메뉴 건너뛰기




Volumn 27, Issue 4, 2008, Pages 176-191

Role of the immune system in aging

Author keywords

Aging; Inmunosenescence; Oxi inflamm aging; Oxidation inflammation

Indexed keywords

ACETYLCYSTEINE; CD27 ANTIGEN; CD38 ANTIGEN; CD8 ANTIGEN; ESTROGEN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 6; NEUROTRANSMITTER; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 62749173602     PISSN: 02139626     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0213-9626(08)70066-0     Document Type: Review
Times cited : (5)

References (109)
  • 2
    • 0018861356 scopus 로고
    • Asessment of biological age using a profile of physical parameters
    • Borkan A, Norris AH. Asessment of biological age using a profile of physical parameters. J Gerontol 1980; 35:177-184.
    • (1980) J Gerontol , vol.35 , pp. 177-184
    • Borkan, A.1    Norris, A.H.2
  • 3
    • 0028839467 scopus 로고
    • Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
    • Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 1995; 50: B378-382.
    • (1995) J Gerontol A Biol Sci Med Sci , vol.50
    • Ferguson, F.G.1    Wikby, A.2    Maxson, P.3    Olsson, J.4    Johansson, B.5
  • 5
    • 0037012047 scopus 로고    scopus 로고
    • Leukocyte function and life span in a murine model of premature immunosenescence
    • Guayerbas N, Puerto M, Victor VM, Miquel J, De la Fuente M. Leukocyte function and life span in a murine model of premature immunosenescence. Exp Gerontol 2002; 37:249-256.
    • (2002) Exp Gerontol , vol.37 , pp. 249-256
    • Guayerbas, N.1    Puerto, M.2    Victor, V.M.3    Miquel, J.4    De la Fuente, M.5
  • 6
    • 0037151259 scopus 로고    scopus 로고
    • Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence
    • Guayerbas N, Catalan M, Victor VM, Miquel J, De la Fuente M. Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence. Behav Brain Res 2002; 134:41-48.
    • (2002) Behav Brain Res , vol.134 , pp. 41-48
    • Guayerbas, N.1    Catalan, M.2    Victor, V.M.3    Miquel, J.4    De la Fuente, M.5
  • 7
    • 0037393466 scopus 로고    scopus 로고
    • An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice
    • Guayerbas N, De La Fuente M. An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice. Dev Comp Immunol 2003; 27: 339-350.
    • (2003) Dev Comp Immunol , vol.27 , pp. 339-350
    • Guayerbas, N.1    De La Fuente, M.2
  • 8
    • 0036049037 scopus 로고    scopus 로고
    • Effects of antioxidants on immune system ageing
    • De la Fuente M. Effects of antioxidants on immune system ageing. Eur J Clin Nutr 2002; 56: S5-S8.
    • (2002) Eur J Clin Nutr , vol.56
    • De la Fuente, M.1
  • 9
    • 24144436152 scopus 로고    scopus 로고
    • The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise
    • De la Fuente M, Hernanz A, Vallejo MC. The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise. Antioxid Redox Signal 2005; 7:1356-1366.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1356-1366
    • De la Fuente, M.1    Hernanz, A.2    Vallejo, M.C.3
  • 10
    • 0025117953 scopus 로고
    • An attempt at a rational classification of theories of aging
    • Medvedev ZA. An attempt at a rational classification of theories of aging. Biol Rev 1990;65:375-398.
    • (1990) Biol Rev , vol.65 , pp. 375-398
    • Medvedev, Z.A.1
  • 11
    • 34249672703 scopus 로고    scopus 로고
    • Biological aging is no longer an unsolved problem
    • Hayflick L. Biological aging is no longer an unsolved problem. Ann N Y Acad Sci 2007; 1100:1-13.
    • (2007) Ann N Y Acad Sci , vol.1100 , pp. 1-13
    • Hayflick, L.1
  • 12
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerontol 1956; 2: 298-300.
    • (1956) J Gerontol , vol.2 , pp. 298-300
    • Harman, D.1
  • 13
    • 0015319592 scopus 로고    scopus 로고
    • Harman D The biological clock. The mitochondria? J Am Geriatr Soc 1972; 20:99-117.
    • Harman D The biological clock. The mitochondria? J Am Geriatr Soc 1972; 20:99-117.
