-
1
-
-
35549001736
-
The PAR proteins: Fundamental players in animal cell polarization
-
Goldstein B, Macara IG. The PAR proteins: Fundamental players in animal cell polarization. Dev Cell 2007; 13:609-22.
-
(2007)
Dev Cell
, vol.13
, pp. 609-622
-
-
Goldstein, B.1
Macara, I.G.2
-
2
-
-
54549091120
-
From cells to organs: Building polarized tissue
-
Bryant DM, Mostov KE. From cells to organs: Building polarized tissue. Nat Rev Mol Cell Biol 2008; 9:887-901.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 887-901
-
-
Bryant, D.M.1
Mostov, K.E.2
-
4
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996; 87:159-70.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
5
-
-
34548295877
-
Cell polarity in development and cancer
-
Wodarz A, Nathke I. Cell polarity in development and cancer. Nat Cell Biol 2007; 9:1016-24.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1016-1024
-
-
Wodarz, A.1
Nathke, I.2
-
6
-
-
33750505436
-
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
-
Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, et al. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol 2006; 8:1235-45.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1235-1245
-
-
Aranda, V.1
Haire, T.2
Nolan, M.E.3
Calarco, J.P.4
Rosenberg, A.Z.5
Fawcett, J.P.6
-
7
-
-
25444443688
-
Modelling glandular epithelial cancers in three-dimensional cultures
-
Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005; 5:675-88.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 675-688
-
-
Debnath, J.1
Brugge, J.S.2
-
8
-
-
0344845001
-
Tissue architecture: The ultimate regulator of breast epithelial function
-
Bissell MJ, Rizki A, Mian IS. Tissue architecture: The ultimate regulator of breast epithelial function. Curr Opin Cell Biol 2003; 15:753-62.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 753-762
-
-
Bissell, M.J.1
Rizki, A.2
Mian, I.S.3
-
9
-
-
4043170088
-
Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors
-
Bilder D. Epithelial polarity and proliferation control: Links from the Drosophila neoplastic tumor suppressors. Genes Dev 2004; 18:1909-25.
-
(2004)
Genes Dev
, vol.18
, pp. 1909-1925
-
-
Bilder, D.1
-
10
-
-
23144434969
-
Using Drosophila melanogaster to map human cancer pathways
-
Brumby AM, Richardson HE. Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer 2005; 5:626-39.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 626-639
-
-
Brumby, A.M.1
Richardson, H.E.2
-
11
-
-
33845478597
-
Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila
-
Hariharan IK, Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 2006; 40:335-61.
-
(2006)
Annu Rev Genet
, vol.40
, pp. 335-361
-
-
Hariharan, I.K.1
Bilder, D.2
-
12
-
-
33847206401
-
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
-
Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer 2007; 7:182-91.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 182-191
-
-
Harvey, K.1
Tapon, N.2
-
13
-
-
0242641565
-
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
-
Brumby AM, Richardson HE. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 2003; 22:5769-79.
-
(2003)
EMBO J
, vol.22
, pp. 5769-5779
-
-
Brumby, A.M.1
Richardson, H.E.2
-
14
-
-
0242666126
-
A genetic screen in Drosophila for metastatic behavior
-
Pagliarini RA, Xu T. A genetic screen in Drosophila for metastatic behavior. Science 2003; 302:1227-31.
-
(2003)
Science
, vol.302
, pp. 1227-1231
-
-
Pagliarini, R.A.1
Xu, T.2
-
15
-
-
39849097037
-
Polarity complex proteins
-
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. Polarity complex proteins. Biochim Biophys Acta 2008; 1778:614-30.
-
(2008)
Biochim Biophys Acta
, vol.1778
, pp. 614-630
-
-
Assemat, E.1
Bazellieres, E.2
Pallesi-Pocachard, E.3
Le Bivic, A.4
Massey-Harroche, D.5
-
16
-
-
44449135987
-
Cell polarity and cancer - cell and tissue polarity as a non-canonical tumor suppressor
-
Lee M, Vasioukhin V. Cell polarity and cancer - cell and tissue polarity as a non-canonical tumor suppressor. J Cell Sci 2008; 121:1141-50.
