-
1
-
-
0036791348
-
How death shapes life during development
-
Baehrecke E.H. How death shapes life during development. Nat. Rev. Mol. Cell Biol. 3 (2002) 779-787
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 779-787
-
-
Baehrecke, E.H.1
-
2
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267 (1995) 1456-1462
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
3
-
-
0036205587
-
Mechanisms of caspase activation and inhibition during apoptosis
-
Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell 9 (2002) 459-470
-
(2002)
Mol. Cell
, vol.9
, pp. 459-470
-
-
Shi, Y.1
-
4
-
-
36849028626
-
Lucifer's labyrinth-ten years of path finding in cell death
-
Meier P., and Vousden K.H. Lucifer's labyrinth-ten years of path finding in cell death. Mol. Cell 28 (2007) 746-754
-
(2007)
Mol. Cell
, vol.28
, pp. 746-754
-
-
Meier, P.1
Vousden, K.H.2
-
5
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
6
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P., et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
-
7
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou H., et al. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90 (1997) 405
-
(1997)
Cell
, vol.90
, pp. 405
-
-
Zou, H.1
-
8
-
-
27144529182
-
Ubiquitylation and cell signaling
-
Haglund K., and Dikic I. Ubiquitylation and cell signaling. EMBO J. 24 (2005) 3353-3359
-
(2005)
EMBO J.
, vol.24
, pp. 3353-3359
-
-
Haglund, K.1
Dikic, I.2
-
9
-
-
34748884951
-
Caspase-7 mediated cleavage of proteasome subunits during apoptosis
-
Jang M., et al. Caspase-7 mediated cleavage of proteasome subunits during apoptosis. Biochem. Biophys. Res. Commun. 363 (2007) 388-394
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.363
, pp. 388-394
-
-
Jang, M.1
-
10
-
-
1842472483
-
Caspase activation inhibits proteasome function during apoptosis
-
Sun X.M., et al. Caspase activation inhibits proteasome function during apoptosis. Mol. Cell 14 (2004) 81-93
-
(2004)
Mol. Cell
, vol.14
, pp. 81-93
-
-
Sun, X.M.1
-
11
-
-
31544457877
-
p53 ubiquitination: Mdm2 and beyond
-
Brooks C.L., and Gu W. p53 ubiquitination: Mdm2 and beyond. Mol. Cell 21 (2006) 307-315
-
(2006)
Mol. Cell
, vol.21
, pp. 307-315
-
-
Brooks, C.L.1
Gu, W.2
-
13
-
-
0036163042
-
A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding
-
Shi Y. A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding. Cell Death Differ. 9 (2002) 93-95
-
(2002)
Cell Death Differ.
, vol.9
, pp. 93-95
-
-
Shi, Y.1
-
14
-
-
0034993758
-
Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis
-
Silke J., and Vaux D.L. Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis. J. Cell Sci. 114 (2001) 1821-1827
-
(2001)
J. Cell Sci.
, vol.114
, pp. 1821-1827
-
-
Silke, J.1
Vaux, D.L.2
-
16
-
-
33749252583
-
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
-
Eckelman B.P., et al. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 7 (2006) 988-994
-
(2006)
EMBO Rep.
, vol.7
, pp. 988-994
-
-
Eckelman, B.P.1
-
17
-
-
0035876176
-
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
-
Silke J., et al. Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP. EMBO J. 20 (2001) 3114-3123
-
(2001)
EMBO J.
, vol.20
, pp. 3114-3123
-
-
Silke, J.1
-
18
-
-
0035831021
-
Structural basis of caspase-7 inhibition by XIAP
-
Chai J., et al. Structural basis of caspase-7 inhibition by XIAP. Cell 104 (2001) 769-780
-
(2001)
Cell
, vol.104
, pp. 769-780
-
-
Chai, J.1
-
19
-
-
0035831022
-
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain
-
Huang Y., et al. Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell 104 (2001) 781-790
-
(2001)
Cell
, vol.104
, pp. 781-790
-
-
Huang, Y.1
-
20
-
-
0035831019
-
Structural basis for the inhibition of caspase-3 by XIAP
-
Riedl S.J., et al. Structural basis for the inhibition of caspase-3 by XIAP. Cell 104 (2001) 791-800
-
(2001)
Cell
, vol.104
, pp. 791-800
-
-
Riedl, S.J.1
-
21
-
-
0035920126
-
X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and - 7 in distinct modes
-
Suzuki Y., et al. X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and - 7 in distinct modes. J. Biol. Chem. 276 (2001) 27058-27063
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27058-27063
-
-
Suzuki, Y.1
-
22
-
-
0037291737
-
Mechanism of XIAP-mediated inhibition of caspase-9
-
Shiozaki E.N., et al. Mechanism of XIAP-mediated inhibition of caspase-9. Mol. Cell 11 (2003) 519
-
(2003)
Mol. Cell
, vol.11
, pp. 519
-
-
Shiozaki, E.N.1
-
23
-
-
50049110244
-
Regulation of apoptosis by XIAP ubiquitin-ligase activity
-
Schile A.J., et al. Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 22 (2008) 2256-2266
-
(2008)
Genes Dev.
