Adoptive immunotherapy: Good habits instilled at youth have long-term benefits

Immunologic Research

Volumn 42, Issue 1-3, 2008, Pages 182-196

  Paulos, Chrystal M ^a   Suhoski, Megan M ^a   Plesa, Gabriela ^a   Jiang, Tianying ^a   Basu, Samik ^a   Golovina, Tatiana N ^a   Jiang, Shuguang ^a   Aqui, Nicole A ^a,b   Powell Jr , Daniel J ^a   Levine, Bruce L ^a,b   Carroll, Richard G ^a   Riley, James L ^a,b   June, Carl H ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adoptive cell transfer therapy; Artificial antigen presenting cells; Central Memory T cells; Regulatory T cells; Th17 Cells

Indexed keywords

CD27 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYCLOPHOSPHAMIDE; FLUDARABINE; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; L SELECTIN; LENTIVIRUS VECTOR; RAPAMYCIN; TUMOR ANTIGEN;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; ALLOGENIC BONE MARROW TRANSPLANTATION; ANTIGEN PRESENTING CELL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CANCER IMMUNOTHERAPY; CELL EXPANSION; CELL STIMULATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; DOWN REGULATION; ENGRAFTMENT; EX VIVO STUDY; GENETIC TRANSFECTION; GOOD MANUFACTURING PRACTICE; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNOSURVEILLANCE; IN VITRO STUDY; IN VIVO STUDY; INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOMA; MELANOMA; MEMORY T LYMPHOCYTE; MULTIPLE MYELOMA; NEUROBLASTOMA; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY; UMBILICAL CORD BLOOD; ANIMAL; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METHODOLOGY; NEOPLASM; PATHOLOGY; TRANSPLANTATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; K562 CELLS; LYMPHOCYTE ACTIVATION; NEOPLASMS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 61849091496     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-008-8070-9     Document Type: Review

References (79)

1. CH June 2007 Adoptive T cell therapy for cancer in the clinic J Clin Invest 117 1466 17549249 10.1172/JCI32446 1:CAS:528:DC%2BD2sXmsVWktb8%3D (Pubitemid 46871329)
2. CH June 2007 Principles of adoptive T cell cancer therapy J Clin Invest 117 1204 17476350 10.1172/JCI31446 1:CAS:528:DC%2BD2sXlt1Omt74%3D (Pubitemid 46718405)
3. SA Rosenberg NP Restifo JC Yang RA Morgan ME Dudley 2008 Adoptive cell transfer: a clinical path to effective cancer immunotherapy Nat Rev Cancer 8 299 18354418 10.1038/nrc2355 1:CAS:528:DC%2BD1cXjsFCmsLg%3D
4. JN Blattman PD Greenberg 2004 Cancer immunotherapy: a treatment for the masses Science 305 200 15247469 10.1126/science.1100369 1:CAS:528: DC%2BD2cXlsV2gtrw%3D (Pubitemid 38886725)
5. AM Leen CM Rooney AE Foster 2007 Improving T cell therapy for cancer Annu Rev Immunol 25 243 17129181 10.1146/annurev.immunol.25.022106.141527 1:CAS:528:DC%2BD2sXltlagu7Y%3D (Pubitemid 46697909)
6. RH Collins Jr O Shpilberg WR Drobyski DL Porter S Giralt R Champlin SA Goodman SN Wolff W Hu C Verfaillie A List W Dalton N Ognoskie A Chetrit JH Antin J Nemunaitis 1997 Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation J Clin Oncol 15 433 9053463
7. K Kono A Takahashi F Ichihara H Amemiya H Iizuka H Fujii T Sekikawa Y Matsumoto 2002 Prognostic significance of adoptive immunotherapy with tumor-associated lymphocytes in patients with advanced gastric cancer: a randomized trial Clin Cancer Res 8 1767 12060615 1:CAS:528:DC%2BD38Xlt1CrtLk%3D
