메뉴 건너뛰기




Volumn 8, Issue 8, 2007, Pages 613-621

Filling out the Hippo pathway

Author keywords

[No Author keywords available]

Indexed keywords

BANTAM; BONE MORPHOGENETIC PROTEIN 4; CADHERIN; CYCLIN E; DROSOPHILA INHIBITOR OF APOPTOSIS 1; EPIDERMAL GROWTH FACTOR RECEPTOR; FAT PROTEIN; FERM DOMAIN CONTAINING 6; LONG ACTING THYROID STIMULATOR; MAMMALIAN STERILE 20 LIKE KINASE TYPE 1; MAMMALIAN STERILE 20 LIKE KINASE TYPE 2; MEMBRANE PROTEIN; MICRORNA; MPS ONE BINDER KIA\NASE ACTIVATOR 1; NEUROFIBROMATOSIS TYPE 2 PROTEIN; PROTEIN; PROTEIN EX; PROTEIN HIPPO; PROTEIN P53; PROTEIN WTS; PROTEIN WW45; RIBOSOMAL PROTEIN L36; RIBOSOME PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN; YES ACTIVATED PROTEIN;

EID: 34547124044     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2221     Document Type: Review
Times cited : (308)

References (94)
  • 1
    • 0027267041 scopus 로고
    • Analysis of genetic mosaics in developing and adult Drosophila tissues
    • Xu, T. & Rubin, G. M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237 (1993).
    • (1993) Development , vol.117 , pp. 1223-1237
    • Xu, T.1    Rubin, G.M.2
  • 2
    • 0033621538 scopus 로고    scopus 로고
    • Drosophila in cancer research. An expanding role
    • Potter, C. J., Turenchalk, G. S. & Xu, T. Drosophila in cancer research. An expanding role. Trends Genet. 16, 33-39 (2000).
    • (2000) Trends Genet , vol.16 , pp. 33-39
    • Potter, C.J.1    Turenchalk, G.S.2    Xu, T.3
  • 3
    • 25844447107 scopus 로고    scopus 로고
    • Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin
    • McClatchey, A. I. & Giovannini, M. Membrane organization and tumorigenesis - the NF2 tumor suppressor, Merlin. Genes Dev. 19, 2265-2277 (2005).
    • (2005) Genes Dev , vol.19 , pp. 2265-2277
    • McClatchey, A.I.1    Giovannini, M.2
  • 4
    • 33747591465 scopus 로고    scopus 로고
    • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    • Overholtzer, M. et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc. Natl Acad. Sci. USA 103, 12405-12410 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12405-12410
    • Overholtzer, M.1
  • 5
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender, L. et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 125, 1253-1267 (2006).
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1
  • 6
    • 31044440368 scopus 로고    scopus 로고
    • From cell structure to transcription: Hippo forges a new path
    • Edgar, B. A. From cell structure to transcription: Hippo forges a new path. Cell 124, 267-273 (2006).
    • (2006) Cell , vol.124 , pp. 267-273
    • Edgar, B.A.1
  • 7
    • 34247191134 scopus 로고    scopus 로고
    • Hippo signaling in organ size control
    • Pan, D. Hippo signaling in organ size control. Genes Dev. 21, 886-897 (2007).
    • (2007) Genes Dev , vol.21 , pp. 886-897
    • Pan, D.1
  • 8
    • 33847206401 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network
    • Harvey, K. & Tapon, N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nature Rev. Cancer 7, 182-191 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 182-191
    • Harvey, K.1    Tapon, N.2
  • 9
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice, R. W., Zilian, O., Woods, D. F., Noll, M. & Bryant, P. J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9, 534-546 (1995).
    • (1995) Genes Dev , vol.9 , pp. 534-546
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3    Noll, M.4    Bryant, P.J.5
  • 10
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics - the Drosophila lats gene encodes a putative protein-kinase
    • Xu, T. A., Wang, W. Y., Zhang, S., Stewart, R. A. & Yu, W. Identifying tumor suppressors in genetic mosaics - the Drosophila lats gene encodes a putative protein-kinase. Development 121, 1053-1063 (1995).
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.A.1    Wang, W.Y.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 11
    • 0042733354 scopus 로고    scopus 로고
    • Harvey, K. F., Pfleger, C. M. & Hariharan, I. K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457-467 (2003).
