Structural similarities of Na,K-ATPase and SERCA, the Ca2+-ATPase of the sarcoplasmic reticulum

Biochemical Journal

Volumn 356, Issue 3, 2001, Pages 685-704

  Sweadner, K J ^a   Donnet, C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cross linking; Crystal structure; Membrane protein; P type ATPases; Protein folding

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); MUSCLE PROTEIN; PROTEIN SERCA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING SITE; CELL MEMBRANE; CROSS LINKING; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME STRUCTURE; GENE DELETION; GENE INSERTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; REVIEW; SARCOPLASMIC RETICULUM; SEQUENCE HOMOLOGY; SKELETAL MUSCLE; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; CALCIUM-TRANSPORTING ATPASES; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NA(+)-K(+)-EXCHANGING ATPASE; PROTEIN CONFORMATION; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035875154     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3560685     Document Type: Review

References (149)

1. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
2. + conduction and selectivity
3. 2+ pump of sarcoplasmic reticulum: A view along the lipid bilayer at 9-Å resolution
4. Structure of the calcium pump from sarcoplasmic reticulum at 8-Å resolution
5. +-ATPase in the open conformation
6. Structure of the P-type ATPases
7. Structure and function of the P-type ATPases
8. Structure of renal Na,K-ATPase as observed by cryo-EM of 2-D crystals
9. Structural organization, ion transport, and energy transduction of P-type ATPases
10. Structure-function relationships of E1-E2 transitions and cation binding in Na,K-pump protein
11. Evolution of P-type ATPases
12. Evolution of substrate specificities in the P-type ATPase superfamily
13. ATP-driven cation pumps: Alignment of sequences
14. +-ATPase
15. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
16. What the structure of a calcium pump tells us about its mechanism
17. Pumping ions
18. Organization of P-type ATPases: Significance of structural diversity
19. The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases
20. Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs
21. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
22. 2+ pump
23. Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps
24. A subfamily of P-type ATPases with aminophospholipid transporting activity
25. Loss of Drs2p does not abolish transfer of fluorescence-labeled phospholipids across the plasma membrane of Saccharomyces cerevisiae
26. Identification of two conformationally sensitive cysteine residues at the extracellular surface of the Na,K-ATPase α-subunit
27. 2+-catalyzed oxidative cleavage of Na,K-ATPase at the extracellular surface
28. Site-directed chemical labeling of extracellular loops in a membrane protein. The topology of the Na,K-ATPase α-subunit
29. Na,K-ATPase, structure and transport mechanism
30. Structural basis for E1-E2 conformational transitions in Na,K-pump and Ca-pump proteins
31. Fine specificity mapping and topography of an isozyme-specific epitope of the Na,K-ATPase catalytic subunit
32. +)-ATPase from outside of the cell membrane
33. Na,K-ATPase extracellular surface probed with a monoclonal antibody that enhances ouabain binding
34. Constraints on models for the folding of the Na,K-ATPase
35. Site-directed antibodies as topographical probes of the gastric H,K-ATPase alpha-subunit
36. Topology of Na,K-ATPase alpha subunit epitopes analyzed with oligopeptide-specific antibodies and double-labeling immunoelectron microscopy
37. +-ATPase
38. +-ATPase
39. Immunoelectronmicroscopy of epitopes on Na,K-ATPase catalytic subunit. Implications for the transmembrane organization of the C-terminal domain
40. Isoform-specific monoclonal antibodies to Na-K-ATPase α subunits: Evidence for a tissue-specific post-translational modification of the α subunit
41. Location of a cytoplasmic epitope for monoclonal antibody HK 12.18 on H,K-ATPase α subunit
42. Thermal denaturation of the Na,K-ATPase provides evidence for α-α oligomeric interaction and γ subunit association with the C-terminal domain
43. +-ATPase. Identification of the extra- and intracellular hydrophilic loops of the catalytic subunit by specific antibodies
44. +-ATPase α subunit is ligand-dependent
45. + occlusion and dissociation of the M5/M6 fragment
