메뉴 건너뛰기




Volumn 42, Issue 1, 2009, Pages 11-21

A role for water molecules in DNA-ligand minor groove recognition

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIGAND; WATER;

EID: 61849154273     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar800016q     Document Type: Article
Times cited : (113)

References (56)
  • 1
    • 61849160117 scopus 로고    scopus 로고
    • Tidwell, R. R.; Boykin, D. W. In DAM and RNA Binders: From Small Molecules to Drugs; Demeunynck, M., Bailly, C, Wilson, W. D., Eds.; WILEY-VCH: Weinheim, Germany, 2003; 2; pp 414-460.
    • Tidwell, R. R.; Boykin, D. W. In DAM and RNA Binders: From Small Molecules to Drugs; Demeunynck, M., Bailly, C, Wilson, W. D., Eds.; WILEY-VCH: Weinheim, Germany, 2003; Vol. 2; pp 414-460.
  • 2
    • 22144474782 scopus 로고    scopus 로고
    • Dications that target the DNA minor groove: Compound design and preparation, DNA interactions, cellular distribution and biological activity
    • Wilson, W. D.; Nguyen, B.; Tanious, F. A.; Mathis, A.; Hall, J. E.; Stephens, C. E.; Boykin, D. W. Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity. Curr. Med. Chem. Anticancer Agents 2005, 5, 389-408.
    • (2005) Curr. Med. Chem. Anticancer Agents , vol.5 , pp. 389-408
    • Wilson, W.D.1    Nguyen, B.2    Tanious, F.A.3    Mathis, A.4    Hall, J.E.5    Stephens, C.E.6    Boykin, D.W.7
  • 3
    • 0034951136 scopus 로고    scopus 로고
    • DNA minor-groove recognition by small molecules
    • Neidle, S. DNA minor-groove recognition by small molecules. Nat. Prod. Rep. 2001, 18, 291-309.
    • (2001) Nat. Prod. Rep , vol.18 , pp. 291-309
    • Neidle, S.1
  • 4
    • 34547621809 scopus 로고    scopus 로고
    • Mathis, A. M.; Bridges, A. S.; Ismail, M. A.; Kumar, A.; Francesconi, I.; Anbazhagan, M.; Hu, Q.; Tanious, F. A.; Wenzler, T.; Saulter, J.; Wilson, W. D.; Brun, R.; Boykin, D. W.; Tidwell, R, R.; Hall, J. E. Diphenyl furans and aza analogs: Effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob. Agents Chemother. 2007, 51. 2801- 2810.
    • Mathis, A. M.; Bridges, A. S.; Ismail, M. A.; Kumar, A.; Francesconi, I.; Anbazhagan, M.; Hu, Q.; Tanious, F. A.; Wenzler, T.; Saulter, J.; Wilson, W. D.; Brun, R.; Boykin, D. W.; Tidwell, R, R.; Hall, J. E. Diphenyl furans and aza analogs: Effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. Antimicrob. Agents Chemother. 2007, 51. 2801- 2810.
  • 5
    • 0000127073 scopus 로고
    • Sequence-specific recognition of double helical nucleic acids by proteins
    • Seeman, N. C; Rosenberg, J. M.; Rich, A, Sequence-specific recognition of double helical nucleic acids by proteins. Proc. Natl. Acad. Sci. U.S.A. 1976, 73, 804-808.
    • (1976) Proc. Natl. Acad. Sci. U.S.A , vol.73 , pp. 804-808
    • Seeman, N.C.1    Rosenberg, J.M.2    Rich, A.3
  • 7
    • 0032499635 scopus 로고    scopus 로고
    • The B-DNA dodecamer at high resolution reveals a spine of water on sodium
    • Shui, X.; McFail-lsom, L; Hu, G. G.; Williams, L. D. The B-DNA dodecamer at high resolution reveals a spine of water on sodium. Biochemistry 1998, 37, 8341-8355.
    • (1998) Biochemistry , vol.37 , pp. 8341-8355
    • Shui, X.1    McFail-lsom, L.2    Hu, G.G.3    Williams, L.D.4
  • 8
    • 0020163379 scopus 로고
    • Intrinsic electrostatic properties and base sequence effects in the structure of oligonucleotides
    • Lavery, R.; Pullman, B.; Zakrzewska, K. Intrinsic electrostatic properties and base sequence effects in the structure of oligonucleotides. Biophys. Chem. 1982, 15, 343-351.
