Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases

Cancer Research

Volumn 67, Issue 2, 2007, Pages 756-764

  Phillips, Darren C ^a   Martin, Sophie ^a,b   Doyle, Belinda T ^a   Houghton, Janet A ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; CERAMIDE; CYTOCHROME C; ENDONUCLEASE G; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE OMI; SMALL INTERFERING RNA; SPHINGOSINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL LEVEL; CELL LINEAGE; CELL TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LIPID METABOLISM; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; STEREOSPECIFICITY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; REACTIVE OXYGEN SPECIES; RHABDOMYOSARCOMA, ALVEOLAR; RHABDOMYOSARCOMA, EMBRYONAL; SIGNAL TRANSDUCTION; SPHINGOSINE; STEREOISOMERISM;

EID: 33846655437     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2374     Document Type: Article

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