46. + ions. Mechanistic significance for P-2-type ATPases
47. Transmembrane organization of the Na,K-ATPase determined by epitope addition
48. Studies on the membrane topology of the (Na,K)-ATPase
49. Localization of cytoplasmic and extracellular domains of Na,K-ATPase by epitope tag insertion
50. Residue Leu973 of the rat α1 subunit of the Na,K-ATPase is located on the cytoplasmic side of the plasma membrane
51. +-transporting ATPase
52. H, K-ATPase α-subunit C-terminal membrane topology: Epitope tags in the insect cell expression system
53. +-ATPase derived from β-galactosidase fusion proteins expressed in yeast
54. Endoplasmic reticulum quality control of oligomeric membrane proteins: Topogenic determinants involved in the degradation of the unassembled Na,K-ATPase α subunit and in its stabilization by β subunit assembly
55. Membrane integration of Na,K-ATPase alpha-subunits and beta subunit assembly
56. Involvement of the M7/M8 extracellular loop of the sodium pump α subunit in ion transport. Structural and functional homology to P-loops of ion channels
57. 2+-ATPase with sequence-specific antibodies
58. Subunit interactions in the Na,K-ATPase explored with the yeast two-hybrid system
59. Specific crosslinks between fragments of proteolyzed Na,K-ATPase induced by o-phthalaldehyde
60. Regions of association between the alpha and the beta subunit of the gastric H,K-ATPase
61. +-ATPase by specific and nonspecific proteases with preservation of cation occlusion sites
62. +-ATPase
63. Molecular events in close proximity to the membrane associated with the binding of ligands to the Na,K-ATPase
64. 2+-ATPase of sarcoplasmic reticulum
65. 2+ binding properties after removal of cytoplasmic fragments by proteinase K ?
66. +-ATPase and of its membrane-associated proteolytic peptides
67. + -competitive photoaffinity inhibitor
68. Evidence that the cation occlusion domain of Na/K-ATPase consists of a complex of membrane-spanning segments
69. + ions
70. Structural analysis of the products of chymotryptic cleavage of the E1 form of Na,K-ATPase alpha-subunit: Identification of the N-terminal fragments containing the transmembrane H1-H2 domain
71. Location of Asn 831 of the alpha chain of Na,K-ATPase at the cytoplasmic surface: Implication for topological models
72. +-adenosinetriphosphatase
73. +)-ATPase
74. +-stimulated ATPase
75. Photochemical labeling and inhibition of Na,K-ATPase by 2-azido-ATP. Identification of an amino acid located within the ATP binding site
76. 2+-ATPase
77. The M4M5 cytoplasmic loop of the Na,K-ATPase, overexpressed in Escherichia coli, binds nucleoside triphosphates with the same selectivity as the intact native protein
78. 2+-ATPase probed by affinity labeling and trypsin digestion
79. Catalytic activity of an isolated domain of Na,K-ATPase expressed in Eschericia coli
80. +)-ATPase from outer medulla of mammalian kidney
81. A 19-kDa C-terminal tryptic fragment of the alpha chain of Na/K-ATPase is essential for occlusion and transport of cations
82. Topology of the Na,K-ATPase: Evidence for externalization of a labile transmembrane structure during heating
83. Topology of the α-subunit of Na,K-ATPase based on proteolysis. Lability of the topological organization
84. +-ATPase
85. Phospholamban: Protein structure, mechanism of action, and role in cardiac function
86. 2+ -ATPase forms a functional interaction site with phospholamban
87. 2+ pump of sarcoplasmic reticulum pump of sarcoplasmic reticulum
88. 2+-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban
89. Functional role of cysteine residues in the (Na,K)-ATPase α subunit
90. Expression of an active Na-K-ATPase with an α-subunit lacking all twenty-three native cysteine residues
91. Mutations of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance
92. +-ATPase by N-hydroxysuccinimidyl derivatives of digoxigenin
93. Labeling of a cysteine in the cardiotonic glycoside binding site by the steroid derivative HDMA
94. +-ATPase: A cysteine in the first transmembrane segment
95. 2+
96. In search of ideal inotropic steroids: Recent progress
97. +-ATPase changes out of phase during sequential appearance of reaction intermediates
98. +ATPase
99. Valine 904, tyrosine 898, and cysteine 908 in Na,K-ATPase α-subunits are important for assembly with β-subunits
