RACK1, a receptor for activated C kinase and a homolog of the β subunit of G proteins, inhibits activity of Src tyrosine kinases and growth of NIH 3T3 cells

Molecular and Cellular Biology

Volumn 18, Issue 6, 1998, Pages 3245-3256

  Chang, Betty Y ^a   Conroy, Karen B ^a   Machleder, Eric M ^a   Cartwright, Christine A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN KINASE C; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; RECEPTOR;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE OVEREXPRESSION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ANIMALIA;

EID: 0031814131     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.6.3245     Document Type: Article

References (67)

1. Allen, B. G., and S. Katz. 1991. Isolation and characterization of the calcium and phospholipid dependent protein kinase (protein kinase C) subtypes from bovine heart. Biochemistry 30:4334-4340.
2. Altmeyer, A., R. C. Simmons, S. Krajewski, J. C. Reed, G. W. Bornkamm, and S. Chen-Kiang. 1997. Reversal of EBV immortalization precedes apoptosis in IL-6 induced human B cell terminal differentiation. Immunity 7:667-677.
3. Bartel, P. L., C. T. Chien, R. Stemglanz, and S. Fields. 1993. Using the two hybrid system to detect protein-protein interactions, p. 153-179. In D. A. Hartley (ed.), Development: a practical approach. Oxford University Press, Oxford, England.
4. Bohen, S. P., A. Kralli, and K. R. Yamamoto. 1995. Hold'em and fold'em: chaperones and signal transduction. Science 268:1303-1304.
5. Bolen, J. B., C. J. Thiele, M. A. Israel, W. Yonemoto, L. A. Lipsich, and J. S. Brugge. 1984. Enhancement ot cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell 38:767-777.
6. Brown, M. T., and J. A. Cooper. 1996. Regulation, substrates and function of Src. Biochim. Biophys. Acta 128:121-149.
7. c-src protein kinase is an early event in colonic carcinogenesis. Proc. Natl. Acad. Sci. USA 87:558-562.
8. c-src associated with polyomavirus middle tumor antigen. Mol. Cell. Biol. 6:1562-1570.
9. c-srcmutated in the carbonyl-terminal regulatory domain. Cell 49:83-91.
10. c-src activation in human colon carcinoma. J. Clin. Invest. 83:2025-2033.
11. c-src associated with polyomavirus middle tumor antigen from infected or transformed Cells. Mol. Cell. Biol. 5:2647-2652.
12. Chang, B. Y., and C. A. Cartwright. Unpublished data.
13. cdc2 is a specific and efficient substrate of Src family tyrosine kinases. J. Biol. Chem. 267:9248-9256.
14. Coghlan, V. M., B. A. Perrino, M. Howard, L. K. Langeberg, J. B. Hicks, W. M. Gallatin, and J. D. Scott. 1995. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267:108-111.
15. Coghlan, V. M., Z. E. Hausken, and J. D. Scott. 1995. Subcellular targeting of kinases and phosphatases by association with bifunctional anchoring proteins. Biochem. Soc. Trans. 23:592-596.
16. Courtneidge, S. A., and A. E. Smith. 1983. Polyoma virus transforming protein associates with the product of the c-src cellular gene. Nature (London) 303:435-439.
17. Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M. A. Hotz, P. Lassota, and F. Traganos. 1992. Features of apoptotic cells measured by flow cytometry. Cytometry 13:795-808.
18. Faux, M. C., and J. D. Scott. 1996. Molecular glue: kinase anchoring and scaffold proteins. Cell 85:9-12.
19. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340:245-246.
20. Fumagalli, S., N. F. Totty, J. J. Hsuan, and S. A. Courtneidge. 1994. A target for Src in mitosis. Nature 368:871-874.
21. Gaudet, R., A. Bohm, and P. B. Sigler. 1996. Crystal structure at 2.4Å resolution of the complex of transducin βγ and its regulator, phosducin. Cell 87:577-588.
22. fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. Mol. Cell. Biol. 12:5438-5466.
23. Guillemot, F., A. Billault, and C. Auffray. 1989. Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex. Proc. Natl. Acad. Sci. USA 86:4594-4598.
24. Guy, C. T., S. K. Muthuswamy, R. D. Cardiff, P. Soriano, and W. J. Muller. 1994. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev. 8:23-32.
25. Hardie, D. G. (ed.). 1993. Protein phosphorylation: a practical approach. IRL Press, Oxford, England.
26. Harlow, E., and D. Lane (ed.). 1988. Antibodies: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
27. Klauck, T. M., M. C. Faux, K. Labudda, L. K. Langeberg, S. Jaken, and J. D. Scott. 1996. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271:1589-1592.
28. Klemke, R. L., M. Yebra, E. M. Bayna, and D. A. Cheresh. 1994. Receptor tyrosine kinase signaling required for integrin α v beta 5-directed cell motility but not adhesion on vitronectin. J. Cell Biol. 127:859-866.
29. c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49:65-73.
30. Kuenzel, E., and E. Krebs. 1985. A synthetic peptide substrate specific for casein kinase II. Proc. Natl. Acad. Sci. USA 82:737-741.
31. Kypta, R. M., Y. Goldberg, E. T. Ulug, and S. A. Courtneidge. 1990. Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62:481-492.
32. Lambright, D. G., J. Sondek, A. Bohm, N. P. Skiba, H. E. Hamm, and P. B. Sigler. 1996. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature 379:311-319.
33. Li, S., T. Okamoto, M. Chun, M. Sargiacomo, J. E. Casanova, S. H. Hansen, I. Nishimoto, and M. P. Lisanti. 1996. Evidence of a regulated interaction between heterotrimeric G proteins and caveolin. J. Biol. Chem. 270:15693-15701.
34. Li, S., R. Seitz, and M. P. Lisanti. 1996. Phosphorylation of caveolin by Src tyrosine kinases. J. Biol. Chem. 271:3863-3868.
35. Li, S., J. Couet, and M. P. Lisanti. 1996. Src tyrosine kinases, Gα subunits, and H-ras share a common membrane-anchored scaffolding protein, caveolin. J. Biol. Chem. 271:29182-29190.
36. Lin, X., P. J. Nelson, B. Frankfort, E. Tombler, R. Johnson, and I. H. Gelman. 1995. Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Mol. Cell. Biol. 15:2754-2762.
37. Lin, X., E. Tombler, P. J. Nelson, M. Ross, and I. H. Gelman. 1996. A novel src-and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture. J. Biol. Chem. 271:28430-28438.
38. Lipsich, L. A., A. J. Lewis, and J. S. Brugge. 1983. Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses. J. Virol. 48:352-360.
39. Luttrell, L. M., G. J. Della Rocca, T. van Biesen, D. K. Luttrell, and R. J. Lefkowitz. 1997. Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 272:4637-4644.
40. Mayer, B. J. 1997. Signal transduction: clamping down on Src activity. Curr. Biol. 7:R295-R298.
41. Mochly-Rosen, D., H. Khaner, and J. Lopez. 1991. Identification of intracellular receptor proteins for protein kinase C. Proc. Natl. Acad. Sci. USA 88:3997-4000.
42. Mochly-Rosen, D., B. L. Smith, C. H. Chen, M. H. Disatnik, and D. Ron. 1995. Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in β protein kinase C mediated signal transduction. Biochem. Soc. Trans. 23:596-560.
43. Mochly-Rosen, D. 1995. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268:247-251.
44. Muller, F., D. Kruger, E. Sattlegger, B. Hoffmann, P. Ballario, M. Kanaan, and I. B. Barthelmess. 1995. The cpc-2 gene of Neurospora crassa encodes a protein entirely composed of WD-repeat segments that is involved in general amino acid control and female fertility. Mol. Gen. Genet. 248:162-173.
