메뉴 건너뛰기




Volumn 14, Issue 12, 2003, Pages 1705-1713

The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice

Author keywords

E cadherin; Gastric cancer; Germline; Hereditary diffuse gastric cancer

Indexed keywords

APC PROTEIN; BETA CATENIN; CANCER GROWTH FACTOR; CYCLOOXYGENASE 2; DEATH RECEPTOR 5; FAS ANTIGEN; FIBROBLAST GROWTH FACTOR RECEPTOR; FRAGILE HISTIDINE TRIAD PROTEIN; INTERLEUKIN 1ALPHA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN P14ARF; PROTEIN P16; PROTEIN TYROSINE KINASE; TRANSFORMING GROWTH FACTOR; TREFOIL PEPTIDE; UVOMORULIN;

EID: 0348229127     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdg486     Document Type: Review
Times cited : (138)

References (85)
  • 1
    • 0029160437 scopus 로고
    • Morphogenetic roles of classic cadherins
    • Takeichi M. Morphogenetic roles of classic cadherins. Curr Opin Cell Biol 1995; 7: 619-627.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 619-627
    • Takeichi, M.1
  • 2
    • 0034803431 scopus 로고    scopus 로고
    • E-cadherin is essential for gastric epithelial restitution in vitro: A study using the normal rat gastric mucosal cell line RGM1
    • Moriyama N, Ishihara S, Hirose M et al. E-cadherin is essential for gastric epithelial restitution in vitro: a study using the normal rat gastric mucosal cell line RGM1. J Lab Clin Med 2001; 138: 236-242.
    • (2001) J. Lab. Clin. Med. , vol.138 , pp. 236-242
    • Moriyama, N.1    Ishihara, S.2    Hirose, M.3
  • 3
    • 0032884502 scopus 로고    scopus 로고
    • The role of the E-cadherin complex in gastrointestinal cell differentiation
    • Del Buono R, Pignatelli M. The role of the E-cadherin complex in gastrointestinal cell differentiation. Cell Prolif 1999; 32: 79-84.
    • (1999) Cell Prolif. , vol.32 , pp. 79-84
    • Del Buono, R.1    Pignatelli, M.2
  • 4
    • 0033615002 scopus 로고    scopus 로고
    • Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility
    • Handschuh G, Candidus S, Luber B et al. Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility. Oncogene 1999; 18: 4301-4312.
    • (1999) Oncogene , vol.18 , pp. 4301-4312
    • Handschuh, G.1    Candidus, S.2    Luber, B.3
  • 5
    • 0027522546 scopus 로고
    • E-cadherin expression in primary and metastatic gastric cancer: Down-regulation correlates with cellular dedifferentiation and glandular disintegration
    • Mayer B, Johnson JP, Leitl F et al. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 1993; 53: 1690-1695.
    • (1993) Cancer Res. , vol.53 , pp. 1690-1695
    • Mayer, B.1    Johnson, J.P.2    Leitl, F.3
  • 6
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • Christofori G, Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 1999; 24: 73-76.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 7
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K, Vakaet L Jr, Mareel M et al. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66: 107-119.
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaet Jr., L.2    Mareel, M.3
  • 10
    • 0028208313 scopus 로고
    • E-cadherin gene mutations in human gastric carcinoma cell lines
    • Oda T, Kanai Y, Oyama T et al. E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci USA 1994; 91: 1858-1862.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1858-1862
    • Oda, T.1    Kanai, Y.2    Oyama, T.3
  • 11
    • 0029027286 scopus 로고
    • Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas
    • Becker KF, Hofler H. Frequent somatic allelic inactivation of the E-cadherin gene in gastric carcinomas. J Natl Cancer Inst 1995; 87: 1082-1084.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 1082-1084
    • Becker, K.F.1    Hofler, H.2
  • 12
    • 0033403136 scopus 로고    scopus 로고
    • Molecular biology of gastric carcinoma: From laboratory to bedside
    • Chan AO, Luk JM, Hui WM, Lam SK. Molecular biology of gastric carcinoma: from laboratory to bedside. J Gastroenterol Hepatol 1999; 14: 1150-1160.
