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Volumn 451, Issue 1, 2005, Pages 264-276

Polycystins: Polymodal receptor/ion-channel cellular sensors

Author keywords

Mechanosensation; PKD1; PKD2; Polycystic kidney disease; Polycystins; Primary cilia; Sensory transduction; TRP channels

Indexed keywords

CELL SURFACE RECEPTOR; GENE PRODUCT; GUANINE NUCLEOTIDE BINDING PROTEIN; ION CHANNEL; POLYCYSTIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

EID: 24644485135     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-005-1431-5     Document Type: Review
Times cited : (104)

References (78)
  • 1
    • 6344229834 scopus 로고    scopus 로고
    • Global cytoskeletal control of mechanotransduction in kidney epithelial cells
    • Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE (2004) Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res 301:23-30
    • (2004) Exp Cell Res , vol.301 , pp. 23-30
    • Alenghat, F.J.1    Nauli, S.M.2    Kolb, R.3    Zhou, J.4    Ingber, D.E.5
  • 3
    • 0035806961 scopus 로고    scopus 로고
    • The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway
    • Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW (2001) The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol 11:1341-1346
    • (2001) Curr Biol , vol.11 , pp. 1341-1346
    • Barr, M.M.1    DeModena, J.2    Braun, D.3    Nguyen, C.Q.4    Hall, D.H.5    Sternberg, P.W.6
  • 4
    • 0033598394 scopus 로고    scopus 로고
    • A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
    • Barr MM, Sternberg PW (1999) A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature 401:386-389
    • (1999) Nature , vol.401 , pp. 386-389
    • Barr, M.M.1    Sternberg, P.W.2
  • 5
    • 0037133954 scopus 로고    scopus 로고
    • PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
    • Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109:157-168
    • (2002) Cell , vol.109 , pp. 157-168
    • Bhunia, A.K.1    Piontek, K.2    Boletta, A.3    Liu, L.4    Qian, F.5    Xu, P.N.6    Germino, F.J.7    Germino, G.G.8
  • 8
    • 0038625126 scopus 로고    scopus 로고
    • New insights into ciliary function: Kidney cysts and photoreceptors
    • USA
    • Calvet JP (2003) New insights into ciliary function: kidney cysts and photoreceptors. Proc Natl Acad Sci USA 100:5583-5585
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 5583-5585
    • Calvet, J.P.1
  • 11
    • 0041520528 scopus 로고    scopus 로고
    • New TRP channels in hearing and mechanosensation
    • Corey DP (2003) New TRP channels in hearing and mechanosensation. Neuron 39:585-588
    • (2003) Neuron , vol.39 , pp. 585-588
    • Corey, D.P.1
  • 13
    • 2342573670 scopus 로고    scopus 로고
    • Assembly and gating of TRPC channels in signalling microdomains
    • Delmas P (2004) Assembly and gating of TRPC channels in signalling microdomains. Novartis Found Symp 258:75-102
    • (2004) Novartis Found Symp , vol.258 , pp. 75-102
    • Delmas, P.1
  • 14
    • 3242728834 scopus 로고    scopus 로고
    • Polycystins: From mechanosensation to gene regulation
    • Delmas P (2004) Polycystins: from mechanosensation to gene regulation. Cell 118:145-148
    • (2004) Cell , vol.118 , pp. 145-148
    • Delmas, P.1
  • 19
    • 0034636015 scopus 로고    scopus 로고
    • The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
    • USA
    • Gallagher AR, Cedzich A, Gretz N, Somlo S, Witzgall R (2000) The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proc Natl Acad Sci USA 97:4017-4022
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 4017-4022
    • Gallagher, A.R.1    Cedzich, A.2    Gretz, N.3    Somlo, S.4    Witzgall, R.5
  • 20
    • 0345772211 scopus 로고    scopus 로고
    • PKD2 cation channel is required for directional sperm movement and male fertility
    • Gao Z, Ruden DM, Lu X (2003) PKD2 cation channel is required for directional sperm movement and male fertility. Curr Biol 13:2175-2178
    • (2003) Curr Biol , vol.13 , pp. 2175-2178
    • Gao, Z.1    Ruden, D.M.2    Lu, X.3