  • 15
    • 0003138331 scopus 로고
    • Theoretical and experimental support for an oxygen radical-mitochondrial damage hypothesis of cell aging
    • Johnson JE Jr, Harman D, Walford R, Miquel J, editors, New York: Alan R Liss;
    • Miquel J, Fleming JE. Theoretical and experimental support for an oxygen radical-mitochondrial damage hypothesis of cell aging. En: Johnson JE Jr, Harman D, Walford R, Miquel J, editors. Free radicals, aging and degenerative diseases. New York: Alan R Liss; 1986: p. 51-74.
    • (1986) Free radicals, aging and degenerative diseases , pp. 51-74
    • Miquel, J.1    Fleming, J.E.2
  • 16
    • 0026698066 scopus 로고
    • An updateon the mitochondrial-DNA mutation hypothesis of cell aging
    • Miquel J. An updateon the mitochondrial-DNA mutation hypothesis of cell aging. Mutant Res 1992; 275:209-216.
    • (1992) Mutant Res , vol.275 , pp. 209-216
    • Miquel, J.1
  • 17
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • Barja G. Free radicals and aging. Trends Neurosci 2004; 27: 595-600.
    • (2004) Trends Neurosci , vol.27 , pp. 595-600
    • Barja, G.1
  • 19
    • 14744288037 scopus 로고    scopus 로고
    • Aging rate, mitochondrial free radical production, and constitutive sensitivity to lipid peroxidation: Insights from comparative studies
    • T. von Zglinicki ed, The Netherlands, Kluwer Academic Publishers
    • Pamplona R, Barja G. Aging rate, mitochondrial free radical production, and constitutive sensitivity to lipid peroxidation: Insights from comparative studies. In T. von Zglinicki (ed.). Aging Molecular Level, The Netherlands, Kluwer Academic Publishers, 2003. pp. 47-64.
    • (2003) Aging Molecular Level , pp. 47-64
    • Pamplona, R.1    Barja, G.2
  • 20
    • 0010670229 scopus 로고
    • A systems analysis- thermodynamic view of cellular and organismic aging
    • Johnson JE Jr, editor, New York: Plenum Press;
    • Miquel J, Economos AC, Johnson JE Jr. A systems analysis- thermodynamic view of cellular and organismic aging. In: Johnson JE Jr, editor. Aging and cell structure, vol 2. New York: Plenum Press; 1984. p. 247-80.
    • (1984) Aging and cell structure , vol.2 , pp. 247-280
    • Miquel, J.1    Economos, A.C.2    Johnson Jr, J.E.3
  • 21
    • 84985570313 scopus 로고
    • Biochemistry of oxidative stress
    • Sies H. Biochemistry of oxidative stress. Angewandte Chem 1986; 25:1058-1071.
    • (1986) Angewandte Chem , vol.25 , pp. 1058-1071
    • Sies, H.1
  • 22
    • 0034050669 scopus 로고    scopus 로고
    • Review: Free Radicals, Antioxidants, and Immune System
    • Knight JA. Review: Free Radicals, Antioxidants, and Immune System. Ann Clin Lab Sci 2000; 30:145-158.
    • (2000) Ann Clin Lab Sci , vol.30 , pp. 145-158
    • Knight, J.A.1
  • 23
    • 62749186719 scopus 로고    scopus 로고
    • Dose effect of oxidative stress on signal transduction in aging
    • Yoon SO, Yun ChH, Cheng AS. Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Develop 2002; 50:1-8.
    • (2002) Mech Ageing Develop , vol.50 , pp. 1-8
    • Yoon, S.O.1    Yun, C.H.2    Cheng, A.S.3
  • 24
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senescence
    • Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 2:397-411.
    • (1957) Evolution , vol.2 , pp. 397-411
    • Williams, G.C.1
  • 26
    • 0025864512 scopus 로고
    • An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells
    • Miquel J. An integrated theory of aging as the result of mitochondrial DNA mutation in differentiated cells. Arch Gerontol Geriatr 1991; 12:99-117.
    • (1991) Arch Gerontol Geriatr , vol.12 , pp. 99-117
    • Miquel, J.1
  • 27
    • 0031964919 scopus 로고    scopus 로고
    • An update on the oxygen stress-mitochondrial mutation theory of aging: Genetic and evolutionary implications
    • Miquel J. An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications. Exp Gerontol 1998; 33:113-125.
    • (1998) Exp Gerontol , vol.33 , pp. 113-125
    • Miquel, J.1
  • 28
    • 34248549251 scopus 로고    scopus 로고
    • Critical review: Theories of aging
    • Viña J, Borrás C, Miquel J. Critical review: Theories of aging. IUBMB Life 2007;59: 249-254.
