Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 3, 2007, Pages

  Pasdois, Philippe ^a   Quinlan, Casey L ^b   Rissa, Abraham ^b   Tariosse, Liliane ^a   Vinassa, Béatrice ^a   Costa, Alexandre D T ^b   Pierre, Sandrine V ^c   Dos Santos, Pierre ^a   Garlid, Keith D ^b  

^a INSERM   (France)

^b PORTLAND STATE UNIVERSITY   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Bradykinin; Inotropy; Na+ K+ ATPase; Reactive oxygen species; Signaling pathway

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BRADYKININ; CREATINE KINASE; GUANYLATE CYCLASE INHIBITOR; KT 5823; OUABAIN; POTASSIUM CHANNEL; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; TIOPRONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG PROTEIN BINDING; ENERGY TRANSFER; HEART CONTRACTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE; ANIMALS; CARDIOTONIC AGENTS; CREATINE; DISEASE MODELS, ANIMAL; HEART RATE; MALE; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANES; MYOCARDIAL REPERFUSION INJURY; OUABAIN; OXYGEN CONSUMPTION; PERMEABILITY; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SRC-FAMILY KINASES;

EID: 33847704124     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00877.2006     Document Type: Article

References (51)

1. 2+ exchanger function. J Physiol 575: 845-854, 2006.
2. ATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 291: H2067-H2074, 2006.
3. Baines CP, Goto M, Downey JM. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J Mol Cell Cardiol 29: 207-216, 1997.
4. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force (2nd ed.). Dordrecht, The Netherlands, Kluwer, 2001.
5. Bolli R, Dawn B, Tang XL, Qiu Y, Ping P, Xuan YT, Jones WK, Takano H, Guo Y, Zhang J. The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol 93: 325-338, 1998.
6. ATP channel. Annu Rev Physiol 62: 79-109, 2000.
7. Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD. Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res 97: 329-336, 2005.
8. 2 inhibit the mitochondrial permeability transition. J Biol Chem 281: 20801-20808, 2006.
9. + channel protects the ischemic heart. Am J Physiol Heart Circ Physiol 283: H284-H295, 2002.
10. Dos Santos P, Laclau MN, Boudina S, Garlid KD. Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia. Mol Cell Biochem 256/257: 157-166, 2004.
11. Downey JM, Cohen MV. Signal transduction in ischemic preconditioning. Adv Exp Med Biol 430: 39-55, 1997.
12. Gao J, Wymore RS, Wang Y, Gaudette GR, Krukenkamp IB, Cohen IS, Mathias RT. Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol 119: 297-312, 2002.
13. + channel in cardiac function and cardioprotection. Biochim Biophys Acta 1606: 1-21, 2003.
14. + channels. Possible mechanism of cardioprotection. Circ Res 81: 1072-1082, 1997.
15. ATP in the response to inotropic stress. Am J Physiol Heart Circ Physiol 291: H152-H160, 2006.
16. Garthwaite J, Southam E, Boulton CL, Nielsen EB, Schmidt K, Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol Pharmacol 48: 184-188, 1995.
17. Gross ER, Gross GJ. Ligand triggers of classical preconditioning and postconditioning. Cardiovasc Res 70: 212-221, 2006.
18. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271: 695-701, 1996.
19. ATP channels attenuates the ouabain-induced calcium overload in mitochondria. Circ Res 89: 856-858, 2001.
20. ATP channel by glyburide and 5-hydroxydecanoate. J Biol Chem 273: 13578-13582, 1998.
21. Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 142: 436-440, 1987.
22. Kennedy DJ, Vetteth S, Xie M, Periyasamy SM, Xie Z, Han C, Basrur V, Mutgi KA, Fedorov V, Malhotra D, Shapiro JI. Ouabain decreases sarco(endo)plasmic reticulum calcium ATPase activity in rat hearts by a process involving protein oxidation. Am J Physiol Heart Circ Physiol 291: H3003-H3011, 2006.
23. Krieg T, Philipp S, Cui L, Dostmann WR, Downey JM, Cohen MV. Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart. Am J Physiol Heart Circ Physiol 288: H1976-H1981, 2005.