    • (1982) Biophys. Chem , vol.15 , pp. 343-351
    • Lavery, R.1    Pullman, B.2    Zakrzewska, K.3
  • 9
    • 0344641913 scopus 로고    scopus 로고
    • Sequence-specific DNA recognition by polyamides
    • Dervan, P. B.; Burli, R. W. Sequence-specific DNA recognition by polyamides. Curr. Opin. Chem. Biol. 1999, 3, 688-693.
    • (1999) Curr. Opin. Chem. Biol , vol.3 , pp. 688-693
    • Dervan, P.B.1    Burli, R.W.2
  • 10
    • 0032824383 scopus 로고    scopus 로고
    • Synthetic DNA minor groove-binding drugs
    • Reddy, B. S.; Sondhi, S. M.; Lown, J, W. Synthetic DNA minor groove-binding drugs. Pharmacol. Ther. 1999, 84, 1-111.
    • (1999) Pharmacol. Ther , vol.84 , pp. 1-111
    • Reddy, B.S.1    Sondhi, S.M.2    Lown, J.W.3
  • 11
    • 0022900621 scopus 로고
    • Isohelical analysis of DNA groove-binding drugs
    • Goodsell, D.; Dickerson, R. E. Isohelical analysis of DNA groove-binding drugs. J. Med. Chem. 1986, 29, 727-733.
    • (1986) J. Med. Chem , vol.29 , pp. 727-733
    • Goodsell, D.1    Dickerson, R.E.2
  • 12
    • 0037832279 scopus 로고    scopus 로고
    • Recognition of the DNA minor groove by pyrrole-imidazole polyamides
    • Dervan, P. B.; Edelson, B. S. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr. Opin. Struct. Biol. 2003, 13, 284-299.
    • (2003) Curr. Opin. Struct. Biol , vol.13 , pp. 284-299
    • Dervan, P.B.1    Edelson, B.S.2
  • 13
    • 0026087665 scopus 로고
    • Geometrical correlations useful for design of sequence-specific DNA narrow groove binding ligands
    • Zasedatelev, A. S. Geometrical correlations useful for design of sequence-specific DNA narrow groove binding ligands. FEBS Lett. 1991, 281, 209-211.
    • (1991) FEBS Lett , vol.281 , pp. 209-211
    • Zasedatelev, A.S.1
  • 14
    • 0033887479 scopus 로고    scopus 로고
    • Designed sequence-specific minor groove ligands
    • Wemmer, D. E. Designed sequence-specific minor groove ligands. Annu. Rev. Biophys. Biomol. Struct. 2000, 29, 439-461.
    • (2000) Annu. Rev. Biophys. Biomol. Struct , vol.29 , pp. 439-461
    • Wemmer, D.E.1
  • 15
    • 0141922837 scopus 로고    scopus 로고
    • New structural motifs isohelical to DNA
    • Nikitin, A. M.; Gursky, G. V. New structural motifs isohelical to DNA. Dokl. Biochem. Biophys 2003, 390, 139-142.
    • (2003) Dokl. Biochem. Biophys , vol.390 , pp. 139-142
    • Nikitin, A.M.1    Gursky, G.V.2
  • 16
    • 0036579960 scopus 로고    scopus 로고
    • A new pseudopeptide motif for designing specific DNA-binding compounds capable of recognizing long DNA sequences
    • Nikitin, A. M.; Rodin, S. A.; Pis'menskii, V. F.; Surovaya, A. N.; Gursky, G. V. A new pseudopeptide motif for designing specific DNA-binding compounds capable of recognizing long DNA sequences. Dokl. Biochem. Biophys. 2002, 384, 167-171.
    • (2002) Dokl. Biochem. Biophys , vol.384 , pp. 167-171
    • Nikitin, A.M.1    Rodin, S.A.2    Pis'menskii, V.F.3    Surovaya, A.N.4    Gursky, G.V.5
  • 17
    • 0019843568 scopus 로고
    • Geometry of hydration
    • Drew, H. R. Geometry of hydration. J. Mol. Biol. 1981, 151, 535-556.
    • (1981) J. Mol. Biol , vol.151 , pp. 535-556
    • Drew, H.R.1
  • 19
    • 0033594498 scopus 로고    scopus 로고
    • hydrat-ion spine in a B-DNA minor groove
    • Tereshko, V.; Minasov, G.; Egli, M, A "hydrat-ion" spine in a B-DNA minor groove. J. Am. Chem. Soc. 1999, 121, 3590-3595.