    • (1999) J. Gastroenterol. Hepatol. , vol.14 , pp. 1150-1160
    • Chan, A.O.1    Luk, J.M.2    Hui, W.M.3    Lam, S.K.4
  • 13
    • 0027977943 scopus 로고
    • E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
    • Becker KF, Atkinson MJ, Reich U et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994; 54: 3845-3852.
    • (1994) Cancer Res. , vol.54 , pp. 3845-3852
    • Becker, K.F.1    Atkinson, M.J.2    Reich, U.3
  • 14
    • 0032568370 scopus 로고    scopus 로고
    • E-cadherin germline mutations in familial gastric cancer
    • Guilford P, Hopkins J, Harraway J et al. E-cadherin germline mutations in familial gastric cancer. Nature 1998; 392: 402-405.
    • (1998) Nature , vol.392 , pp. 402-405
    • Guilford, P.1    Hopkins, J.2    Harraway, J.3
  • 15
    • 19244377605 scopus 로고    scopus 로고
    • Identification of germ-line E-cadherin mutations in gastric cancer families of European origin
    • Gayther SA, Gorringe KL, Ram SJ et al. Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. Cancer Res 1998; 58: 4086-4089.
    • (1998) Cancer Res. , vol.58 , pp. 4086-4089
    • Gayther, S.A.1    Gorringe, K.L.2    Ram, S.J.3
  • 16
    • 0033029710 scopus 로고    scopus 로고
    • Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
    • Richards FM, McKee SA, Rajpar MH et al. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum Mol Genet 1999; 8: 607-610.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 607-610
    • Richards, F.M.1    McKee, S.A.2    Rajpar, M.H.3
  • 17
    • 0035491309 scopus 로고    scopus 로고
    • A germline E-cadherin mutation in a family with gastric and colon cancer
    • Salahshor S, Hou H, Diep CB et al. A germline E-cadherin mutation in a family with gastric and colon cancer. Int J Mol Med 2001; 8: 439-443.
    • (2001) Int. J. Mol. Med. , vol.8 , pp. 439-443
    • Salahshor, S.1    Hou, H.2    Diep, C.B.3
  • 18
    • 0032865483 scopus 로고    scopus 로고
    • E-cadherin germline, mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
    • Guilford PJ, Hopkins JB, Grady WM et al. E-cadherin germline, mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. Hum Mutat 1999; 14: 249-255.
    • (1999) Hum. Mutat. , vol.14 , pp. 249-255
    • Guilford, P.J.1    Hopkins, J.B.2    Grady, W.M.3
  • 19
    • 0034800271 scopus 로고    scopus 로고
    • Hereditary diffuse gastric cancer
    • Dunbier A, Guilford P. Hereditary diffuse gastric cancer. Adv Cancer Res 2001; 83: 55-65.
    • (2001) Adv. Cancer Res. , vol.83 , pp. 55-65
    • Dunbier, A.1    Guilford, P.2
  • 20
    • 0032528265 scopus 로고    scopus 로고
    • The concise handbook of family cancer syndromes
    • Lindor NM, Greene MH. The concise handbook of family cancer syndromes. J Natl Cancer hist 1998; 90: 1039-1071.
    • (1998) J. Natl. Cancer Hist. , vol.90 , pp. 1039-1071
    • Lindor, N.M.1    Greene, M.H.2
  • 21
    • 0034607246 scopus 로고    scopus 로고
    • E-cadherin gene promoter hypermethylation in primary human gastric carcinomas
    • Tamura G, Yin J, Wang S et al. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas. J Natl Cancer Just 2000; 92: 569-573.
