Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells

Cancer Research

Volumn 62, Issue 3, 2002, Pages 652-655

  Pianetti, Stefania ^a   Guo, Shangqin ^a   Kavanagh, Kathryn T ^a   Sonenshein, Gail E ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIGALLOCATECHIN GALLATE; GREEN TEA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYPHENOL DERIVATIVE; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG EFFECT; GENE OVEREXPRESSION; MOUSE; NONHUMAN; ONCOGENE NEU; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TEA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTICARCINOGENIC AGENTS; BEVERAGES; CATECHIN; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GROWTH INHIBITORS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ERBB-2; SIGNAL TRANSDUCTION;

EID: 0036468923     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Recent developments in breast cancer therapy
2. Expression of the neu proto-oncogene in the mammary epithelium of transgenic mice induces metastatic disease
3. ERBB-2 overexpression confers PI 3′ kinase-dependent invasion capacity on human mammary epithelial cells
4. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
5. Her-2/neu overexpression induces NF-ΚB via a PI3-kinase/Akt pathway without IKK activation that can be inhibited by the tumor suppressor PTEN
6. Inhibition of carcinogenesis by tea: The evidence from experimental studies
7. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture
8. Protein-tyrosine phosphatase ε
9. The epidermal growth factor receptor couples transforming growth factor-α, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4
10. Involvement of small GTPases in Mycoplasma fermentans membrane lipoproteins-mediated activation of macrophages
11. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
12. Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate
13. Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7, 12-dimethylbenz(a)anthracene
14. Chemoprevention of mammary preneoplasia. In vitro effects of a green tea polyphenol
15. Suppression of extracellular signals and cell proliferation through EGF receptor binding by (-)-epigallocatechin gallate in human A431 epidermoid carcinoma cells
16. Effects of food factors on signal transduction pathways
17. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-κB activation by inhibiting IΚB kinase activity in the intestinal epithelial cell line JEC-6
18. Protective effects of (-)-epigallocatechin-3-gallate on UVA- and UVB-induced skin damage
19. Green tea polyphenols block endotoxin-induced tumor necrosis factor production and lethality in a murine model
20. Roles of IKK kinases and protein kinase CK2 in activation of nuclear factor-κB in breast cancer