8. B Dreno JM Nguyen A Khammari MC Pandolfino MH Tessier S Bercegeay A Cassidanius P Lemarre S Billaudel N Labarriere F Jotereau 2002 Randomized trial of adoptive transfer of melanoma tumor-infiltrating lymphocytes as adjuvant therapy for stage III melanoma Cancer Immunol Immunother 51 539 12384805 10.1007/s00262-002-0315-1 1:CAS:528:DC%2BD38XnvV2ltrY%3D (Pubitemid 35232003)
9. SA Rosenberg JR Yannelli JC Yang SL Topalian DJ Schwartzentruber JS Weber DR Parkinson CA Seipp JH Einhorn DE White 1994 Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2 J Natl Cancer Inst 86 1159 8028037 10.1093/jnci/86.15.1159 1:STN:280:ByuA3c%2FmtlE%3D
10. RA Figlin JA Thompson RM Bukowski NJ Vogelzang AC Novick P Lange GD Steinberg AS Belldegrun 1999 Multicenter, randomized, phase III trial of CD8(+) tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma J Clin Oncol 17 2521 10561318 1:STN:280:DC%2BD3c%2FjtVSntQ%3D%3D
11. ME Dudley JR Wunderlich PF Robbins JC Yang P Hwu DJ Schwartzentruber SL Topalian R Sherry NP Restifo AM Hubicki MR Robinson M Raffeld P Duray CA Seipp L Rogers-Freezer KE Morton SA Mavroukakis DE White SA Rosenberg 2002 Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes Science 298 850 12242449 10.1126/science.1076514 1:CAS:528:DC%2BD38XotFSntbY%3D (Pubitemid 35231542)
12. ME Dudley JR Wunderlich JC Yang RM Sherry SL Topalian NP Restifo RE Royal U Kammula DE White SA Mavroukakis LJ Rogers GJ Gracia SA Jones DP Mangiameli MM Pelletier J Gea-Banacloche MR Robinson DM Berman AC Filie A Abati SA Rosenberg 2005 Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma J Clin Oncol 23 2346 15800326 10.1200/JCO.2005.00.240 1:CAS:528:DC%2BD2MXjsVyhsrs%3D (Pubitemid 46218728)
13. GG Laport BL Levine EA Stadtmauer SJ Schuster SM Luger S Grupp, et al. 2003 Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected Blood 102 6 2004 13 12763934 10.1182/blood-2003-01-0095 1:CAS:528:DC%2BD3sXntlKku70%3D (Pubitemid 37122373)
14. AP Rapoport EA Stadtmauer N Aqui A Badros J Cotte L Chrisley E Veloso Z Zheng S Westphal R Mair N Chi B Ratterree MF Pochran S Natt J Hinkle C Sickles A Sohal K Ruehle C Lynch L Zhang DL Porter S Luger C Guo HB Fang W Blackwelder K Hankey D Mann R Edelman C Frasch BL Levine A Cross CH June 2005 Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer Nat Med 11 1230 16227990 10.1038/nm1310 1:CAS:528: DC%2BD2MXhtFOhsLrF (Pubitemid 43093671)
15. L Gattinoni CA Klebanoff DC Palmer C Wrzesinski K Kerstann Z Yu SE Finkelstein MR Theoret SA Rosenberg NP Restifo 2005 Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells J Clin Invest 115 1616 15931392 10.1172/JCI24480 1:CAS:528:DC%2BD2MXkvF2lsro%3D (Pubitemid 40814670)
16. C Berger MC Jensen PM Lansdorp M Gough C Elliott SR Riddell 2008 Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates J Clin Invest 118 294 18060041 10.1172/JCI32103 1:CAS:528:DC%2BD1cXksFOktA%3D%3D
17. BL Levine WB Bernstein M Connors N Craighead T Lindsten CB Thompson CH June 1997 Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells J Immunol 159 5921 9550389 1:CAS:528:DyaK1cXhtFKksg%3D%3D
18. G Guenechea OI Gan C Dorrell JE Dick 2001 Distinct classes of human stem cells that differ in proliferative and self-renewal potential Nat Immunol 2 75 11135582 10.1038/83199 1:CAS:528:DC%2BD3MXjslylsQ%3D%3D (Pubitemid 33704957)
19. BL Levine 2008 T lymphocyte engineering ex vivo for cancer and infectious disease Expert Opin Biol Ther 8 475 18352851 10.1517/14712598.8.4.475 1:CAS:528:DC%2BD1cXjsFWktbk%3D (Pubitemid 351570411)
20. Varela-Rohena A, Carpenito C, Perez EE, Richardson M, Parry RV, Milone M, et al. Genetic engineering of T cells for adoptive immunotherapy. Immunol Res. 2008 [Epub ahead of print].