    • Harvey, K. F., Pfleger, C. M. & Hariharan, I. K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114, 457-467 (2003).
  • 12
    • 0036926950 scopus 로고    scopus 로고
    • Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    • Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719-5730 (2002).
    • (2002) Development , vol.129 , pp. 5719-5730
    • Kango-Singh, M.1
  • 13
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci, S., Tapon, N. & Leopold, P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nature Cell Biol. 5, 921-927 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 921-927
    • Pantalacci, S.1    Tapon, N.2    Leopold, P.3
  • 14
    • 0037162714 scopus 로고    scopus 로고
    • salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon, N. et al. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 467-478 (2002).
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1
  • 15
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C. & Halder, G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nature Cell Biol. 5, 914-920 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 16
    • 0042232429 scopus 로고    scopus 로고
    • hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu, S., Huang, J., Dong, J. & Pan, D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114, 445-456 (2003).
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 17
    • 14844297327 scopus 로고    scopus 로고
    • Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    • Lai, Z. C. et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 120, 675-685 (2005).
    • (2005) Cell , vol.120 , pp. 675-685
    • Lai, Z.C.1
  • 18
    • 34247182696 scopus 로고    scopus 로고
    • Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    • Wei, X., Shimizu, T. & Lai, Z. C. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J. 26, 1772-1781 (2007).
    • (2007) EMBO J , vol.26 , pp. 1772-1781
    • Wei, X.1    Shimizu, T.2    Lai, Z.C.3
  • 19
    • 16444373346 scopus 로고    scopus 로고
    • The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
    • Chan, E. H. et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24, 2076-2086 (2005).
    • (2005) Oncogene , vol.24 , pp. 2076-2086
    • Chan, E.H.1
  • 20
    • 33646422520 scopus 로고    scopus 로고
    • The human tumour suppressor LATS1 is activated by human MOB1 at the membrane
    • Hergovich, A., Schmitz, D. & Hemmings, B. A. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem. Biophys. Res. Commun. 345, 50-58 (2006).
    • (2006) Biochem. Biophys. Res. Commun , vol.345 , pp. 50-58
    • Hergovich, A.1    Schmitz, D.2    Hemmings, B.A.3
  • 21
    • 33748308721 scopus 로고    scopus 로고
    • Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
    • Callus, B. A., Verhagen, A. M. & Vaux, D. L. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 273, 4264-4276 (2006).
    • (2006) FEBS J , vol.273 , pp. 4264-4276
    • Callus, B.A.1    Verhagen, A.M.2    Vaux, D.L.3
  • 22
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP
    • Huang, J., Wu, S., Barrera, J., Matthews, K. & Pan, D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122, 421-434 (2005).
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3    Matthews, K.4    Pan, D.5
  • 23
    • 21044442524 scopus 로고    scopus 로고
    • The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage
    • Strano, S. et al. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage. Mol. Cell 18, 447-459 (2005).
    • (2005) Mol. Cell , vol.18 , pp. 447-459
    • Strano, S.1
  • 24
    • 2942754004 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription
    • Howell, M., Borchers, C. & Milgram, S. L. Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. J. Biol. Chem. 279, 26300-26306 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 26300-26306
    • Howell, M.1    Borchers, C.2    Milgram, S.L.3
  • 25
    • 1842457741 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    • Zaidi, S. K. et al. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J. 23, 790-799 (2004).
    • (2004) EMBO J , vol.23 , pp. 790-799
    • Zaidi, S.K.1
  • 26
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro, A., Nagai, M., Navin, N. E. & Sudol, M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J. Biol. Chem. 278, 33334-33341 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 27
    • 0037173716 scopus 로고    scopus 로고
    • Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling
    • Ferrigno, O. et al. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling. Oncogene 21, 4879-4884 (2002).
    • (2002) Oncogene , vol.21 , pp. 4879-4884
    • Ferrigno, O.1
  • 28
    • 0035957958 scopus 로고    scopus 로고
    • Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains
    • Espanel, X. & Sudol, M. Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains. J. Biol. Chem. 276, 14514-14523 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 14514-14523
    • Espanel, X.1    Sudol, M.2
  • 29
    • 0033522472 scopus 로고    scopus 로고
    • WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator
    • Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y. & Ito, Y. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 18, 2551-2562 (1999).