    • (2000) J. Natl. Cancer Just , vol.92 , pp. 569-573
    • Tamura, G.1    Yin, J.2    Wang, S.3
  • 22
    • 0036284631 scopus 로고    scopus 로고
    • Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma
    • Lee TL, Leung WK, Chan MW et al. Detection of gene promoter hypermethylation in the tumor and serum of patients with gastric carcinoma. Clin Cancer Res 2002; 8: 1761-1766.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1761-1766
    • Lee, T.L.1    Leung, W.K.2    Chan, M.W.3
  • 23
    • 0033816924 scopus 로고    scopus 로고
    • Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
    • Grady WM, Willis J, Guilford PJ et al. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nature Genet 2000; 26: 16-17.
    • (2000) Nature Genet. , vol.26 , pp. 16-17
    • Grady, W.M.1    Willis, J.2    Guilford, P.J.3
  • 24
    • 0035932396 scopus 로고    scopus 로고
    • E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma
    • Machado JC, Oliveira C, Carvalho R et al. E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. Oncogene 2001; 20: 1525-1528.
    • (2001) Oncogene , vol.20 , pp. 1525-1528
    • Machado, J.C.1    Oliveira, C.2    Carvalho, R.3
  • 25
    • 0037146740 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer
    • To KF, Leung WK, Lee TL et al. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int J Cancer 2002; 102: 623-628.
    • (2002) Int. J. Cancer , vol.102 , pp. 623-628
    • To, K.F.1    Leung, W.K.2    Lee, T.L.3
  • 26
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001; 134: 573-586.
    • (2001) Ann. Intern. Med. , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 27
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors - State of the art
    • Goffin J, Eisenhauer E. DNA methyltransferase inhibitors - state of the art. Ann Oncol 2002; 13: 1699-1716.
    • (2002) Ann. Oncol. , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 28
    • 0033432725 scopus 로고    scopus 로고
    • Familial gastric cancer: Overview and guidelines for management
    • Caldas C, Carneiro F, Lynch HT et al. Familial gastric cancer: overview and guidelines for management. J Med Genet 1999; 36: 873-880.
    • (1999) J. Med. Genet. , vol.36 , pp. 873-880
    • Caldas, C.1    Carneiro, F.2    Lynch, H.T.3
  • 29
    • 0035211026 scopus 로고    scopus 로고
    • Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families
    • Pharoah PD, Guilford P, Caldas C. Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology 2001; 121: 1348-1353.
    • (2001) Gastroenterology , vol.121 , pp. 1348-1353
    • Pharoah, P.D.1    Guilford, P.2    Caldas, C.3
  • 30
    • 0034329587 scopus 로고    scopus 로고
    • Report of the first meeting of the International Collaborative Group on Hereditary Gastric Cancer
    • Park JG, Yang HK, Kim WH et al. Report of the first meeting of the International Collaborative Group on Hereditary Gastric Cancer. J Natl Cancer Inst 2000; 92: 1781-1782.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1781-1782
    • Park, J.G.1    Yang, H.K.2    Kim, W.H.3
  • 31
    • 18344384564 scopus 로고    scopus 로고
    • Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred
    • Oliveira C, Bordin MC, Grehan N et al. Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Hum Mutat 2002; 19: 510-517.
    • (2002) Hum. Mutat. , vol.19 , pp. 510-517
    • Oliveira, C.1    Bordin, M.C.2    Grehan, N.3
  • 32
    • 0037140125 scopus 로고    scopus 로고
    • Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer
    • Jonsson BA, Bergh A, Stattin P et al. Germline mutations in E-cadherin do not explain association of hereditary prostate cancer, gastric cancer and breast cancer. Int J Cancer 2002; 98: 838-843.
    • (2002) Int. J. Cancer , vol.98 , pp. 838-843
    • Jonsson, B.A.1    Bergh, A.2    Stattin, P.3
  • 33
    • 0034957209 scopus 로고    scopus 로고
    • Absence of microsatellite instability and germline mutations of E-cadherin, APC and p53 genes in Japanese familial gastric cancer
    • Kusano M, Kakiuchi H, Mihara M et al. Absence of microsatellite instability and germline mutations of E-cadherin, APC and p53 genes in Japanese familial gastric cancer. Tumour Biol 2001; 22: 262-268.