21. LD Shultz BL Lyons LM Burzenski B Gott X Chen S Chaleff M Kotb SD Gillies M King J Mangada DL Greiner R Handgretinger 2005 Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells J Immunol 174 6477 15879151 1:CAS:528: DC%2BD2MXjvV2mu7k%3D
22. H Zemon 2003 An artificial solution for adoptive immunotherapy Trends Biotechnol 21 418 14512224 10.1016/j.tibtech.2003.08.005 1:CAS:528: DC%2BD3sXnsVKnsr8%3D (Pubitemid 38366059)
23. J Banchereau RM Steinman 1998 Dendritic cells and the control of immunity Nature 392 245 9521319 10.1038/32588 1:CAS:528:DyaK1cXitFWrsr8%3D (Pubitemid 28155090)
24. B Almand JR Resser B Lindman S Nadaf JI Clark ED Kwon DP Carbone DI Gabrilovich 2000 Clinical significance of defective dendritic cell differentiation in cancer Clin Cancer Res 6 1755 10815894 1:STN:280: DC%2BD3cvhtVOhsw%3D%3D
25. NP Weng LD Palmer BL Levine HC Lane CH June RJ Hodes 1997 Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging Immunol Rev 160 43 9476664 10.1111/j.1600-065X.1997.tb01026.x 1:CAS:528:DyaK1cXlvVSmsQ%3D%3D (Pubitemid 28021365)
26. RG Carroll JL Riley BL Levine PJ Blair L St CH June 1998 The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes Semin Immunol 10 195 9653046 10.1006/smim.1998.0131 1:CAS:528:DyaK1cXlt1ektLw%3D (Pubitemid 28347036)
27. BL Levine JD Mosca JL Riley RG Carroll MT Vahey LL Jagodzinski KF Wagner DL Mayers DS Burke OS Weislow L St CH June 1996 Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation Science 272 1939 8658167 10.1126/science.272.5270.1939 1:CAS:528:DyaK28XjvVOisL8%3D
28. BL Levine WB Bernstein NE Aronson K Schlienger J Cotte S Perfetto MJ Humphries S Ratto-Kim DL Birx C Steffens A Landay RG Carroll CH June 2002 Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection Nat Med 8 47 11786906 10.1038/nm0102-47 1:CAS:528:DC%2BD38Xjtlygsg%3D%3D (Pubitemid 34101728)
29. BL Levine LM Humeau J Boyer RR MacGregor T Rebello X Lu GK Binder V Slepushkin F Lemiale JR Mascola FD Bushman B Dropulic CH June 2006 Gene transfer in humans using a conditionally replicating lentiviral vector Proc Natl Acad Sci USA 103 17372 17090675 10.1073/pnas.0608138103 1:CAS:528:DC%2BD28Xht1KqsbjM (Pubitemid 44788976)
30. DL Porter BL Levine N Bunin EA Stadtmauer SM Luger S Goldstein A Loren J Phillips S Nasta A Perl S Schuster D Tsai A Sohal E Veloso S Emerson CH June 2006 A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation Blood 107 1325 16269610 10.1182/blood-2005-08- 3373 1:CAS:528:DC%2BD28XhsFemsLg%3D (Pubitemid 43242365)
31. GG Laport BL Levine EA Stadtmauer SJ Schuster SM Luger S Grupp N Bunin FJ Strobl J Cotte Z Zheng B Gregson P Rivers RH Vonderheide DN Liebowitz DL Porter CH June 2003 Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation Blood 102 2004 12763934 10.1182/blood-2003- 01-0095 1:CAS:528:DC%2BD3sXntlKku70%3D (Pubitemid 37122373)
32. AP Rapoport BL Levine A Badros B Meisenberg K Ruehle A Nandi S Rollins S Natt B Ratterree S Westphal D Mann CH June 2004 Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells Bone Marrow Transplant 33 53 14578928 10.1038/sj.bmt.1704317 1:STN:280:DC%2BD2c%2FgslSqtA%3D%3D (Pubitemid 38159704)
33. MV Maus AK Thomas DG Leonard D Allman K Addya K Schlienger JL Riley CH June 2002 Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB Nat Biotechnol 20 143 11821859 10.1038/nbt0202-143 1:CAS:528:DC%2BD38Xht1eqsLY%3D (Pubitemid 34158029)
34. H Zhang KM Snyder MM Suhoski MV Maus V Kapoor CH June CL Mackall 2007 4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy J Immunol 179 4910 17878391 1:CAS:528:DC%2BD2sXhtVCrurfP