    • (2007) IUBMB Life , vol.59 , pp. 249-254
    • Viña, J.1    Borrás, C.2    Miquel, J.3
  • 29
    • 0842324563 scopus 로고    scopus 로고
    • Infection as a cause of age-related morbidity and mortality
    • High KP: Infection as a cause of age-related morbidity and mortality. Ageing Res Rev 2004; 3:1-14.
    • (2004) Ageing Res Rev , vol.3 , pp. 1-14
    • High, K.P.1
  • 30
    • 0025213974 scopus 로고
    • Cell-mediated immunity as a predictor of morbility and mortality in subjects over 60
    • Wayne SL, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbility and mortality in subjects over 60. J Gerontol 1990; 45:M45-48.
    • (1990) J Gerontol , vol.45
    • Wayne, S.L.1    Rhyne, R.L.2    Garry, P.J.3    Goodwin, J.S.4
  • 31
    • 0033795955 scopus 로고    scopus 로고
    • Ortega E, García JJ, De la Fuente M. Ageing modulates some aspects on the non-specific immune response of murine macrophages and lymphocytes. Exp Physiol 2000; 85.5:519-525.
    • Ortega E, García JJ, De la Fuente M. Ageing modulates some aspects on the non-specific immune response of murine macrophages and lymphocytes. Exp Physiol 2000; 85.5:519-525.
  • 34
    • 33847640493 scopus 로고    scopus 로고
    • Immunosenescence: Emerging challenges for an ageing population
    • Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology 2007; 120:435- 446.
    • (2007) Immunology , vol.120 , pp. 435-446
    • Aw, D.1    Silva, A.B.2    Palmer, D.B.3
  • 35
    • 57149096659 scopus 로고    scopus 로고
    • Role of neuroimmunomodulation in aging
    • De la Fuente M. Role of neuroimmunomodulation in aging. Neuroimmunomodulation 2008; 15:213-223.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 213-223
    • De la Fuente, M.1
  • 36
    • 43649085158 scopus 로고    scopus 로고
    • Age-related decline in immunity: Implications for vaccine responsiveness
    • Kumar R, Burns EA. Age-related decline in immunity: Implications for vaccine responsiveness. Expert Rev Vaccines 2008; 7:467-479.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 467-479
    • Kumar, R.1    Burns, E.A.2
  • 39
    • 20444497416 scopus 로고    scopus 로고
    • The number of human peripheral blood CD4+CD25high regulatory T cells increases with age
    • Gregg R, Smith CM, Clark FJ, Dunnion D, Khan N, Chakraverty R, et al. The number of human peripheral blood CD4+CD25high regulatory T cells increases with age. Clin Exp Immunol 2005; 140: 540-546.
    • (2005) Clin Exp Immunol , vol.140 , pp. 540-546
    • Gregg, R.1    Smith, C.M.2    Clark, F.J.3    Dunnion, D.4    Khan, N.5    Chakraverty, R.6
  • 40
    • 33646397029 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans- impact of immunosenescence
    • Trzonkowski P, Szmit E, Mysliwska J, Mysliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans- impact of immunosenescence. Clin Immunol 2006; 119: 307-316.
    • (2006) Clin Immunol , vol.119 , pp. 307-316
    • Trzonkowski, P.1    Szmit, E.2    Mysliwska, J.3    Mysliwski, A.4
  • 43
    • 21744437451 scopus 로고    scopus 로고
    • Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence
    • De la Fuente M, Hernanz A, Guayerbas N, Álvarez P, Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol 2004; 50, 683-690.
    • (2004) Cell Mol Biol , vol.50 , pp. 683-690
    • De la Fuente, M.1    Hernanz, A.2    Guayerbas, N.3    Álvarez, P.4    Alvarado, C.5
  • 46
    • 0021871082 scopus 로고
    • Changes in the macrophage function with aging
    • De la Fuente M. Changes in the macrophage function with aging. Comp Biochem Physiol 1985; 81:935-938.
    • (1985) Comp Biochem Physiol , vol.81 , pp. 935-938
    • De la Fuente, M.1
  • 48
    • 0041345879 scopus 로고    scopus 로고
    • Immune disfunction in the elderly and its reversal by antihistamins
    • Rafi A, Castle SC, Uyemura K, Makinodan T. Immune disfunction in the elderly and its reversal by antihistamins. Biomed Pharmacother 2003; 57: 246-250.