, vol.22
, pp. 2256-2266
-
-
Schile, A.J.1
-
24
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki Y., et al. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8662-8667
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
-
25
-
-
17044368875
-
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO
-
Morizane Y., et al. X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J. Biochem. 137 (2005) 125-132
-
(2005)
J. Biochem.
, vol.137
, pp. 125-132
-
-
Morizane, Y.1
-
26
-
-
2942674780
-
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase
-
Bartke T., et al. Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol. Cell 14 (2004) 801-811
-
(2004)
Mol. Cell
, vol.14
, pp. 801-811
-
-
Bartke, T.1
-
27
-
-
4444329609
-
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
-
Hao Y., et al. Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat. Cell Biol. 6 (2004) 849-860
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 849-860
-
-
Hao, Y.1
-
28
-
-
0037654554
-
Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila
-
Arama E., et al. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 4 (2003) 687-697
-
(2003)
Dev. Cell
, vol.4
, pp. 687-697
-
-
Arama, E.1
-
29
-
-
0037046814
-
Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death
-
Vernooy S.Y., et al. Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death. Curr. Biol. 12 (2002) 1164-1168
-
(2002)
Curr. Biol.
, vol.12
, pp. 1164-1168
-
-
Vernooy, S.Y.1
-
30
-
-
0027537461
-
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
-
Crook N.E., et al. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J. Virol. 67 (1993) 2168-2174
-
(1993)
J. Virol.
, vol.67
, pp. 2168-2174
-
-
Crook, N.E.1
-
31
-
-
0033980888
-
Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
-
Lisi S., et al. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 154 (2000) 669-678
-
(2000)
Genetics
, vol.154
, pp. 669-678
-
-
Lisi, S.1
-
32
-
-
0033588273
-
The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
-
Wang S.L., et al. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98 (1999) 453-463
-
(1999)
Cell
, vol.98
, pp. 453-463
-
-
Wang, S.L.1
-
33
-
-
0036300214
-
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
-
Wilson R., et al. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat. Cell Biol. 4 (2002) 445-450
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 445-450
-
-
Wilson, R.1
-
34
-
-
0242574748
-
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
-
Chai J., et al. Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nat. Struct. Biol. 10 (2003) 892-898
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 892-898
-
-
Chai, J.1
-
35
-
-
33947384611
-
Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways
-
Herman-Bachinsky Y., et al. Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 14 (2007) 861-871
-
(2007)
Cell Death Differ.
, vol.14
, pp. 861-871
-
-
Herman-Bachinsky, Y.1
-
36
-
-
12344300349
-
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
-
Tenev T., et al. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Nat. Cell Biol. 7 (2005) 70-77
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 70-77
-
-
Tenev, T.1
-
37
-
-
0037936841
-
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis
-
Ditzel M., et al. Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat. Cell Biol. 5 (2003) 467-473
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 467-473
-
-
Ditzel, M.1
-
38
-
-
5044248528
-
Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways
-
Ryoo H.D., et al. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev. Cell 7 (2004) 491-501
-
(2004)
Dev. Cell
, vol.7
, pp. 491-501
-
-
Ryoo, H.D.1
-
39
-
-
0346668315
-
The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
-
Muro I., et al. The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. J. Biol. Chem. 277 (2002) 49644-49650
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49644-49650
-
-
Muro, I.1
-
40
-
-
57049143644
-
Regulation of the Drosophila apoptosome through feedback inhibition
-
Shapiro P.J., et al. Regulation of the Drosophila apoptosome through feedback inhibition. Nat. Cell Biol. 10 (2008) 1440-1446
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1440-1446
-
-
Shapiro, P.J.1
-
41
-
-
0034282432
-
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
-
Huang H., et al. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J. Biol. Chem. 275 (2000) 26661-26664
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26661-26664
-
-
Huang, H.1
-
42
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin H., et al. Characterization of XIAP-deficient mice. Mol. Cell. Biol. 21 (2001) 3604-3608
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
-
43
-
-
55949118522
-
Inactivation of effector caspases through nondegradative polyubiquitylation
-
Ditzel M., et al. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol. Cell 32 (2008) 540-553
-
(2008)
Mol. Cell
, vol.32
, pp. 540-553
-
-
Ditzel, M.1
-
44
-
-
35548974677
-
The mammalian N-end rule pathway: new insights into its components and physiological roles
-
Tasaki T., and Kwon Y.T. The mammalian N-end rule pathway: new insights into its components and physiological roles. Trends Biochem. Sci. 32 (2007) 520-528
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 520-528
-
-
Tasaki, T.1
Kwon, Y.T.2
-
45
-
-
38049016966
-
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells
-
Ribeiro P.S., et al. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J. Cell Biol. 179 (2007) 1467-1480
-
(2007)
J. Cell Biol.
, vol.179
, pp. 1467-1480
-
-
Ribeiro, P.S.1
-
46
-
-
0037128923
-
The role of ARK in stress-induced apoptosis in Drosophila cells
-
Zimmermann K.C., et al. The role of ARK in stress-induced apoptosis in Drosophila cells. J. Cell Biol. 156 (2002) 1077-1087
-
(2002)
J. Cell Biol.
, vol.156
, pp. 1077-1087
-
-
Zimmermann, K.C.1
-
47
-
-
27344453240
-
An RNA interference screen identifies Inhibitor of apoptosis protein 2 as a regulator of innate immune signalling in Drosophila
-
Gesellchen V., et al. An RNA interference screen identifies Inhibitor of apoptosis protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Rep. 6 (2005) 979-984
-
(2005)
EMBO Rep.