35. MM Suhoski TN Golovina NA Aqui VC Tai A Varela-Rohena MC Milone RG Carroll JL Riley CH June 2007 Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules Mol Ther 15 981 17375070 10.1038/mt.sj.6300134 1:CAS:528:DC%2BD2sXhtVejt7fO (Pubitemid 46621657)
36. RG Carroll CH June 2007 Programming the next generation of dendritic cells Mol Ther 15 846 17446871 10.1038/sj.mt.6300166 1:CAS:528: DC%2BD2sXhtVejt7fE (Pubitemid 46621642)
37. CC Bertozzi CY Chang S Jairaj X Shan J Huang BL Weber CS Chu RG Carroll 2006 Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens In Vitro Cell Dev Biol Anim 42 58 16759149 10.1290/0512084.1 1:CAS:528:DC%2BD28XmtlKgtr8%3D (Pubitemid 44264507)
38. S Ward D Casey MC Labarthe M Whelan A Dalgleish H Pandha S Todryk 2002 Immunotherapeutic potential of whole tumour cells. Cancer Immunol Immunother 51 351 12192534 10.1007/s00262-002-0286-2 (Pubitemid 35002039)
39. JD Gordan RH Vonderheide 2002 Universal tumor antigens as targets for immunotherapy Cytotherapy 4 317 12396831 10.1080/146532402760271091 1:CAS:528:DC%2BD38XosFSks7Y%3D
40. RH Vonderheide CH June 2003 A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy Immunol Res 27 341 12857980 10.1385/IR:27:2-3:341 1:CAS:528:DC%2BD3sXmvFyhsLo%3D (Pubitemid 36995017)
41. LM Nadler JL Schultze 2002 From genomics to cancer vaccines: patient-tailored or universal vaccines? Curr Opin Mol Ther 4 572 12596359 1:CAS:528:DC%2BD3sXhsVGjsr4%3D
42. G Parmiani FA De L Novellino C Castelli 2007 Unique human tumor antigens: immunobiology and use in clinical trials J Immunol 178 1975 17277099 1:CAS:528:DC%2BD2sXht1CgtLc%3D
43. S Kusmartsev DI Gabrilovich 2006 Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer Cancer Metastasis Rev 25 323 16983515 10.1007/s10555-006-9002-6 1:CAS:528:DC%2BD28Xht1yktb3O (Pubitemid 44922353)
44. EE Perez Y Jouvenot J Wang JC Miller KA Kim O Liu, et al. 2008 Establishment of HIV-1 resistance in CD4(+) T cells by genome editing using zinc-finger nucleases Nature Biotechnol. 26 7 808 16 10.1038/nbt1410 1:CAS:528:DC%2BD1cXot1ent7k%3D (Pubitemid 351961450)
45. LA Emens 2003 A new twist on autologous cancer vaccines Cancer Biol Ther 2 161 12750555
46. S Sakaguchi M Ono R Setoguchi H Yagi S Hori Z Fehervari J Shimizu T Takahashi T Nomura 2006 Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease Immunol Rev 212 8 16903903 10.1111/j.0105-2896.2006.00427.x 1:CAS:528:DC%2BD28XpvFegsbY%3D (Pubitemid 44116697)
47. TJ Curiel 2007 Tregs and rethinking cancer immunotherapy J Clin Invest 117 1167 17476346 10.1172/JCI31202 1:CAS:528:DC%2BD2sXlt1Omtrg%3D (Pubitemid 46718401)
48. MJ Turk JA Guevara-Patino GA Rizzuto ME Engelhorn S Sakaguchi AN Houghton 2004 Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells J Exp Med 200 771 15381730 10.1084/jem.20041130 1:CAS:528:DC%2BD2cXnvFeis74%3D (Pubitemid 39299463)
49. PA Antony CA Piccirillo A Akpinarli SE Finkelstein PJ Speiss DR Surman DC Palmer CC Chan CA Klebanoff WW Overwijk SA Rosenberg NP Restifo 2005 CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells J Immunol 174 2591 15728465 1:CAS:528:DC%2BD2MXhsFeru7Y%3D
50. CH June BR Blazar 2006 Clinical application of expanded CD4+25+ cells Semin Immunol 18 78 16458015 10.1016/j.smim.2006.01.006 1:CAS:528: DC%2BD28Xhslymu7k%3D (Pubitemid 43248735)
51. JA Bluestone Q Tang 2005 How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol 17 638 16209918 10.1016/j.coi.2005.09.002 1:CAS:528:DC%2BD2MXhtFKhsb3F (Pubitemid 41506909)
52. Golovina TN, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, et al. CD28 costimulation is essential for human T regulatory cell expansion and function. J Immunol. 2008 (In Press).