  • 21
    • 0142073812 scopus 로고    scopus 로고
    • Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist
    • Gattone VH, Wang X, Harris PC, Torres VE (2003) Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist. Nat Med 9:1323-1326
    • (2003) Nat Med , vol.9 , pp. 1323-1326
    • Gattone, V.H.1    Wang, X.2    Harris, P.C.3    Torres, V.E.4
  • 23
    • 0035069134 scopus 로고    scopus 로고
    • Molecular basis of mechanotransduction in living cells
    • Hamill OP, Martinac B (2001) Molecular basis of mechanotransduction in living cells. Physiol Rev 81:685-740
    • (2001) Physiol Rev , vol.81 , pp. 685-740
    • Hamill, O.P.1    Martinac, B.2
  • 25
    • 3042641823 scopus 로고    scopus 로고
    • Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signalling remains unaffected
    • Hang Le N et al (2004) Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signalling remains unaffected. J Biol Chem 26:27472-27481
    • (2004) J Biol Chem , vol.26 , pp. 27472-27481
    • Hang Le, N.1
  • 26
    • 0041561057 scopus 로고    scopus 로고
    • Cell adhesion system and human cancer morphogenesis
    • Hirohashi S, Kanai Y (2003) Cell adhesion system and human cancer morphogenesis. Cancer Sci 94:575-581
    • (2003) Cancer Sci , vol.94 , pp. 575-581
    • Hirohashi, S.1    Kanai, Y.2
  • 27
    • 0037059738 scopus 로고    scopus 로고
    • 2+ channels involved in triggering the sea urchin sperm acrosome reaction
    • 2+ channels involved in triggering the sea urchin sperm acrosome reaction. J Biol Chem 277:1182-1189
    • (2002) J Biol Chem , vol.277 , pp. 1182-1189
    • Hirohashi, N.1    Vacquier, V.D.2
  • 28
    • 0032744937 scopus 로고    scopus 로고
    • Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins
    • Huan Y, van Adelsberg J (1999) Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest 104:1459-1468
    • (1999) J Clin Invest , vol.104 , pp. 1459-1468
    • Huan, Y.1    Van Adelsberg, J.2
  • 30
    • 0033060073 scopus 로고    scopus 로고
    • Interaction between RGS7 and polycystin
    • USA
    • Kim E et al (1999) Interaction between RGS7 and polycystin. Proc Natl Acad Sci USA 96:6371-6376
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 6371-6376
    • Kim, E.1
  • 32
    • 20144383835 scopus 로고    scopus 로고
    • Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
    • Köttgen M et al (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. EMBO J 24:705-716
    • (2005) EMBO J , vol.24 , pp. 705-716
    • Köttgen, M.1
  • 35
    • 0037051960 scopus 로고    scopus 로고
    • The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation
    • Li Q, Liu Y, Zhao W, Chen XZ (2002) The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. FEBS Lett 516:270-278
    • (2002) FEBS Lett , vol.516 , pp. 270-278
    • Li, Q.1    Liu, Y.2    Zhao, W.3    Chen, X.Z.4
  • 36
    • 0038485616 scopus 로고    scopus 로고
    • Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes
    • Li A, Tian X, Sung SW, Somlo S (2003) Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. Genomics 81:596-608
    • (2003) Genomics , vol.81 , pp. 596-608
    • Li, A.1    Tian, X.2    Sung, S.W.3    Somlo, S.4
  • 39
    • 0038784537 scopus 로고    scopus 로고
    • Two populations of node monocilia initiate left-right asymmetry in the mouse
    • McGrath J, Somlo S, Makova S, Tian X, Brueckner M (2003) Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 114:61-73
    • (2003) Cell , vol.114 , pp. 61-73
    • McGrath, J.1    Somlo, S.2    Makova, S.3    Tian, X.4    Brueckner, M.5
  • 41
    • 0002230688 scopus 로고    scopus 로고
    • suREJ proteins: New signalling molecules in sea urchin spermatozoa
    • Mengerink KJ, Moy GW, Vacquier VD (2000) suREJ proteins: new signalling molecules in sea urchin spermatozoa. Zygote 8:S28-S30
    • (2000) Zygote , vol.8
    • Mengerink, K.J.1    Moy, G.W.2    Vacquier, V.D.3
  • 42
    • 18244402941 scopus 로고    scopus 로고
    • A unified nomenclature for the superfamily of TRP cation channels