-
(2008)
J Cell Sci
, vol.121
, pp. 1141-1150
-
-
Lee, M.1
Vasioukhin, V.2
-
17
-
-
0029045343
-
Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
-
Wodarz A, Hinz U, Engelbert M, Knust E. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 1995; 82:67-76.
-
(1995)
Cell
, vol.82
, pp. 67-76
-
-
Wodarz, A.1
Hinz, U.2
Engelbert, M.3
Knust, E.4
-
18
-
-
0034628471
-
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
-
Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 2000; 403:676-80.
-
(2000)
Nature
, vol.403
, pp. 676-680
-
-
Bilder, D.1
Perrimon, N.2
-
19
-
-
0037456795
-
-
Betschinger J, Mechtler K, Knoblich JA. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 2003; 422:326-30.
-
Betschinger J, Mechtler K, Knoblich JA. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 2003; 422:326-30.
-
-
-
-
20
-
-
0347596668
-
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
-
Benton R, St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell 2003; 115:691-704.
-
(2003)
Cell
, vol.115
, pp. 691-704
-
-
Benton, R.1
St Johnston, D.2
-
21
-
-
5444257614
-
Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
-
Harris TJ, Peifer M. Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. J Cell Biol 2004; 167:135-47.
-
(2004)
J Cell Biol
, vol.167
, pp. 135-147
-
-
Harris, T.J.1
Peifer, M.2
-
22
-
-
18044376860
-
E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila
-
Le Bivic A. E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila. Trends Cell Biol 2005; 15:237-40.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 237-240
-
-
Le Bivic, A.1
-
23
-
-
0037461735
-
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
-
Martin SG, St. Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 2003; 421:379-84.
-
(2003)
Nature
, vol.421
, pp. 379-384
-
-
Martin, S.G.1
St. Johnston, D.2
-
24
-
-
7944234859
-
HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation
-
Massimi P, Gammoh N, Thomas M, Banks L. HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation. Oncogene 2004; 23:8033-9.
-
(2004)
Oncogene
, vol.23
, pp. 8033-8039
-
-
Massimi, P.1
Gammoh, N.2
Thomas, M.3
Banks, L.4
-
25
-
-
0026337295
-
Tumor suppressor genes
-
Weinberg RA. Tumor suppressor genes. Science 1991; 254:1138-46.
-
(1991)
Science
, vol.254
, pp. 1138-1146
-
-
Weinberg, R.A.1
-
26
-
-
33846270032
-
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
-
Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, et al. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 2007; 128:383-97.
-
(2007)
Cell
, vol.128
, pp. 383-397
-
-
Martin-Belmonte, F.1
Gassama, A.2
Datta, A.3
Yu, W.4
Rescher, U.5
Gerke, V.6
-
28
-
-
0348229127
-
The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice
-
Graziano F, Humar B, Guilford P. The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice. Ann Oncol 2003; 14:1705-13.
-
(2003)
Ann Oncol
, vol.14
, pp. 1705-1713
-
-
Graziano, F.1
Humar, B.2
Guilford, P.3
-
29
-
-
33750614651
-
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
-
Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, et al. Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell 2006; 10:437-49.
-
(2006)
Cancer Cell
, vol.10
, pp. 437-449
-
-
Derksen, P.W.1
Liu, X.2
Saridin, F.3
van der Gulden, H.4
Zevenhoven, J.5
Evers, B.6
-
30
-
-
0032510494
-
A causal role for E-cadherin in the transition from adenoma to carcinoma
-
Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998; 392:190-3.
-
(1998)
Nature
, vol.392
, pp. 190-193
-
-
Perl, A.K.1
Wilgenbus, P.2
Dahl, U.3
Semb, H.4
Christofori, G.5
-
31
-
-
0025818032
-
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
-
Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66:107-19.