100. Structure of the 5th transmembrane segment of the Na,K-ATPase α subunit: A cysteine-scanning mutagenesis study
101. +-ATPase
102. Sites of reaction of the gastric H,K-ATPase with extracytoplasmic thiol reagents
103. Identification of the site of inhibition by omeprazole of a alpha-beta fusion protein of the H,K-ATPase using site-directed mutagenesis
104. 2+ ATPase of fast twitch skeletal muscle sarcoplasmic reticulum
105. 2+-ATPase
106. 2+-ATPase of sarcoplasmic reticulum. High and low affinity nucleotide binding and evidence of active site closure in E2-P
107. 2+ and o-phenanthroline
108. +)-dependent adenosine triphosphatase. Chemical cross-linking studies
109. +-ATPase revealed by controlled proteolysis and chemical cross-linking
110. Characterization of disulfide cross-links between fragments of proteolyzed Na,K-ATPase
111. +-ATPase
112. Packing of the transmembrane helices of Na,K-ATPase: Direct contact between β-subunit and H8 segment of α-subunit revealed by oxidative cross-linking
113. +ATPase. III. Amino acid sequence of cysteinyl peptides. Location of disulfide bonds of the α-subunit
114. Functional expression of rat alpha 1 Na,K-ATPase containing substitutions for cysteines 454, 458, 513, and 551
115. +-ATPase in the cytoplasmic loop between trans-membrane segments M6 and M7 of the α subunit
116. 2+ transport (SERCA) ATPase
117. Fe-catalyzed cleavage of the alpha subunit of Na,K-ATPase: Evidence lot conformation-sensitive interactions between cytoplasmic domains
118. The energy transduction mechanism of Na,K-ATPase studied with iron-catalyzed oxidative cleavage
119. A proposal for the Mg2 + binding site of P-type ion motive ATPases and the mechanism of phosphoryl group transfer
120. Site-directed mutagenesis of the sodium pump: Analysis of mutations to amino acids in the proposed nucleotide binding site by stable oxygen isotope exchange
121. 2+ binding, phosphorylation, and energy transduction in Na,K-ATPase
122. 2+) ions accompanies the E1P-E2P conformational change
123. +-ATPase studied with transition metal-catalyzed oxidative cleavage
124. Predicted location and limited accessibility of the protein kinase A phosphorylation site on Na,K-ATPase
125. Ankyrin binds to two distinct cytoplasmic domains of Na,K-ATPase alpha subunit
126. Structure of the ankyrin-binding domain of alpha-Na,K-ATPase
127. +-ATPase
128. +-ATPase α subunit and regulates its trafficking
129. +-ATPase: Relation to genetic hypertension
130. Active transport of cations in giant axons from Sepia and Loligo
131. Sodium and potassium movements in human red cells
132. Structure-function relationships in the Na,K-ATPase alpha subunit: Site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme
133. Site-directed mutagenesis of a conserved, extracellular aspartic acid residue affects the ouabain sensitivity of sheep Na,K-ATPase
134. Mutation of a tyrosine in the H3-H4 ectodomain of Na,K-ATPase α subunit confers ouabain resistance
135. Substitution of transmembrane residues with hydrogen-bonding potential in the α subunit of Na,K-ATPase reveals alterations in ouabain sensitivity
136. Kinetic analysis of ouabain binding to native and mutated forms of Na,K-ATPase and identification of a new region involved in cardiac glycoside interactions
137. Random mutagenesis of the sheep Na,K-ATPase α-1 subunit generates a novel T797N mutation that results in a ouabain-resistant enzyme
138. Ouabain interactions with the H5-H6 hairpin of the Na,K-ATPase reveal a possible inhibition mechanism via the cation binding domain
139. Random mutagenesis of the sheep Na,K-ATPase α1 subunit generating the ouabain-resistant mutant L793P
140. Extensive random mutagenesis analysis of the Na,K-ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity. Implications lot ouabain binding
141. Structural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMR
142. +-ATPase by SCH28080 demonstrated by mutagenesis of glutamic acid 820
143. Comparison of covalent with reversible inhibitor binding sites of the gastric H,K-ATPase by site-directed mutagenesis
144. Functional properties of an H,K-ATPase/Na,K-ATPase chimera
145. +-ATPase
146. A chimeric gastric H,K-ATPase inhibitable with both ouabain and SCH 28080
147. +-ATPase
148. +-ATPase is sensitive to palytoxin, ouabain, and SCH28080
149. 2+, and thapsigargin-sensitive ATPase activity expressed in chimeras between the calcium and the sodium pump α subunits