    • (1999) EMBO J , vol.18 , pp. 2551-2562
    • Yagi, R.1    Chen, L.F.2    Shigesada, K.3    Murakami, Y.4    Ito, Y.A.5
  • 30
    • 33947382284 scopus 로고    scopus 로고
    • The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    • Levy, D., Adamovich, Y., Reuven, N. & Shaul, Y. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ. 14, 743-751 (2007).
    • (2007) Cell Death Differ , vol.14 , pp. 743-751
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 31
    • 33750595408 scopus 로고    scopus 로고
    • Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma
    • Guo, J. et al. Yes-associated protein (YAP65) in relation to Smad7 expression in human pancreatic ductal adenocarcinoma. Int. J. Mol. Med. 17, 761-767 (2006).
    • (2006) Int. J. Mol. Med , vol.17 , pp. 761-767
    • Guo, J.1
  • 32
    • 0035873391 scopus 로고    scopus 로고
    • Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y. & DePamphilis, M. L. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 15, 1229-1241 (2001).
    • Vassilev, A., Kaneko, K. J., Shu, H., Zhao, Y. & DePamphilis, M. L. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 15, 1229-1241 (2001).
  • 33
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu, S., Totty, N. F., Irwin, M. S., Sudol, M. & Downward, J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol. Cell 11, 11-23 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 34
    • 0035805487 scopus 로고    scopus 로고
    • Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    • Strano, S. et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J. Biol. Chem. 276, 15164-15173 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 15164-15173
    • Strano, S.1
  • 35
  • 36
    • 0027291288 scopus 로고
    • expanded: A gene involved in the control of cell proliferation in imaginal discs
    • Boedigheimer, M. & Laughon, A. expanded: a gene involved in the control of cell proliferation in imaginal discs. Development 118, 1291-1301 (1993).
    • (1993) Development , vol.118 , pp. 1291-1301
    • Boedigheimer, M.1    Laughon, A.2
  • 37
    • 0030972542 scopus 로고    scopus 로고
    • expanded functions in the apical cell domain to regulate the growth rate of imaginal discs
    • Boedigheimer, M. J., Nguyen, K. P. & Bryant, P. J. expanded functions in the apical cell domain to regulate the growth rate of imaginal discs. Dev. Genet. 20, 103-110 (1997).
    • (1997) Dev. Genet , vol.20 , pp. 103-110
    • Boedigheimer, M.J.1    Nguyen, K.P.2    Bryant, P.J.3
  • 38
    • 0034033896 scopus 로고    scopus 로고
    • McCartney, B. M., Kulikauskas, R. M., LaJeunesse, D. R. & Fehon, R. G. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127, 1315-1324 (2000).
    • McCartney, B. M., Kulikauskas, R. M., LaJeunesse, D. R. & Fehon, R. G. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 127, 1315-1324 (2000).
  • 39
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu, F. et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nature Cell Biol. 8, 27-36 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1
  • 40
    • 33947105009 scopus 로고    scopus 로고
    • The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling
    • Pellock, B. J., Buff, E., White, K. & Hariharan, I. K. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev. Biol. 304, 102-115 (2007).
    • (2007) Dev. Biol , vol.304 , pp. 102-115
    • Pellock, B.J.1    Buff, E.2    White, K.3    Hariharan, I.K.4
  • 41
    • 27544514090 scopus 로고    scopus 로고
    • NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    • Okada, T., Lopez-Lago, M. & Giancotti, F. G. Merlin/ NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J. Cell Biol. 171, 361-371 (2005).
    • (2005) J. Cell Biol , vol.171 , pp. 361-371
    • Okada, T.1    Lopez-Lago, M.2
  • 42
    • 18044399847 scopus 로고    scopus 로고
    • The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling
    • Shaw, R. J. et al. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev. Cell 1, 63-72 (2001).
    • (2001) Dev. Cell , vol.1 , pp. 63-72
    • Shaw, R.J.1
  • 43
    • 0038077566 scopus 로고    scopus 로고
    • NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
    • Lallemand, D., Curto, M., Saotome, I., Giovannini, M. & McClatchey, A. I. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 17, 1090-1100 (2003).
    • (2003) Genes Dev , vol.17 , pp. 1090-1100
    • Lallemand, D.1    Curto, M.2    Saotome, I.3    Giovannini, M.4    McClatchey, A.I.5
  • 44
    • 20844449390 scopus 로고    scopus 로고
    • Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity
    • McPherson, J. P. et al. Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity. EMBO J. 23, 3677-3688 (2004).