-
(1991)
Cell
, vol.66
, pp. 107-119
-
-
Vleminckx, K.1
Vakaet Jr, L.2
Mareel, M.3
Fiers, W.4
van Roy, F.5
-
32
-
-
44449111555
-
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
-
Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008; 68:3645-54.
-
(2008)
Cancer Res
, vol.68
, pp. 3645-3654
-
-
Onder, T.T.1
Gupta, P.B.2
Mani, S.A.3
Yang, J.4
Lander, E.S.5
Weinberg, R.A.6
-
33
-
-
34147093740
-
Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling
-
Herzig M, Savarese F, Novatchkova M, Semb H, Christofori G. Tumor progression induced by the loss of E-cadherin independent of beta-catenin/Tcf-mediated Wnt signaling. Oncogene 2007; 26:2290-8.
-
(2007)
Oncogene
, vol.26
, pp. 2290-2298
-
-
Herzig, M.1
Savarese, F.2
Novatchkova, M.3
Semb, H.4
Christofori, G.5
-
34
-
-
0030949463
-
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
-
Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275:1787-90.
-
(1997)
Science
, vol.275
, pp. 1787-1790
-
-
Morin, P.J.1
Sparks, A.B.2
Korinek, V.3
Barker, N.4
Clevers, H.5
Vogelstein, B.6
-
35
-
-
0345006147
-
Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas
-
de La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, et al. Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998; 95:8847-51.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8847-8851
-
-
de La Coste, A.1
Romagnolo, B.2
Billuart, P.3
Renard, C.A.4
Buendia, M.A.5
Soubrane, O.6
-
36
-
-
28844507521
-
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
-
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, et al. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. Hum Mutat 2005; 26:513-9.
-
(2005)
Hum Mutat
, vol.26
, pp. 513-519
-
-
Aretz, S.1
Stienen, D.2
Uhlhaas, S.3
Loff, S.4
Back, W.5
Pagenstecher, C.6
-
37
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, et al. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 2002; 99:12327-32.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
-
38
-
-
33845411885
-
The LKB1 tumor suppressor kinase in human disease
-
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, et al. The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta 2007; 1775:63-75.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 63-75
-
-
Katajisto, P.1
Vallenius, T.2
Vaahtomeri, K.3
Ekman, N.4
Udd, L.5
Tiainen, M.6
-
39
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 1998; 391:184-7.
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
-
40
-
-
33744782567
-
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
-
Hearle N, Schumacher V, Menko FH, Olschwang S, Boardman LA, Gille JJ, et al. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 2006; 12:3209-15.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3209-3215
-
-
Hearle, N.1
Schumacher, V.2
Menko, F.H.3
Olschwang, S.4
Boardman, L.A.5
Gille, J.J.6
-
41
-
-
34547828813
-
Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
-
Conde E, Suarez-Gauthier A, Garcia-Garcia E, Lopez-Rios F, Lopez-Encuentra A, Garcia-Lujan R, et al. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol 2007; 38:1351-60.
-
(2007)
Hum Pathol
, vol.38
, pp. 1351-1360
-
-
Conde, E.1
Suarez-Gauthier, A.2
Garcia-Garcia, E.3
Lopez-Rios, F.4
Lopez-Encuentra, A.5
Garcia-Lujan, R.6
-
42
-
-
34748845413
-
Prevalence and specificity of LKB1 genetic alterations in lung cancers
-
Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y, et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 2007; 26:5911-8.
-
(2007)
Oncogene
, vol.26
, pp. 5911-5918
-
-
Matsumoto, S.1
Iwakawa, R.2
Takahashi, K.3
Kohno, T.4
Nakanishi, Y.5
Matsuno, Y.6
-
43
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, et al. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 2002; 62:3659-62.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
-
44
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 2007; 448:807-10.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
-
45
-
-
0032054770
-
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
-
Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 1998; 58:1384-6.
-
(1998)
Cancer Res
, vol.58
, pp. 1384-1386
-
-
Bignell, G.R.1
Barfoot, R.2
Seal, S.3
Collins, N.4
Warren, W.5
Stratton, M.R.6
-
46
-
-
0033775035
-
An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers
-
Forster LF, Defres S, Goudie DR, Baty DU, Carey FA. An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers. J Clin Pathol 2000; 53:791-3.