    • (2003) Biomed Pharmacother , vol.57 , pp. 246-250
    • Rafi, A.1    Castle, S.C.2    Uyemura, K.3    Makinodan, T.4
  • 49
    • 33646550890 scopus 로고    scopus 로고
    • Age-dependent modifications of type 1 and type 2 cytokines whitin virgin and memory CD4+ T cells in humans
    • Alberti S, Cevenini E, Ostan R, Capri M, SalvioliS, Bucci L, et al. Age-dependent modifications of type 1 and type 2 cytokines whitin virgin and memory CD4+ T cells in humans. Mech Ageing Develop 2006; 127: 560-566.
    • (2006) Mech Ageing Develop , vol.127 , pp. 560-566
    • Alberti, S.1    Cevenini, E.2    Ostan, R.3    Capri, M.4    Salvioli, S.5    Bucci, L.6
  • 50
    • 33244457799 scopus 로고    scopus 로고
    • Neural-immune interactions: An integrative view of bidirectional relationship between the brain and immune systems
    • Wrona D. Neural-immune interactions: An integrative view of bidirectional relationship between the brain and immune systems. J Neuroimmunol 2006; 172:38-58.
    • (2006) J Neuroimmunol , vol.172 , pp. 38-58
    • Wrona, D.1
  • 51
    • 33845186911 scopus 로고    scopus 로고
    • Physiology of psychoneuroimmunology: A personal view
    • Besedovsky HO, Del Rey A. Physiology of psychoneuroimmunology: a personal view. Brain Behav Immun 2007; 21: 34-44.
    • (2007) Brain Behav Immun , vol.21 , pp. 34-44
    • Besedovsky, H.O.1    Del Rey, A.2
  • 52
    • 17044380815 scopus 로고    scopus 로고
    • Molecular endocrinology and physiology of the aging central nervous system
    • Smith RG, Betancourt L, Sun Y. Molecular endocrinology and physiology of the aging central nervous system. Endocrine Rev 2005; 26: 203-250.
    • (2005) Endocrine Rev , vol.26 , pp. 203-250
    • Smith, R.G.1    Betancourt, L.2    Sun, Y.3
  • 53
    • 0001127165 scopus 로고    scopus 로고
    • Age-related alterations in neural-immune interactions and neural strategies in immunosenescence
    • Ader R, Felten DL, Cohen N eds, Academic Press San Diego
    • Bellinger DL, Madden KS, Lorton D, Thyagarajan S, Felten DL. Age-related alterations in neural-immune interactions and neural strategies in immunosenescence. In: Psychoneuroimmunology Ader R, Felten DL, Cohen N (eds). Academic Press San Diego. 2001, pp 241-286.
    • (2001) Psychoneuroimmunology , pp. 241-286
    • Bellinger, D.L.1    Madden, K.S.2    Lorton, D.3    Thyagarajan, S.4    Felten, D.L.5
  • 54
    • 0025417859 scopus 로고
    • A neuroendocrine-immune theory of aging
    • Fabris N. A neuroendocrine-immune theory of aging. Int J Neurosci 1990;51: 373-375.
    • (1990) Int J Neurosci , vol.51 , pp. 373-375
    • Fabris, N.1
  • 55
    • 33846234579 scopus 로고    scopus 로고
    • Protective and damaging effects of stress mediators: Central role of the brain
    • McEwen BS. Protective and damaging effects of stress mediators: Central role of the brain. Dialogues Clin Neurosci 2006; 8:367- 381.
    • (2006) Dialogues Clin Neurosci , vol.8 , pp. 367-381
    • McEwen, B.S.1
  • 56
    • 57149100571 scopus 로고    scopus 로고
    • Chronic stress and immunosenescence. A review
    • Bauer ME. Chronic stress and immunosenescence. A review. Neuroimmunomodulation 2008; 15:244-253.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 244-253
    • Bauer, M.E.1
  • 57
    • 57149104111 scopus 로고    scopus 로고
    • Gouin JP, Hantsoo L, Kiecolt.Glaser JK. Immune dysregulation and chronic stress among older adults: A review. Neuroimmuno- modulation. 2008; 15: 254-262.
    • Gouin JP, Hantsoo L, Kiecolt.Glaser JK. Immune dysregulation and chronic stress among older adults: A review. Neuroimmuno- modulation. 2008; 15: 254-262.
  • 58
    • 37049027109 scopus 로고    scopus 로고
    • A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence
    • Viveros MP, Arranz L, Hernanz A, Miquel J, De la Fuente M: A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence. Neuroimmunomodulation 2007; 14: 157-162.