    • (1999) J. Am. Chem. Soc , vol.121 , pp. 3590-3595
    • Tereshko, V.1    Minasov, G.2    Egli, M.A.3
  • 20
    • 0034608901 scopus 로고    scopus 로고
    • The NMR structure of a DNA dodecamer in an aqueous dilute liquid crystalline phase
    • Tjandra, N.; Tate, S.-i.; Ono, A.; Kainosho, M.; Bax, A. The NMR structure of a DNA dodecamer in an aqueous dilute liquid crystalline phase. J. Am. Chem. Soc. 2000, 122, 6190-6200.
    • (2000) J. Am. Chem. Soc , vol.122 , pp. 6190-6200
    • Tjandra, N.1    Tate, S.-I.2    Ono, A.3    Kainosho, M.4    Bax, A.5
  • 22
    • 0034647435 scopus 로고    scopus 로고
    • A new crystal form for the dodecamer C-G- C-G-A-A-T-T-C-G-C-G: Symmetry effects on sequence-dependent DNA structure
    • Johansson, E.; Parkinson, G.; Neidle, S. A new crystal form for the dodecamer C-G- C-G-A-A-T-T-C-G-C-G: Symmetry effects on sequence-dependent DNA structure. J. Mol. Biol. 2000, 300, 551-561.
    • (2000) J. Mol. Biol , vol.300 , pp. 551-561
    • Johansson, E.1    Parkinson, G.2    Neidle, S.3
  • 23
    • 0028956354 scopus 로고    scopus 로고
    • Refinement of netropsin bound to DNA: Bias and feedback in electron density map interpretation
    • Goodsell, D. S.; Kopka, M. L; Dickerson, R. E. Refinement of netropsin bound to DNA: Bias and feedback in electron density map interpretation. Biochemistry 34, 4983-4993.
    • Biochemistry , vol.34 , pp. 4983-4993
    • Goodsell, D.S.1    Kopka, M.L.2    Dickerson, R.E.3
  • 24
    • 0020394591 scopus 로고    scopus 로고
    • Patel, D. J. Antibiotic-DNA interactions: Intermolecular nuclear Overhauser effects in the netropsin-d(C-G-C-G-A-A-T-T-C-G-C-G) complex in solution. Proc. Natl. Acad. Sci. U.S.A. 1982, 79, 6424-6428.
    • Patel, D. J. Antibiotic-DNA interactions: Intermolecular nuclear Overhauser effects in the netropsin-d(C-G-C-G-A-A-T-T-C-G-C-G) complex in solution. Proc. Natl. Acad. Sci. U.S.A. 1982, 79, 6424-6428.
  • 25
    • 33746312998 scopus 로고    scopus 로고
    • Binding of netropsin and 4, 6-diamidino-2-phenylindole to an A2T2 DNA hairpin: A comparison of biophysical techniques
    • Freyer, M. W.; Buscaglia, R.; Nguyen, B.; Wilson, W. D.; Lewis, E. A. Binding of netropsin and 4, 6-diamidino-2-phenylindole to an A2T2 DNA hairpin: A comparison of biophysical techniques. Anal. Biochem. 2006, 355, 259-266.
    • (2006) Anal. Biochem , vol.355 , pp. 259-266
    • Freyer, M.W.1    Buscaglia, R.2    Nguyen, B.3    Wilson, W.D.4    Lewis, E.A.5
  • 26
    • 34249037167 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of the prodrug DB289 (2, 5-bis[4-(N- methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2, 5-bis(4-guanylphenyl)furan dihydrochloride)
    • Midgley, I.; Fitzpatrick, K.; Taylor, L M.; Houchen, T. L.; Henderson, S. J.; Wright, S. J.; Cybulski, Z. R.; John, B. A.; McBurney, A.; Boykin, D. W.; Trendler, K. L. Pharmacokinetics and metabolism of the prodrug DB289 (2, 5-bis[4-(N- methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2, 5-bis(4-guanylphenyl)furan dihydrochloride). Drug Metab. Dispos. 2007, 35, 955-967.