    • (2001) Tumour Biol. , vol.22 , pp. 262-268
    • Kusano, M.1    Kakiuchi, H.2    Mihara, M.3
  • 34
    • 0035132528 scopus 로고    scopus 로고
    • E-cadherin is not frequently mutated in hereditary gastric cancer
    • Avizienyte E, Launonen V, Salovaara R et al. E-cadherin is not frequently mutated in hereditary gastric cancer. J Med Genet 2001; 38: 49-52.
    • (2001) J. Med. Genet. , vol.38 , pp. 49-52
    • Avizienyte, E.1    Launonen, V.2    Salovaara, R.3
  • 35
    • 0032920262 scopus 로고    scopus 로고
    • Germline mutations of E-cadherin gene in Korean familial gastric cancer patients
    • Yoon KA, Ku JL, Yang HK et al. Germline mutations of E-cadherin gene in Korean familial gastric cancer patients. J Hum Genet 1999; 44: 177-180.
    • (1999) J. Hum. Genet. , vol.44 , pp. 177-180
    • Yoon, K.A.1    Ku, J.L.2    Yang, H.K.3
  • 36
    • 0033038712 scopus 로고    scopus 로고
    • Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer
    • Stone J, Bevan S, Cunningham D et al. Low frequency of germline E-cadherin mutations in familial and nonfamilial gastric cancer. Br J Cancer 1999; 79: 1935-1937.
    • (1999) Br. J. Cancer , vol.79 , pp. 1935-1937
    • Stone, J.1    Bevan, S.2    Cunningham, D.3
  • 37
    • 0033011770 scopus 로고    scopus 로고
    • Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds
    • Iida S, Akiyama Y, Ichikawa W et al. Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clin Cancer Res 1999; 5: 1445-1447.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1445-1447
    • Iida, S.1    Akiyama, Y.2    Ichikawa, W.3
  • 38
    • 0041927967 scopus 로고    scopus 로고
    • Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer. An analysis in the District of Urbino, Region Marche, Central Italy
    • in press
    • Graziano F, Ruzzo A, Bearzi I et al. Screening E-cadherin germline mutations in Italian patients with familial diffuse gastric cancer. An analysis in the District of Urbino, Region Marche, Central Italy. Tumori 2003; in press.
    • (2003) Tumori
    • Graziano, F.1    Ruzzo, A.2    Bearzi, I.3
  • 39
    • 0029951738 scopus 로고    scopus 로고
    • E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain
    • Berx G, Cleton-Jansen AM, Strumane K et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996; 13: 1919-1925.
    • (1996) Oncogene , vol.13 , pp. 1919-1925
    • Berx, G.1    Cleton-Jansen, A.M.2    Strumane, K.3
  • 40
    • 0035347391 scopus 로고    scopus 로고
    • Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast
    • Chan JK, Wong CS. Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast. Adv Anat Pathol 2001; 8: 165-172.
    • (2001) Adv. Anat. Pathol. , vol.8 , pp. 165-172
    • Chan, J.K.1    Wong, C.S.2
  • 41
    • 0034125482 scopus 로고    scopus 로고
    • Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: Preliminary results
    • Kuhl CK, Schmutzler RK, Leutner CC et al. Breast MR imaging screening in 192 women proved or suspected to be carriers of a breast cancer susceptibility gene: preliminary results. Radiology 2000; 215: 267-279.
    • (2000) Radiology , vol.215 , pp. 267-279
    • Kuhl, C.K.1    Schmutzler, R.K.2    Leutner, C.C.3
  • 42
    • 0035824069 scopus 로고    scopus 로고
    • Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers
    • Hartmann LC, Sellers TA, Schaid DJ et al. Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. J Natl Cancer Inst 2001; 93: 1633-1637.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 1633-1637
    • Hartmann, L.C.1    Sellers, T.A.2    Schaid, D.J.3
  • 43
    • 0035861037 scopus 로고    scopus 로고
    • Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial
    • National Surgical Adjuvant Breast and Bowel Project
    • King MC, Wieand S, Hale K et al. National Surgical Adjuvant Breast and Bowel Project. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial. JAMA 2001; 286: 2251-2256.
