Neuroimmunomodulation during exercise: Role of catecholamines as 'stress mediator' and/or 'danger signal' for the innate immune response

NeuroImmunoModulation

Volumn 14, Issue 3-4, 2007, Pages 206-212

  Ortega, Eduardo ^a   Giraldo, Esther ^a   Hinchado, María Dolores ^a   Martín, Leticia ^a   García, Juan José ^a   De La Fuente, Mónica ^b  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Adrenaline; Chemotaxis; Exercise; Macrophages; Microbicide activity; Neutrophils; Noradrenaline; Phagocytosis; Stress

Indexed keywords

ANTIGEN; CATECHOLAMINE; IMMUNOSUPPRESSIVE AGENT; STRESS HORMONE;

ADAPTIVE IMMUNITY; ATHLETE; CONFERENCE PAPER; EXERCISE; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; INNATE IMMUNITY; LABORATORY TEST; MACROPHAGE; NEUROENDOCRINE SYSTEM; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS;

CATECHOLAMINES; EXERCISE; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; MACROPHAGES; NEUROIMMUNOMODULATION; NEUTROPHILS; PHAGOCYTES; SIGNAL TRANSDUCTION; STRESS;

EID: 37049025795     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000110648     Document Type: Conference Paper

References (33)

1. Ortega E: Physiology and biochemistry: influence of exercise on phagocytosis. Int J Sports Med 1994;15:5172-5178.
2. Ortega E: Neuroendocrine mediators in the modulation of phagocytosis by exercise: physiological implications. Exerc Immunol Rev 2003;9:70-94.
3. Wilder R, Elenkov I: Ovarian and sympathoadrenal hormones, pregnancy and autoimmunity diseases; in Ader R, Felten DL, Cohen N (eds): Psychoneuroimmunology, ed 3. London, Academic Press, 2001, p 421.
4. Elenkov IJ, Chrousos GP: Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann NY Acad Sci 2002;966:290-303.
5. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES: The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
6. Sanders VM: Interdisciplinary research: Noradrenergic regulation of adaptive immunity. Brain Behav Immun 2006;20:1-8.
7. Nance DM, Sanders VM: Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun 2007;21:736-745.
8. Besedovsky HO, del Rey A: Physiology of psychoneuroimmunology: a personal view. Brain Behav Immun 2007;21:34-44.
9. Ceddia MA, Voss EW, Woods JA: Intracellular mechanism responsible for exercise-induced suppression of macrophage antigen presentation. J Appl Physiol 2000;88:804-810.
10. Woods JA, Ceddia MA, Kozak C, Wolters BW: Effect of exercise on the macrophage MHC II response to inflammation. Int J Sports Med 1997;18:483-488.
11. Abrass CK, O'Connor SW, Scarpace PJ, Abrass IB: Characterization of the β-adrenergic receptor of the rat peritoneal macrophage. J Immunol 1985;135:1338-1341.
12. Madden KS, Sanders VM, Felten DL: Catecholamine influences and sympathetic neural modulation of immune responsiveness. Ann Rev Pharmacol Toxicol 1995;35:417-448.
13. Ortega E, Marchena JM, García JJ, Schmidt A, Schulz T, Malpica I, Rodríguez AB, Barriga C, Michna H, Lötzerich H: Phagocytic function in cyclists: correlation with catecholamines and cortisol. J Appl Physiol 2001;91:1067-1072.
14. Kohut ML, Davis JM, Jackson DA, Colbert LH, Strasner A, Essig D, Pate RR, Ghaffar A, Mayer EP: The role of stress hormones in exercise-induced suppression of alveolar macrophage antiviral function. J Neuroimmunol 1998;81:193-200.
15. Koff WC, Dunegan MA: Modulation of macrophage-mediated tumoricidal activity by neuropeptides and neurohormones. J Immunol 1985;135:1338-1341.
