The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 3, 2009, Pages 635-644

  Li, Zhichuan ^a   Xie, Zijian ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Na K ATPase; Protein kinase; Protein phosphorylation; Receptor; Tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARDIOTONIC AGENT; PROTEIN TYROSINE KINASE; RECEPTOR; STEROID;

CELL GROWTH; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOTONIC AGENTS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; PROTEIN CONFORMATION; SECOND MESSENGER SYSTEMS; SODIUM-POTASSIUM-EXCHANGING ATPASE; SRC-FAMILY KINASES; STEROIDS;

EID: 62149104775     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0470-0     Document Type: Review

References (116)

1. T Akera TM Brody 1976 Inotropic action of digitalis and ion transport Life Sci 18 135 144
2. K Alexandropoulos D Baltimore 1996 Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin Genes Dev 10 1341 1355
3. G Alonso M Koegl N Mazurenko SA Courtneidge 1995 Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors J Biol Chem 270 9840 9848
4. 2+ exchanger function J Physiol 575 845 854
5. H Ando A Mizutani T Matsu-ura K Mikoshiba 2003 IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor J Biol Chem 278 10602 10612
6. A Aydemir-Koksoy J Abramowitz JC Allen 2001 Ouabain-induced signaling and vascular smooth muscle cell proliferation J Biol Chem 276 46605 46611
7. SP Barwe G Anilkumar SY Moon Y Zheng JP Whitelegge SA Rajasekaran AK Rajasekaran 2005 Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility Mol Biol Cell 16 1082 1094
8. M Baumgartner H Patel DL Barber 2004 Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes Am J Physiol Cell Physiol 287 C844 850
9. K Bielawski K Winnicka A Bielawska 2006 Inhibition of DNA topoisomerases I and II, and growth inhibition of breast cancer MCF-7 cells by ouabain, digoxin and proscillaridin A Biol Pharm Bull 29 1493 1497
10. G Blanco RW Mercer 1998 Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function Am J Physiol 275 F633 650
11. LD Bozulic WL Dean NA Delamere 2004 The influence of Lyn kinase on Na,K-ATPase in porcine lens epithelium Am J Physiol Cell Physiol 286 C90 96
12. LD Bozulic WL Dean NA Delamere 2005 The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium Invest Ophthalmol Vis Sci 46 618 622
13. LJ Bruce R Beckmann ML Ribeiro LL Peters JA Chasis J Delaunay N Mohandas DJ Anstee MJ Tanner 2003 A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane Blood 101 4180 4188
14. JS Brugge RL Erikson 1977 Identification of a transformation-specific antigen induced by an avian sarcoma virus Nature 269 346 348
15. MR Burnham PJ Bruce-Staskal MT Harte CL Weidow A Ma SA Weed AH Bouton 2000 Regulation of c-SRC activity and function by the adapter protein CAS Mol Cell Biol 20 5865 5878
16. +-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site J Biol Chem 257 5601 5606
17. BY Chang M Chiang CA Cartwright 2001 The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1 J Biol Chem 276 20346 20356
18. BY Chang KB Conroy EM Machleder CA Cartwright 1998 RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells Mol Cell Biol 18 3245 3256
19. SC Chueh JH Guh J Chen MK Lai CM Teng 2001 Dual effects of ouabain on the regulation of proliferation and apoptosis in human prostatic smooth muscle cells J Urol 166 347 353
20. JL Clements GA Koretzky 1999 Recent developments in lymphocyte activation: linking kinases to downstream signaling events J Clin Invest 103 925 929
21. BS Cobb MD Schaller TH Leu JT Parsons 1994 Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK Mol Cell Biol 14 147 155
22. RG Contreras L Shoshani C Flores-Maldonado A Lazaro M Cereijido 1999 Relationship between Na(+),K(+)-ATPase and cell attachment J Cell Sci 112 Pt 23 4223 4232
23. SA Courtneidge AE Smith 1983 Polyoma virus transforming protein associates with the product of the c-src cellular gene Nature 303 435 439
24. JM Cuff A Lichtman 1975 The early effects of ouabain on potassium metabolism and rate of proliferation of mouse lymphoblasts J Cell Physiol 85 209 215
25. P Delmas 2005 Polycystins: polymodal receptor/ion-channel cellular sensors Pflugers Arch 451 264 276
26. RI Dmitrieva PA Doris 2003 Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells J Biol Chem 278 28160 28166