    • (2007) Drug Metab. Dispos , vol.35 , pp. 955-967
    • Midgley, I.1    Fitzpatrick, K.2    Taylor, L.M.3    Houchen, T.L.4    Henderson, S.J.5    Wright, S.J.6    Cybulski, Z.R.7    John, B.A.8    McBurney, A.9    Boykin, D.W.10    Trendler, K.L.11
  • 28
    • 0032526314 scopus 로고    scopus 로고
    • Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex
    • Guerri, A.; Simpson, I. J.; Neidle, S. Visualisation of extensive water ribbons and networks in a DNA minor-groove drug complex. Nucleic Acids Res. 1998, 26, 2873-2878.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2873-2878
    • Guerri, A.1    Simpson, I.J.2    Neidle, S.3
  • 30
    • 0034606447 scopus 로고    scopus 로고
    • DNA minor groove interactions and the biological activity of 2, 5-bis-[4-(N-alkylamidino)phenyl] furans
    • Simpson, I. J.; Lee, M.; Kumar, A.; Boykin, D. W.; Neidle, S. DNA minor groove interactions and the biological activity of 2, 5-bis-[4-(N-alkylamidino)phenyl] furans. Bioorg. Med. Chem, Lett. 2000, 10, 2593-2597.
    • (2000) Bioorg. Med. Chem, Lett , vol.10 , pp. 2593-2597
    • Simpson, I.J.1    Lee, M.2    Kumar, A.3    Boykin, D.W.4    Neidle, S.5
  • 32
    • 35648989558 scopus 로고    scopus 로고
    • Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove
    • Liu, Y.; Kumar, A.; Boykin, D. W.; Wilson, W. D. Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove. Biophys. Chem. 2007, 131, 1-14.
    • (2007) Biophys. Chem , vol.131 , pp. 1-14
    • Liu, Y.1    Kumar, A.2    Boykin, D.W.3    Wilson, W.D.4
  • 33
    • 0026707681 scopus 로고
    • Crystal structure of a pentamidine- oligonucleotide complex: Implications for DNA-binding properties
    • Edwards, K. J.; Jenkins, T. C; Neidle, S. Crystal structure of a pentamidine- oligonucleotide complex: implications for DNA-binding properties. Biochemistry 1992, 31, 7104-7109.
    • (1992) Biochemistry , vol.31 , pp. 7104-7109
    • Edwards, K.J.1    Jenkins, T.C.2    Neidle, S.3
  • 34
    • 0028670449 scopus 로고
    • Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition
    • Nunn, C. M.; Jenkins, T. C; Neidle, S. Crystal structure of gamma-oxapentamidine complexed with d(CGCGAATTCGCG)2. The effects of drug structural change on DNA minor-groove recognition. Eur. J. Biochem. 1994, 226, 953-961.
    • (1994) Eur. J. Biochem , vol.226 , pp. 953-961
    • Nunn, C.M.1    Jenkins, T.C.2    Neidle, S.3
  • 35
    • 0026578006 scopus 로고
    • Structure and DNA binding activity of analogues of 1, 5-bis(4- amidinophenoxy)pentane (pentamidine)
    • Cory, M.; Tidwell, R. R.; Fairley, T. A. Structure and DNA binding activity of analogues of 1, 5-bis(4- amidinophenoxy)pentane (pentamidine). J. Med. Chem. 1992, 35, 431-438.
    • (1992) J. Med. Chem , vol.35 , pp. 431-438
    • Cory, M.1    Tidwell, R.R.2    Fairley, T.A.3
  • 36
    • 0025272657 scopus 로고
    • Crystal structure of a bereniI-dod ecanucieotide complex: The role of water in sequence-specific ligand binding
    • Brown, D. G.; Sanderson, M. R.; Skelly, J. V.; Jenkins, T. C; Brown, T.; Garman, E.; Stuart, D. I.; Neidle, S. Crystal structure of a bereniI-dod ecanucieotide complex: The role of water in sequence-specific ligand binding, EMBO J. 1990, 9, 1329-1334.
    • (1990) EMBO J , vol.9 , pp. 1329-1334
    • Brown, D.G.1    Sanderson, M.R.2    Skelly, J.V.3    Jenkins, T.C.4    Brown, T.5    Garman, E.6    Stuart, D.I.7    Neidle, S.8
  • 37
    • 0026654185 scopus 로고
    • Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features
    • Brown, D. G.; Sanderson, M. R.; Garman, E.; Neidle, S. Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features. J. Mol. Biol. 1992, 226, 481-490.
