Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation

Cell Death and Differentiation

Volumn 11, Issue 12, 2004, Pages 1287-1298

  Kang, Y C ^a   Kim, K M ^a   Lee, K S ^a   Namkoong, S ^a   Lee, S J ^a   Han, J A ^a   Jeoung, D ^a   Ha, K S ^a   Kwon, Y G ^b   Kim, Y M ^a  

^a Kangwon National University   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Albumin bound lysophosphatidic acid; Caspase; Cytochrome c; Mitochondria

Indexed keywords

BOVINE SERUM ALBUMIN; CASPASE; CASPASE 8; CYTOCHROME C; FLICE INHIBITORY PROTEIN; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAD; PROTEIN KINASE B; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MITOCHONDRION; MOLECULAR DYNAMICS; OVARY CANCER; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; SEROLOGY; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CATTLE; CELL LINE, TUMOR; CLONE CELLS; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOPHOSPHOLIPIDS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHINGOSINE; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

BOVINAE;

EID: 9944245492     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401489     Document Type: Article

References (55)

1. Wiley SR, Schooley K and Smolak PJ (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3: 673-682
2. Pitt RM, Marsters SA, Ruppert TS, Donahne CJ, Moore A and Ashkenazi A (1996) Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271: 12687-12690
3. Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305-1308
4. Ashkenazi A and Dixit VM (1999) Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 11: 255-260
5. Chao DT and Korsmeyer SJ (1998) BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 16: 395-419
6. Irmler M, Thome M, Schneider P and Hofmann K (1997) Inhibition of death receptor signals by cellular FLIP. Nature 10: 190-195
7. Wang CY, Mayo MW, Korneluk RG, Goeddel DV and Baldwin Jr. AS (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 28: 1680-1683
8. Gibson EM, Henson ES, Haney N, Villanueva J and Gibson SB (2002) Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release. Cancer Res. 62: 488-496
9. Kothny-Wilkes G, Kulms D, Luger TA, Kubin M and Schwarz T (1998) Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand. J. Biol. Chem. 273: 29247-29253
10. Jo M, Kim TH, Seol, Esplen JE, Dorko K, Billiar TR and Strom SC (2000) Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med. 6: 564-567
11. Lawrence D, Shahrokh Z, Marsters S and Ashkenazi A (2001) Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat. Med. 7: 383-385
12. Tigyi G and Miledi R (1992) Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J. Biol. Chem. 267: 21360-21367
13. Gaits F, Fourcade O and Le Belle F (1997) Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis. FEBS Lett. 410: 54-58
14. Fang X, Schummer M and Mao M (2002) Lysophosphatidic acid is a bioactive mediator in ovarian cancer. Biochim. Biophys. Acta 1582: 257-264
15. Svetlov SI, Sautin YY and Crawford JM (2002) EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury. Biochim. Biophys. Acta 1582: 251-256
16. Baudhuin ILM, Cristina KL, Lu J and Xu Y (2002) Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. Mol. Pharmacol. 62: 660-671
17. Khwaja A (1999) Akt is more than just a Bad kinase. Nature 401: 33-34
18. Kobayashi T, Tanaka-Ishii R, Taguchi R, Ikezawa H and Murakami-Murofushi K (1999) Existence of a bioactive lipid, cyclic phosphatidic acid, bound to human serum albumin. Life Sci. 65: 2185-2191
19. Thumser AE, Voysey JE and Wilton DC (1994) The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin. Biochem. J. 301: 801-806
20. Goetzl EJ and An S (1998) Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine-1-phosphate. FASEB J. 12: 1589-1598
21. Le Stunff H, Peterson C, Liu H, Milstien S and Spiegel S (2002) Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim. Biophys. Acta 23: 8-17
22. Johnstone RW, Ruefli AA and Lowe SW (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108: 153-164
23. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem. J. 15: 1-16
24. Crowder RJ and Freeman RS (1998) Phosphatidlylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci. 15: 2933-2943
25. Datta SD, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241
26. Del Peso L, Gonzalez-Garcia M, Page C, Herrera and Nunez G (1997) Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 24: 687-689