27. J Elkareh DJ Kennedy B Yashaswi S Vetteth A Shidyak EG Kim S Smaili SM Periyasamy IM Hariri L Fedorova J Liu L Wu MB Kahaleh Z Xie D Malhotra OV Fedorova VA Kashkin AY Bagrov JI Shapiro 2007 Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy Hypertension 49 215 224
28. OV Fedorova PA Doris AY Bagrov 1998 Endogenous marinobufagenin-like factor in acute plasma volume expansion Clin Exp Hypertens 20 581 591
29. M Ferrandi I Molinari P Barassi E Minotti G Bianchi P Ferrari 2004 Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238 J Biol Chem 279 33306 33314
30. MS Feschenko RK Wetzel KJ Sweadner 1997 Phosphorylation of Na,K-ATPase by protein kinases. Sites, susceptibility, and consequences Ann N Y Acad Sci 834 479 488
31. WC Golden LJ Martin 2006 Low-dose ouabain protects against excitotoxic apoptosis and up-regulates nuclear Bcl-2 in vivo Neuroscience 137 133 144
32. E Golomb MR Hill RG Brown HR Keiser 1994 Ouabain enhances the mitogenic effect of serum in vascular smooth muscle cells Am J Hypertens 7 69 74
33. NM Griffiths PH Ogden R Cormack JF Lamb 1991 Discrepancy between the short and long term effects of ouabain on the sodium pumps of human cells grown in culture Br J Pharmacol 104 419 427
34. +-ATPase J Biol Chem 275 27832 27837
35. +-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases J Biol Chem 277 18694 18702
36. JM Hamlyn MP Blaustein S Bova DW DuCharme DW Harris F Mandel WR Mathews JH Ludens 1991 Identification and characterization of a ouabain-like compound from human plasma Proc Natl Acad Sci U S A 88 6259 6263
37. SK Hanks AM Quinn T Hunter 1988 The protein kinase family: conserved features and deduced phylogeny of the catalytic domains Science 241 42 52
38. M Hilge G Siegal GW Vuister P Guntert SM Gloor JP Abrahams 2003 ATP-induced conformational changes of the nucleotide-binding domain of Na,K-ATPase Nat Struct Biol 10 468 474
39. EK Hoffmann 2001 The pump and leak steady-state concept with a variety of regulated leak pathways J Membr Biol 184 321 330
40. JD Horisberger 2004 Recent insights into the structure and mechanism of the sodium pump Physiology (Bethesda) 19 377 387
41. L Huang H Li Z Xie 1997 Ouabain-induced hypertrophy in cultured cardiac myocytes is accompanied by changes in expression of several late response genes J Mol Cell Cardiol 29 429 437
42. JN Ihle IM Kerr 1995 Jaks and Stats in signaling by the cytokine receptor superfamily Trends Genet 11 69 74
43. C Jordan B Puschel R Koob D Drenckhahn 1995 Identification of a binding motif for ankyrin on the alpha-subunit of Na+,K(+)-ATPase J Biol Chem 270 29971 29975
44. PL Jorgensen KO Hakansson SJ Karlish 2003 Structure and mechanism of Na,K-ATPase: functional sites and their interactions Annu Rev Physiol 65 817 849
45. J Jung M Kim S Choi MJ Kim JK Suh EC Choi K Lee 2006 Molecular mechanism of cofilin dephosphorylation by ouabain Cell Signal 18 2033 2040
46. M Kanagawa S Watanabe S Kaya K Togawa T Imagawa A Shimada K Kikuchi K Taniguchi 2000 Membrane enzyme systems responsible for the Ca(2+)-dependent phosphorylation of Ser(27), the independent phosphorylation of Tyr(10) and Tyr(7), and the dephosphorylation of these phosphorylated residues in the alpha-chain of H/K-ATPase J Biochem (Tokyo) 127 821 828
47. JG Kaplan 1978 Membrane cation transport and the control of proliferation of mammalian cells Annu Rev Physiol 40 19 41
48. JH Kaplan 2002 Biochemistry of Na,K-ATPase Annu Rev Biochem 71 511 535
49. N Kawazoe M Watabe Y Masuda S Nakajo K Nakaya 1999 Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells Oncogene 18 2413 2421
50. DJ Kennedy S Vetteth SM Periyasamy M Kanj L Fedorova S Khouri MB Kahaleh Z Xie D Malhotra NI Kolodkin EG Lakatta OV Fedorova AY Bagrov JI Shapiro 2006 Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy Hypertension 47 488 495
51. DJ Kennedy S Vetteth M Xie SM Periyasamy Z Xie C Han V Basrur K Mutgi V Fedorov D Malhotra JI Shapiro 2006 Ouabain decreases sarco(endo)plasmic reticulum calcium ATPase activity in rat hearts by a process involving protein oxidation Am J Physiol Heart Circ Physiol 291 H3003 3011
52. SJ Khundmiri V Amin J Henson J Lewis M Ameen MJ Rane NA Delamere 2007 Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway Am J Physiol Cell Physiol 293 C1171 1180
