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Volumn 30, Issue 4, 2009, Pages 203-211

Subcellular neuropharmacology: the importance of intracellular targeting

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CELL PENETRATING PEPTIDE; LIPOSOME; MESSENGER RNA; POLYMER; RNA BINDING PROTEIN; SMALL MOLECULE TRANSPORT AGENT;

EID: 62949114441     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2009.01.005     Document Type: Review
Times cited : (14)

References (79)
  • 1
    • 0002917999 scopus 로고
    • Axonal dynamics and regeneration
    • Gorio A. (Ed), Raven Press
    • Brady S.T. Axonal dynamics and regeneration. In: Gorio A. (Ed). Neuroregeneration (1993), Raven Press 7-36
    • (1993) Neuroregeneration , pp. 7-36
    • Brady, S.T.1
  • 2
    • 0001938773 scopus 로고    scopus 로고
    • Dendrite Structure
    • 2nd edn, pp, Oxford University Press
    • Fiala, J. et al. (2008) Dendrite Structure. In Dendrites (2nd edn), pp. 1-42, Oxford University Press
    • (2008) Dendrites , pp. 1-42
    • Fiala, J.1
  • 3
    • 0019815917 scopus 로고
    • A quantitative light microscopic study of the dendrites of cat spinal α-motoneurons after intracellular staining with horseradish peroxidase
    • Ulfhake B., and Kellerth J.O. A quantitative light microscopic study of the dendrites of cat spinal α-motoneurons after intracellular staining with horseradish peroxidase. J. Comp. Neurol. 202 (1981) 571-583
    • (1981) J. Comp. Neurol. , vol.202 , pp. 571-583
    • Ulfhake, B.1    Kellerth, J.O.2
  • 4
    • 33847259240 scopus 로고    scopus 로고
    • βIV-spectrin forms a diffusion barrier against L1CAM at the axon initial segment
    • Nishimura K., et al. βIV-spectrin forms a diffusion barrier against L1CAM at the axon initial segment. Mol. Cell. Neurosci. 34 (2007) 422-430
    • (2007) Mol. Cell. Neurosci. , vol.34 , pp. 422-430
    • Nishimura, K.1
  • 5
    • 42049104329 scopus 로고    scopus 로고
    • Biochemical compartmentalization in dendrites
    • 2nd edn, pp, Oxford University Press
    • Helmchen, F. (2008). Biochemical compartmentalization in dendrites. In Dendrites (2nd edn), pp. 251-286, Oxford University Press
    • (2008) Dendrites , pp. 251-286
    • Helmchen, F.1
  • 6
    • 0141987863 scopus 로고    scopus 로고
    • Polarized domains of myelinated axons
    • Salzer J.L. Polarized domains of myelinated axons. Neuron 40 (2003) 297-318
    • (2003) Neuron , vol.40 , pp. 297-318
    • Salzer, J.L.1
  • 7
    • 0033152923 scopus 로고    scopus 로고
    • Structure, development, and plasticity of dendritic spines
    • Harris K.M. Structure, development, and plasticity of dendritic spines. Curr. Opin. Neurobiol. 9 (1999) 343-348
    • (1999) Curr. Opin. Neurobiol. , vol.9 , pp. 343-348
    • Harris, K.M.1
  • 8
    • 0346024190 scopus 로고    scopus 로고
    • Genesis of dendritic spines: insights from ultrastructural and imaging studies
    • Yuste R., and Bonhoeffer T. Genesis of dendritic spines: insights from ultrastructural and imaging studies. Nat. Rev. Neurosci. 5 (2004) 24-34
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 24-34
    • Yuste, R.1    Bonhoeffer, T.2
  • 9
    • 0029162513 scopus 로고
    • Evidence for silent synapses: implications for the expression of LTP
    • Isaac J.T., et al. Evidence for silent synapses: implications for the expression of LTP. Neuron 15 (1995) 427-434
    • (1995) Neuron , vol.15 , pp. 427-434
    • Isaac, J.T.1
  • 10
    • 0034633667 scopus 로고    scopus 로고
    • Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites
    • Kacharmina J.E., et al. Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 11545-11550
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 11545-11550
    • Kacharmina, J.E.1
  • 11
    • 18244380295 scopus 로고    scopus 로고
    • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation
    • Terry-Lorenzo R.T., et al. Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. Mol. Biol. Cell 16 (2005) 2349-2362
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2349-2362
    • Terry-Lorenzo, R.T.1
  • 12
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander E.S., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1
  • 13