-
(2000)
J Clin Pathol
, vol.53
, pp. 791-793
-
-
Forster, L.F.1
Defres, S.2
Goudie, D.R.3
Baty, D.U.4
Carey, F.A.5
-
47
-
-
33745412698
-
LKB1 protein expression in human breast cancer
-
Fenton H, Carlile B, Montgomery EA, Carraway H, Herman J, Sahin F, et al. LKB1 protein expression in human breast cancer. Appl Immunohistochem Mol Morphol 2006; 14:146-53.
-
(2006)
Appl Immunohistochem Mol Morphol
, vol.14
, pp. 146-153
-
-
Fenton, H.1
Carlile, B.2
Montgomery, E.A.3
Carraway, H.4
Herman, J.5
Sahin, F.6
-
48
-
-
56749184298
-
Reflecting on 25 years with MYC
-
Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer 2008; 8:976-90.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 976-990
-
-
Meyer, N.1
Penn, L.Z.2
-
51
-
-
0036781812
-
c-MYC: More than just a matter of life and death
-
Pelengaris S, Khan M, Evan G. c-MYC: more than just a matter of life and death. Nat Rev Cancer 2002; 2:764-76.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 764-776
-
-
Pelengaris, S.1
Khan, M.2
Evan, G.3
-
52
-
-
35848962271
-
c-Myc blazing a trail of death: Coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc
-
Nieminen AI, Partanen JI, Klefstrom J. c-Myc blazing a trail of death: Coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle 2007; 6:2464-72.
-
(2007)
Cell Cycle
, vol.6
, pp. 2464-2472
-
-
Nieminen, A.I.1
Partanen, J.I.2
Klefstrom, J.3
-
53
-
-
54949149565
-
Apoptotic signaling by c-MYC
-
Hoffman B, Liebermann DA. Apoptotic signaling by c-MYC. Oncogene 2008; 27:6462-72.
-
(2008)
Oncogene
, vol.27
, pp. 6462-6472
-
-
Hoffman, B.1
Liebermann, D.A.2
-
54
-
-
0025251664
-
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
-
Strasser A, Harris AW, Bath ML, Cory S. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990; 348:331-3.
-
(1990)
Nature
, vol.348
, pp. 331-333
-
-
Strasser, A.1
Harris, A.W.2
Bath, M.L.3
Cory, S.4
-
55
-
-
0037013147
-
Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
-
Pelengaris S, Khan M, Evan GI. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002; 109:321-34.
-
(2002)
Cell
, vol.109
, pp. 321-334
-
-
Pelengaris, S.1
Khan, M.2
Evan, G.I.3
-
56
-
-
0033001621
-
Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
-
Pelengaris S, Littlewood T, Khan M, Elia G, Evan G. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell 1999; 3:565-77.
-
(1999)
Mol Cell
, vol.3
, pp. 565-577
-
-
Pelengaris, S.1
Littlewood, T.2
Khan, M.3
Elia, G.4
Evan, G.5
-
57
-
-
0029102871
-
Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice
-
Sandgren EP, Schroeder JA, Qui TH, Palmiter RD, Brinster RL, Lee DC. Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res 1995; 55:3915-27.
-
(1995)
Cancer Res
, vol.55
, pp. 3915-3927
-
-
Sandgren, E.P.1
Schroeder, J.A.2
Qui, T.H.3
Palmiter, R.D.4
Brinster, R.L.5
Lee, D.C.6
-
58
-
-
0023673619
-
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription
-
Schoenenberger CA, Andres AC, Groner B, van der Valk M, LeMeur M, Gerlinger P. Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J 1988; 7:169-75.
-
(1988)
EMBO J
, vol.7
, pp. 169-175
-
-
Schoenenberger, C.A.1
Andres, A.C.2
Groner, B.3
van der Valk, M.4
LeMeur, M.5
Gerlinger, P.6
-
59
-
-
0035126052
-
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations
-
D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE, et al. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 2001; 7:235-9.