53. M Battaglia A Stabilini MG Roncarolo 2005 Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells Blood 105 4743 15746082 10.1182/blood-2004- 10-3932 1:CAS:528:DC%2BD2MXlsVWju7s%3D (Pubitemid 40807298)
54. D Valmori V Tosello NE Souleimanian E Godefroy L Scotto Y Wang M Ayyoub 2006 Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells J Immunol 177 944 16818749 1:CAS:528:DC%2BD28XmsVart78%3D
55. CJ Fox PS Hammerman CB Thompson 2005 The Pim kinases control rapamycin-resistant T cell survival and activation J Exp Med 201 259 15642745 10.1084/jem.20042020 1:CAS:528:DC%2BD2MXot12muw%3D%3D (Pubitemid 40189435)
56. S Basu T Golovina T Mikheeva CH June JL Riley 2008 Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin J Immunol 180 5794 18424697 1:CAS:528:DC%2BD1cXkvVequ7Y%3D
57. MV Maus B Kovacs WW Kwok GT Nepom K Schlienger JL Riley D Allman TH Finkel CH June 2004 Extensive replicative capacity of human central memory T cells J Immunol 172 6675 15153483 1:CAS:528:DC%2BD2cXktFSktr4%3D
58. A Laurence JJ O'Shea 2007 T (H)-17 differentiation: of mice and men Nat Immunol 8 958 10.1038/ni0907-903 (Pubitemid 47300001)
59. G Trinchieri 1993 Interleukin-12 and its role in the generation of TH1 cells Immunol Today 14 335 8103338 10.1016/0167-5699(93)90230-I 1:CAS:528:DyaK3sXlsFOks7c%3D (Pubitemid 23198164)
60. G Trinchieri 1994 Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes Blood 84 4008 7994020 1:CAS:528:DyaK2MXislShsbg%3D
61. SL Constant K Bottomly 1997 Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches Annu Rev Immunol 15 297 9143690 10.1146/annurev.immunol.15.1.297 1:CAS:528:DyaK2sXisVCnuro%3D (Pubitemid 27169283)
62. CP Broeren GS Gray BM Carreno CH June 2000 Costimulation light: activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile J Immunol 165 6908 11120816 1:CAS:528:DC%2BD3cXovFyhu7w%3D
63. P Muranski A Boni PA Antony L Cassard KR Irvine A Kaiser, et al. 2008 Tumor-specific Th17-polarized cells eradicate large established melanoma Blood. 112 2 362 73 18354038 10.1182/blood-2007-11-120998 1:CAS:528: DC%2BD1cXos1Cit70%3D
64. L Yang DE Anderson C Baecher-Allan WD Hastings E Bettelli M Oukka, et al. 2008 IL-21 and TGF-beta are required for differentiation of human T(H)17 cells Nature. 454 7202 350 2 18469800 10.1038/nature07021 1:CAS:528: DC%2BD1cXosFCqs7o%3D
65. T Korn E Bettelli W Gao A Awasthi A Jager TB Strom M Oukka VK Kuchroo 2007 IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Nature 448 484 17581588 10.1038/nature05970 1:CAS:528:DC%2BD2sXotFajurw%3D (Pubitemid 47123515)
66. E Bettelli M Oukka VK Kuchroo 2007 T(H)-17 cells in the circle of immunity and autoimmunity Nat Immunol 8 345 17375096 10.1038/ni0407-345 1:CAS:528:DC%2BD2sXjt1Sqs7c%3D (Pubitemid 46745409)