    • (2007) Neuroimmunomodulation , vol.14 , pp. 157-162
    • Viveros, M.P.1    Arranz, L.2    Hernanz, A.3    Miquel, J.4    De la Fuente, M.5
  • 59
    • 33845588007 scopus 로고    scopus 로고
    • Impairment of several immune functions in anxious women
    • Arranz L, Guayerbas N, De la Fuente M: Impairment of several immune functions in anxious women. J Psychosom Res 2007; 62:1- 8.
    • (2007) J Psychosom Res , vol.62 , pp. 1-8
    • Arranz, L.1    Guayerbas, N.2    De la Fuente, M.3
  • 60
    • 85031346566 scopus 로고    scopus 로고
    • De la Fuente M, Medina S. NPY and phagocytic cell functions. In: The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer. Zukowska Z, Feuerstein GZ. (eds) Birkhaauser Verlang Basel/Switzerland 2005; pp. 107-122.
    • De la Fuente M, Medina S. NPY and phagocytic cell functions. In: The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer. Zukowska Z, Feuerstein GZ. (eds) Birkhaauser Verlang Basel/Switzerland 2005; pp. 107-122.
  • 61
    • 22144481264 scopus 로고    scopus 로고
    • Puerto M, Guayerbas N, Alvarez, P, De la Fuente M: Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice.} Neuroimmunol 2005; 165: 33-40.
    • Puerto M, Guayerbas N, Alvarez, P, De la Fuente M: Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice.} Neuroimmunol 2005; 165: 33-40.
  • 62
    • 33751527236 scopus 로고    scopus 로고
    • Immunity and ageing in man
    • Pawelec G. Immunity and ageing in man. Exp Gerontol 2006; 41:1239-1242.
    • (2006) Exp Gerontol , vol.41 , pp. 1239-1242
    • Pawelec, G.1
  • 64
    • 34547253128 scopus 로고    scopus 로고
    • Biochemical aspects of inflammation
    • Kulinsky VI. Biochemical aspects of inflammation. Biochemistry 2007; 72:595-607.
    • (2007) Biochemistry , vol.72 , pp. 595-607
    • Kulinsky, V.I.1
  • 65
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-kB
    • Csiszar A, Wang M, Lakatia EG, Ungvari Z. Inflammation and endothelial dysfunction during aging: Role of NF-kB. J Appl Physiol 2008; 105:1333-1341.
    • (2008) J Appl Physiol , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatia, E.G.3    Ungvari, Z.4
  • 66
    • 39649083371 scopus 로고    scopus 로고
    • Inflammatory mechanisms: The molecular basis of inflammation and disease
    • Lobby P. Inflammatory mechanisms: The molecular basis of inflammation and disease. Nutr Rev 2007; 65: S140-146.
    • (2007) Nutr Rev , vol.65
    • Lobby, P.1
  • 67
    • 34249085348 scopus 로고    scopus 로고
    • Patogenesis of Parkinson's disease: Oxidative stress, environmental impact factors and inflammatory process
    • Yuan H, Zheng JC, Liu P, Zhang SF, Xu JY, Bai LM. Patogenesis of Parkinson's disease: Oxidative stress, environmental impact factors and inflammatory process. Neurosci Bull 2007; 23:125-130.
    • (2007) Neurosci Bull , vol.23 , pp. 125-130
    • Yuan, H.1    Zheng, J.C.2    Liu, P.3    Zhang, S.F.4    Xu, J.Y.5    Bai, L.M.6
  • 69
    • 39649121718 scopus 로고    scopus 로고
    • Age-associated inflammatory changes: Role of nutritional intervention
    • Meydani SN, Wu D. Age-associated inflammatory changes: Role of nutritional intervention. Nutr Rev 2007; 65: S213-216.
    • (2007) Nutr Rev , vol.65
    • Meydani, S.N.1    Wu, D.2
  • 70
    • 39649085837 scopus 로고    scopus 로고
    • Inflammaging as a major characteristic of old people: Can it be prevented or cured?
    • Franceschi C. Inflammaging as a major characteristic of old people: Can it be prevented or cured?. Nutr Rev 2007; 65: S173-176.
    • (2007) Nutr Rev , vol.65
    • Franceschi, C.1
  • 72
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. Nuclear factor-kB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 73
    • 0037245316 scopus 로고    scopus 로고
    • Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-kB
    • Victor VM, De la Fuente M. Immune cells redox state from mice with endotoxin-induced oxidative stress. Involvement of NF-kB. Free Radic Res 2003; 37:19-27.