24. Krieg T, Qin Q, McIntosh EC, Cohen MV, Downey JM. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol Heart Circ Physiol 283: H2322-H2330, 2002.
25. Krieg T, Qin Q, Philipp S, Alexeyev MF, Cohen MV, Downey JM. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am J Physiol Heart Circ Physiol 287: H2606-H2611, 2004.
26. Laclau MN, Boudina S, Thambo JB, Tariosse L, Gouverneur G, Bonoron-Adele S, Saks VA, Garlid KD, Dos Santos P. Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J Mol Cell Cardiol 33: 947-956, 2001.
27. Leier CV. General overview and update of positive inotropic therapy. Am J Med 81: 40-45, 1986.
28. 2+ concentrations. J Biol Chem 275: 27838-27844, 2000.
29. Miyakawa-Naito A, Uhlen P, Lal M, Aizman O, Mikoshiba K, Brismar H, Zelenin S, Aperia A. Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations. J Biol Chem 278: 50355-50361, 2003.
30. +-ATPase to ERK1/2. J Biol Chem 276: 42050-42056, 2001.
31. Nakano A, Cohen MV, Downey JM. Ischemic preconditioning. From basic mechanisms to clinical applications. Pharmacol Ther 86: 263-275, 2000.
32. Noland TA Jr, Raynor RL, Jideama NM, Guo X, Kazanietz MG, Blumberg PM, Solaro RJ, Kuo JF. Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry 35: 14923-14931, 1996.
33. ATP channel induces early and delayed cardioprotective effect: role of nitric oxide. Am J Physiol Heart Circ Physiol 277: H2425-H2434, 1999.
34. Ogbi M, Wingard CJ, Ogbi S, Johnson JA, Chew CS, Pohl J, Stuchlik O. Epsilon protein kinase C lengthens the quiescent period between spontaneous contractions in rat ventricular cardiac myocytes and trabecula. Naunyn Schmiedebergs Arch Pharmacol 370: 251-261, 2004.
35. ATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol 286: H468-H476, 2004.
36. ATP channels triggers the preconditioned state by generating free radicals. Circ Res 87: 460-466, 2000.
37. Pasdois PP, Lefevre J, Beauvoit B, Vinassa B, Bonoron-Adèle S, Garlid KD, Dos Santos P. Ouabain protects Langendorff-perfused rat hearts against ischemia-reperfusion-induced alterations (Abstract). Arch Mal Vaiss 97: 21, 2004.
38. 2+ exchanger is essential for the action of cardiac glycosides. Circ Res 90: 305-308, 2002.
39. Saks VA, Vasil'eva E, Belikova Yu O, Kuznetsov AV, Lyapina S, Petrova L, Perov NA. Retarded diffusion of ADP in cardiomyocytes: possible role of mitochondrial outer membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochim Biophys Acta 1144: 134-148, 1993.
40. i in rat cardiac myocytes. Am J Physiol Heart Circ Physiol 281: H1899-H1907, 2001.
41. ATP channels. Mol Cell Biochem 242: 181-187, 2003.
42. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT. Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes. J Biol Chem 273: 18092-18098, 1998.
43. Veksler VI, Kuznetsov AV, Sharov VG, Kapelko VI, Saks VA. Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. Biochim Biophys Acta 892: 191-196, 1987.
44. Vondriska TM, Zhang J, Song C, Tang XL, Cao X, Baines CP, Pass JM, Wang S, Bolli R, Ping P. Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res 88: 1306-1313, 2001.
45. ATP channels in diazoxide-mediated protection in isolated rabbit hearts. Am J Physiol Heart Circ Physiol 280: H246-H255, 2001.
46. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ Res 85: 731-741, 1999.
47. +-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol Interv 3: 157-168, 2003.
48. Young JB. Whither Withering's legacy? Digoxin's role in our contemporary pharmacopeia for heart failure. J Am Coll Cardiol 46: 505-507, 2005.
49. Ytrehus K, Liu Y, Tsuchida A, Miura T, Liu GS, Yang XM, Herbert D, Cohen MV, Downey JM. Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing. Am J Physiol Heart Circ Physiol 267: H2383-H2390, 1994.
50. 3 receptor into a calcium-regulatory complex. Mol Biol Cell 16: 4034-4045, 2005.
51. Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71: 310-321, 2006.