Umbilical Cord Blood Xenografts in Immunodeficient Mice Reveal That T Cells Enhance Hematopoietic Engraftment Beyond Overcoming Immune Barriers by Stimulating Stem Cell Differentiation

Biology of Blood and Marrow Transplantation

Volumn 13, Issue 10, 2007, Pages 1135-1144

  Hexner, Elizabeth O ^a   Danet Desnoyers, Gwenn aël H ^a   Zhang, Yi ^a   Frank, Dale M ^a   Riley, James L ^a   Levine, Bruce L ^a,b   Porter, David L ^a   June, Carl H ^a,b   Emerson, Stephen G ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Engraftment; T cells; Umbilical cord blood

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CELL STIMULATION; COHORT ANALYSIS; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DILUTION; ENGRAFTMENT; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; LYMPHOCYTE FUNCTION; MONONUCLEAR CELL; MOUSE; NONHUMAN; SCID MOUSE; T LYMPHOCYTE ACTIVATION; XENOGRAFT;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; CELL DIFFERENTIATION; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; GRAFT SURVIVAL; HUMANS; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION, HETEROLOGOUS;

EID: 34548670967     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2007.06.010     Document Type: Article

References (44)

1. Szabolcs P., Park K.D., Reese M., et al. Coexistent naive phenotype and higher cycling rate of cord blood T cells as compared to adult peripheral blood. Exp Hematol 31 (2003) 708-714
2. Wagner J.E., Kernan N.A., Steinbuch M., et al. Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 346 (1995) 214-219
3. Gluckman E., Rocha V., Arcese W., et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol 32 (2004) 397-407
4. Laughlin M.J., Eapen M., Rubinstein P., et al. Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351 (2004) 2265-2275
5. Rocha V., Labopin M., Sanz G., et al. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351 (2004) 2276-2285
6. Christianson S.W., Greiner D.L., Hesselton R.A., et al. Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice. J Immunol 158 (1997) 3578-3586
7. McCune J.M., Namikawa R., Kaneshima H., et al. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241 (1988) 1632-1639
8. Larochelle A., Vormoor J., Hanenberg H., et al. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med 2 (1996) 1329-1337
9. Shultz L.D., Schweitzer P.A., Christianson S.W., et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol 154 (1995) 180-191
10. Kollet O., Peled A., Byk T., et al. Beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood 95 (2000) 3102-3105
11. McKenzie J.L., Gan O.I., Doedens M., and Dick J.E. Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cells. Blood 106 (2005) 1259-1261
12. Shultz L.D., Lyons B.L., Burzenski L.M., et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174 (2005) 6477-6489
13. Levine B.L., Bernstein W.B., Connors M., et al. Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. J Immunol 159 (1997) 5921-5930
14. Porter D.L., Levine B.L., Bunin N., et al. A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation. Blood 107 (2006) 1325-1331
15. Rapoport A.P., Stadtmauer E.A., Aqui N., et al. Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nat Med 11 (2005) 1230-1237
16. Laport G.G., Levine B.L., Stadtmauer E.A., et al. Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation. Blood 102 (2003) 2004-2013
17. Wang J.C., Doedens M., and Dick J.E. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 89 (1997) 3919-3924
18. Porter E.H., and Berry R.J. The efficient design of transplantable tumour assays. Br J Cancer 17 (1963) 583-595
19. Danet G.H., Pan Y., Luongo J.L., et al. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 112 (2003) 126-135
20. Thompson C.B., Lindsten T., Ledbetter J.A., et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci USA 86 (1989) 1333-1337
21. Guba S.C., Stella G., Turka L.A., et al. Regulation of interleukin 3 gene induction in normal human T cells. J Clin Invest 84 (1989) 1701-1706
22. Donahue R.E., Wang E.A., Stone D.K., et al. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF. Nature 321 (1986) 872-875
23. Goodman J.W., Burch K.T., and Basford N.L. Graft-vs.-host activity of thymocytes: relationship to the role of thymocytes in hemopoiesis. Blood 39 (1972) 850-861
24. Goodman J.W., and Shinpock S.G. Influence of thymus cells on erythropoiesis of parental marrow in irradiated hybrid mice. Proc Soc Exp Biol Med 129 (1968) 417-422
25. Nathan D.G., Chess L., Hillman D.G., et al. Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro. J Exp Med 147 (1978) 324-339
26. Ho V.T., and Soiffer R.J. The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood 98 (2001) 3192-3204
27. Martin P.J., Hansen J.A., Torok-Storb B., et al. Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants. Bone Marrow Transplant 3 (1988) 445-456
28. Storb R., Doney K.C., Thomas E.D., et al. Marrow transplantation with or without donor buffy coat cells for 65 transfused aplastic anemia patients. Blood 59 (1982) 236-246
29. Kim D.W., Chung Y.J., Kim T.G., et al. Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation. Blood 103 (2004) 1941-1948
30. Barker J.N., Weisdorf D.J., DeFor T.E., et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood 105 (2005) 1343-1347
31. Bonnet D., Bhatia M., Wang J.C., et al. Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice. Bone Marrow Transplant 23 (1999) 203-209
32. Adams G.B., Chabner K.T., Foxall R.B., et al. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 101 (2003) 45-51
33. Jiang Z., Adams G.B., Hanash A.M., et al. The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation. Biol Blood Marrow Transplant 8 (2002) 588-596
34. Martin P.J., Akatsuka Y., Hahne M., and Sale G. Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection. Blood 92 (1998) 2177-2181
35. Gandy K.L., Domen J., Aguila H., and Weissman I.L. CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11 (1999) 579-590
36. Kaufman C.L., Colson Y.L., Wren S.M., et al. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84 (1994) 2436-2446
37. Fugier-Vivier I.J., Rezzoug F., Huang Y., et al. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J Exp Med 201 (2005) 373-383
38. Theilgaard-Monch K., Raaschou-Jensen K., Palm H., et al. Flow cytometric assessment of lymphocyte subsets, lymphoid progenitors, and hematopoietic stem cells in allogeneic stem cell grafts. Bone Marrow Transplant 28 (2001) 1073-1082
39. Monteiro J.P., Benjamin A., Costa E.S., et al. Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells. Blood 105 (2005) 1484-1491
40. Martin P.J., Rowley S.D., Anasetti C., et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood 94 (1999) 2192-2199
41. Nissen-Druey C., Tichelli A., and Meyer-Monard S. Human hematopoietic colonies in health and disease. Acta Haematol 113 (2005) 5-96
42. Tan W., Huang W., Zhong Q., and Schwarzenberger P. IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J Immunol 176 (2006) 6186-6193
43. Schwarzenberger P., Huang W., Ye P., et al. Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J Immunol 164 (2000) 4783-4789
44. Schwarzenberger P., La Russa V., Miller A., et al. IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. J Immunol 161 (1998) 6383-6389