67. E Bettelli Y Carrier W Gao T Korn TB Strom M Oukka HL Weiner VK Kuchroo 2006 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells Nature 441 235 16648838 10.1038/nature04753 1:CAS:528:DC%2BD28XksVGns7g%3D
68. CT Weaver LE Harrington PR Mangan M Gavrieli KM Murphy 2006 Th17: an effector CD4 T cell lineage with regulatory T cell ties Immunity 24 677 16782025 10.1016/j.immuni.2006.06.002 1:CAS:528:DC%2BD28Xms1Crt7s%3D (Pubitemid 43867371)
69. LE Harrington PR Mangan CT Weaver 2006 Expanding the effector CD4 T-cell repertoire: the Th17 lineage Curr Opin Immunol 18 349 16616472 10.1016/j.coi.2006.03.017 1:CAS:528:DC%2BD28XktVGhsbg%3D
70. EV Acosta-Rodriguez G Napolitani A Lanzavecchia F Sallusto 2007 Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells Nat Immunol 8 942 17676045 10.1038/ni1496 1:CAS:528:DC%2BD2sXptlSku7w%3D (Pubitemid 47300008)
71. N Manel D Unutmaz DR Littman 2008 The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat Nat Immunol 9 641 18454151 10.1038/ni.1610 1:CAS:528:DC%2BD1cXmtVWqurg%3D (Pubitemid 351714729)
72. J Du C Huang B Zhou SF Ziegler 2008 Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3 J Immunol 180 4785 18354202 1:CAS:528:DC%2BD1cXjsVKqtrg%3D
73. MJ McGeachy DJ Cua 2008 Th17 cell differentiation: the long and winding road Immunity. 28 445 18400187 10.1016/j.immuni.2008.03.001 1:CAS:528: DC%2BD1cXkvV2itrk%3D
74. J Kurtzberg M Laughlin ML Graham C Smith JF Olson EC Halperin G Ciocci C Carrier CE Stevens P Rubinstein 1996 Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients N Engl J Med 335 157 8657213 10.1056/NEJM199607183350303 1:STN:280:BymB1c3ks1w%3D (Pubitemid 26249452)
75. Kurtzberg J. State of the art in umbilical cord transplantation. Oncology (Williston. Park). 1996;10:1086, 1091.
76. CE Stevens J Gladstone PE Taylor A Scaradavou AR Migliaccio J Visser NL Dobrila C Carrier M Cabbad P Wernet J Kurtzberg P Rubinstein 2002 Placental/umbilical cord blood for unrelated-donor bone marrow reconstitution: relevance of nucleated red blood cells Blood 100 2662 12239183 10.1182/blood.V100.7.2662 1:CAS:528:DC%2BD38XnvVGit7s%3D
77. WR Godfrey DJ Spoden YG Ge SR Baker B Liu BL Levine CH June BR Blazar SB Porter 2005 Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function Blood 105 750 15374887 10.1182/blood-2004-06-2467 1:CAS:528:DC%2BD2MXltlGntA%3D%3D (Pubitemid 40070762)
78. X Huang H Guo J Kang S Choi TC Zhou S Tammana CJ Lees ZZ Li M Milone BL Levine J Tolar CH June MR Scott JE Wagner BR Blazar X Zhou 2008 Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies Mol Ther 16 580 18227839 10.1038/sj.mt.6300404 1:CAS:528:DC%2BD1cXisFOrsrs%3D (Pubitemid 351314999)
79. EO Hexner GA net-Desnoyers Y Zhang DM Frank JL Riley BL Levine DL Porter CH June SG Emerson 2007 Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation Biol Blood Marrow Transplant 13 1135 17889349 10.1016/j.bbmt.2007.06.010 (Pubitemid 47413014)