    • 0036337915 scopus 로고    scopus 로고
    • A genomic view of alternative splicing
    • Modrek B., and Lee C. A genomic view of alternative splicing. Nat. Genet. 30 (2002) 13-19
    • (2002) Nat. Genet. , vol.30 , pp. 13-19
    • Modrek, B.1    Lee, C.2
  • 14
    • 0347224274 scopus 로고    scopus 로고
    • Cell-specific alternative splicing increases calcium channel current density in the pain pathway
    • Bell T.J., et al. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41 (2004) 127-138
    • (2004) Neuron , vol.41 , pp. 127-138
    • Bell, T.J.1
  • 15
    • 33847198227 scopus 로고    scopus 로고
    • Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors
    • Raingo J., et al. Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors. Nat. Neurosci. 10 (2007) 285-292
    • (2007) Nat. Neurosci. , vol.10 , pp. 285-292
    • Raingo, J.1
  • 16
    • 0035818529 scopus 로고    scopus 로고
    • Identification of sites for exponential translation in living dendrites
    • Job C., and Eberwine J. Identification of sites for exponential translation in living dendrites. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13037-13042
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 13037-13042
    • Job, C.1    Eberwine, J.2
  • 17
    • 33748133059 scopus 로고    scopus 로고
    • Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons
    • Grooms S.Y., et al. Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons. J. Neurosci. 26 (2006) 8339-8351
    • (2006) J. Neurosci. , vol.26 , pp. 8339-8351
    • Grooms, S.Y.1
  • 18
    • 41149085493 scopus 로고    scopus 로고
    • Ca channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
    • Ca channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 1901-1906
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 1901-1906
    • Bell, T.J.1
  • 19
    • 4143088149 scopus 로고    scopus 로고
    • Kinesin transports RNA: isolation and characterization of an RNA-transporting granule
    • Kanai Y., et al. Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 43 (2004) 513-525
    • (2004) Neuron , vol.43 , pp. 513-525
    • Kanai, Y.1
  • 20
    • 33644833422 scopus 로고    scopus 로고
    • The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons
    • Elvira G., et al. The zinc-finger protein ZFR is critical for Staufen 2 isoform specific nucleocytoplasmic shuttling in neurons. J. Neurochem. 96 (2006) 105-117
    • (2006) J. Neurochem. , vol.96 , pp. 105-117
    • Elvira, G.1
  • 21
    • 0036808018 scopus 로고    scopus 로고
    • Analysis of subcellularly localized mRNAs using in situ hybridization, mRNA amplification, and expression profiling
    • Eberwine J., et al. Analysis of subcellularly localized mRNAs using in situ hybridization, mRNA amplification, and expression profiling. Neurochem. Res. 27 (2002) 1065-1077
    • (2002) Neurochem. Res. , vol.27 , pp. 1065-1077
    • Eberwine, J.1
  • 22
    • 0033570305 scopus 로고    scopus 로고
    • Identification of a cis-acting dendritic targeting element in MAP2 mRNAs
    • Blichenberg A., et al. Identification of a cis-acting dendritic targeting element in MAP2 mRNAs. J. Neurosci. 19 (1999) 8818-8829
    • (1999) J. Neurosci. , vol.19 , pp. 8818-8829
    • Blichenberg, A.1
  • 23
    • 0033769356 scopus 로고    scopus 로고
    • Two cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting
    • Mori Y., et al. Two cis-acting elements in the 3′ untranslated region of α-CaMKII regulate its dendritic targeting. Nat. Neurosci. 3 (2000) 1079-1084
    • (2000) Nat. Neurosci. , vol.3 , pp. 1079-1084
    • Mori, Y.1
  • 24
    • 14844331501 scopus 로고    scopus 로고
    • Molecular motors and mechanisms of directional transport in neurons
    • Hirokawa N., and Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat. Rev. Neurosci. 6 (2005) 201-214
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 201-214
    • Hirokawa, N.1    Takemura, R.2
  • 25
    • 0035036344 scopus 로고    scopus 로고
    • Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
    • Steward O., and Worley P.F. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30 (2001) 227-240
    • (2001) Neuron , vol.30 , pp. 227-240
    • Steward, O.1    Worley, P.F.2
  • 26
    • 0030473999 scopus 로고    scopus 로고
    • Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis
    • Crino P.B., and Eberwine J. Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis. Neuron 17 (1996) 1173-1187
    • (1996) Neuron , vol.17 , pp. 1173-1187
    • Crino, P.B.1    Eberwine, J.2
  • 27
    • 0034257926 scopus 로고    scopus 로고
    • CaMKIIα 3′ untranslated region-directed mRNA translocation in living neurons: visualization by GFP linkage
    • Rook M.S., et al. CaMKIIα 3′ untranslated region-directed mRNA translocation in living neurons: visualization by GFP linkage. J. Neurosci. 20 (2000) 6385-6393
    • (2000) J. Neurosci. , vol.20 , pp. 6385-6393
    • Rook, M.S.1
  • 28
    • 0037996871 scopus 로고    scopus 로고
    • Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and β-actin mRNA in dendrites and spines of hippocampal neurons
    • Tiruchinapalli D.M., et al. Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and β-actin mRNA in dendrites and spines of hippocampal neurons. J. Neurosci. 23 (2003) 3251-3261
    • (2003) J. Neurosci. , vol.23 , pp. 3251-3261
    • Tiruchinapalli, D.M.1
  • 29
    • 14644442259 scopus 로고    scopus 로고
    • Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons
    • Smith W.B., et al. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45 (2005) 765-779
    • (2005) Neuron , vol.45 , pp. 765-779
    • Smith, W.B.1
  • 30
    • 0028117753 scopus 로고
    • On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning
    • Miyashiro K., et al. On the nature and differential distribution of mRNAs in hippocampal neurites: implications for neuronal functioning. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 10800-10804
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 10800-10804
    • Miyashiro, K.1
  • 31
    • 0034990497 scopus 로고    scopus 로고
    • Dynamic visualization of local protein synthesis in hippocampal neurons
    • Aakalu G., et al. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30 (2001) 489-502
    • (2001) Neuron , vol.30 , pp. 489-502
    • Aakalu, G.1
  • 32
    • 23444445375 scopus 로고    scopus 로고
    • The mRNA for elongation factor 1α is localized in dendrites and translated in response to treatments that induce long-term depression
    • Huang F., et al. The mRNA for elongation factor 1α is localized in dendrites and translated in response to treatments that induce long-term depression. J. Neurosci. 25 (2005) 7199-7209
    • (2005) J. Neurosci. , vol.25 , pp. 7199-7209
    • Huang, F.1
  • 33
    • 20544458394 scopus 로고    scopus 로고
    • Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation
    • Tsokas P., et al. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J. Neurosci. 25 (2005) 5833-5843
    • (2005) J. Neurosci. , vol.25 , pp. 5833-5843
    • Tsokas, P.1
  • 34
    • 3042521496 scopus 로고    scopus 로고
    • Regulation of dendritic protein synthesis by miniature synaptic events
    • Sutton M.A., et al. Regulation of dendritic protein synthesis by miniature synaptic events. Science 304 (2004) 1979-1983
    • (2004) Science , vol.304 , pp. 1979-1983
    • Sutton, M.A.1
  • 35
    • 34547683444 scopus 로고    scopus 로고
    • Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis
    • Sutton M.A., et al. Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis. Neuron 55 (2007) 648-661
    • (2007) Neuron , vol.55 , pp. 648-661
    • Sutton, M.A.1
  • 36
    • 30344449514 scopus 로고    scopus 로고
    • Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
    • Ashraf S.I., et al. Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 124 (2006) 191-205
    • (2006) Cell , vol.124 , pp. 191-205
    • Ashraf, S.I.1
  • 37
    • 33746196574 scopus 로고    scopus 로고
    • Local protein synthesis and spine morphogenesis: fragile X syndrome and beyond
    • Grossman A.W., et al. Local protein synthesis and spine morphogenesis: fragile X syndrome and beyond. J. Neurosci. 26 (2006) 7151-7155
    • (2006) J. Neurosci. , vol.26 , pp. 7151-7155
    • Grossman, A.W.1
  • 38
    • 0037168109 scopus 로고    scopus 로고
    • Disruption of dendritic translation of CaMKIIα impairs stabilization of synaptic plasticity and memory consolidation