16. Koff WC, Dunegan MA: Neuroendocrine hormones suppress macrophage mediated lysis of herpes simplex virus infected cells. J Immunol 1986;136:705-709.
17. Ignatowski TA, Gallant S, Spengler RN: Temporal regulation by adrenergic receptor stimulation of macrophage (M phi)-derived tumor necrosis factor (TNF) production post-LPS challenge. J Neuroimmunol 1996;65:107-117.
18. Meltzer JC, MacNeil BJ, Sanders V, Pylypas S, Jansen AH, Greenberg AH, Nance DM: Stress-induced suppression of in vivo splenic cytokine production in the rat by neural and hormonal mechanisms. Brain Behav Immun 2004;18:262-273.
19. Ortega E, Garcia JJ, de la Fuente M: Modulation of adherence and chemotaxis of macrophages by norepinephrine: influence of ageing. Mol Cell Biochem 2000;203:113-117.
20. Straub RH, Mayer M, Kreutz M, Leeb S, Scholmerich, Falk W: Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes. J Leukoc Biol 2000;67:553-558.
21. Garcia JJ, Saez MC, de la Fuente M, Ortega E: Noradrenaline and its end metabolite 3-methoxy-4-hydroxyphenylglycol inhibit lymphocyte chemotaxis: role of α- and β-adrenoreceptors. Mol Cell Biochem 2003;254:305-309.
22. Woods JA: Exercise and neuroendocrine modulation of macrophage function. Int J Sports Med 2000;21:24-30.
23. Brenner I, Shek PN, Zamecnik J, Shepard RJ: Stress hormones and the immunological responses to heat and exercise. Int J Sports Med 1998;19:130-143.
24. Pedersen BK, Bruunsgaard H, Klokker M, Kappel M, MacLean DA, Nielsen HB, Rohde T, Ullum H, Zacho M: Exercise-induced immunomodulation possible roles of neuroendocrine and metabolic factors. Int J Sports Med 1997;18:S2-S7.
25. Peake JM: Exercise-induced alterations in neutrophil degranulation and respiratory burst activity: possible mechanism of action. Exerc Immunol Rev 2002;8:49-100.
26. Hack V, Strobel G, Weiss M, Weicker H: PMN cell counts and phagocytic activity of highly trained athletes depend on training period. J Appl Physiol 1994;77:1731-1735.
27. Suzuki K, Sato H, Kikuchi T, Abe T, Nakaji S, Sugawara K, Totsuka M, Sato K, Yamaya K: Capacity of circulating neutrophils to produce reactive oxygen species after exhaustive exercise. J Appl Physiol 1996;81:1213-1222.
28. Malpica MI, Rodriguez AB, Saez MC, Garcia JJ, Barriga C, Ortega E: In vitro study of the effect of adrenaline on the functional capacity of human neutrophils: role during exercise. J Neuroendocrinol 2002;14:824-828.
29. Ortega E, Marchena JM, Garcia JJ, Barriga C, Rodriguez AB: Norepinephrine as mediator in the stimulation of phagocytosis induced by moderate exercise. Eur J Appl Physiol 2005;93:714-718.
30. Ortega E, Giraldo E, Hinchado MD, Martinez M, Ibañez S, Cidoncha A, Collazos ME, Garcia JJ: Role of HSP72 and norepinephrine in the moderate exercise-induced stimulation of neutrophils microbicide capacity. Eur J Appl Physiol 2006;98:250-255.
31. Carter L, Ferrari JK, Davison JS, Befus D:Inhibition of neutrophil chemotaxis and activation following decentralization of the superior cervical ganglia. J Leukoc Biol 1992;51:597-602.
32. Nagatomi R, Kaifu T, Okutsu M, Zhang X, Kanemi O, Ohmori H: Modulation of the immune system by the autonomic nervous system and its implication in immunological changes after training. Exerc Immunol Rev 2000;6:54-74.
33. Wenisch C, Parschalk B, Weiss A, Zedwitz-Liebenstein K, Hahsler B, Wenisch H, Georgopoulos A, Graninger W: High-dose catecholamine treatment decreases polymorphonuclear leukocyte phagocytic capacity and reactive oxygen production. Clin Diagn Lab Immunol 1996;3:423-428.