A transcriptional defect underlies B lymphocyte dysfunction in a patient diagnosed with non-X-linked hyper-IgM syndrome

Journal of Immunology

Volumn 164, Issue 6, 2000, Pages 2871-2880

  Bhushan, Ameesha ^a   Barnhart, Bryan ^a   Shone, Scott ^a   Song, Charles ^b   Covey, Lori R ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b HARBOR UCLA MEDICAL CENTER   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD20 ANTIGEN; CD40 ANTIGEN; INTERLEUKIN 4;

ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; FEMALE; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERIMMUNOGLOBULINEMIA; IMMUNOPHENOTYPING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034654318     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.6.2871     Document Type: Article

References (38)

1. Notarangelo, L. D., M. Duse, and A. G. Ugazio. 1992. Immunodeficiency with hyper-IgM (HIM). Immunodefic. Rev. 3:101.
2. Callard, R. E., R. J. Armitage, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559.
3. Aruffo, A., M. Farrington, D. Hollenbaugh, X. Li, A. Milatovich, S. Nonoyama, J. Bajorath, L. S. Grosmaire, R. Stenkamp, M. Neubauer, et al. 1993. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked immunodeficiency with hyper-IgM. Cell 72:291.
4. Korthauer, U., D. Graf, H. W. Mages, F. Briere, M. Padayachee, S. Malcolm, A. G. Ugazio, L. D. Notarangelo, R. J. Levinsky, and R. A. Kroczek. 1993. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 361:539.
5. DiSanto, J. P., J. Y. Bonnefoy, J. F. Gauchat, A. Fischer, and G. de SaintBasile. 1993. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature 361:539.
6. Allen, R. C., R. J. Armitage, M. E. Conley, H. Rosenblatt, N. A. Jenkins, N. G. Copeland, M. A. Bedell, S. Edelhoff, C. M. Disteche, D. K. Simoneaux, et al. 1993. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259:990.
7. Fuleihan, R., N. Ramesh, R. Loh, H. Jabara, R. S. Rosen, T. Chatila, S. M. Fu, I. Stamenkovic, and R. S. Geha. 1993. Defective expression of the CD40 ligand in X-chromosome-linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl. Acad. Sci. USA 90:2170.
8. Durandy, A., C. Schiff, J. Y. Bonnefoy, M. Forveille, F. Rousset, G. Mazzei, M. Milili, and A. Fischer. 1993. Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA, and IgE production by B cells from patients with X-linked hyper-IgM syndrome. Eur. J. Immunol. 23:2294.
9. Jamieson, W. M., and M. R. Kerr. 1962. A family with several cases of hypogammaglobulinemia. Arch. Dis. Child. 37:330.
10. Krantman, H. J. K., E. R. Stiehm, R. H. Stevens, A. Saxon, and R. C. Seeger. 1980. Abnormal B cell differentiation and variable increased T cell suppression in immunodeficiency with hyper-IgM. Clin. Exp. Immunol. 40:147.
11. Espanol, T., A. Guarro, J. Barquinero, and R. M. Garcia-Arumi. 1984. Familial incidence of hyper-IgM syndrome. In Progress in Immunodeficiency Research and Therapy. C. Griscelli, and J. Vosen, eds. Elsevier, Amsterdam, p. 211.
12. Beall, G. N., R. F. Ashman, M. E. Miller, C. Easwaran, R. Raghunathan, J. Louie, and T. Yoshikawa. 1980. Hypogammaglobulinemia in mother and son. J. Allergy Clin. Immunol. 65:471.
13. Brahmi, Z., K. H. Lazarus, M. E. Hodes, and R. L. Baehner. 1983. Immunologic studies of three family members with the immunodeficiency with hyper-IgM syndrome. J. Clin. Immunol. 3:137.
14. Callard, R. E., S. H. Smith, J. Herbert, G. Morgan, M. Padayachee, S. Lederman, L. Chess, R. A. Kroczek, W. C. Fanslow, and R. J. Armitage. 1994. CD40 ligand (CD40L) expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM (HIM). J. Immunol. 153:3295.