-
(2001)
Nat Med
, vol.7
, pp. 235-239
-
-
D'Cruz, C.M.1
Gunther, E.J.2
Boxer, R.B.3
Hartman, J.L.4
Sintasath, L.5
Moody, S.E.6
-
60
-
-
0030669560
-
Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice
-
Jager R, Herzer U, Schenkel J, Weiher H. Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene 1997; 15:1787-95.
-
(1997)
Oncogene
, vol.15
, pp. 1787-1795
-
-
Jager, R.1
Herzer, U.2
Schenkel, J.3
Weiher, H.4
-
61
-
-
6944235079
-
Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice
-
Jamerson MH, Johnson MD, Korsmeyer SJ, Furth PA, Dickson RB. Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice. Br J Cancer 2004; 91:1372-9.
-
(2004)
Br J Cancer
, vol.91
, pp. 1372-1379
-
-
Jamerson, M.H.1
Johnson, M.D.2
Korsmeyer, S.J.3
Furth, P.A.4
Dickson, R.B.5
-
62
-
-
35548952703
-
Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
-
Partanen JI, Nieminen AI, Makela TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci USA 2007; 104:14694-9.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 14694-14699
-
-
Partanen, J.I.1
Nieminen, A.I.2
Makela, T.P.3
Klefstrom, J.4
-
63
-
-
0037603113
-
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
-
Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30:256-68.
-
(2003)
Methods
, vol.30
, pp. 256-268
-
-
Debnath, J.1
Muthuswamy, S.K.2
Brugge, J.S.3
-
64
-
-
2942729619
-
LKB1 tumor suppressor protein: PARtaker in cell polarity
-
Baas AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol 2004; 14:312-9.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 312-319
-
-
Baas, A.F.1
Smit, L.2
Clevers, H.3
-
65
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
-
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 2004; 116:457-66.
-
(2004)
Cell
, vol.116
, pp. 457-466
-
-
Baas, A.F.1
Kuipers, J.2
van der Wel, N.N.3
Batlle, E.4
Koerten, H.K.5
Peters, P.J.6
-
66
-
-
38849204971
-
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
-
Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 2008; 68:740-8.
-
(2008)
Cancer Res
, vol.68
, pp. 740-748
-
-
Zhang, S.1
Schafer-Hales, K.2
Khuri, F.R.3
Zhou, W.4
Vertino, P.M.5
Marcus, A.I.6
-
67
-
-
39749194712
-
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
-
Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, et al. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 2008; 28:2414-25.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2414-2425
-
-
Hezel, A.F.1
Gurumurthy, S.2
Granot, Z.3
Swisa, A.4
Chu, G.C.5
Bailey, G.6
-
68
-
-
56749176442
-
LKB1; linking cell structure and tumor suppression
-
Hezel AF, Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008; 27:6908-19.
-
(2008)
Oncogene
, vol.27
, pp. 6908-6919
-
-
Hezel, A.F.1
Bardeesy, N.2
-
69
-
-
33751204464
-
AMP-activated protein kinase regulates the assembly of epithelial tight junctions
-
Zhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 2006; 103:17272-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17272-17277
-
-
Zhang, L.1
Li, J.2
Young, L.H.3
Caplan, M.J.4
-
70
-
-
33846521353
-
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
-
Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 2007; 104:819-22.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 819-822
-
-
Zheng, B.1
Cantley, L.C.2
-
71
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 2007; 447:1017-20.
-
(2007)
Nature
, vol.447
, pp. 1017-1020
-
-
Lee, J.H.1
Koh, H.2
Kim, M.3
Kim, Y.4
Lee, S.Y.5
Karess, R.E.6
-
72
-
-
41149117383
-
LKB1 and AMPK in cell polarity and division
-
Williams T, Brenman JE. LKB1 and AMPK in cell polarity and division. Trends Cell Biol 2008; 18:193-8.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 193-198
-
-
Williams, T.1
Brenman, J.E.2
-
73
-
-
37249011204
-
-
Brenman JE. AMPK/LKB1 signaling in epithelial cell polarity and cell division. Cell Cycle 2007; 6:2755-9.