    • (2004) EMBO J , vol.23 , pp. 3677-3688
    • McPherson, J.P.1
  • 45
    • 0032568795 scopus 로고    scopus 로고
    • Coordination of growth and cell division in the Drosophila wing
    • Neufeld, T. P., de la Cruz, A. F., Johnston, L. A. & Edgar, B. A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183-1193 (1998).
    • (1998) Cell , vol.93 , pp. 1183-1193
    • Neufeld, T.P.1    de la Cruz, A.F.2    Johnston, L.A.3    Edgar, B.A.4
  • 46
    • 34047097318 scopus 로고    scopus 로고
    • A double-assurance mechanism controls cell cycle exit at differentiation in Drosophila
    • Buttitta, L. A double-assurance mechanism controls cell cycle exit at differentiation in Drosophila. Dev. Cell 12, 631-643 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 631-643
    • Buttitta, L.1
  • 47
    • 0035807242 scopus 로고    scopus 로고
    • Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis
    • Yang, X., Li, D. M., Chen, W. & Xu, T. Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis. Oncogene 20, 6516-6523 (2001).
    • (2001) Oncogene , vol.20 , pp. 6516-6523
    • Yang, X.1    Li, D.M.2    Chen, W.3    Xu, T.4
  • 48
    • 85047699404 scopus 로고    scopus 로고
    • LATS1 tumor suppressor regulates G2/M transition and apoptosis
    • Xia, H. et al. LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene 21, 1233-1241 (2002).
    • (2002) Oncogene , vol.21 , pp. 1233-1241
    • Xia, H.1
  • 49
    • 0041302154 scopus 로고    scopus 로고
    • Lats2, a putative tumor suppressor, inhibits G1/S transition
    • Li, Y. et al. Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene 22, 4398-4405 (2003).
    • (2003) Oncogene , vol.22 , pp. 4398-4405
    • Li, Y.1
  • 50
    • 0035379556 scopus 로고    scopus 로고
    • MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
    • Lee, K. K., Ohyama, T., Yajima, N., Tsubuki, S. & Yonehara, S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276, 19276-19285 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 19276-19285
    • Lee, K.K.1    Ohyama, T.2    Yajima, N.3    Tsubuki, S.4    Yonehara, S.5
  • 51
    • 33744505111 scopus 로고    scopus 로고
    • Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases
    • Avruch, J., Praskova, M., Ortiz-Vega, S., Liu, M. & Zhang, X. F. Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases. Methods Enzymol. 407, 290-310 (2005).
    • (2005) Methods Enzymol , vol.407 , pp. 290-310
    • Avruch, J.1    Praskova, M.2    Ortiz-Vega, S.3    Liu, M.4    Zhang, X.F.5
  • 52
    • 3242794878 scopus 로고    scopus 로고
    • Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
    • Praskova, M., Khoklatchev, A., Ortiz-Vega, S. & Avruch, J. Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem. J. 381, 453-462 (2004).
    • (2004) Biochem. J , vol.381 , pp. 453-462
    • Praskova, M.1    Khoklatchev, A.2    Ortiz-Vega, S.3    Avruch, J.4
  • 53
    • 34047250808 scopus 로고    scopus 로고
    • RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
    • Guo, C. et al. RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr. Biol. 17, 700-705 (2007).
    • (2007) Curr. Biol , vol.17 , pp. 700-705
    • Guo, C.1
  • 54
    • 0024094911 scopus 로고
    • Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila
    • Bryant, P. J., Huettner, B., Held, L. I. Jr, Ryerse, J. & Szidonya, J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev. Biol. 129, 541-554 (1988).
    • (1988) Dev. Biol , vol.129 , pp. 541-554
    • Bryant, P.J.1    Huettner, B.2    Held Jr, L.I.3    Ryerse, J.4    Szidonya, J.5
  • 55
    • 0025748166 scopus 로고
    • The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily
    • Mahoney, P. A. et al. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67, 853-868 (1991).
    • (1991) Cell , vol.67 , pp. 853-868
    • Mahoney, P.A.1
  • 56
    • 4444240972 scopus 로고    scopus 로고
    • Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    • Matakatsu, H. & Blair, S. S. Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131, 3785-3794 (2004).