    • (2003) Free Radic Res , vol.37 , pp. 19-27
    • Victor, V.M.1    De la Fuente, M.2
  • 75
    • 0029900649 scopus 로고    scopus 로고
    • Evidence for lowered induction of nuclear factor kappa B in activated T lymphocytes during aging
    • Trebilcock GU, Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated T lymphocytes during aging. Gerontology 1996; 42:137-146.
    • (1996) Gerontology , vol.42 , pp. 137-146
    • Trebilcock, G.U.1    Ponnappan, U.2
  • 76
    • 33646518593 scopus 로고    scopus 로고
    • Inflammation markers predicting frailty and mortality in the elderly
    • De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006; 80:219-227.
    • (2006) Exp Mol Pathol , vol.80 , pp. 219-227
    • De Martinis, M.1    Franceschi, C.2    Monti, D.3    Ginaldi, L.4
  • 78
    • 33750737290 scopus 로고    scopus 로고
    • Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens
    • Vina J, Sastre J, Pallardo FV, Gambini J, Borras C. Role of mitochondrial oxidative stress to explain the different longevity between genders. Protective effect of estrogens. Free Rad Res 2006; 40:1359-1365.
    • (2006) Free Rad Res , vol.40 , pp. 1359-1365
    • Vina, J.1    Sastre, J.2    Pallardo, F.V.3    Gambini, J.4    Borras, C.5
  • 79
    • 0032752273 scopus 로고    scopus 로고
    • Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load
    • Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafe M. Biomarkers of immunosenescence within an evolutionary perspective: The challenge of heterogeneity and the role of antigenic load. Exp Gerontol 1999; 34:911-921.
    • (1999) Exp Gerontol , vol.34 , pp. 911-921
    • Franceschi, C.1    Valensin, S.2    Fagnoni, F.3    Barbi, C.4    Bonafe, M.5
  • 82
    • 0036784566 scopus 로고    scopus 로고
    • Insect hemocytes and their role in immunity
    • Lavina MD, Strand MR. Insect hemocytes and their role in immunity. Insect Biochem Mol Biol 2002; 32:1295-1309.
    • (2002) Insect Biochem Mol Biol , vol.32 , pp. 1295-1309
    • Lavina, M.D.1    Strand, M.R.2
  • 83
    • 1542357677 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes
    • Tirouvanzian R, Davidson CJ, Lipsick JS, Herzenberg LA. Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes. Proc Natl Acad Sci USA 2003; 101:2912-2917.
    • (2003) Proc Natl Acad Sci USA , vol.101 , pp. 2912-2917
    • Tirouvanzian, R.1    Davidson, C.J.2    Lipsick, J.S.3    Herzenberg, L.A.4
  • 84
    • 1042302152 scopus 로고    scopus 로고
    • Meister M. Blood cells of Drosophila. Cell linages and role in host defence. Curr Opin Immunol 2004;16:10-15.
    • Meister M. Blood cells of Drosophila. Cell linages and role in host defence. Curr Opin Immunol 2004;16:10-15.
  • 85
    • 9144269002 scopus 로고    scopus 로고
    • Draper-mediated and phosphatidilserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/ macrophages
    • Manaka J, Kuraishi T, Shiratsuchi A, Nakai Y, Higashida H, Henson P, Nakanishi Y. Draper-mediated and phosphatidilserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/ macrophages. J Biol Chem 2004; 279:48466-48476.
    • (2004) J Biol Chem , vol.279 , pp. 48466-48476
    • Manaka, J.1    Kuraishi, T.2    Shiratsuchi, A.3    Nakai, Y.4    Higashida, H.5    Henson, P.6    Nakanishi, Y.7
  • 86
    • 33745339387 scopus 로고    scopus 로고
    • Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice
    • Alvarado C, Alvarez P, Puerto M, Gausserés N, Jimenez L, De la Fuente M. Dietary supplementation with antioxidants improves functions and decreases oxidative stress of leukocytes from prematurely aging mice. Nutrition 2006; 22: 767-777.
    • (2006) Nutrition , vol.22 , pp. 767-777
    • Alvarado, C.1    Alvarez, P.2    Puerto, M.3    Gausserés, N.4    Jimenez, L.5    De la Fuente, M.6
  • 87
    • 33747194129 scopus 로고    scopus 로고
    • Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol- rich cereals
    • Alvarez P, Alvarado C, Puerto M, Schlumberger A, Jimenez L, De la Fuente M. Improvement of leukocyte functions in prematurely aging mice after five weeks of diet supplementation with polyphenol- rich cereals. Nutrition 2006; 22: 913-921.
