Single nucleotide changes in the human Iγ1 and Iγ4 promoters underlie different transcriptional responses to CD401

Journal of Immunology

Volumn 182, Issue 4, 2009, Pages 2185-2193

  Sinquett, Frank L ^a   Dryer, Rebecca L ^a   Marcelli, Valentina ^a   Batheja, Ameesha ^a   Covey, Lori R ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; CD40 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; IMMUNOGLOBULIN G;

ARTICLE; B LYMPHOCYTE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; DNA MICROARRAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOGLOBULIN GENE; IMMUNOLOGY; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

ANTIGENS, CD40; B-LYMPHOCYTES; DNA MUTATIONAL ANALYSIS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN G; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 61449148444     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802700     Document Type: Article

References (71)

1. Dray, S. 1960. Three γ-globulins in normal human serum revealed by monkey precipitins. Science 132: 1313-1314.
2. Grey, H. M., and H. G. Kunkel. 1964. H chain subgroups of myeloma proteins and normal 7S γ-globulin. J. Exp. Med. 120: 253-266.
3. Terry, W. D., and J. L. Fahey. 1964. Subclasses of human γ-2-globulin based on differences in the heavy polypeptide chains. Science 146: 400-401.
4. French, M. A., and G. Harrison. 1984. Serum IgG subclass concentrations in healthy adults: a study using monoclonal antisera. Clin. Exp. Immunol. 56: 473-475.
5. Jefferis, R., and D. S. Kumararatne. 1990. Selective IgG subclass deficiency: quantification and clinical relevance. Clin. Exp. Immunol. 81: 357-367.
6. Ravetch, J. V., and S. Bolland. 2001. IgG Fc receptors. Annu. Rev. Immunol. 19: 275-290.
7. van de Winkel, J. G., and P. J. Capel. 1993. Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol. Today 14: 215-221.
8. Woof, J. M., and D. R. Burton. 2004. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat. Rev. Immunol. 4: 89-99.
9. Aalberse, R. C., P. H. Dieges, V. Knul-Bretlova, P. Vooren, M. Aalbers, and J. van Leeuwen. 1983. IgG4 as a blocking antibody. Clin. Rev. Allergy 1: 289-302.
10. Aalberse, R. C., and J. Schuurman. 2002. IgG4 breaking the rules. Immunology 105: 9-19.
11. Devey, M. E., K. M. Bleasdale, M. A. French, and G. Harrison. 1985. The IgG4 subclass is associated with a low affinity antibody response to tetanus toxoid in man. Immunology 55: 565-567.
12. van der Zee, J. S., P. van Swieten, and R. C. Aalberse. 1986. Serologic aspects of IgG4 antibodies: II. IgG4 antibodies form small, nonprecipitating immune complexes due to functional monovalency. J. Immunol. 137: 3566-3571.
13. van der Zee, J. S., P. van Swieten, and R. C. Aalberse. 1986. Inhibition of complement activation by IgG4 antibodies. Clin. Exp. Immunol. 64: 415-422.
14. Manis, J. P., M. Tian, and F. W. Alt. 2002. Mechanism and control of class-switch recombination. Trends Immunol. 23: 31-39.
15. Snapper, C. M., K. B. Marcu, and P. Zelazowdski. 1997. The immunoglobulin class switch: beyond "accessibility." Immunity 6: 217-223.
16. Stavnezer, J. 1996. Antibody class switching. Adv. Immunol. 61: 79-146.
17. Chaudhuri, J., and F. W. Alt. 2004. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat. Rev. Immunol. 4: 541-552.
18. Zhang, J., A. Bottaro, S. Li, V. Stewart, and F. W. Alt. 1993. A selective defect in IgG2b switching as a result of targeted mutation of the Iγ2b promoter and exon. EMBO J. 12: 3529-3537.
19. Bottaro, A., R. Lansford, L Xu, J. Zhang, P. Rothman, and F. W. Alt. 1994. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 13: 665-674.
20. Lorenz, M., S. Jung, and A. Radbruch. 1995. Switch transcripts in immunoglobulin class switching. Science 267: 1825-1828.
21. Hein, K., M. G. Lorenz, G. Siebenkotten, K. Petry, R. Christine, and A. Radbruch. 1998. Processing of switch transcripts is required for targeting of antibody class switch recombination. J. Exp. Med. 188: 2369-2374.
22. Stavnezer, J., J. E. Guikema, and C. E. Schrader. 2008. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26: 261-292.
23. Iciek, L. A., S. A. Delphin, and J. Stavnezer. 1997. CD40 cross-linking induces Igε germline transcripts in B cells via activation of NF-κB. J. Immunol. 158: 4769-4779.
