Green tea (-)-epigallocatechin-3-gallate down-regulates VASP expression and inhibits breast cancer cell migration and invasion by attenuating Rac1 activity

European Journal of Pharmacology

Volumn 606, Issue 1-3, 2009, Pages 172-179

  Zhang, Yimin ^b,c   Han, Guoge ^b,c   Fan, Biao ^a,b   Zhou, Yunfeng ^a   Zhou, Xuan ^b   Wei, Lei ^b   Zhang, Jingwei ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b Department of Pathology and Pathophysiology   (China)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

( ) Epigallocatechin 3 gallate (EGCG); Breast cancer cell; Invasion; Migration; Rac1; Vasodilator stimulated phosphoprotein (VASP)

Indexed keywords

DOCETAXEL; EPIDERMAL GROWTH FACTOR; EPIGALLOCATECHIN GALLATE; RAC1 PROTEIN; SMALL INTERFERING RNA; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; MIGRATION INHIBITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TEA; WESTERN BLOTTING; WOUND HEALING;

ANIMALS; BREAST NEOPLASMS; CATECHIN; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICROFILAMENT PROTEINS; NEUROPEPTIDES; PHOSPHOPROTEINS; RAC GTP-BINDING PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; TEA; TIME FACTORS; UP-REGULATION;

EID: 61449185347     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.033     Document Type: Article

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