    • (2001) JAMA , vol.286 , pp. 2251-2256
    • King, M.C.1    Wieand, S.2    Hale, K.3
  • 44
    • 0035187022 scopus 로고    scopus 로고
    • Association of E-cadherin germ-line alterations with prostate cancer
    • Ikonen T, Matikainen M, Mononen N et al. Association of E-cadherin germ-line alterations with prostate cancer. Clin Cancer Res 2001; 7: 3465-3471.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3465-3471
    • Ikonen, T.1    Matikainen, M.2    Mononen, N.3
  • 45
    • 0020047043 scopus 로고
    • Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma
    • Graham DY, Schwartz JT, Cain GD, Gyorkey F. Prospective evaluation of biopsy number in the diagnosis of esophageal and gastric carcinoma. Gastroenterology 1982; 82: 228-233.
    • (1982) Gastroenterology , vol.82 , pp. 228-233
    • Graham, D.Y.1    Schwartz, J.T.2    Cain, G.D.3    Gyorkey, F.4
  • 46
    • 0036584656 scopus 로고    scopus 로고
    • Prophylactic gastrectomy for CDH1 mutation carriers
    • Giarelli E. Prophylactic gastrectomy for CDH1 mutation carriers. Clin J Oncol Nurs 2002; 6: 161-162.
    • (2002) Clin. J. Oncol. Nurs , vol.6 , pp. 161-162
    • Giarelli, E.1
  • 47
    • 0034792297 scopus 로고    scopus 로고
    • Prophylactic total gastrectomy for familial gastric cancer
    • Lewis FR, Mellinger JD, Hayashi A et al. Prophylactic total gastrectomy for familial gastric cancer. Surgery 2001; 130: 612-617.
    • (2001) Surgery , vol.130 , pp. 612-617
    • Lewis, F.R.1    Mellinger, J.D.2    Hayashi, A.3
  • 48
    • 0035395151 scopus 로고    scopus 로고
    • Germline E-cadherin gene mutations: Is prophylactic total gastrectomy indicated?
    • Chun YS, Lindor NM, Smyrk TC et al. Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? Cancer 2001; 92: 181-187.
    • (2001) Cancer , vol.92 , pp. 181-187
    • Chun, Y.S.1    Lindor, N.M.2    Smyrk, T.C.3
  • 49
    • 0035927967 scopus 로고    scopus 로고
    • Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations
    • Huntsman DG, Carneiro F, Lewis FR et al. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med 2001; 344: 1904-1909.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1904-1909
    • Huntsman, D.G.1    Carneiro, F.2    Lewis, F.R.3
  • 50
    • 0034305948 scopus 로고    scopus 로고
    • E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma
    • Lynch HT, Grady W, Lynch JF et al. E-cadherin mutation-based genetic counseling and hereditary diffuse gastric carcinoma. Cancer Genet Cytogenet 2000; 122: 1-6.
    • (2000) Cancer Genet. Cytogenet. , vol.122 , pp. 1-6
    • Lynch, H.T.1    Grady, W.2    Lynch, J.F.3
  • 51
    • 0029893466 scopus 로고    scopus 로고
    • Surgery for gastric cancer: The American view
    • Brennan MF, Karpeh MS Jr. Surgery for gastric cancer: the American view. Semin Oncol 1996; 23: 352-354.
    • (1996) Semin. Oncol. , vol.23 , pp. 352-354
    • Brennan, M.F.1    Karpeh Jr., M.S.2
  • 52
    • 0036144678 scopus 로고    scopus 로고
    • Global gene expression analysis of gastric cancer by oligonucleotide microarrays
    • Hippo Y, Taniguchi H, Tsutsumi S et al. Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res 2002; 62: 233-240.
    • (2002) Cancer Res. , vol.62 , pp. 233-240
    • Hippo, Y.1    Taniguchi, H.2    Tsutsumi, S.3
  • 53
    • 0035976712 scopus 로고    scopus 로고
    • Single amino acid substitutions in conserved extracellular domains of E-cadherin differ in their functional consequences
    • Handschuh G, Luber B, Hutzler P et al. Single amino acid substitutions in conserved extracellular domains of E-cadherin differ in their functional consequences. J Mol Biol 2001; 314: 445-454.