24. Messner, B., A. M. Stutz, B. Albrecht, S. Peiritsch, and M. Woisetschlager. 1997. Cooperation of binding sites for STAT6 and NFκ]B/rel in the IL-4-induced up-regulation of the human IgE germline promoter. J. Immunol. 159: 3330-3337.
25. Linehan, L. A., W. D. Warren, P. A. Thompson, M. J. Grusby, and M. T. Berton. 1998. STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J. Immunol. 161: 302-310.
26. Shen, C.-H., and J. Stavnezer. 1998. Interaction of Stat6 and NF-κ]B: direct association and synergistic activation of interleukin-4-induced transcription. Mol. Cell. Biol. 18: 3395-3404.
27. Stutz, A. M., and M. Woisetschlager. 1999. Functional synergism of STAT6 with either NF-κB or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J. Immunol. 163: 4383-4391.
28. Berton, M. T., L. A. Linehan, K. R. Wick, and W. A. Dunnick. 2004. NF-κB elements associated with the Stat6 site in the germline γ1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand. Int. Immunol. 16: 1741-1749.
29. Bhushan, A., and L. R. Covey. 2001. CREB/ATF proteins enhance the basal and CD154- and IL-4-induced transcriptional activity of the human Iγ1 proximal promoter. Eur. J. Immunol. 31: 653-664.
30. Dryer, R. L., and L. R. Covey. 2005. A novel NF-κB-regulated site within the human Iγ1 promoter requires p300 for optimal transcriptional activity. J. Immunol. 175: 4499-4507.
31. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells. J. Immunol. 152: 438-445.
32. Fujieda, S., K. Zhang, and A. Saxon. 1995. IL-4 plus CD40 monoclonal antibody induces human B cells γ subclass-specific isotype switch: switching to γ1, γ3, and γ4, but not γ2. J. Immunol. 155: 2318-2328.
33. + human B cell lymphoma line. J. Immunol. 160: 595-605.
34. + B cell line. J. Immunol. 160: 2145-2157.
35. Bhushan, A., B. Barnhart, S. Shone, C. Song, and L. R. Covey. 2000. A transcriptional defect underlies B lymphocyte dysfunction in a patient diagnosed with non-X-linked hyper-IgM syndrome. J. Immunol. 164: 2871-2880.
36. Sideras, P., L. Nilsson, K. B. Islam, I. Z. Quintana, L. Freihof, A. Rosen, G. Juliusson, L. Hammarstrom, and C. I. Smith. 1992. Transcription of unrearranged Ig H chain genes in human B cell malignancies. Biased expression of genes encoded within the first duplication unit of the Ig H chain locus. J. Immunol. 149: 244-252.
37. Siegel, J. P., and H. S. Mostowski. 1990. A bioassay for the measurement of human interleukin-4. J. Immunol. Methods 132: 287-295.
38. + T cells mediating identity with the CD40-ligand. Mol. Immunol. 31: 471-484.
39. Umlauf, D., Y. Goto, and R. Feil. 2004. Site-specific analysis of histone methylation and acetylation. Methods Mol. Biol. 287: 99-120.
40. Saccani, S., S. Pantano, and G. Natoli. 2001. Two waves of nuclear factor κB recruitment to target promoters. J. Exp. Med. 193: 1351-1359.
41. Dryer, R. L., and L. R. Covey. 2006. Use of chromatin immunoprecipitation (ChIP) to detect transcription factor binding to highly homologous promoters in chromatin isolated from unstimulated and activated primary human B cells. Biol. Proc. Online 8: 44-54.
42. Nambu, Y., M. Sugai, H. Gonda, C. G. Lee, T. Katakai, Y. Agata, Y. Yokota, and A. Shimizu. 2003. Transcription-coupled events associating with immunoglobulin switch region chromatin. Science 302: 2137-2140.
43. Wang, L., N. Whang, R. Wuerffel, and A. L. Kenter. 2006. AID-dependent hi-stone acetylation is detected in immunoglobulin S regions. J. Exp. Med. 203: 215-226.
44. Lee, C. G., K. Kinoshita, A. Arudchandran, S. M. Cerritelli, R. J. Crouch, and T. Honjo. 2001. Quantitative regulation of class switch recombination by switch region transcription. J. Exp. Med. 194: 365-374.
45. Acton, T. B., H. Zhong, and A. K. Vershon. 1997. DNA-binding specificity of Mcm1: operator mutations that alter DNA-bending and transcriptional activities by a MADS box protein. Mol. Cell Biol. 17: 1881-1889.
46. Roemer, S. C., D. C. Donham, L. Sherman, V. H. Pon, D. P. Edwards, and M. E. Churchill. 2006. Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements. Mol. Endocrinol. 20: 3042-3052.
47. Perkins, N. D. 1997. Achieving transcriptional specificity with NF-κB. Int. J. Biochem. Cell Biol. 29: 1433-1448.
48. Perkins, N. D., L. K. Felzien, J. C. Betts, K. Leung, D. H. Beach, and G. J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275: 523-527.