53. SJ Khundmiri MA Metzler M Ameen V Amin MJ Rane NA Delamere 2006 Ouabain induces cell proliferation through calcium-dependent phosphorylation of Akt (protein kinase B) in opossum kidney proximal tubule cells Am J Physiol Cell Physiol 291 C1247 1257
54. DR Knighton JH Zheng LF Ten Eyck VA Ashford NH Xuong SS Taylor JM Sowadski 1991 Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science 253 407 414
55. +-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases J Biol Chem 273 15249 15256
56. +-ATPase in human breast cancer cells Mol Pharmacol 67 929 936
57. Y Komiyama XH Dong N Nishimura H Masaki M Yoshika M Masuda H Takahashi 2005 A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure Clin Biochem 38 36 45
58. O Kotova L Al-Khalili S Talia C Hooke OV Fedorova AY Bagrov AV Chibalin 2006 Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism J Biol Chem 281 20085 20094
59. W Kuhlbrandt 2004 Biology, structure and mechanism of P-type ATPases Nat Rev Mol Cell Biol 5 282 295
60. A Kulikov A Eva U Kirch A Boldyrev G Scheiner-Bobis 2007 Ouabain activates signaling pathways associated with cell death in human neuroblastoma Biochim Biophys Acta 1768 1691 1702
61. J Laredo JR Shah ZR Lu BP Hamilton JM Hamlyn 1997 Angiotensin II stimulates secretion of endogenous ouabain from bovine adrenocortical cells via angiotensin type 2 receptors Hypertension 29 401 407
62. K Lee J Jung M Kim G Guidotti 2001 Interaction of the alpha subunit of Na,K-ATPase with cofilin Biochem J 353 377 385
63. J Li S Zelenin A Aperia O Aizman 2006 Low doses of ouabain protect from serum deprivation-triggered apoptosis and stimulate kidney cell proliferation via activation of NF-{kappa}B J Am Soc Nephrol 17 1848 1857
64. M Li Q Wang L Guan 2007 Effects of ouabain on proliferation, intracellular free calcium and c-myc mRNA expression in vascular smooth muscle cells J Comp Physiol [B] 177 589 595
65. M Liang T Cai J Tian W Qu ZJ Xie 2006 Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay J Biol Chem 281 19709 19719
66. DH Lin H Sterling B Yang SC Hebert G Giebisch WH Wang 2004 Protein tyrosine kinase is expressed and regulates ROMK1 location in the cortical collecting duct Am J Physiol Renal Physiol 286 F881 892
67. J Liu R Kesiry SM Periyasamy D Malhotra Z Xie JI Shapiro 2004 Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism Kidney Int 66 227 241
68. +-ATPase Am J Physiol Cell Physiol 284 C1550 1560
69. L Liu X Zhao SV Pierre A Askari 2007 Association of PI3K/Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes Am J Physiol Cell Physiol 293 C1489 C1497
70. M Lopez-Lazaro N Pastor SS Azrak MJ Ayuso CA Austin F Cortes 2005 Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients J Nat Prod 68 1642 1645
71. S Lutsenko JH Kaplan 1995 Organization of P-type ATPases: significance of structural diversity Biochemistry 34 15607 15613
72. YC Ma J Huang S Ali W Lowry XY Huang 2000 Src tyrosine kinase is a novel direct effector of G proteins Cell 102 635 646
73. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells Cancer Res 60 3807 3812
74. D McGarrigle XY Huang 2007 GPCRs signaling directly through Src-family kinases Sci STKE 2007 pe35
75. T Mijatovic I Roland E Van Quaquebeke B Nilsson A Mathieu F Van Vynckt F Darro G Blanco V Facchini R Kiss 2007 The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers J Pathol 212 170 179
76. I Moarefi M LaFevre-Bernt F Sicheri M Huse CH Lee J Kuriyan WT Miller 1997 Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature 385 650 653
77. JP Morth BP Pedersen MS Toustrup-Jensen TL Sorensen J Petersen JP Andersen B Vilsen P Nissen 2007 Crystal structure of the sodium-potassium pump Nature 450 1043 1049
78. + conductances in rabbit cortical collecting ducts Am J Physiol 276 F143 158
79. Y Nakagawa V Rivera AC Larner 1992 A role for the Na/K-ATPase in the control of human c-fos and c-jun transcription J Biol Chem 267 8785 8788
80. S Nakamura S Braun E Racker 1987 A tyrosine-specific protein kinase from Ehrlich ascites tumor cells Arch Biochem Biophys 252 538 548
81. AN Nguyen DP Wallace G Blanco 2007 Ouabain binds with high affinity to the Na,K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation J Am Soc Nephrol 18 46 57