    • Miller S., et al. Disruption of dendritic translation of CaMKIIα impairs stabilization of synaptic plasticity and memory consolidation. Neuron 36 (2002) 507-519
    • (2002) Neuron , vol.36 , pp. 507-519
    • Miller, S.1
  • 39
    • 0027383316 scopus 로고
    • Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor
    • Aroeti B., et al. Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor. J. Cell Biol. 123 (1993) 1149-1160
    • (1993) J. Cell Biol. , vol.123 , pp. 1149-1160
    • Aroeti, B.1
  • 40
    • 0029155983 scopus 로고
    • Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture
    • de Hoop M., et al. Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture. J. Cell Biol. 130 (1995) 1447-1459
    • (1995) J. Cell Biol. , vol.130 , pp. 1447-1459
    • de Hoop, M.1
  • 41
    • 0027989516 scopus 로고
    • Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells
    • Matter K., et al. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells. J. Cell Biol. 126 (1994) 991-1004
    • (1994) J. Cell Biol. , vol.126 , pp. 991-1004
    • Matter, K.1
  • 42
    • 0030857180 scopus 로고    scopus 로고
    • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor
    • West A.E., et al. Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J. Neurosci. 17 (1997) 6038-6047
    • (1997) J. Neurosci. , vol.17 , pp. 6038-6047
    • West, A.E.1
  • 43
    • 27844451078 scopus 로고    scopus 로고
    • A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons
    • Rosales C.R., et al. A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. Eur. J. Neurosci. 22 (2005) 2381-2386
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 2381-2386
    • Rosales, C.R.1
  • 44
    • 19444384837 scopus 로고    scopus 로고
    • Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals
    • Silverman M.A., et al. Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals. Mol. Cell. Neurosci. 29 (2005) 173-180
    • (2005) Mol. Cell. Neurosci. , vol.29 , pp. 173-180
    • Silverman, M.A.1
  • 45
    • 13944251668 scopus 로고    scopus 로고
    • A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites
    • Mitsui S., et al. A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites. J. Neurosci. 25 (2005) 1122-1131
    • (2005) J. Neurosci. , vol.25 , pp. 1122-1131
    • Mitsui, S.1
  • 46
    • 0033757858 scopus 로고    scopus 로고
    • + channel in hippocampal neurons
    • + channel in hippocampal neurons. Neuron 25 (2000) 385-397
    • (2000) Neuron , vol.25 , pp. 385-397
    • Lim, S.T.1
  • 47
    • 0037088919 scopus 로고    scopus 로고
    • Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1
    • Francesconi A., and Duvoisin R.M. Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1. J. Neurosci. 22 (2002) 2196-2205
    • (2002) J. Neurosci. , vol.22 , pp. 2196-2205
    • Francesconi, A.1    Duvoisin, R.M.2
  • 48
    • 0037374279 scopus 로고    scopus 로고
    • + channels mediates dendritic targeting
    • + channels mediates dendritic targeting. Nat. Neurosci. 6 (2003) 243-250
    • (2003) Nat. Neurosci. , vol.6 , pp. 243-250
    • Rivera, J.F.1
  • 49
    • 42549148456 scopus 로고    scopus 로고
    • Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting
    • Rajendran L., et al. Efficient inhibition of the Alzheimer's disease β-secretase by membrane targeting. Science 320 (2008) 520-523
    • (2008) Science , vol.320 , pp. 520-523
    • Rajendran, L.1
  • 50
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin M.T., and Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 (2006) 787-795
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 51
    • 34447558681 scopus 로고    scopus 로고
    • Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases
    • James A.M., et al. Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J. Biol. Chem. 282 (2007) 14708-14718
    • (2007) J. Biol. Chem. , vol.282 , pp. 14708-14718
    • James, A.M.1
  • 52
    • 49149124239 scopus 로고    scopus 로고
    • Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel
    • D'Souza G.G., et al. Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. J. Drug Target. 16 (2008) 578-585
    • (2008) J. Drug Target. , vol.16 , pp. 578-585
    • D'Souza, G.G.1
  • 53
    • 34547637590 scopus 로고    scopus 로고