15. Durandy, A., C. Hivrox, F. Mazerolles, C. Schiff, F. Bernard, E. Jouanguy, P. Revy, J. P. DiSanto, J. F. Gauchat, J. Y. Bonnefoy, et al. 1997. Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression. J. Immunol. 158:2576.
16. Conley, M. E., M. Larche, V. R. Bonagura, A. R. Lawton III, R. H. Buckley, S. M. Fu, E. Coustan-Smith, H. G. Herrod, and D. Campana. 1994. Hyper-IgM syndrome associated with defective CD40 mediated B cell activation. J. Clin. Invest. 94:1404.
17. Saiki, O., T. Tanaka, Y. Wada, H. Uda, A. Inoue, Y. Datada, M. Izeki, M. Iwata, H. Nunoi, I. Matsuda, et al. 1995. Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM. J. Clin. Invest. 95:510.
18. Wu, L. Y., A. R. Lawton, and M. D. Cooper. 1973. Differentiation capacity of cultures of B lymphocytes from immunodeficient patients. J. Clin. Invest. 52: 3180.
19. Choi, T., W. D. Bigger, and R. Good. 1972. Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinemia. Lancet 1:1149.
20. Cunningham-Rundles, C. 1989. Clinical and immunological analyses of 103 patients with common variable immunodeficiency. J. Clin. Immunol. 9:22.
21. Eisenstein, E. M., K. Chua, and W. Strober. 1994. B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. J. Immunol. 152:5957.
22. Nonoyama, S., M. Farringon, H. Ishida, M. Howard, and H. D. Ochs. 1993. Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin. J. Clin. Invest. 92:1282.
23. + T cells mediating identity with the CD40-ligand. Mol. Immunol. 31:471.
24. Lederman, S., M. J. Yellin, A. M. Cleary, A. Pernis, G. Inghirami, L. E. Cohn, L. R. Covey, J. J. Lee, P. Rothman, and L. Chess. 1994. T-Bam/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death. J. Immunol. 152:2163.
25. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells. J. Immunol. 152:438.
26. + human B cell lymphoma line. J. Immunol. 160:595.
27. Kitani, A., and W. Strober. 1993. Regulation of Cγ subclass germ-line transcripts in human peripheral blood B cells. J. Immunol. 151:3478.
28. Mills, F. C., M. P. Mitchell, N. Harindranath, and E. E. Max. 1995. Human Ig Sg regions and their participation in sequential switching to IgE. J. Immunol. 155: 3021.
29. Yellin, M. J., K. Sippel, G. Inghirami, L. R. Covey, J. J. Lee, J. Sinning, E. A. Clark, L. Chess, and S. Lederman. 1994. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. J. Immunol. 152:598.
30. Kehry, M. R. 1996. CD40-mediated signaling in B cells: balancing cell survival, growth, and death. J. Immunol. 156:2345.
31. Baker, S. J., and E. P. Reddy. 1998. Modulation of life and death by the TNF receptor superfamily. Oncogene 17:3261.
32. Hostager, B. S., and G. A. Bishop. 1999. Contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation. J. Immunol. 162:6307.
33. Lalmanach-Girard, A.-C., T. C. Chiles, D. C. Parker, and T. L. Rothstein. 1993. T cell-dependent induction of NF-κB in B cells. J. Exp. Med. 177:1215.
34. Berberich, I., G. L. Shu, and E. A. Clark. 1994. Cross-linking CD40 on B cells rapidly activates nuclear factor-κB. J. Immunol. 153:4357.
35. Francis, D. A., J. G. Darras, X. Ke, R. Sen, and T. L. Rothstein. 1995. Induction of the transcription factors NF-κB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol 7:151.
36. Huo, L., and T. L. Rothstein. 1995. Receptor-specific induction of individual AP-1 components in B lymphocytes. J. Immunol. 154:3300.
37. Hsing, Y., and G. A. Bishop. 1999. Requirement for nuclear factor-κB activation by a distinct subset of CD40-mediated effector functions in B lymphocytes. J. Immunol. 162:2804.
38. Lin, S.-C., H. H. Wortis, and J. Stavnezer. 1998. The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-κB/Rel proteins. Mol. Cell. Biol. 18:5523.