27. Hawes BE, Luttrell LM, van Biesen T and Lefkowitz RJ (1996) Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 271: 12133-12136
28. WeinerJA and Chun J (1999) Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci. USA 96: 5233-5238
29. Yuan J and Yankner BA (2000) Apoptosis in the nervous system. Nature 407: 802-809
30. Kennedy SG, Kandel ES, Cross TK and Hay N (1999) Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19: 5800-5810
31. Pastorino JG, Tafani M and Farber JL (1999) Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH kinase-dependent pathway. J. Biol. Chem. 274: 19411-19416
32. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y and Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241
33. Panka DJ, Mano T, Suhara T, Walsh K and Mier JW (2001) Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J. Biol. Chem. 276: 6893-6896
34. Eder AM, Sasagawa T, Mao M, Aoki J and Mills GB (2000) Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. Clin. Cancer Res. 6: 2482-2491
35. Xu Y, Shen Z, Wiper DW, Wu M, Morton RE, Elson P, Kennedy AW, Belinson J, Markman M and Casey G (1998) Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 280: 719-723
36. Ashkenazi A, Pai RC, Fong S, Leung S and Lawrence DA (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104: 155-162
37. Walczak H, Miller RE, Ariail K and Lynch DH (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5: 157-163
38. Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S and Tigyi G (2002) International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54: 265-269
39. Jalink K, Hordijk PL and Moolenaar WH (1994) Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator. Biochim. Biophys. Acta 1198: 185-196
40. Murakami-Murofushi K and Uchiyama A (2002) Biological functions of a novel lipid mediator, cyclic phosphatidic acid. Biochim. Biophys. Acta 1582: 1-7
41. Xu Y, Shen Z, Wiper DW, Wu M, Morton RE, Elson P, Kennedy AW, Belinson J, Markman M and Casey G (1998) Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers. JAMA 26: 719-723
42. Sautin YY, Crawford JM and Svetlov SI (2001) Enhancement of survival by LPA via Erk1/Erk2 and PI3-kinase/Akt pathways in a murine hepatocyte cell line. Am. J. Physiol. Cell physiol. 281: C2010-C2019
43. Frankel A and Mills GB (1996) Peptide and lipid growth factors decrease cis-diaminedichloroplatinum-induced cell death in human ovarian cancer cells. Clin. Cancer Res. 2: 1307-1313
44. Goetzl EJ (2001) Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. Prostaglandins 64: 11-20
45. Koh JS, Lieberthal W, Heydrick S and Levine JS (1998) Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway. J. Clin. Invest. 102: 716-727
46. Aza-Blanc P, Cooper CL, Wagner K, Batalov S, Deveraux QL and Cooke MP (2003) Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol. Cell 12: 627-637
47. Krueger A, Schmitz I, Baumann S, Krammer PH and Kirchhoff S (2001) Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276: 20633-20640
48. Yatomi Y, Yamamura S, Ruan F and Igarashi Y (1997) Sphingosine-1-phosphate induces platelet activation through an extracellular action and shares a platelet surface receptor with lysophosphatidic acid. J. Biol. Chem. 272: 5291-5297
49. Yatomi Y, Ozaki Y, Ohmori T and Igarashi Y (2001) Sphingosine-1-phosphate: synthesis and release. Prostaglandins Other Lipid Mediat. 64: 107-122
50. Tokumura A, Iimori M, Nishioka Y, Kitahara M, Sakashita M and Tanaka S (1994) Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta. Am. J. Physiol. 267: C204-C210
51. Sasagawa T, Suzuki K, Shiota T, Kondo T and Okita M (1998) The significance of plasma lysophospholipids in patients with renal failure on hemodialysis. J. Nutr. Sci. Vitaminol. (Tokyo) 44: 809-818
52. Meyer zu Heringdorf D, Himmel HM and Jakobs KH (2002) Sphingosylphosphorylcholine - biological functions and mechanisms of action. Biochim. Biophys. Acta 23: 178-189
53. Kim YM, Talanian RV and Billiar TR (1997) Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272: 31138-31148
54. Kim YM, Kim TH, Chung HT, Talanian RV, Yin XM and Billiar TR (2000) Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology 32: 770-778
55. Kim YM, de Vera ME, Watkins SC and Billiar TR (1997) Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-α-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272: 1402-1411