    • Drug targeting to the brain
    • Pardridge W.M. Drug targeting to the brain. Pharm. Res. 24 (2007) 1733-1744
    • (2007) Pharm. Res. , vol.24 , pp. 1733-1744
    • Pardridge, W.M.1
  • 54
    • 0032600640 scopus 로고    scopus 로고
    • A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases
    • Ghose A.K., et al. A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J. Comb. Chem. 1 (1999) 55-68
    • (1999) J. Comb. Chem. , vol.1 , pp. 55-68
    • Ghose, A.K.1
  • 55
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 44 (2000) 235-249
    • (2000) J. Pharmacol. Toxicol. Methods , vol.44 , pp. 235-249
    • Lipinski, C.A.1
  • 56
    • 0007540552 scopus 로고    scopus 로고
    • Liposome pharmacokinetics. Classical, sterically stabilized, cationic liposomes and immunoliposomes
    • Janoff A.S. (Ed), Marcel Dekker
    • Allen T.M., and Stuart D.D. Liposome pharmacokinetics. Classical, sterically stabilized, cationic liposomes and immunoliposomes. In: Janoff A.S. (Ed). Liposomes: Rational Design (1999), Marcel Dekker 63-87
    • (1999) Liposomes: Rational Design , pp. 63-87
    • Allen, T.M.1    Stuart, D.D.2
  • 57
    • 0029877551 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine
    • Holland J.W., et al. Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine. Biochemistry 35 (1996) 2618-2624
    • (1996) Biochemistry , vol.35 , pp. 2618-2624
    • Holland, J.W.1
  • 58
    • 0035980981 scopus 로고    scopus 로고
    • Enzyme-activated targeting of liposomes
    • Meers P. Enzyme-activated targeting of liposomes. Adv. Drug Deliv. Rev. 53 (2001) 265-272
    • (2001) Adv. Drug Deliv. Rev. , vol.53 , pp. 265-272
    • Meers, P.1
  • 59
    • 0038387390 scopus 로고    scopus 로고
    • The dawning era of polymer therapeutics
    • Duncan R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2 (2003) 347-360
    • (2003) Nat. Rev. Drug Discov. , vol.2 , pp. 347-360
    • Duncan, R.1
  • 60
    • 53849146005 scopus 로고    scopus 로고
    • Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: a comparative study with epithelial cell cultures
    • Foerg C., et al. Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: a comparative study with epithelial cell cultures. AAPS J. 10 (2008) 349-359
    • (2008) AAPS J. , vol.10 , pp. 349-359
    • Foerg, C.1
  • 61
    • 0034141430 scopus 로고    scopus 로고
    • In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA
    • Schwarze S.R., and Dowdy S.F. In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA. Trends Pharmacol. Sci. 21 (2000) 45-48
    • (2000) Trends Pharmacol. Sci. , vol.21 , pp. 45-48
    • Schwarze, S.R.1    Dowdy, S.F.2
  • 62
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: delivery of a biologically active protein into the mouse
    • Schwarze S.R., et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999) 1569-1572
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1
  • 63
    • 0035989846 scopus 로고    scopus 로고
    • Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates
    • Koppelhus U., et al. Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates. Antisense Nucleic Acid Drug Dev. 12 (2002) 51-63
    • (2002) Antisense Nucleic Acid Drug Dev. , vol.12 , pp. 51-63
    • Koppelhus, U.1
  • 64
    • 0037474028 scopus 로고    scopus 로고
    • No entry for TAT(44-57) into liposomes and intact MDCK cells: novel approach to study membrane permeation of cell-penetrating peptides
    • Kramer S.D., and Wunderli-Allenspach H. No entry for TAT(44-57) into liposomes and intact MDCK cells: novel approach to study membrane permeation of cell-penetrating peptides. Biochim. Biophys. Acta 1609 (2003) 161-169
    • (2003) Biochim. Biophys. Acta , vol.1609 , pp. 161-169
    • Kramer, S.D.1    Wunderli-Allenspach, H.2
  • 65
    • 9444289278 scopus 로고    scopus 로고
    • Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus
    • Kerkis A., et al. Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus. FASEB J. 18 (2004) 1407-1409
    • (2004) FASEB J. , vol.18 , pp. 1407-1409
    • Kerkis, A.1
  • 66
    • 33645104169 scopus 로고    scopus 로고
    • Properties of cell penetrating peptides (CPPs)
    • Kerkis A., et al. Properties of cell penetrating peptides (CPPs). IUBMB Life 58 (2006) 7-13