49. Sheppard, K. A., D. W. Rose, Z. K. Haque, R. Kurokawa, E. McInerney, S. Westin, D. Thanos, M. G. Rosenfeld, C. K. Glass, and T. Collins. 1999. Transcriptional activation by NF-κB requires multiple coactivators. Mol. Cell Biol. 19: 6367-6378.
50. Merika, M., A. J. Williams, G. Chen, T. Collins, and D. Thanos. 1998. Recruitment of CBP/p300 by the IFNβ enhanceosome is required for synergistic activation of transcription. Mol. Cell 1: 277-287.
51. Kunsch, C., S. M. Ruben, and C. A. Rosen. 1992. Selection of optimal κB/Rel DNA-binding motifs: interaction of both subunits of NF-κB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12: 4412-4421.
52. Ghosh, G., G. van Duyne, S. Ghosh, and P. B. Sigler. 1995. Structure of NF-κB p50 homodimer bound to a κB site. Nature 373: 303-310.
53. Muller, C. W., F. A. Rey, M. Sodeoka, G. L. Verdine, and S. C. Harrison. 1995. Structure of the NF-κB p50 homodimer bound to DNA. Nature 373: 311-317.
54. Chen, Y. Q., S. Ghosh, and G. Ghosh. 1998. A novel DNA recognition mode by the NF-κB p65 homodimer. Nat. Struct. Biol. 5: 67-73.
55. Wilson, G. M., K. Sutphen, M. Moutafis, S. Sinha, and G. Brewer. 2001. Structural remodeling of an A + U-rich RNA element by cation or AUF1 binding. J. Biol. Chem. 276: 38400-38409.
56. Chen, F. E., and G. Ghosh. 1999. Regulation of DNA binding by Rel/NF-κB transcription factors: structural views. Oncogene 18: 6845-6852.
57. Berkowitz, B., D. B. Huang, F. E. Chen-Park, P. B. Sigler, and G. Ghosh. 2002. The x-ray crystal structure of the NF-κB p50.p65 heterodimer bound to the interferon β-κB site. J. Biol. Chem. 277: 24694-24700.
58. Escalante, C. R., L. Shen, D. Thanos, and A. K. Aggarwal. 2002. Structure of NF-κB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-β promoter. Structure 10: 383-391.
59. Chen-Park, F. E., D. B. Huang, B. Noro, D. Thanos, and G. Ghosh. 2002. The κB DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J. Biol. Chem. 277: 24701-24708.
60. Ping, D., P. L. Jones, and J. M. Boss. 1996. TNF regulates the in vivo occupancy of both distal and proximal regulatory regions of the MCP-1/JE gene. Immunity 4: 455-469.
61. Ueda, A., K. Okuda, S. Ohno, A. Shirai, T. Igarashi, K. Matsunaga, J. Fukushima, S. Kawamoto, Y. Ishigatsubo, and T. Okubo. 1994. NF-κB and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J. Immunol. 153: 2052-2063.
62. Paxton, L. L., L. J. Li, V. Secor, J. L. Duff, S. M. Naik, N. Shibagaki, and S. W. Caughman. 1997. Flanking sequences for the human intercellular adhesion molecule-1 NF-κB response element are necessary for tumor necrosis factor α-induced gene expression. J. Biol. Chem. 272: 15928-15935.
63. Hoffmann, A., T. H. Leung, and D. Baltimore. 2003. Genetic analysis of NF-κB/Rel transcription factors defines functional specificities. EMBO J. 22: 5530-5539.
64. Thanos, D., and T. Maniatis. 1995. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell 83: 1091-1100.
65. Leung, T. H., A. Hoffmann, and D. Baltimore. 2004. One nucleotide in a κB site can determine cofactor specificity for NF-κB dimers. Cell. 118: 453-464.
66. Cogne, M., R. Lansford, A. Bottaro, J. Zhang, J. Gorman, F. Young, H. L. Cheng, and F. W. Alt. 1994. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell 77: 737-747.
67. Manis, J. P., N. van der Stoep, M. Tian, R. Ferrini, L. Davidson, A. Bottaro, and F. W. Alt. 1998. Class switching in B cells lacking 3′ immunoglobulin heavy chain enhancers. J. Exp. Med. 188: 1421-1431.
68. Aalberse, R. C., R. van der Gaag, and J. van Leeuwen. 1983. Serologic aspects of IgG4 antibodies: I. Prolonged immunization results in an IgG4-restricted response. J. Immunol. 130: 722-726.
69. Hussain, R., and E. A. Ottesen. 1985. IgE responses in human filariasis. III. Specificities of IgE and IgG antibodies compared by immunoblot analysis. J. Immunol. 135: 1415-1420.
70. Ottesen, E. A., F. Skvaril, S. P. Tripathy, R. W. Poindexter, and R. Hussain. 1985. Prominence of IgG4 in the IgG antibody response to human filariasis. J. Immunol. 134: 2707-2712.
71. Kurniawan, A., M. Yazdanbakhsh, R. van Ree, R. Aalberse, M. E. Selkirk, F. Partono, and R. M. Maizels. 1993. Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. J. Immunol. 150: 3941-3950.