195-1201
    • (1999) Peptides , vol.20 , pp. 1195-1201
    • Oliveira, M.A.1    Bruno Fortes, Z.B.2    Santos, R.A.3    Kosla, M.C.4    De Carvalho, M.H.5
  • 98
  • 100
    • 0036830185 scopus 로고    scopus 로고
    • Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver
    • Paizis G., Cooper M.E., Schembri J.M., Tikellis C., Burrell L.M., and Angus P.W. Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver. Gastroenterology 123 (2002) 1667-1676
    • (2002) Gastroenterology , vol.123 , pp. 1667-1676
    • Paizis, G.1    Cooper, M.E.2    Schembri, J.M.3    Tikellis, C.4    Burrell, L.M.5    Angus, P.W.6
  • 102
    • 33745845825 scopus 로고    scopus 로고
    • Physiology of local renin-angiotensin systems
    • Paul M., Poyan Mehr A., and Kreutz R. Physiology of local renin-angiotensin systems. Physiol. Rev. 86 (2006) 747-803
    • (2006) Physiol. Rev. , vol.86 , pp. 747-803
    • Paul, M.1    Poyan Mehr, A.2    Kreutz, R.3
  • 103
    • 0028822339 scopus 로고
    • Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats
    • Paula R.D., Lima C.V., Khosla M.C., and Santos R.A.S. Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats. Hypertension 26 (1995) 1154-1159
    • (1995) Hypertension , vol.26 , pp. 1154-1159
    • Paula, R.D.1    Lima, C.V.2    Khosla, M.C.3    Santos, R.A.S.4
  • 104
    • 0034987434 scopus 로고    scopus 로고
    • Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes
    • Peltoniemi P., Yki-Jarvinen H., Oikonen V., Oksanen A., Takala T.O., Ronnemaa T., Erkinjuntti M., Knuuti M.J., and Nuutila P. Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes. Diabetes 50 (2001) 1371-1377
    • (2001) Diabetes , vol.50 , pp. 1371-1377
    • Peltoniemi, P.1    Yki-Jarvinen, H.2    Oikonen, V.3    Oksanen, A.4    Takala, T.O.5    Ronnemaa, T.6    Erkinjuntti, M.7    Knuuti, M.J.8    Nuutila, P.9
  • 105
    • 18144382988 scopus 로고    scopus 로고
    • The global spread of type 2 diabetes mellitus in children and adolescents
    • Pinhas-Hamiel O., and Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J. Pediatr. 146 (2005) 693-700
    • (2005) J. Pediatr. , vol.146 , pp. 693-700
    • Pinhas-Hamiel, O.1    Zeitler, P.2
  • 106
    • 0028275331 scopus 로고
    • Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor
    • Portsi I., Bara A., Busse R., and Hecker M. Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br. J. Pharmacol. 111 (1994) 652-654
    • (1994) Br. J. Pharmacol. , vol.111 , pp. 652-654
    • Portsi, I.1    Bara, A.2    Busse, R.3    Hecker, M.4
  • 108
    • 4043117221 scopus 로고    scopus 로고
    • Diabetes and cardiovascular outcomes in elderly subjects treated with ace-inhibitors or diuretics: findings from the 2ND Australian national blood pressure study
    • Reid C.M., Johnston C.I., Ryan P., Willson K., and Wing L.M. Diabetes and cardiovascular outcomes in elderly subjects treated with ace-inhibitors or diuretics: findings from the 2ND Australian national blood pressure study. Am. J. Hypertens. 16 (2003) A11
    • (2003) Am. J. Hypertens. , vol.16
    • Reid, C.M.1    Johnston, C.I.2    Ryan, P.3    Willson, K.4    Wing, L.M.5
  • 109
    • 5644248079 scopus 로고    scopus 로고
    • Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    • Robertson R.P. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J. Biol. Chem. 279 (2004) 42351-42354
    • (2004) J. Biol. Chem. , vol.279 , pp. 42351-42354
    • Robertson, R.P.1
  • 110
    • 0024214951 scopus 로고
    • Intra-islet regulation
    • Samols E., and Stagner J. Intra-islet regulation. Am. J. Med. 85 (1988) 31-35
    • (1988) Am. J. Med. , vol.85 , pp. 31-35
    • Samols, E.1    Stagner, J.2
  • 115
    • 0142213897 scopus 로고    scopus 로고
    • Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases
    • Schmid H., Henger A., Cohen C.D., Frach K., Grone H.-J., Schlondorff D., and Kretzler M. Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J. Am. Soc. Nephrol. 14 (2003) 2958-2966
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2958-2966
    • Schmid, H.1    Henger, A.2    Cohen, C.D.3    Frach, K.4    Grone, H.-J.5    Schlondorff, D.6    Kretzler, M.7
  • 117
    • 58149243501 scopus 로고    scopus 로고
    • Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury
    • Shao Y., He M., Zhou L., Yao T., Huang Y., and Lu L.M. Chronic angiotensin (1-7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacol. Sin. 29 (2008) 829-837
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 829-837
    • Shao, Y.1    He, M.2    Zhou, L.3    Yao, T.4    Huang, Y.5    Lu, L.M.6
  • 118
    • 34548153521 scopus 로고    scopus 로고
    • ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice
    • Soler M.J., Wysocki J., Ye M., Lloveras J., Kanwar Y., and Batlle D. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice. Kidney Int. 72 (2007) 614-623
    • (2007) Kidney Int. , vol.72 , pp. 614-623
    • Soler, M.J.1    Wysocki, J.2    Ye, M.3    Lloveras, J.4    Kanwar, Y.5    Batlle, D.6
  • 119
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
    • Steinberg H., Chaker H., Leaming R., Johnson A., Brechtel G., and Baron A.D. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J. Clin. Invest. 97 (1996) 2601-2610
    • (1996) J. Clin. Invest. , vol.97 , pp. 2601-2610
    • Steinberg, H.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 120
    • 0026708833 scopus 로고
    • A continuous 48-hour glucose infusion in rats causes both an acute and a persistent redistribution of the blood flow within the pancreas
    • Styrud J., Eriksson U.J., and Jansson L. A continuous 48-hour glucose infusion in rats causes both an acute and a persistent redistribution of the blood flow within the pancreas. Endocrinology 130 (1992) 2692-2696
    • (1992) Endocrinology , vol.130 , pp. 2692-2696
    • Styrud, J.1    Eriksson, U.J.2    Jansson, L.3
  • 121
    • 33644783770 scopus 로고    scopus 로고
    • Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • Susztak K., Raff A.C., Schiffer M., and Bottinger E.P. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55 (2006) 225-233
    • (2006) Diabetes , vol.55 , pp. 225-233
    • Susztak, K.1    Raff, A.C.2    Schiffer, M.3    Bottinger, E.P.4
  • 124
    • 25444473110 scopus 로고    scopus 로고
    • Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor
    • Tallant E.A., Ferrario C.M., and Gallagher P.E. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H1560-H1566
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289
    • Tallant, E.A.1    Ferrario, C.M.2    Gallagher, P.E.3
  • 127
    • 33644843826 scopus 로고    scopus 로고
    • Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes
    • Tikellis C., Cooper M.E., and Thomas M.C. Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes. Int. J. Biochem. Cell. Biol. 38 (2006) 737-751
    • (2006) Int. J. Biochem. Cell. Biol. , vol.38 , pp. 737-751
    • Tikellis, C.1    Cooper, M.E.2    Thomas, M.C.3
  • 129
  • 131
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    • Tipnis S.R., Hooper N.M., Hyde R., Karran E., Christie G., and Turner A.J. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem. 275 (2000) 33238-33243
    • (2000) J. Biol. Chem. , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 132
    • 41549156590 scopus 로고    scopus 로고
    • ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese zucker rats
    • Toblli J.E., Munoz M.C., Cao G., Mella J., Pereyra L., and Mastai R. ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese zucker rats. Obesity 16 (2007) 770-776
    • (2007) Obesity , vol.16 , pp. 770-776
    • Toblli, J.E.1    Munoz, M.C.2    Cao, G.3    Mella, J.4    Pereyra, L.5    Mastai, R.6
  • 133
    • 0026078571 scopus 로고
    • ACE-inhibition increases hepatic and extrahepatic sensitivity to insulin in patients with Type 2 (non-insulin-dependent) diabetes mellitus and arterial hypertension
    • Torlone E., Rambotti A.M., Perriello G., Botta G., Santeusanio F., Brunetti P., and Bolli G.B. ACE-inhibition increases hepatic and extrahepatic sensitivity to insulin in patients with Type 2 (non-insulin-dependent) diabetes mellitus and arterial hypertension. Diabetologia 34 (1991) 119-125
    • (1991) Diabetologia , vol.34 , pp. 119-125
    • Torlone, E.1    Rambotti, A.M.2    Perriello, G.3    Botta, G.4    Santeusanio, F.5    Brunetti, P.6    Bolli, G.B.7
  • 134
    • 9644280976 scopus 로고    scopus 로고
    • Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic [beta]-cell line, MIN6-a role of NAD(P)H oxidase in [beta]-cells
    • Tsubouchi H., Inoguchi T., Inuo M., Kakimoto M., Sonta T., Sonoda N., Sasaki S., Kobayashi K., Sumimoto H., and Nawata H. Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic [beta]-cell line, MIN6-a role of NAD(P)H oxidase in [beta]-cells. Biochem. Biophys. Res. Commun. 326 (2004) 60-65
    • (2004) Biochem. Biophys. Res. Commun. , vol.326 , pp. 60-65
    • Tsubouchi, H.1    Inoguchi, T.2    Inuo, M.3    Kakimoto, M.4    Sonta, T.5    Sonoda, N.6    Sasaki, S.7    Kobayashi, K.8    Sumimoto, H.9    Nawata, H.10
  • 138
    • 0037432313 scopus 로고    scopus 로고
    • Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD)
    • Vermes E., Ducharme A., Bourassa M.G., Lessard M., White M., and Tardif J.-C. Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 107 (2003) 1291-1296
    • (2003) Circulation , vol.107 , pp. 1291-1296
    • Vermes, E.1    Ducharme, A.2    Bourassa, M.G.3    Lessard, M.4    White, M.5    Tardif, J.-C.6