    • (2006) Nutrition , vol.22 , pp. 913-921
    • Alvarez, P.1    Alvarado, C.2    Puerto, M.3    Schlumberger, A.4    Jimenez, L.5    De la Fuente, M.6
  • 88
    • 53449091546 scopus 로고    scopus 로고
    • The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women
    • Arranz L, Fernandez C, Rodriguez A, Ribera JM, De la Fuente M. The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women. Free Rad Biol Med 2008; 45: 1252-1262.
    • (2008) Free Rad Biol Med , vol.45 , pp. 1252-1262
    • Arranz, L.1    Fernandez, C.2    Rodriguez, A.3    Ribera, J.M.4    De la Fuente, M.5
  • 89
    • 0025345560 scopus 로고
    • Effect of age, culture media and lymphocyte presence in ascorbate content of peritoneal macrophages from mice and guinea pigs during phagocytosis
    • Hernaz A, Collazos ME, De la Fuente M. Effect of age, culture media and lymphocyte presence in ascorbate content of peritoneal macrophages from mice and guinea pigs during phagocytosis. Int Arch Allergy Appl Immun 1990; 91:166-170.
    • (1990) Int Arch Allergy Appl Immun , vol.91 , pp. 166-170
    • Hernaz, A.1    Collazos, M.E.2    De la Fuente, M.3
  • 90
    • 0036486754 scopus 로고    scopus 로고
    • The amount of thiolic antioxidant ingestion needed to improve the immune functions is higher in aged than in adult mice
    • De la Fuente M, Guayerbas N, Catalan MP, Victor VM, Miquel J. The amount of thiolic antioxidant ingestion needed to improve the immune functions is higher in aged than in adult mice. Free Rad Res 2002; 36:119-126.
    • (2002) Free Rad Res , vol.36 , pp. 119-126
    • De la Fuente, M.1    Guayerbas, N.2    Catalan, M.P.3    Victor, V.M.4    Miquel, J.5
  • 91
    • 33845888226 scopus 로고    scopus 로고
    • Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leukocytes
    • Alvarez P, Alvarado C, Mathieu F, Jimenez L, De la Fuente M. Diet supplementation for 5 weeks with polyphenol-rich cereals improves several functions and the redox state of mouse leukocytes. Eur J Nutr 2006; 45:428-438.
    • (2006) Eur J Nutr , vol.45 , pp. 428-438
    • Alvarez, P.1    Alvarado, C.2    Mathieu, F.3    Jimenez, L.4    De la Fuente, M.5
  • 93
    • 0017834614 scopus 로고
    • Spectrophotometric and electron microscopic study of lipofuscin accumulation in the testis of aging mice
    • Miquel J, Lundgren PR, Johnson JE. Spectrophotometric and electron microscopic study of lipofuscin accumulation in the testis of aging mice. J Gerontol 1978; 33: 5-19.
    • (1978) J Gerontol , vol.33 , pp. 5-19
    • Miquel, J.1    Lundgren, P.R.2    Johnson, J.E.3
  • 94
    • 0033953297 scopus 로고    scopus 로고
    • Antioxidants as modulators of immune function
    • De la Fuente M, Victor VM. Antioxidants as modulators of immune function. Immunol Cell Biol 2000; 78:49-54.
    • (2000) Immunol Cell Biol , vol.78 , pp. 49-54
    • De la Fuente, M.1    Victor, V.M.2
  • 96
    • 12344284137 scopus 로고    scopus 로고
    • Thiolic antioxidant supplementation of the diet reverses age- related behavioral dysfunction in prematurely ageing mice
    • Guayerbas N, Puerto M, Hernanz A, Miquel J, De la Fuente M. Thiolic antioxidant supplementation of the diet reverses age- related behavioral dysfunction in prematurely ageing mice. Pharmacol Biochem Behav 2005; 80:45-51.
    • (2005) Pharmacol Biochem Behav , vol.80 , pp. 45-51
    • Guayerbas, N.1    Puerto, M.2    Hernanz, A.3    Miquel, J.4    De la Fuente, M.5
  • 97
    • 0018688665 scopus 로고
    • Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice
    • Miquel J, Economos AC. Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Exp Gerontol 1979;14: 279-285.