    • (2001) J. Mol. Biol. , vol.314 , pp. 445-454
    • Handschuh, G.1    Luber, B.2    Hutzler, P.3
  • 54
    • 0034969975 scopus 로고    scopus 로고
    • A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination
    • Dussaulx-Garin L, Blayau M, Pagenault M et al. A new mutation of E-cadherin gene in familial gastric linitis plastica cancer with extra-digestive dissemination. Eur J Gastroenterol Hepatol 2001; 13: 711-715.
    • (2001) Eur. J. Gastroenterol. Hepatol. , vol.13 , pp. 711-715
    • Dussaulx-Garin, L.1    Blayau, M.2    Pagenault, M.3
  • 55
    • 0033931066 scopus 로고    scopus 로고
    • The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea
    • Kim HC, Wheeler JM, Kim JC et al. The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea. Gut 2000; 47: 262-267.
    • (2000) Gut , vol.47 , pp. 262-267
    • Kim, H.C.1    Wheeler, J.M.2    Kim, J.C.3
  • 56
    • 0037057509 scopus 로고    scopus 로고
    • E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer
    • Yabuta T, Shinmura K, Tani M et al. E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. Int J Cancer 2002; 101: 434-441.
    • (2002) Int. J. Cancer , vol.101 , pp. 434-441
    • Yabuta, T.1    Shinmura, K.2    Tani, M.3
  • 57
    • 0028892269 scopus 로고
    • Single nucleotide polymorphisms in the human E-cadherin gene
    • Becker KF, Reich U, Schott C, Hofler H. Single nucleotide polymorphisms in the human E-cadherin gene. Hum Genet 1995; 96: 739-740.
    • (1995) Hum. Genet. , vol.96 , pp. 739-740
    • Becker, K.F.1    Reich, U.2    Schott, C.3    Hofler, H.4
  • 58
    • 0037342636 scopus 로고    scopus 로고
    • Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands
    • Suriano G, Oliveira C, Ferreira P et al. Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet 2003; 12: 575-582.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 575-582
    • Suriano, G.1    Oliveira, C.2    Ferreira, P.3
  • 59
    • 18344380427 scopus 로고    scopus 로고
    • Novel germline CDH1 mutations in hereditary diffuse gastric cancer families
    • Humar B, Toro T, Graziano F et al. Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. Hum Mutat 2002; 19: 518-525.
    • (2002) Hum. Mutat. , vol.19 , pp. 518-525
    • Humar, B.1    Toro, T.2    Graziano, F.3
  • 60
    • 0037157225 scopus 로고    scopus 로고
    • Characterization of DNA polymorphisms in the E-cadherin gene (CDH1) promoter region
    • Nakamura A, Shimazaki T, Kaneko K et al. Characterization of DNA polymorphisms in the E-cadherin gene (CDH1) promoter region. Mutat Res 2002; 502: 19-24.
    • (2002) Mutat. Res. , vol.502 , pp. 19-24
    • Nakamura, A.1    Shimazaki, T.2    Kaneko, K.3
  • 61
    • 0034652622 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities
    • Li LC, Chui RM, Sasaki M et al. A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. Cancer Res 2000; 71: 873-877.
    • (2000) Cancer Res. , vol.71 , pp. 873-877
    • Li, L.C.1    Chui, R.M.2    Sasaki, M.3
  • 62
    • 0346254281 scopus 로고    scopus 로고
    • An analysis of the C/A polymorphism at position - 160 of the E-cadherin gene (CDH1) promoter. Potential role for diffuse gastric cancer susceptibility
    • (Abstr 43)
    • Graziano F, Humar B, Catalano V et al. An analysis of the C/A polymorphism at position - 160 of the E-cadherin gene (CDH1) promoter. Potential role for diffuse gastric cancer susceptibility: Ann Oncol 2002; 13 (Suppl 5): 13 (Abstr 43).