82. P Pasdois CL Quinlan A Rissa L Tariosse B Vinassa AD Costa SV Pierre P Dos Santos KD Garlid 2007 Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS Am J Physiol Heart Circ Physiol 292 H1470 1478
83. RL Patterson D Boehning SH Snyder 2004 Inositol 1,4,5-trisphosphate receptors as signal integrators Annu Rev Biochem 73 437 465
84. 2+- dependent expressions of early-response genes in cardiac myocytes J Biol Chem 271 10372 10378
85. + or ouabain J Cell Physiol 106 85 97
86. J Qiu HQ Gao RH Zhou Y Liang XH Zhang XP Wang BA You M Cheng 2007 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells Biol Pharm Bull 30 247 253
87. M Ramirez-Ortega V Maldonado-Lagunas J Melendez-Zajgla JF Carrillo-Hernandez G Pastelin-Hernandez O Picazo-Picazo G Ceballos-Reyes 2006 Proliferation and apoptosis of HeLa cells induced by in vitro stimulation with digitalis Eur J Pharmacol 534 71 76
88. 2+ exchanger is essential for the action of cardiac glycosides Circ Res 90 305 308
89. G Sanchez AN Nguyen B Timmerberg JS Tash G Blanco 2006 The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic properties and is important for sperm motility Mol Hum Reprod 12 565 576
90. R Saunders G Scheiner-Bobis 2004 Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump Eur J Biochem 271 1054 1062
91. W Schoner G Scheiner-Bobis 2007 Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth Am J Physiol Cell Physiol 293 C509 C536
92. RJ Schulte BM Sefton 2003 Inhibition of the activity of SRC and Abl tyrosine protein kinases by the binding of the Wiskott-Aldrich syndrome protein Biochemistry 42 9424 9430
93. - cotransporter 1 (pNBC1) Proc Natl Acad Sci U S A 103 9542 9547
94. F Sicheri I Moarefi J Kuriyan 1997 Crystal structure of the Src family tyrosine kinase Hck Nature 385 602 609
95. JC Skou 1957 The influence of some cations on an adenosine triphosphatase from peripheral nerves Biochim Biophys Acta 23 394 401
96. +-ATPase Nippon Yakurigaku Zasshi 86 181 188
97. +-ATPase Biochim Biophys Acta 988 185 220
98. KJ Sweadner C Donnet 2001 Structural similarities of Na,K-ATPase and SERCA, the Ca(2+)-ATPase of the sarcoplasmic reticulum Biochem J 356 685 704
99. SM Thomas JS Brugge 1997 Cellular functions regulated by Src family kinases Annu Rev Cell Dev Biol 13 513 609
100. + ATPase as a signaling molecule during bovine sperm capacitation Biol Reprod 75 308 317
101. +-ATPase forms a functional signaling complex Mol Biol Cell 17 317 326
102. C Toyoshima M Nakasako H Nomura H Ogawa 2000 Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution Nature 405 647 655
103. C Toyoshima H Nomura 2002 Structural changes in the calcium pump accompanying the dissociation of calcium Nature 418 605 611
104. L Trevisi B Visentin F Cusinato I Pighin S Luciani 2004 Antiapoptotic effect of ouabain on human umbilical vein endothelial cells Biochem Biophys Res Commun 321 716 721
105. RP Trible L Emert-Sedlak TE Smithgall 2006 HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction J Biol Chem 281 27029 27038
106. RC Valente LS Capella RQ Monteiro VM Rumjanek AG Lopes MA Capella 2003 Mechanisms of ouabain toxicity FASEB J 17 1700 1702
107. +-ATPase J Biol Chem 279 17250 17259
108. T Wang Y Jiao C Montell 2005 Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel J Cell Biol 171 685 694
109. + channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase J Gen Physiol 101 673 694
110. PA Welling 1995 Cross-talk and the role of KATP channels in the proximal tubule Kidney Int 48 1017 1023
111. W Xu SC Harrison MJ Eck 1997 Three-dimensional structure of the tyrosine kinase c-Src Nature 385 595 602
112. H Yamaguchi WA Hendrickson 1996 Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation Nature 384 484 489
113. Z Yuan T Cai J Tian AV Ivanov DR Giovannucci Z Xie 2005 Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex Mol Biol Cell 16 4034 4045
114. +-ATPase alpha subunit and regulates its trafficking Proc Natl Acad Sci U S A 97 6556 6561
115. S Zhang S Malmersjo J Li H Ando O Aizman P Uhlen K Mikoshiba A Aperia 2006 Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer J Biol Chem 281 21954 21962
116. Z Zhang P Devarajan AL Dorfman JS Morrow 1998 Structure of the ankyrin-binding domain of alpha-Na,K-ATPase J Biol Chem 273 18681 18684