Oxidative Stress Is a Mediator of Glucose Toxicity in Insulin-secreting Pancreatic Islet Cell Lines

Journal of Biological Chemistry

Volumn 279, Issue 13, 2004, Pages 12126-12134

  Wu, Lan ^a   Nicholson, Wendell ^a   Knobel, Susan M ^b   Steffner, Robert J ^a   May, James M ^a,c   Piston, David W ^b   Powers, Alvin C ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCOSE; INSULIN; METABOLISM; OXIDATION; TOXICITY;

EXTRACELLULAR GLUCOSE; REACTIVE OXYGEN SPECIES (ROS);

CELLS;

ADENOSINE TRIPHOSPHATE; GLUCOKINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; ENZYME ACTIVITY; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; INSULIN RELEASE; INSULIN RESPONSE; MEDIATOR RELEASE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TARGET CELL; TOXICITY TESTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELL LINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; FREE RADICAL SCAVENGERS; GLUCOKINASE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; LIPID METABOLISM; NADP; OXIDATIVE STRESS; OXYGEN; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

ANIMALIA;

EID: 1842582779     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307097200     Document Type: Article

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