  • 141
    • 0036900194 scopus 로고    scopus 로고
    • AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium
    • Wiemer G., Dobrucki L.W., Louka F.R., Malinski T., and Heitsch H. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension 40 (2002) 852-875
    • (2002) Hypertension , vol.40 , pp. 852-875
    • Wiemer, G.1    Dobrucki, L.W.2    Louka, F.R.3    Malinski, T.4    Heitsch, H.5
  • 142
    • 0030007350 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Williams S.B., Cusco J.A., Roddy M.A., Johnstone M.T., and Creager M.A. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J. Am. Coll. Cardiol. 27 (1996) 567-574
    • (1996) J. Am. Coll. Cardiol. , vol.27 , pp. 567-574
    • Williams, S.B.1    Cusco, J.A.2    Roddy, M.A.3    Johnstone, M.T.4    Creager, M.A.5
  • 144
    • 1842582779 scopus 로고    scopus 로고
    • Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
    • Wu L., Nicholson W., Knobel S.M., Steffner R.J., May J.M., Piston D.W., and Powers A.C. Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. J. Biol. Chem. 279 (2004) 12126-12134
    • (2004) J. Biol. Chem. , vol.279 , pp. 12126-12134
    • Wu, L.1    Nicholson, W.2    Knobel, S.M.3    Steffner, R.J.4    May, J.M.5    Piston, D.W.6    Powers, A.C.7
  • 148
    • 0027479442 scopus 로고
    • Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy
    • Yamamoto T., Nakamura T., Noble N.A., Ruoslahti E., and Border W.A. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 1814-1818
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 1814-1818
    • Yamamoto, T.1    Nakamura, T.2    Noble, N.A.3    Ruoslahti, E.4    Border, W.A.5
  • 149
    • 34047193877 scopus 로고    scopus 로고
    • Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
    • Yamazato M., Yamazato Y., Sun C., Diez-Freire C., and Raizada M.K. Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 49 (2007) 926-931
    • (2007) Hypertension , vol.49 , pp. 926-931
    • Yamazato, M.1    Yamazato, Y.2    Sun, C.3    Diez-Freire, C.4    Raizada, M.K.5
  • 150
    • 2342472108 scopus 로고    scopus 로고
    • Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
    • Ye M., Wysocki J., Naaz P., Salabat M.R., LaPointe M.S., and Batlle D. Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?. Hypertension 43 (2004) 1120-1125
    • (2004) Hypertension , vol.43 , pp. 1120-1125
    • Ye, M.1    Wysocki, J.2    Naaz, P.3    Salabat, M.R.4    LaPointe, M.S.5    Batlle, D.6
  • 151
    • 33750722109 scopus 로고    scopus 로고
    • Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes
    • Ye M., Wysocki J., William J., Soler M.J., Cokic I., and Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J. Am. Soc. Nephrol. 17 (2006) 3067-3075
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 3067-3075
    • Ye, M.1    Wysocki, J.2    William, J.3    Soler, M.J.4    Cokic, I.5    Batlle, D.6
  • 152
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka M., Kayo T., Ikeda T., and Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46 (1997) 887-894
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 153
    • 21344446946 scopus 로고    scopus 로고
    • Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria
    • Yu D., Petermann A., Kunter U., Rong S., Shankland S.J., and Floege J. Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J. Am. Soc. Nephrol. 16 (2005) 1733-1741
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 1733-1741
    • Yu, D.1    Petermann, A.2    Kunter, U.3    Rong, S.4    Shankland, S.J.5    Floege, J.6
  • 155
    • 0035907347 scopus 로고    scopus 로고
    • Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys
    • Zhang H., Wada J., Hida K., Tsuchiyama Y., Hiragushi K., Shikata K., Wang H., Lin S., Kanwar Y.S., and Makino H. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys. J. Biol. Chem. 276 (2001) 17132-17139
    • (2001) J. Biol. Chem. , vol.276 , pp. 17132-17139
    • Zhang, H.1    Wada, J.2    Hida, K.3    Tsuchiyama, Y.4    Hiragushi, K.5    Shikata, K.6    Wang, H.7    Lin, S.8    Kanwar, Y.S.9    Makino, H.10
  • 157
    • 62949134955 scopus 로고    scopus 로고
    • Enhanced angiotensin converting enzyme 2 regulates the insulin//Akt signalling pathway by blockade of macrophage migration inhibitory factor expression
    • Zhong J.C., Yu X.Y., Lin Q.X., Li X.H., Huang X.Z., Xiao D.Z., and Lin S.G. Enhanced angiotensin converting enzyme 2 regulates the insulin//Akt signalling pathway by blockade of macrophage migration inhibitory factor expression. Br. J. Pharmacol. (2007)
    • (2007) Br. J. Pharmacol.
    • Zhong, J.C.1    Yu, X.Y.2    Lin, Q.X.3    Li, X.H.4    Huang, X.Z.5    Xiao, D.Z.6    Lin, S.G.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.