Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 92, Issue 4, 2007, Pages 1524-1529

  Serlie, M J ^a   Meijer, A J ^a   Groener, J E ^a   Duran, M ^a   Endert, E ^a   Fliers, E ^a   Aerts, J M ^a   Sauerwein, H P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; FATTY ACID; GLUCOSYLCERAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE OXIDATION; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; LEAN BODY WEIGHT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 34147145049     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-2347     Document Type: Article

References (27)

1. Boden G, Carnell LH 2003 Nutritional effects of fat on carbohydrate metabolism. Best Pract Res Clin Endocrinol Metab 17:399-410
2. Reynoso R, Salgado LM, Calderon V 2003 High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1. Mol Cell Biochem 246:155-162
3. Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS 2004 Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 382(Pt 2):619-629
4. Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA 2003 A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278:10297-10303
5. Adams JM, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ 2004 Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53:25-31
6. Straczkowski M, Kowalska I, Nikolajuk A, Dzienis-Straczkowska S, Kinalska I, Baranowski M, Zendzian-Piotrowska M, Brzezinska Z, Gorski J 2004 Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes 53:1215-1221
7. Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA 2005 Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem 280:20148-20153
8. Schmitz-Peiffer C, Craig DL, Biden TJ 1999 Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274:24202-24210
9. Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS 2001 Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia 44:173-183
10. Tagami S, Inokuchi Ji J, Kabayama K, Yoshimura H, Kitamura F, Uemura S, Ogawa C, Ishii A, Saito M, Ohtsuka Y, Sakaue S, Igarashi Y 2002 Ganglioside GM3 participates in the pathological conditions of insulin resistance. J Biol Chem 277:3085-3092
11. Nojiri H, Stroud M, Hakomori S 1991 A specific type of ganglioside as a modulator of insulin-dependent cell growth and insulin receptor tyrosine kinase activity. Possible association of ganglioside-induced inhibition of insulin receptor function and monocytic differentiation induction in HL-60 cells. J Biol Chem 266:4531-4537
12. Yamashita T, Hashiramoto A, Haluzik M, Mizukami H, Beck S, Norton A, Kono M, Tsuji S, Daniotti JL, Werth N, Sandhoff R, Sandhoff K, Proia RL 2003 Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci USA 100:3445-3449
13. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C 1991 Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88:960-966
14. Santomauro AT, Boden G, Silva ME, Rocha DM, Santos RF, Ursich MJ, Strassmann PG, Wajchenberg BL 1999 Overnight lowering of free fatty acids with acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes 48:1836-1841
15. Taketomi T, Hara A, Uemura K, Sugiyama E 1996 Rapid method of preparation of lysoglycosphingolipids and their confirmation by delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Biochem (Tokyo) 120:573-579
16. Folch J, Lees M, Sloane Stanley GH 1957 A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
17. Merrill Jr AH, Wang E, Mullins RE, Jamison WC, Nimkar S, Liotta DC 1988 Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal Biochem 171:373-381
18. Frayn KN 1983 Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634
19. Wiegmann Katja, Schutze Stefan, Machleidt Thomas, Witte Dorothee, Kronke Martin 1994 Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005-1015
20. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM 1996 Tumor necrosis factor (TNF)- inhibits insulin signaling through stimulation of the P55 TNF receptor and activation of sphingomyelinase. J Biol Chem 271:13018-13022
21. Futerman AH, Hannun YA 2004 The complex life of simple sphingolipids. EMBO Rep 5:777-782
22. Hannun Yusuf A, Obeid Lina M 2002 The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277:25847-25850
23. Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, DeFronzo RA, Cusi K 2005 Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes 54:1640-1648
24. Ledeen RW, Wu G 2006 Sphingolipids of the nucleus and their role in nuclear signaling. Biochim Biophys Acta 1761:588-598
25. Scarlatti Francesca, Bauvy Chantal, Ventruti Annamaria, Sala Giusy, Cluzeaud Francoise, Vandewalle Alain, Ghidoni Riccardo, Codogno Patrice 2004 Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J Biol Chem 279:18384-18391
26. Hulver MW, Berggren JR, Carper MJ, Miyazaki M, Ntambi JM, Hoffman EP, Thyfault JP, Stevens R, Dohm GL, Houmard JA, Muoio DM 2005 Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab 2:251-261
27. Chatterjee S1998 Sphingolipids in atherosclerosis and vascular biology. Arterioscler Thromb Vasc Biol 18:1523-1533