Cytoplasmic BKCa channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 6, 2008, Pages 1901-1906

  Bell, Thomas J ^a   Miyashiro, Kevin Y ^a   Sul, Jai Yoon ^a   McCullough, Ronald ^c   Buckley, Peter T ^a   Jochems, Jeanine ^a   Meaney, David F ^b   Haydon, Phil ^a   Cantor, Charles ^d   Parsons, Thomas D ^a   Eberwine, James ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BOSTON UNIVERSITY   (United States)

^d SEQUENOM INC   (United States)

Author keywords

Dendrite; Epilepsy; Intron retention; KCNMA1; Local splicing

Indexed keywords

LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; MESSENGER RNA;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DENDRITIC SPINE; GENE EXPRESSION; HIPPOCAMPUS; INTRON; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN VARIANT; RAT; RNA INTERFERENCE;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; DENDRITES; HIPPOCAMPUS; INTRONS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; NEURONS; RATS; RNA, MESSENGER; RNA, SMALL INTERFERING; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBCELLULAR FRACTIONS;

EID: 41149085493     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0711796105     Document Type: Article

References (43)

1. Lancaster B, Nicoll RA (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurons. J Physiol 389:187-203.
2. Gu N, Vervaeke K, Storm JF (2007) BK potassium channels facilitate high-frequency firing and cause early spike frequency adaptation in rat CA1 hippocampal pyramidal cells. J Physiol 580:859-882.
3. Callaway JC, Ross WN (1997) Spatial distribution of synaptically activated sodium concentration changes in cerebellar Purkinje neurons. J Neurophysiol 77(1):145-152.
4. Swensen AM, Bean BP (2003) Ionic mechanisms of burst firing in dissociated Purkinje neurons. J Neurosci 23:9650-9663.
5. Swensen AM, Bean BP (2005) Robustness of burst firing in dissociated purkinje neurons with acute or long-term reductions in sodium conductance. J Neurosci 25:3509-3520.
6. Burdakov D, Ashcroft FM (2002) Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-type potassium channels. J Neurosci 22:6380-6387.
7. Salkoff L, et al. (2006) High-conductance potassium channels of the SLO family. Nat Rev Neurosci 7(12):921-931.
8. Atkinson NS, Robertson GA, Ganetzky B (1991) A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science 253:551-555.
9. + channel isoforms from human brain. Neuron 13:1315-1330.
10. Fettiplace R, Fuchs PA (1999) Mechanisms of hair cell tuning. Annu Rev Physiol 61:809-834.
11. + channel splice variant. Proc Natl Acad Sci USA 101:10072-10077.
12. Poolos NP, Johnston D (1999) Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neurons. J Neurosci 19:5205-5212.
13. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA, PKC. J Neurosci 18:3521-3528.
14. Johnston D, Hoffman DA, Poolos NP (2000) Potassium channels and dendritic function in hippocampal pyramidal neurons. Epilepsia 41:1072-1073.
15. Glanzer J, et al. (2005)RNAsplicing capability of live neuronal dendrites. Proc Natl Acad Sci USA 102:16859-16864.
16. Chen L, et al. (2005) Functionally diverse complement of large conductance calciumand voltage-activated potassium channel (BK) α-subunits generated from a single site of splicing. J Biol Chem 280:33599-33609.
17. Jiang Y, et al. (2002) Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417:515-522.
18. McCullough RM, Cantor CR, Ding C (2005) High-throughput alternative splicing quantification by primer extension and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Nucleic Acids Res 33:e99.
19. MacDonald SH, et al. (2006) Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS. BMC Dev Biol 6:37.
20. Misonou H, et al. (2004) Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci 7:711-718.
21. Mu Y, et al. (2003) Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors. Neuron 40:581-594.
22. Hille B (2001) Ion Channels of Excitable Membranes (Sinauer, Sunderland, MA), 3rd Ed, p xviii
23. + channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells. J Physiol 521:135-146.
24. Thomas MJ, et al. (1998) Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation. J Neurosci 18:7118-7126.
25. Du W, et al. (2005) Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat Genet 37:733-738.
26. Brenner R, et al. (2005) BK channel β4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci 8:1752-1759.
27. Cai X, et al. (2004) Unique roles of SK, Kv4.2 potassium channels in dendritic integration. Neuron 44:351-364.
28. Rutz B, Seraphin B (2000) A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing. EMBO J 19:1873-1886.
29. Hillman RT, Green RE, Brenner SE (2004) An unappreciated role for RNA surveillance. Genome Biol 5:R8.
30. Shaftel SS, et al. (2003) COX-3: A splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res Mol Brain Res 119:213-215.
31. Lin CL, et al. (1998) Aberrant RNA processing in a neurodegenerative disease: The cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron 20:589-602.
32. Galante PA, et al. (2004) Detection and evaluation of intron retention events in the human transcriptome. RNA 10:757-765.
33. Denis MM, et al. (2005) Escaping the nuclear confines: Signal-dependent pre-mRNA splicing in anucleate platelets. Cell 122:379-391.
34. Li Y, et al. (2006) An intron with a constitutive transport element is retained in a Tap messenger RNA. Nature 443:234-237.
35. Job C, Eberwine J (2001) Identification of sites for exponential translation in living dendrites. Proc Natl Acad Sci USA 98:13037-13042.
36. Steward O, Schuman EM (2001) Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci 24:299-325.
37. Konig H, et al. (2007) Splicing segregation: The minor spliceosome acts outside the nucleus and controls cell proliferation. Cell 131:718-729.
38. 2+ channels in hippocampal neurons. Nature 395:900-905.
39. + signaling. Science 314:615-620.
40. Tian L, et al. (2006) A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J 20:2588-2590.
41. + current. Am J Physiol Cell Physiol 289:C49-C57.
42. + channel deficiency. Proc Natl Acad Sci USA 101:9474-9478.
43. Ca channel, a synaptic regulator of neuronal excitability, with autism and mental retardation. Am J Psychiatry 163:1622-1629.