    • Montell C et al (2002) A unified nomenclature for the superfamily of TRP cation channels. Mol Cell 9:229-231
    • (2002) Mol Cell , vol.9 , pp. 229-231
    • Montell, C.1
  • 43
    • 0029977293 scopus 로고    scopus 로고
    • The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1
    • Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier VD (1996) The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. J Cell Biol 133:809-817
    • (1996) J Cell Biol , vol.133 , pp. 809-817
    • Moy, G.W.1    Mendoza, L.M.2    Schulz, J.R.3    Swanson, W.J.4    Glabe, C.G.5    Vacquier, V.D.6
  • 45
    • 1542286234 scopus 로고    scopus 로고
    • Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa
    • Neill AT, Moy GW, Vacquier VD (2004) Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa. Mol Reprod Dev 67:472-477
    • (2004) Mol Reprod Dev , vol.67 , pp. 472-477
    • Neill, A.T.1    Moy, G.W.2    Vacquier, V.D.3
  • 46
    • 0037036350 scopus 로고    scopus 로고
    • Identification, characterization, and localization of a novel kidney polycystin-1- Polycystin-2 complex
    • Newby LJ, Streets AJ, Zhao Y, Harris PC, Ward CJ, Ong AC (2002) Identification, characterization, and localization of a novel kidney polycystin-1- polycystin-2 complex. J Biol Chem 277:20763-20773
    • (2002) J Biol Chem , vol.277 , pp. 20763-20773
    • Newby, L.J.1    Streets, A.J.2    Zhao, Y.3    Harris, P.C.4    Ward, C.J.5    Ong, A.C.6
  • 47
    • 0037334326 scopus 로고    scopus 로고
    • Polycystic kidney disease-the ciliary connection
    • Ong AC, Wheatley DN (2003) Polycystic kidney disease-the ciliary connection. Lancet 361:774-776
    • (2003) Lancet , vol.361 , pp. 774-776
    • Ong, A.C.1    Wheatley, D.N.2
  • 49
    • 0037205429 scopus 로고    scopus 로고
    • Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins
    • Parnell SC, Magenheimer BS, Maser RL, Zien CA, Frischauf AM, Calvet JP (2002) Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins. J Biol Chem 277:19566-19572
    • (2002) J Biol Chem , vol.277 , pp. 19566-19572
    • Parnell, S.C.1    Magenheimer, B.S.2    Maser, R.L.3    Zien, C.A.4    Frischauf, A.M.5    Calvet, J.P.6
  • 50
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to the kidney cilia and the ciliary level is elevated in ORPK mice with polycystic kidney disease
    • Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB (2002) Polycystin-2 localizes to the kidney cilia and the ciliary level is elevated in ORPK mice with polycystic kidney disease. Curr Biol 12:R378-R380
    • (2002) Curr Biol , vol.12
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3    Rosenbaum, J.L.4    Witman, G.B.5
  • 52
    • 11144261699 scopus 로고    scopus 로고
    • Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells
    • Praetorius HA, Frokiaer J, Leipziger J (2005) Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells. Am J Physiol 288:F133-F141
    • (2005) Am J Physiol , vol.288
    • Praetorius, H.A.1    Frokiaer, J.2    Leipziger, J.3
  • 53
    • 0035498717 scopus 로고    scopus 로고
    • Bending the MDCK cell primary cilium increases intracellular calcium
    • Praetorius HA, Spring KR (2001) Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184:71-79
    • (2001) J Membr Biol , vol.184 , pp. 71-79
    • Praetorius, H.A.1    Spring, K.R.2
  • 54
    • 0037557518 scopus 로고    scopus 로고
    • Removal of the MDCK cell primary cilium abolishes flow sensing
    • Praetorius HA, Spring KR (2003) Removal of the MDCK cell primary cilium abolishes flow sensing. J Membr Biol 191:69-76
    • (2003) J Membr Biol , vol.191 , pp. 69-76
    • Praetorius, H.A.1    Spring, K.R.2
  • 55
    • 0041831249 scopus 로고    scopus 로고
    • The renal cell primary cilium functions as a flow sensor
    • Praetorius HA, Spring KR (2003) The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens 12:517-520
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 517-520
    • Praetorius, H.A.1    Spring, K.R.2
  • 57
    • 0037168674 scopus 로고    scopus 로고
    • Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations
    • USA
    • Qian F, Boletta A, Bhunia AK, Xu H, Liu L, Ahrabi AK, Watnick TJ, Zhou F, Germino GG (2002) Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. Proc Natl Acad Sci USA 99:16981-16986
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 16981-16986
    • Qian, F.1    Boletta, A.2    Bhunia, A.K.3    Xu, H.4    Liu, L.5    Ahrabi, A.K.6    Watnick, T.J.7    Zhou, F.8    Germino, G.G.9
  • 61
    • 0034213071 scopus 로고    scopus 로고
    • LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors
    • Stacey M, Lin HH, Gordon S, McKnight AJ (2000). LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors. Trends Biochem Sci 25:284-289
    • (2000) Trends Biochem Sci , vol.25 , pp. 284-289
    • Stacey, M.1    Lin, H.H.2    Gordon, S.3    McKnight, A.J.4
  • 63
    • 0037320210 scopus 로고    scopus 로고
    • Autosomal dominant polycystic kidney disease: Molecular genetics and pathophysiology
    • Sutters M, Germino GG (2003) Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med 141:91-101
    • (2003) J Lab Clin Med , vol.141 , pp. 91-101
    • Sutters, M.1    Germino, G.G.2
  • 65
    • 4644339559 scopus 로고    scopus 로고
    • Genetic models of mechanotransduction: The nematode Caenorhabditis elegans
    • Syntichaki P, Tavernarakis N (2004) Genetic models of mechanotransduction: the nematode Caenorhabditis elegans. Physiol Rev 84:1097-1153
    • (2004) Physiol Rev , vol.84 , pp. 1097-1153
    • Syntichaki, P.1    Tavernarakis, N.2
  • 66
    • 0038317844 scopus 로고    scopus 로고
    • Autosomal dominant polycystic kidney disease
    • Torres VE, Harris PC (2003) Autosomal dominant polycystic kidney disease. Nefrologia 23:14-22
    • (2003) Nefrologia , vol.23 , pp. 14-22
    • Torres, V.E.1    Harris, P.C.2
  • 67
    • 1942486801 scopus 로고    scopus 로고
    • Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
    • Torres VE, Wang X, Qian Q, Somlo L, Harris PC, Gattone VH (2004) Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 10:363-364
    • (2004) Nat Med , vol.10 , pp. 363-364
    • Torres, V.E.1    Wang, X.2    Qian, Q.3    Somlo, L.4    Harris, P.C.5    Gattone, V.H.6
  • 70
    • 0346403328 scopus 로고    scopus 로고
    • A flagellar polycystin-2 homolog required for male fertility in Drosophila
    • Watnick TJ, Jin Y, Matunis E, Kernan MJ, Montell C (2003) A flagellar polycystin-2 homolog required for male fertility in Drosophila. Curr Biol 13:2179-2184
    • (2003) Curr Biol , vol.13 , pp. 2179-2184
    • Watnick, T.J.1    Jin, Y.2    Matunis, E.3    Kernan, M.J.4    Montell, C.5
  • 72
    • 0033972998 scopus 로고    scopus 로고
    • Molecular genetics and mechanism of autosomal dominant polycystic kidney disease
    • Wu G, Somlo S (2000) Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. Mol Genet Metab 69:1-15
    • (2000) Mol Genet Metab , vol.69 , pp. 1-15
    • Wu, G.1    Somlo, S.2
  • 75
    • 0037513435 scopus 로고    scopus 로고
    • Cyclic AMP activates B-raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys
    • Yamaguchi T et al (2003) Cyclic AMP activates B-raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys. Kidney Int 63:1983-1994
    • (2003) Kidney Int , vol.63 , pp. 1983-1994
    • Yamaguchi, T.1
  • 76
    • 4644367485 scopus 로고    scopus 로고
    • Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
    • Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP (2004) Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J Biol Chem 279:40419-40430
    • (2004) J Biol Chem , vol.279 , pp. 40419-40430
    • Yamaguchi, T.1    Wallace, D.P.2    Magenheimer, B.S.3    Hempson, S.J.4    Grantham, J.J.5    Calvet, J.P.6
  • 77
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder BK, Hou X, Guay-Woodford LM (2002) The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13:2508-2516
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3


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