Phosphorylation of Na,K-ATPase by protein kinases. Sites, susceptibility, and consequences

Annals of the New York Academy of Sciences

Volumn 834, Issue , 1997, Pages 479-488

  Feschenko, Marina S ^a   Wetzel, Randall K ^a   Sweadner, Kathleen J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); PROTEIN KINASE; PROTEIN KINASE C; SERINE;

AUTOPHOSPHORYLATION; CONFERENCE PAPER; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION;

EID: 0031442615     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb52306.x     Document Type: Conference Paper

References (13)

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2. LOWNDES, J. M., M. HOKIN NEAVERSON & P. J. BERTICS. 1990. Kinetics of phosphorylation of Na+/K(+)-ATPase by protein kinase C. Biochim. Biophys. Acta 1052: 143-151.
3. BERTORELLO, A. M., A. APERIA, S. I. WALAAS, A. C. NAIRN & P. GREENGARD. 1991. Phosphorylation of the catalytic subunit of Na+,K(+)-ATPase inhibits the activity of the enzyme. Proc. Natl. Acad. Sci. USA 88: 11359-11362.
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5. FESCHENKO, M. S. & K. J. SWEADNER. 1994. Conformation-dependent phosphorylation of Na,K-ATPase by protein kinase A and protein kinase C. J. Biol. Chem. 269: 30,436-30,444.
6. ARYSTARKHOVA, E., D. L. GIBBONS & K. J. SWEADNER. 1995. Topology of the Na,K-ATPase: Evidence for externalization of a labile transmembrane structure during heating. J. Biol. Chem. 270: 8785-8796.
7. FESCHENKO, M. S. & K. J. SWEADNER. 1995. Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C. J. Biol. Chem. 270: 14072-14077.
8. KHATRI, A., T. R. OSTREA, M. S. FESCHENKO & K. J. SWEADNER. 1995. Sequence analysis and radiometric quantitation of phosphorylation sites in the alpha subunit of Na,K-ATPase on PVDF blot: A non-covalent approach. Protein Sci. 4(Suppl. 2): 153.
9. SANDO, J. J., M. C. MAURER, E. J. BOLEN & C. M. GRISHAM. 1992. Role of cofactors in protein kinase C activation. Cell. Signalling 4: 595-609.
10. FELSENFELD, D. P. & K. J. SWEADNER. 1988. Fine specificity mapping and topography of an isozyme-specific epitope of the Na,K-ATPase catalytic subunit. J. Biol. Chem. 263: 10932-10942.
11. ARYSTARKHOVA, E. A. & K. J. SWEADNER. 1996. Isoform-specific monoclonal antibodies to Na-K-ATPase α subunits: Evidence for a tissue-specific post-translational modification of the a subunit. J. Biol. Chem. 271: 23,407-23,417.
12. MCGRAIL, K. M. & K. J. SWEADNER. 1989. Complex expression patterns for Na,K-ATPase isoforms in retina and optic nerve. Eur. J. Neurosci. 2: 170-176.
13. FESCHENKO, M. S. & K. J. SWEADNER. 1997. Phosphorylation of Na,K-ATPase by protein kinase C at Ser 18 occurs in intact cells but does not result in direct inhibition of ATP hydrolysis. J. Biol. Chem. 272: 17726-17733.