    • (2002) Ann. Oncol. , vol.13 , Issue.SUPPL. 5 , pp. 13
    • Graziano, F.1    Humar, B.2    Catalano, V.3
  • 63
    • 0036500566 scopus 로고    scopus 로고
    • Association of the - 160 C/A promoter polymorphism of E-cadherin gene with gastric carcinoma risk
    • Wu MS, Huang SP, Chang YT et al. Association of the - 160 C/A promoter polymorphism of E-cadherin gene with gastric carcinoma risk. Cancer 2002; 94: 1443-1448.
    • (2002) Cancer , vol.94 , pp. 1443-1448
    • Wu, M.S.1    Huang, S.P.2    Chang, Y.T.3
  • 64
    • 0037056235 scopus 로고    scopus 로고
    • CDH1 c-160a promoter polymorphism is not associated with risk of stomach cancer
    • Pharoah PD, Oliveira C, Machado JC et al. CDH1 c-160a promoter polymorphism is not associated with risk of stomach cancer. Int J Cancer 2002; 101: 198-197.
    • (2002) Int. J. Cancer , vol.101 , pp. 197-198
    • Pharoah, P.D.1    Oliveira, C.2    Machado, J.C.3
  • 65
    • 18744408111 scopus 로고    scopus 로고
    • Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer
    • Humar B, Graziano F, Cascinu S et al. Association of CDH1 haplotypes with susceptibility to sporadic diffuse gastric cancer. Oncogene 2002; 21: 8192-8195.
    • (2002) Oncogene , vol.21 , pp. 8192-8195
    • Humar, B.1    Graziano, F.2    Cascinu, S.3
  • 66
    • 0030091627 scopus 로고    scopus 로고
    • Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract
    • Hanby AM, Chinery R, Poulsom R et al. Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract. Am J Pathol 1996; 148: 723-729.
    • (1996) Am. J. Pathol. , vol.148 , pp. 723-729
    • Hanby, A.M.1    Chinery, R.2    Poulsom, R.3
  • 67
    • 0031809678 scopus 로고    scopus 로고
    • H. pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control
    • Terres AM, Pajares JM, O'Toole D et al. H. pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control. J Clin Pathol 1998; 51: 410-412.
    • (1998) J. Clin. Pathol. , vol.51 , pp. 410-412
    • Terres, A.M.1    Pajares, J.M.2    O'Toole, D.3
  • 68
    • 0036120562 scopus 로고    scopus 로고
    • The cadherin-catenin adhesion system in signalling and cancer
    • Conacci-Sorrell M, Zhurinsky J, BeD-Ze'ev A. The cadherin-catenin adhesion system in signalling and cancer. J Clin Invest 2002; 109: 987-991.
    • (2002) J. Clin. Invest. , vol.109 , pp. 987-991
    • Conacci-Sorrell, M.1    Zhurinsky, J.2    BeD-Ze'ev, A.3
  • 69
    • 0033579480 scopus 로고    scopus 로고
    • Regulation of E-cadherin/catenin association by tyrosine phosphorylation
    • Roura S, Miravet S, Piedra J et al. Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J Biol Chem 1999; 274: 36734-36740.
    • (1999) J. Biol. Chem. , vol.274 , pp. 36734-36740
    • Roura, S.1    Miravet, S.2    Piedra, J.3
  • 70
    • 0032848957 scopus 로고    scopus 로고
    • Epithelial cell plasticity in development and tumor progression
    • Thiery JP, Chopin D. Epithelial cell plasticity in development and tumor progression. Cancer Metastasis Rev 1999; 18: 31-42.
    • (1999) Cancer Metastasis Rev. , vol.18 , pp. 31-42
    • Thiery, J.P.1    Chopin, D.2
  • 72
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2: 84-89.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3
  • 73
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2: 76-83.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3
  • 74
    • 0037168958 scopus 로고    scopus 로고
    • Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells
    • Potla L, Boghaert ER, Armellino D et al. Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells. Cancer Lett 2002; 175: 187-195.