    • (2006) IUBMB Life , vol.58 , pp. 7-13
    • Kerkis, A.1
  • 67
    • 34548735210 scopus 로고    scopus 로고
    • Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes
    • Rozema D.B., et al. Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 12982-12987
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 12982-12987
    • Rozema, D.B.1
  • 68
    • 0026073856 scopus 로고
    • Intrathecal baclofen for spasticity in cerebral palsy
    • Albright A.L., et al. Intrathecal baclofen for spasticity in cerebral palsy. J. Am. Med. Assoc. 265 (1991) 1418-1422
    • (1991) J. Am. Med. Assoc. , vol.265 , pp. 1418-1422
    • Albright, A.L.1
  • 69
    • 4644237284 scopus 로고    scopus 로고
    • Materials science. Smart biomaterials
    • Anderson D.G., et al. Materials science. Smart biomaterials. Science 305 (2004) 1923-1924
    • (2004) Science , vol.305 , pp. 1923-1924
    • Anderson, D.G.1
  • 70
    • 0037204998 scopus 로고    scopus 로고
    • Biodegradable, elastic shape-memory polymers for potential biomedical applications
    • Lendlein A., and Langer R. Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science 296 (2002) 1673-1676
    • (2002) Science , vol.296 , pp. 1673-1676
    • Lendlein, A.1    Langer, R.2
  • 71
    • 33751019968 scopus 로고    scopus 로고
    • Anomalous diffusion in Purkinje cell dendrites caused by spines
    • Santamaria F., et al. Anomalous diffusion in Purkinje cell dendrites caused by spines. Neuron 52 (2006) 635-648
    • (2006) Neuron , vol.52 , pp. 635-648
    • Santamaria, F.1
  • 72
    • 20444369248 scopus 로고    scopus 로고
    • 2+ signaling in dendrites
    • 2+ signaling in dendrites. Neuron 46 (2005) 609-622
    • (2005) Neuron , vol.46 , pp. 609-622
    • Noguchi, J.1
  • 73
    • 33750519045 scopus 로고    scopus 로고
    • Spatially confined diffusion of calcium in dendrites of hippocampal neurons revealed by flash photolysis of caged calcium
    • Korkotian E., and Segal M. Spatially confined diffusion of calcium in dendrites of hippocampal neurons revealed by flash photolysis of caged calcium. Cell Calcium 40 (2006) 441-449
    • (2006) Cell Calcium , vol.40 , pp. 441-449
    • Korkotian, E.1    Segal, M.2
  • 74
    • 40349106008 scopus 로고    scopus 로고
    • Modular transporters for subcellular cell-specific targeting of anti-tumor drugs
    • Sobolev A.S. Modular transporters for subcellular cell-specific targeting of anti-tumor drugs. Bioessays 30 (2008) 278-287
    • (2008) Bioessays , vol.30 , pp. 278-287
    • Sobolev, A.S.1
  • 75
    • 0032125579 scopus 로고    scopus 로고
    • Caged RNA: photo-control of a ribozyme reaction
    • Chaulk S.G., and MacMillan A.M. Caged RNA: photo-control of a ribozyme reaction. Nucleic Acids Res. 26 (1998) 3173-3178
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3173-3178
    • Chaulk, S.G.1    MacMillan, A.M.2
  • 76
    • 36248965157 scopus 로고    scopus 로고
    • Light-dependent RNA interference with nucleobase-caged siRNAs
    • Mikat V., and Heckel A. Light-dependent RNA interference with nucleobase-caged siRNAs. RNA 13 (2007) 2341-2347
    • (2007) RNA , vol.13 , pp. 2341-2347
    • Mikat, V.1    Heckel, A.2
  • 77
    • 33744505179 scopus 로고    scopus 로고
    • Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor
    • Barrett L.E., et al. Region-directed phototransfection reveals the functional significance of a dendritically synthesized transcription factor. Nat. Methods 3 (2006) 455-460
    • (2006) Nat. Methods , vol.3 , pp. 455-460
    • Barrett, L.E.1
  • 78
    • 0038360785 scopus 로고    scopus 로고
    • Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development
    • Lee S.H., and Hannink M. Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development. Adv. Drug Deliv. Rev. 55 (2003) 717-731
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 717-731
    • Lee, S.H.1    Hannink, M.2
  • 79
    • 33745546232 scopus 로고    scopus 로고
    • 111In in human myeloid leukemia cells
    • 111In in human myeloid leukemia cells. J. Nucl. Med. 47 (2006) 827-836
    • (2006) J. Nucl. Med. , vol.47 , pp. 827-836
    • Chen, P.1


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