    • (2004) Development , vol.131 , pp. 3785-3794
    • Matakatsu, H.1    Blair, S.S.2
  • 57
    • 18544395824 scopus 로고    scopus 로고
    • Identification of new human cadherin genes using a combination of protein motif search and gene finding methods
    • Hong, J. C. et al. Identification of new human cadherin genes using a combination of protein motif search and gene finding methods. J. Mol. Biol. 337, 307-317 (2004).
    • (2004) J. Mol. Biol , vol.337 , pp. 307-317
    • Hong, J.C.1
  • 58
  • 59
    • 6944253410 scopus 로고    scopus 로고
    • Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    • Cho, E. & Irvine, K. D. Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development 131, 4489-4500 (2004).
    • (2004) Development , vol.131 , pp. 4489-4500
    • Cho, E.1    Irvine, K.D.2
  • 60
    • 33645543689 scopus 로고    scopus 로고
    • Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila
    • Jaiswal, M., Agrawal, N. & Sinha, P. Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila. Development 133, 925-935 (2006).
    • (2006) Development , vol.133 , pp. 925-935
    • Jaiswal, M.1    Agrawal, N.2    Sinha, P.3
  • 61
    • 30444431554 scopus 로고    scopus 로고
    • Long-range coordination of planar polarity in Drosophila
    • Strutt, H. & Strutt, D. Long-range coordination of planar polarity in Drosophila. Bioessays 27, 1218-1227 (2005).
    • (2005) Bioessays , vol.27 , pp. 1218-1227
    • Strutt, H.1    Strutt, D.2
  • 62
    • 33750611115 scopus 로고    scopus 로고
    • Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ Hippo signaling pathway
    • Bennett, F. C. & Harvey, K. F. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/ Hippo signaling pathway. Curr. Biol. 16, 2101-2110 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 2101-2110
    • Bennett, F.C.1    Harvey, K.F.2
  • 63
    • 33749125438 scopus 로고    scopus 로고
    • Delineation of a Fat tumor suppressor pathway
    • Cho, E. et al. Delineation of a Fat tumor suppressor pathway. Nature Genet. 38, 1142-1150 (2006).
    • (2006) Nature Genet , vol.38 , pp. 1142-1150
    • Cho, E.1
  • 64
    • 33750624298 scopus 로고    scopus 로고
    • The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    • Silva, E., Tsatskis, Y., Gardano, L., Tapon, N. & McNeill, H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr. Biol. 16, 2081-2089 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 2081-2089
    • Silva, E.1    Tsatskis, Y.2    Gardano, L.3    Tapon, N.4    McNeill, H.5
  • 65
    • 33750614445 scopus 로고    scopus 로고
    • The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    • Willecke, M. et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16, 2090-2100 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 2090-2100
    • Willecke, M.1
  • 66
    • 34247134640 scopus 로고    scopus 로고
    • Tyler, D. M. & Baker, N. E. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev. Biol. 305, 187-201 (2007). References 62-66 all report independent findings that provide a considerable amount of biochemical and genetic data to position the Hippo pathway as the general mediator of Fat signalling in growth control.
    • Tyler, D. M. & Baker, N. E. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev. Biol. 305, 187-201 (2007). References 62-66 all report independent findings that provide a considerable amount of biochemical and genetic data to position the Hippo pathway as the general mediator of Fat signalling in growth control.
  • 67
    • 20144379646 scopus 로고    scopus 로고
    • Protein interaction mapping: A Drosophila case study
    • Formstecher, E. et al. Protein interaction mapping: a Drosophila case study. Genome Res. 15, 376-384 (2005).
    • (2005) Genome Res , vol.15 , pp. 376-384
    • Formstecher, E.1
  • 68
    • 33746410714 scopus 로고    scopus 로고
    • Dachs: An unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    • Mao, Y. et al. Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133, 2539-2551 (2006).
    • (2006) Development , vol.133 , pp. 2539-2551
    • Mao, Y.1
  • 69
    • 33749242966 scopus 로고
    • The bantam microRNA is a target of the hippo tumor-suppressor pathway
    • 2006
    • Nolo, R., Morrison, C. M., Tao, C., Zhang, X. & Halder, G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr. Biol. 16, 1895-1904 (2006).
    • (1895) Curr. Biol , vol.16
    • Nolo, R.1    Morrison, C.M.2    Tao, C.3    Zhang, X.4    Halder, G.5
  • 70
    • 33747159113 scopus 로고    scopus 로고
    • Thompson, B. J. & Cohen, S. M. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 126, 767-774 (2006). References 69 and 70 demonstrate that activation of Yki (normally inhibited by Hippo signalling) leads to the transcriptional induction of bantam, a microRNA that has the ability to promote tissue growth and inhibit apoptosis.