    • (1979) Exp Gerontol , vol.14 , pp. 279-285
    • Miquel, J.1    Economos, A.C.2
  • 99
    • 0033922490 scopus 로고    scopus 로고
    • Exercise and the immune system: Regulation, integration and adaptation
    • Pedersen BK, and Hoffman-Goetz L. Exercise and the immune system: regulation, integration and adaptation. Physiol Rev 2000; 80:1055-1081.
    • (2000) Physiol Rev , vol.80 , pp. 1055-1081
    • Pedersen, B.K.1    Hoffman-Goetz, L.2
  • 100
    • 85013724383 scopus 로고    scopus 로고
    • l00. Gleeson M. Immune Function in Sport and Exercise. Elsevier, Edinburgh, 2005.
    • l00. Gleeson M. Immune Function in Sport and Exercise. Elsevier, Edinburgh, 2005.
  • 101
    • 0344298914 scopus 로고    scopus 로고
    • Exercise training-induced alterations in skeletal muscle antioxidant capacity: A brief review
    • Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: A brief review. Med Sci Sports Exerc 1999; 31: 987-997.
    • (1999) Med Sci Sports Exerc , vol.31 , pp. 987-997
    • Powers, S.K.1    Ji, L.L.2    Leeuwenburgh, C.3
  • 102
  • 103
    • 0036893288 scopus 로고    scopus 로고
    • Antioxidant enzyme expression in health and disease: Effects of exercise and hypertension
    • Johson P. Antioxidant enzyme expression in health and disease: Effects of exercise and hypertension. Comp Biochem Physiol C 2002; 133:493-505.
    • (2002) Comp Biochem Physiol C , vol.133 , pp. 493-505
    • Johson, P.1
  • 104
    • 0028831518 scopus 로고
    • Effect of physical exercise and aging on ascorbic acid and superoxide anion levels in peritoneal macrophagesfrom mice and guinea pigs
    • De la Fuente M, Hernanz A, Collazos ME, Barriga C, Ortega E. Effect of physical exercise and aging on ascorbic acid and superoxide anion levels in peritoneal macrophagesfrom mice and guinea pigs. J Comp Physiol 1995; 165:315-319.
    • (1995) J Comp Physiol , vol.165 , pp. 315-319
    • De la Fuente, M.1    Hernanz, A.2    Collazos, M.E.3    Barriga, C.4    Ortega, E.5
  • 105
    • 37049025795 scopus 로고    scopus 로고
    • Neuroimmunomodulation during exercise: Role of catecholamines as "stress mediator" and /or "danger signal" for the innate immune response
    • Ortega E, Giraldo E, Hinchado MD, Martin L, García JJ, De la Fuente M. Neuroimmunomodulation during exercise: Role of catecholamines as "stress mediator" and /or "danger signal" for the innate immune response. Neuroimmunomodulation. 2007; 14: 206-212.
    • (2007) Neuroimmunomodulation , vol.14 , pp. 206-212
    • Ortega, E.1    Giraldo, E.2    Hinchado, M.D.3    Martin, L.4    García, J.J.5    De la Fuente, M.6
  • 106
    • 0033026518 scopus 로고    scopus 로고
    • Effect of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages
    • Ferrandez MD, De la Fuente M. Effect of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages. Acta Physiol Scand 1999; 166:47-53.
    • (1999) Acta Physiol Scand , vol.166 , pp. 47-53
    • Ferrandez, M.D.1    De la Fuente, M.2
  • 107
    • 0030955978 scopus 로고    scopus 로고
    • Exercise, training and neutrophil function
    • Smith JA, and Pyne DB. Exercise, training and neutrophil function. Exercise Immunol Rev 1997; 3: 96-117.
    • (1997) Exercise Immunol Rev , vol.3 , pp. 96-117
    • Smith, J.A.1    Pyne, D.B.2
  • 108
    • 3042719532 scopus 로고    scopus 로고
    • Physical activity, exercise, and inflammatory markers in older adults: Findings from the health, aging and body composition study
    • Colbert LH, Visser M, Siminosick EM, Tracy RP, Newman AB, Kritchevsky SB, et al. Physical activity, exercise, and inflammatory markers in older adults: Findings from the health, aging and body composition study. J Am Geriatr Soc 2004; 52: 1098-1104.
    • (2004) J Am Geriatr Soc , vol.52 , pp. 1098-1104
    • Colbert, L.H.1    Visser, M.2    Siminosick, E.M.3    Tracy, R.P.4    Newman, A.B.5    Kritchevsky, S.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.