-
Brenman JE. AMPK/LKB1 signaling in epithelial cell polarity and cell division. Cell Cycle 2007; 6:2755-9.
-
-
-
-
75
-
-
34548212805
-
The Par-1/MARK family of protein kinases: From polarity to metabolism
-
Hurov J, Piwnica-Worms H. The Par-1/MARK family of protein kinases: From polarity to metabolism. Cell Cycle 2007; 6:1966-9.
-
(2007)
Cell Cycle
, vol.6
, pp. 1966-1969
-
-
Hurov, J.1
Piwnica-Worms, H.2
-
76
-
-
58049217333
-
Using kinomics to delineate signaling pathways: Control of CRTC2/TORC2 by the AMPK family
-
Fu A, Screaton RA. Using kinomics to delineate signaling pathways: Control of CRTC2/TORC2 by the AMPK family. Cell Cycle 2008; 7.
-
(2008)
Cell Cycle
, pp. 7
-
-
Fu, A.1
Screaton, R.A.2
-
77
-
-
56749171378
-
Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA
-
Hatakeyama M. Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA. Oncogene 2008; 27:7047-54.
-
(2008)
Oncogene
, vol.27
, pp. 7047-7054
-
-
Hatakeyama, M.1
-
78
-
-
1442358790
-
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton
-
Cohen D, Brennwald PJ, Rodriguez-Boulan E, Musch A. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol 2004; 164:717-27.
-
(2004)
J Cell Biol
, vol.164
, pp. 717-727
-
-
Cohen, D.1
Brennwald, P.J.2
Rodriguez-Boulan, E.3
Musch, A.4
-
79
-
-
34250844968
-
The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division
-
Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, et al. The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development 2007; 134:2183-93.
-
(2007)
Development
, vol.134
, pp. 2183-2193
-
-
Bonaccorsi, S.1
Mottier, V.2
Giansanti, M.G.3
Bolkan, B.J.4
Williams, B.5
Goldberg, M.L.6
-
80
-
-
34249090814
-
Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
-
Saadat I, Higashi H, Obuse C, Umeda M, Murata-Kamiya N, Saito Y, et al. Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature 2007; 447:330-3.
-
(2007)
Nature
, vol.447
, pp. 330-333
-
-
Saadat, I.1
Higashi, H.2
Obuse, C.3
Umeda, M.4
Murata-Kamiya, N.5
Saito, Y.6
-
82
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6:91-9.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
-
83
-
-
0031948093
-
C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
-
Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, 3rd, Wu Z, et al. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ 1998; 9:197-208.
-
(1998)
Cell Growth Differ
, vol.9
, pp. 197-208
-
-
Peng, C.Y.1
Graves, P.R.2
Ogg, S.3
Thoma, R.S.4
Byrnes 3rd, M.J.5
Wu, Z.6
-
84
-
-
0035930343
-
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
-
Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell 2001; 8:983-93.
-
(2001)
Mol Cell
, vol.8
, pp. 983-993
-
-
Muller, J.1
Ory, S.2
Copeland, T.3
Piwnica-Worms, H.4
Morrison, D.K.5
-
85
-
-
0037096833
-
Growth arrest by the LKB1 tumor suppressor: Induction of p21(WAF1/CIP1)
-
Tiainen M, Vaahtomeri K, Ylikorkala A, Makela TP. Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1). Hum Mol Genet 2002; 11:1497-504.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1497-1504
-
-
Tiainen, M.1
Vaahtomeri, K.2
Ylikorkala, A.3
Makela, T.P.4
-
86
-
-
33644773928
-
Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA
-
Sourisseau T, Georgiadis A, Tsapara A, Ali RR, Pestell R, Matter K, et al. Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol Cell Biol 2006; 26:2387-98.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2387-2398
-
-
Sourisseau, T.1
Georgiadis, A.2
Tsapara, A.3
Ali, R.R.4
Pestell, R.5
Matter, K.6
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