    • Thompson, B. J. & Cohen, S. M. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 126, 767-774 (2006). References 69 and 70 demonstrate that activation of Yki (normally inhibited by Hippo signalling) leads to the transcriptional induction of bantam, a microRNA that has the ability to promote tissue growth and inhibit apoptosis.
  • 71
    • 0036670695 scopus 로고    scopus 로고
    • The bantam gene regulates Drosophila growth
    • Hipfner, D. R., Weigmann, K. & Cohen, S. M. The bantam gene regulates Drosophila growth. Genetics 161, 1527-1537 (2002).
    • (2002) Genetics , vol.161 , pp. 1527-1537
    • Hipfner, D.R.1    Weigmann, K.2    Cohen, S.M.3
  • 72
    • 0037418839 scopus 로고    scopus 로고
    • bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B. & Cohen, S. M. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113, 25-36 (2003).
    • (2003) Cell , vol.113 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 73
    • 33745899356 scopus 로고    scopus 로고
    • Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
    • Matakatsu, H. & Blair, S. S. Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development 133, 2315-2324 (2006).
    • (2006) Development , vol.133 , pp. 2315-2324
    • Matakatsu, H.1    Blair, S.S.2
  • 74
    • 33645868635 scopus 로고    scopus 로고
    • The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling
    • Maitra, S., Kulikauskas, R. M., Gavilan, H. & Fehon, R. G. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16, 702-709 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 702-709
    • Maitra, S.1    Kulikauskas, R.M.2    Gavilan, H.3    Fehon, R.G.4
  • 75
    • 12344280216 scopus 로고    scopus 로고
    • The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster
    • Garoia, F. et al. The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster. Mech. Dev. 122, 175-187 (2005).
    • (2005) Mech. Dev , vol.122 , pp. 175-187
    • Garoia, F.1
  • 76
    • 0037343951 scopus 로고    scopus 로고
    • Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye
    • Yang, L. & Baker, N. E. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev. Cell 4, 359-369 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 359-369
    • Yang, L.1    Baker, N.E.2
  • 77
    • 21344467538 scopus 로고    scopus 로고
    • Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo
    • O'Neill, E. & Kolch, W. Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo. Cell Cycle 4, 365-367 (2005).
    • (2005) Cell Cycle , vol.4 , pp. 365-367
    • O'Neill, E.1    Kolch, W.2
  • 78
    • 33745997665 scopus 로고    scopus 로고
    • Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage
    • Colombani, J., Polesello, C., Josue, F. & Tapon, N. Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage. Curr. Biol. 16, 1453-1458 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 1453-1458
    • Colombani, J.1    Polesello, C.2    Josue, F.3    Tapon, N.4
  • 79
    • 33845426464 scopus 로고    scopus 로고
    • The Drosophila RASSF homolog antagonizes the hippo pathway
    • Polesello, C., Huelsmann, S., Brown, N. H. & Tapon, N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr. Biol. 16, 2459-2465 (2006).
    • (2006) Curr. Biol , vol.16 , pp. 2459-2465
    • Polesello, C.1    Huelsmann, S.2    Brown, N.H.3    Tapon, N.4
  • 80
    • 0016613341 scopus 로고
    • Minutes: Mutants of Drosophila autonomously affecting cell division rate
    • Morata, G. & Ripoll, P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42, 211-221 (1975).
    • (1975) Dev. Biol , vol.42 , pp. 211-221
    • Morata, G.1    Ripoll, P.2
  • 81
    • 0031613939 scopus 로고    scopus 로고
    • The minute genes in Drosophila and their molecular functions
    • Lambertsson, A. The minute genes in Drosophila and their molecular functions. Adv. Genet. 38, 69-134 (1998).
    • (1998) Adv. Genet , vol.38 , pp. 69-134
    • Lambertsson, A.1
  • 82
    • 1842816486 scopus 로고    scopus 로고
    • Drosophila myc regulates organ size by inducing cell competition
    • de la Cova, C., Abril, M., Bellosta, P., Gallant, P. & Johnston, L. A. Drosophila myc regulates organ size by inducing cell competition. Cell 117, 107-116 (2004).