    • (2002) Cancer Lett. , vol.175 , pp. 187-195
    • Potla, L.1    Boghaert, E.R.2    Armellino, D.3
  • 75
    • 0033581834 scopus 로고    scopus 로고
    • Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells - Regulation by Rho, Rac and Rab small G proteins
    • Kamei T, Matozaki T, Sakisaka T et al. Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells - regulation by Rho, Rac and Rab small G proteins. Oncogene 1999; 18: 6776-6784.
    • (1999) Oncogene , vol.18 , pp. 6776-6784
    • Kamei, T.1    Matozaki, T.2    Sakisaka, T.3
  • 76
    • 0032572526 scopus 로고    scopus 로고
    • E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1)
    • St Croix B, Sheehan C, Rak JW et al. E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol 1998; 142: 557-571.
    • (1998) J. Cell Biol. , vol.142 , pp. 557-571
    • St Croix, B.1    Sheehan, C.2    Rak, J.W.3
  • 77
    • 0037101783 scopus 로고    scopus 로고
    • Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes
    • Symons JR, LeVea CM, Mooney RA. Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes. Biochem J 2002; 15: 513-519.
    • (2002) Biochem. J. , vol.15 , pp. 513-519
    • Symons, J.R.1    LeVea, C.M.2    Mooney, R.A.3
  • 78
    • 0036840363 scopus 로고    scopus 로고
    • Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
    • Rosivatz E, Becker I, Specht K et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol 2002; 161: 1881-1891.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1881-1891
    • Rosivatz, E.1    Becker, I.2    Specht, K.3
  • 79
    • 0036280716 scopus 로고    scopus 로고
    • Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer
    • Van Golen KL, Bao LW, Pan Q et al. Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer. Clin Exp Metastasis 2002; 19: 301-311.
    • (2002) Clin. Exp. Metastasis , vol.19 , pp. 301-311
    • Van Golen, K.L.1    Bao, L.W.2    Pan, Q.3
  • 80
    • 0030968177 scopus 로고    scopus 로고
    • The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell - Cell contacts
    • Braga VM, Machesky LM, Hall A, Hotchin NA. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell - cell contacts. J Cell Biol 1997; 137: 1421-1431.
    • (1997) J. Cell Biol. , vol.137 , pp. 1421-1431
    • Braga, V.M.1    Machesky, L.M.2    Hall, A.3    Hotchin, N.A.4
  • 81
    • 0036992767 scopus 로고    scopus 로고
    • Altered expression of the catenin p120 in human cancer: Implications for tumor progression
    • Thoreson MA, Reynolds AB. Altered expression of the catenin p120 in human cancer: implications for tumor progression. Differentiation 2002; 70: 583-589.
    • (2002) Differentiation , vol.70 , pp. 583-589
    • Thoreson, M.A.1    Reynolds, A.B.2
  • 82
    • 0033519239 scopus 로고    scopus 로고
    • p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
    • Aono S, Nakagawa S, Reynolds AB, Takeichi M. p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J Cell Biol 1999; 145: 551-562.
    • (1999) J. Cell Biol. , vol.145 , pp. 551-562
    • Aono, S.1    Nakagawa, S.2    Reynolds, A.B.3    Takeichi, M.4
  • 84
    • 0037155159 scopus 로고    scopus 로고
    • E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts
    • Kovacs EM, Ali RG, McCormack AJ, Yap AS. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. Biol Chem 2002; 277: 6708-6718.
    • (2002) Biol. Chem. , vol.277 , pp. 6708-6718
    • Kovacs, E.M.1    Ali, R.G.2    McCormack, A.J.3    Yap, A.S.4
  • 85
    • 0034994490 scopus 로고    scopus 로고
    • Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
    • Nakagawa M, Fukata M, Yamaga M et al. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci 2001; 114: 1829-1838.
    • (2001) J. Cell Sci. , vol.114 , pp. 1829-1838
    • Nakagawa, M.1    Fukata, M.2    Yamaga, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.