Thiolic antioxidant supplementation of the diet reverses age-related behavioural dysfunction in prematurely ageing mice

Pharmacology Biochemistry and Behavior

Volumn 80, Issue 1, 2005, Pages 45-51

  Guayerbas, N ^a   Puerto, M ^a   Hernanz, A ^b   Miquel, J ^a   De La Fuente, M ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Ageing; Exploratory activity; N acetylcysteine; Neuromuscular coordination; Thioproline

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; GLUTATHIONE; TIMONACIC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BEHAVIOR DISORDER; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; MALE; MAZE TEST; MOUSE; NEUROMUSCULAR SYSTEM; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL;

AGING; AGING, PREMATURE; ANIMALS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; FEMALE; MALE; MAZE LEARNING; MICE; MICE, INBRED BALB C; MICE, INBRED ICR; SULFHYDRYL COMPOUNDS;

ANIMALIA;

EID: 12344284137     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2004.10.015     Document Type: Article

References (35)

1. P. Arivazhagan, S. Shila, S. Kumaran, and C. Panneerselvam Effect of dl-a-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats Exp. Gerontol. 37 2002 803 811
2. G. Benzi, and A. Moretti Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system Free Radic. Biol. Med. 19 1995 77 101
3. B. Blanco, M.D. Ferrández, R. Correa, M. Del Río, C. Guaza, and M. De la Fuente Changes in several functions of murine peritoneal macrophages by N-acetylcysteine and thioproline ingestion. Comparative effect between two strains of mice BioFactors 10 1999 179 185
4. D. Boffoli, S.C. Scacco, R. Vergari, M.T. Persio, G. Solarino, and R. Laforgia Ageing is associated in females with a decline in the content and activity on the b-cl complex in skeletal muscle mitochondria Biochim. Biophys. Acta 1315 1996 66 72
5. S.C. Bondy, Y.E. Yang, T.J. Walsh, Y.W. Gie, and D.K. Lahiri Dietary modulation of age-related changes in cerebral pro-oxidant status Neurochem. Int. 40 2002 123 130
6. G.J. Brewer Neuronal plasticicy and stressor toxicity during aging Exp. Res. 35 2000 1165 1183
7. J. Busciglio, J.K. Andersen, H.M. Schipper, G.M. Gilad, R. McCarty, and F. Marzatico Stress, aging, and neurodegenerative disorders Ann. N.Y. Acad. Sci. 851 1998 429 443
8. J.H. Choi, and B.P. Yu Brain synaptosomal ageing: free radicals and membrane fluidity Free Radic. Biol. Med. 18 1995 133 139
9. A.J. Cooper, and B.S. Kristal Multiple roles of glutathione in the central nervous system Biol. Biochem. 378 1997 793 902
10. M. De la Fuente, J. Miquel, M.P. Catalán, V.M. Víctor, and N. Guayerbas The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice Free Radic. Res. 36 2002 119 126
11. M. De la Fuente, A. Hernánz, S. Medina, N. Guayerbas, B. Fernandez, and P. Viveros Characterization of monoaminergic systems in brain regions of prematurely aging mice Neurochem. Int. 1305 2003 1 8
12. W. Dröge Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants Exp. Gerontol. 37 2002 1331 1343
13. M. Drouet, F. Lauthier, J.P. Charmes, P. Sauvage, and M.H. Ratinaud Age-associated changes in mitochondrial parameters on peripheral human lymphocytes Exp. Gerontol. 34 1999 843 852
14. M.J. Forster, A. Dubey, K.M. Dawson, W.A. Stutts, H. Lal, and R.S. Sohal Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain Proc. Natl. Acad. Sci. U. S. A. 93 1996 4765 4769
15. J. García de la Asunción, A. Millán, R. Plá, L. Bruseghini, A. Esteras, and F.V. Palllardó Mitochondrial glutathione oxidation correlates with age associated oxidative damage to mitochondrial DNA FASEB J. 10 1996 333 338
16. N. Guayerbas, A.I. Sánchez, A. Gamallo, and M. De la Fuente Mouse performance in an exploratory activity test as a longevity biomarker J.A. Tur-Marí J.M. Orellana-Muriana Animal research welfare. A partnership 2000 Laboratory Animals London 159 161
17. N. Guayerbas, M. Puerto, V.M. Víctor, J. Miquel, and M. De la Fuente Leukocyte function and life span in a murine model of premature immunosenescence Exp. Gerontol. 37 2002 249 256
18. N. Guayerbas, M.P. Catalán, V.M. Víctor, J. Miquel, and M. De la Fuente Relation of behavior and macrophage function with the life span in a murine model of premature immunosenescence Behav. Brain Res. 134 2002 41 48
19. N. Guayerbas, and M. De la Fuente An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely-ageing mice Dev. Comp. Immunol. 27 2003 339 350
20. B. Halliwell Reactive oxygen species and the central nervous system J. Neurochem. 59 1992 1609 1623
21. J.A. Knight Reactive oxygen species and the neurodegenerative disorders Ann. Clin. Lab. Sci. 27 1997 11 25
22. J. Liu, D.W. Killilea, and B.N. Ames Age-associated mitochondrial oxidative decay: improvement of carnitine acetylstransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l-carnitine and/or R-a-lipoic acid Proc. Natl. Acad. Sci. 99 2002 1876 1881
23. M. Martínez, A.I. Hernández, N. Martínez, and M.L. Ferrándiz Age-related increase in oxidized proteins in mouse synaptic mitochondria Brain Res. 731 1997 246 248
24. M. Martínez, A.I. Hernández, and N. Martínez N-acetylcysteine delays age-associated memory impairment in mice: role in synaptic mitochondria Brain Res. 855 2000 100 106
25. A. Meister, and M.E. Anderson Gluthatione Ann. Rev. Biochem. 52 1983 711 760
26. J. Miquel, and M. Blasco A simple technique for evaluation of vitality loss in aging mice, by testing their muscular coordination and vigor Exp. Gerontol. 13 1978 389 396
27. J. Miquel Can antioxidant diet supplementation protect against age-related mitochondrial damage? Ann. N.Y. Acad. Sci. 959 2002 508 516
28. A. Navarro, M.J. Sánchez del Pino, C. Gómez, J.L. Peralta, and A. Boveris Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice Am. J. Physiol., Regul. Integr. Comp. Physiol. 282 2002 985 992
29. R.J. Reiter Oxidative processes and antioxidative defense mechanisms in the aging brain FASEB J. 9 1995 526 533
30. C. Rice-Evans, and R. Burdon Free radical-lipid interactions and their pathological consequences Prog. Lipid Res. 32 1993 71 110
31. J. Sastre, F.V. Pallardó, and J. Viña Mitochondrial oxidative stress plays a key role in aging and apoptosis Life 49 2000 1 9
32. B. Shukitt-Hale The effects of aging and oxidative stress on psychomotor and cognitive behavior Age 22 1999 9 17
33. B. Shukitt-Hale, D.E. Smith, M. Meydani, and J.A. Joseph The effects of dietary antioxidants on psychomotor performance in aged mice Exp. Gerontol. 34 1999 797 808
34. B. Topic, E. Tani, K. Tsiakitzis, P.N. Kourounakis, E. Dere, and R.U. Hasenöhrl Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and gingkgo biloba in the aged rat Neurobiol. Aging 23 2002 135 143
35. M.P. Viveros, B. Fernández, N. Guayerbas, and M. De la Fuente Behavioral characterization of a mouse model of premature immunosenescence J. Neuroimmunol. 114 2001 80 88