45. Nauert, J. B., T. M. Klauck, L. K. Langeberg, and J. D. Scott. 1997. Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. Curr. Biol. 7:52-62.
46. Neer, E. J., C. J. Schmidt, R. Nambudripad, and T. F. Smith. 1994. The ancient regulatory-protein family of WD-repeat proteins. Nature 371:297-300.
47. Neer, E. J., and T. F. Smith. 1996. G protein heterodimers: new structures propel new questions. Cell 84:175-178.
48. Park, J., A. I. Meisler, and C. A. Cartwright. 1993. c-Yes tyrosine kinase activity in human colon carcinomas. Oncogene 8:2627-2635.
49. Park, J., and C. A. Cartwright. 1995. Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells. Mol. Cell. Biol. 15:2374-2382.
50. Peng, Z.-Y., and C. A. Cartwright. 1995. Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association. Oncogene 11:1955-1962.
51. Pitcher, J. A., J. Inglesse, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. 1992. Role of βγ subunits of G proteins in targeting the β-adrenergic receptor kinase to membrane-bound receptors. Science 257:1264-1267.
52. c-src synthesized in vitro and overproduced in vivo. Mol. Cell. Biol. 6:2033-2040.
53. c-src. Cell 49:75-82.
54. Preito, A. L., G. M. Edelman, and K. L. Crossin. 1993. Multiple integrins mediate cell attachment to cytotactin/tenacin. Proc. Natl. Acad. Sci. USA 90:10154-10158.
55. Rannels, S. R., A. Beasley, and J. D. Corbin. 1983. Regulatory subunits of bovine heart and rabbit skeletal muscle cAMP dependent protein kinase isozymes. Methods Enzymol. 99:55-62.
56. Reynolds, A. B., J. Vila, T. J. Lansing, W. M. Potts, M. J. Weber, and J. T. Parsons. 1987. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxyl terminus. EMBO J. 6:2359-2364.
57. Roche, S., M. Koegl, M. V. Barone, M. F. Roussel, and S. A. Courtneidge. 1995. DNA synthesis induced by some but not all growth factors requires Src family tyrosine kinases. Mol. Cell. Biol. 15:1102-1109.
58. Ron, D., and D. Mochly-Rosen. 1994. Agonists and antagonists of protein kinase C function, derived from its binding proteins. J. Biol. Chem. 269: 21395-21398.
59. Ron, D., J. Luo, and D. Mochly-Rosen. 1995. C2 region-derived peptides inhibit translocation and function of β protein kinase C in vivo. J. Biol. Chem. 270:24180-24187.
60. Ron, D., C. H. Chen, J. Caldwell, L. Jamieson, E. Orr, and D. Mochly-Rosen. 1994. Cloning of the intracellular receptor for protein kinase C: a homolog of the β subunits of G proteins. Proc. Natl. Acad. Sci. USA 91:839-843.
61. Shan, X., H. Luo, B. Houle, and J. Wu. 1994. Expression of a G-protein β subunit-related gene during lymphocyte activation. Int. Immunol. 6:739-749.
62. Sicheri, F., I. Moarefi, and J. Kuriyan. 1997. Crystal structure of the Src family tyrosine kinase Hck. Nature 385:602-609.
63. Taylor, S. J., and D. Shalloway. 1994. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis. Nature 368:867-871.
64. lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell 60:755-765.
65. Twamley-Stein, G. M., R. Pepperkok, W. Ansorge, and S. A. Courtneidge. 1993. The Src family tyrosine kinases are required for PDGF mediated signal transduction in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 90:7696-7700.
66. Xu, W., S. C. Harrison, and M. J. Eck. 1997. Three-dimensional structure of the tyrosine kinase c-Src. Nature 385:595-602.
67. Zang, Q., Z. Lu, M. Curto, N. Barile, D. Shalloway, and D. A. Foster. 1997. Association between v-Src and protein kinase C δ in v-Src transformed fibroblasts. J. Biol. Chem. 272:13275-13280.