    • (2004) Cell , vol.117 , pp. 107-116
    • de la Cova, C.1    Abril, M.2    Bellosta, P.3    Gallant, P.4    Johnston, L.A.5
  • 83
    • 1842665674 scopus 로고    scopus 로고
    • dMyc transforms cells into super-competitors
    • Moreno, E. & Basler, K. dMyc transforms cells into super-competitors. Cell 117, 117-129 (2004).
    • (2004) Cell , vol.117 , pp. 117-129
    • Moreno, E.1    Basler, K.2
  • 84
    • 34247885980 scopus 로고    scopus 로고
    • Tyler, D., Li, W., Zhuo, N., Pellock, B. J. & Baker, N. E. Genes affecting cell competition in Drosophila melanogaster. Genetics 175, 643-657 (2006). Shows that mutations in components of the Hippo pathway enable cells to outcompete and eliminate wild-type neighbouring cells. However, the mechanisms that underlie this phenotype remain unclear.
    • Tyler, D., Li, W., Zhuo, N., Pellock, B. J. & Baker, N. E. Genes affecting cell competition in Drosophila melanogaster. Genetics 175, 643-657 (2006). Shows that mutations in components of the Hippo pathway enable cells to outcompete and eliminate wild-type neighbouring cells. However, the mechanisms that underlie this phenotype remain unclear.
  • 85
    • 14744297005 scopus 로고    scopus 로고
    • Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
    • Grewal, S. S., Li, L., Orian, A., Eisenman, R. N. & Edgar, B. A. Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nature Cell Biol. 7, 295-302 (2005).
    • (2005) Nature Cell Biol , vol.7 , pp. 295-302
    • Grewal, S.S.1    Li, L.2    Orian, A.3    Eisenman, R.N.4    Edgar, B.A.5
  • 86
    • 14744288294 scopus 로고    scopus 로고
    • The Myc trilogy: Lord of RNA polymerases
    • Oskarsson, T. & Trumpp, A. The Myc trilogy: lord of RNA polymerases. Nature Cell Biol. 7, 215-217 (2005).
    • (2005) Nature Cell Biol , vol.7 , pp. 215-217
    • Oskarsson, T.1    Trumpp, A.2
  • 87
    • 34547101487 scopus 로고    scopus 로고
    • Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
    • 26 Feb, doi:10.1038/sj.onc.1210330
    • Nakaya, K. et al. Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene 26 Feb 2007 (doi:10.1038/sj.onc.1210330).
    • (2007) Oncogene
    • Nakaya, K.1
  • 88
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 89
    • 33750578091 scopus 로고    scopus 로고
    • Comparative integromics on FAT1, FAT2, FAT3 and FAT4
    • Katoh, Y. & Katoh, M. Comparative integromics on FAT1, FAT2, FAT3 and FAT4. Int. J. Mol. Med. 18, 523-528 (2006).
    • (2006) Int. J. Mol. Med , vol.18 , pp. 523-528
    • Katoh, Y.1    Katoh, M.2
  • 90
    • 0027405720 scopus 로고
    • A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
    • Trofatter, J. A. et al. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72, 791-800 (1993).
    • (1993) Cell , vol.72 , pp. 791-800
    • Trofatter, J.A.1
  • 91
    • 0028264119 scopus 로고
    • Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas
    • Ruttledge, M. H. et al. Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nature Genet. 6, 180-184 (1994).
    • (1994) Nature Genet , vol.6 , pp. 180-184
    • Ruttledge, M.H.1
  • 92
    • 0141519256 scopus 로고    scopus 로고
    • Mutational analysis of salvador gene in human carcinomas
    • Yoo, N. J. et al. Mutational analysis of salvador gene in human carcinomas. APMIS 111, 595-598 (2003).
    • (2003) APMIS , vol.111 , pp. 595-598
    • Yoo, N.J.1
  • 93
    • 0032907439 scopus 로고    scopus 로고
    • Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
    • St John, M. A. et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nature Genet. 21, 182-186 (1999).
    • (1999) Nature Genet , vol.21 , pp. 182-186
    • St John, M.A.1
  • 94
    • 0036800399 scopus 로고    scopus 로고
    • Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma
    • Hisaoka, M., Tanaka, A. & Hashimoto, H. Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma. Lab. Invest. 82, 1427-1435 (2002).
    • (2002) Lab. Invest , vol.82 , pp. 1427-1435
    • Hisaoka, M.1    Tanaka, A.2    Hashimoto, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.