    • (1992) J. Mol. Biol , vol.226 , pp. 481-490
    • Brown, D.G.1    Sanderson, M.R.2    Garman, E.3    Neidle, S.4
  • 38
    • 0037145991 scopus 로고    scopus 로고
    • Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove
    • Nguyen, B.; Lee, M. P.; Hamelberg, D.; Joubert, A.; Bailly, C; Brun, R.; Neidle, S.; Wilson, W. D. Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J. Am. Chem. Soc. 2002, 124, 13680-13681.
    • (2002) J. Am. Chem. Soc , vol.124 , pp. 13680-13681
    • Nguyen, B.1    Lee, M.P.2    Hamelberg, D.3    Joubert, A.4    Bailly, C.5    Brun, R.6    Neidle, S.7    Wilson, W.D.8
  • 39
    • 0347720652 scopus 로고    scopus 로고
    • DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives
    • Tanious, F. A.; Hamelberg, D.; Bailly, C; Czarny, A.; Boykin, D. W.; Wilson, W. D. DNA sequence dependent monomer-dimer binding modulation of asymmetric benzimidazole derivatives. J. Am. Chem. Soc. 2004, 126, 143-153.
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 143-153
    • Tanious, F.A.1    Hamelberg, D.2    Bailly, C.3    Czarny, A.4    Boykin, D.W.5    Wilson, W.D.6
  • 40
    • 0020692923 scopus 로고
    • Ordered water structure around a B-DNA dodecamer. A quantitative study
    • Kopka, M. L; Fratini, A. V.; Drew, H. R.; Dickerson, R. E. Ordered water structure around a B-DNA dodecamer. A quantitative study. J. Mol. Biol. 1983, 163, 129-146.
    • (1983) J. Mol. Biol , vol.163 , pp. 129-146
    • Kopka, M.L.1    Fratini, A.V.2    Drew, H.R.3    Dickerson, R.E.4
  • 41
    • 0030797734 scopus 로고    scopus 로고
    • Structure of a bis-amidinium derivative of Hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: The role of hydrogen bonding in minor groove drug-DNA recognition
    • Clark, G. R.; Boykin, D. W.; Czarny, A.; Neidle, S. Structure of a bis-amidinium derivative of Hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: The role of hydrogen bonding in minor groove drug-DNA recognition. Nucleic Acids Res. 1997, 25, 1510-1515.
    • (1997) Nucleic Acids Res , vol.25 , pp. 1510-1515
    • Clark, G.R.1    Boykin, D.W.2    Czarny, A.3    Neidle, S.4
  • 42
    • 27744567336 scopus 로고    scopus 로고
    • Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure
    • Campbell, N. H.; Evans, D. A.; Lee, M. P.; Parkinson, G. N.; Neidle, S. Targeting the DNA minor groove with fused ring dicationic compounds: Comparison of in silico screening and a high-resolution crystal structure. Bioorg. Med. Chem. Lett. 2006, 16, 15-19.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 15-19
    • Campbell, N.H.1    Evans, D.A.2    Lee, M.P.3    Parkinson, G.N.4    Neidle, S.5
  • 44
    • 0034602772 scopus 로고    scopus 로고
    • Specific molecular recognition of mixed nucleic acid sequences: An aromatic dication that binds in the DNA minor groove as a dimer
    • Wang, L; Bailly, C; Kumar, A.; Ding, D.; Bajic, M.; Boykin, D. W.; Wilson, W. D. Specific molecular recognition of mixed nucleic acid sequences: An aromatic dication that binds in the DNA minor groove as a dimer. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 12-16.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 12-16
    • Wang, L.1    Bailly, C.2    Kumar, A.3    Ding, D.4    Bajic, M.5    Boykin, D.W.6    Wilson, W.D.7
  • 45
  • 46
    • 34247880252 scopus 로고    scopus 로고
    • Induced fit conformational changes of a "reversed amidine" heterocycle: Optimized interactions in a DNA minor groove complex
    • Munde, M.; Lee, M.; Neidle, S.; Arafa, R.; Boykin, D. W.; Liu, Y.; Bailly, C; Wilson, W. D. Induced fit conformational changes of a "reversed amidine" heterocycle: Optimized interactions in a DNA minor groove complex. J. Am. Chem. Soc. 2007, 129, 5688-5698.
    • (2007) J. Am. Chem. Soc , vol.129 , pp. 5688-5698
    • Munde, M.1    Lee, M.2    Neidle, S.3    Arafa, R.4    Boykin, D.W.5    Liu, Y.6    Bailly, C.7    Wilson, W.D.8
  • 49
    • 33645768556 scopus 로고    scopus 로고
    • Binding-linked protonation of a DNA minor- groove agent
    • Nguyen, B.; Stanek, J.; Wilson, W. D. Binding-linked protonation of a DNA minor- groove agent. Biophys. J. 2006, 90, 1319-1328.
    • (2006) Biophys. J , vol.90 , pp. 1319-1328
    • Nguyen, B.1    Stanek, J.2    Wilson, W.D.3
  • 50
    • 27744550401 scopus 로고    scopus 로고
    • Out-of-shape DNA minor groove binders: Induced fit interactions of heterocyclic dications with the DNA minor groove
    • Miao, Y.; Lee, M. P.; Parkinson, G. N.; Batista-Parra, A.; Ismail, M. A.; Neidle, S.; Boykin, D. W.; Wilson, W. D. Out-of-shape DNA minor groove binders: Induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry 2005, 44, 14701-14708.
    • (2005) Biochemistry , vol.44 , pp. 14701-14708
    • Miao, Y.1    Lee, M.P.2    Parkinson, G.N.3    Batista-Parra, A.4    Ismail, M.A.5    Neidle, S.6    Boykin, D.W.7    Wilson, W.D.8
  • 51
    • 0037130293 scopus 로고    scopus 로고
    • Targeting critical regions in genomic DNA with AT-specific anticancer drugs
    • Woynarowski, J. M. Targeting critical regions in genomic DNA with AT-specific anticancer drugs. Biochim. Biophys. Acta 2002, 1587, 300-308.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 300-308
    • Woynarowski, J.M.1
  • 52
    • 35948967317 scopus 로고    scopus 로고
    • Munde, M.; Ismail, M. A.; Arafa, R.; Peixoto, P.; Collar, C. J.; Liu, Y.; Hu, L; David- Cordonnier, M. H.; Lansiaux, A.; Bailly, C; Boykin, D. W.; Wilson, W. D. Design of DNA minor groove binding diamidines that recognize GC base pair sequences: A dimeric-hinge interaction motif. J. Am. Chem. Soc. 2007, 129, 13732-13743.
    • Munde, M.; Ismail, M. A.; Arafa, R.; Peixoto, P.; Collar, C. J.; Liu, Y.; Hu, L; David- Cordonnier, M. H.; Lansiaux, A.; Bailly, C; Boykin, D. W.; Wilson, W. D. Design of DNA minor groove binding diamidines that recognize GC base pair sequences: A dimeric-hinge interaction motif. J. Am. Chem. Soc. 2007, 129, 13732-13743.
  • 53
    • 0032732283 scopus 로고    scopus 로고
    • Adenosine transporters in bloodstream forms of Trypanosoma brucei brucet Substrate recognition motifs and affinity for trypanocidal drugs
    • De Koning, H. P.; Jarvis, S. M. Adenosine transporters in bloodstream forms of Trypanosoma brucei brucet Substrate recognition motifs and affinity for trypanocidal drugs. Mol. Pharmacol. 1999, 56, 1162-1170.
    • (1999) Mol. Pharmacol , vol.56 , pp. 1162-1170
    • De Koning, H.P.1    Jarvis, S.M.2
  • 54
    • 0033119815 scopus 로고    scopus 로고
    • The biochemical basis of arsenical-diamidine cross- resistance in African trypanosomes
    • Barrett, M, P.; Fairlamb, A. H. The biochemical basis of arsenical-diamidine cross- resistance in African trypanosomes. Parasitol. Today 1999, 15, 136-140.
    • (1999) Parasitol. Today , vol.15 , pp. 136-140
    • Barrett, M.P.1    Fairlamb, A.H.2
  • 55
    • 17444433224 scopus 로고    scopus 로고
    • Drug transport and drug resistance in African trypanosomes
    • Maser, P.; Luscher, A.; Kaminsky, R. Drug transport and drug resistance in African trypanosomes. Drug Resist. Updates 2003, 6, 281-290.
    • (2003) Drug Resist. Updates , vol.6 , pp. 281-290
    • Maser, P.1    Luscher, A.2    Kaminsky, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.