, vol.6
, pp. 979-984
-
-
Gesellchen, V.1
-
48
-
-
33847273186
-
The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers
-
Huh J.R., et al. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. J. Biol. Chem. 282 (2007) 2056-2068
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2056-2068
-
-
Huh, J.R.1
-
49
-
-
27144475536
-
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
-
Kleino A., et al. Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway. EMBO J. 24 (2005) 3423-3434
-
(2005)
EMBO J.
, vol.24
, pp. 3423-3434
-
-
Kleino, A.1
-
50
-
-
33750330952
-
The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection
-
Leulier F., et al. The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. Mol. Cell. Biol. 26 (2006) 7821-7831
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7821-7831
-
-
Leulier, F.1
-
51
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau O., and Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114 (2003) 181
-
(2003)
Cell
, vol.114
, pp. 181
-
-
Micheau, O.1
Tschopp, J.2
-
52
-
-
4444341939
-
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles
-
Schneider-Brachert W., et al. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity 21 (2004) 415-428
-
(2004)
Immunity
, vol.21
, pp. 415-428
-
-
Schneider-Brachert, W.1
-
53
-
-
33646034316
-
Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea C.K., et al. Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22 (2006) 245-257
-
(2006)
Mol. Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
-
54
-
-
54249133441
-
FLIP and the death effector domain family
-
Yu J.W., and Shi Y. FLIP and the death effector domain family. Oncogene 27 (2008) 6216-6227
-
(2008)
Oncogene
, vol.27
, pp. 6216-6227
-
-
Yu, J.W.1
Shi, Y.2
-
55
-
-
35648935968
-
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
-
Santoro M.M., et al. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat. Genet. 39 (2007) 1397-1402
-
(2007)
Nat. Genet.
, vol.39
, pp. 1397-1402
-
-
Santoro, M.M.1
-
56
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis
-
Vince J.E., et al. IAP antagonists target cIAP1 to induce TNFα-dependent apoptosis. Cell 131 (2007) 682-693
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
-
57
-
-
37549000486
-
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling
-
Gaither A., et al. A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-α signaling. Cancer Res. 67 (2007) 11493-11498
-
(2007)
Cancer Res.
, vol.67
, pp. 11493-11498
-
-
Gaither, A.1
-
58
-
-
35948994157
-
Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen S.L., et al. Autocrine TNFα signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12 (2007) 445-456
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
-
59
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
-
Varfolomeev E., et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis. Cell 131 (2007) 669-681
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
-
60
-
-
44949240664
-
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand M.J., et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 (2008) 689-700
-
(2008)
Mol. Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
-
61
-
-
33847251527
-
Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling
-
O'Donnell M.A., et al. Ubiquitination of RIP1 regulates an NF-κB-independent cell-death switch in TNF signaling. Curr. Biol. 17 (2007) 418-424
-
(2007)
Curr. Biol.
, vol.17
, pp. 418-424
-
-
O'Donnell, M.A.1
-
62
-
-
56349164232
-
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
-
Vallabhapurapu S., et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling. Nat. Immunol. 9 (2008) 1364-1370
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
-
63
-
-
42149110830
-
Control of canonical NF-κB activation through the NIK-IKK complex pathway
-
Zarnegar B., et al. Control of canonical NF-κB activation through the NIK-IKK complex pathway. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 3503-3508
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 3503-3508
-
-
Zarnegar, B.1
-
64
-
-
54049155149
-
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
-
Varfolomeev E., et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation. J. Biol. Chem. 283 (2008) 24295-24299
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
-
65
-
-
2342445559
-
Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells
-
Yang Q.H., and Du C. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J. Biol. Chem. 279 (2004) 16963-16970
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16963-16970
-
-
Yang, Q.H.1
Du, C.2
-
66
-
-
55549140475
-
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
-
Gyrd-Hansen M., et al. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis. Nat. Cell Biol. 10 (2008) 1309-1317
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1309-1317
-
-
Gyrd-Hansen, M.1
-
67
-
-
0033847542
-
The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation
-
Baens M., et al. The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation. Am. J. Pathol. 156 (2000) 1433-1439
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 1433-1439
-
-
Baens, M.1
-
68
-
-
10744232926
-
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim
-
Akiyama T., et al. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J. 22 (2003) 6653-6664
-
(2003)
EMBO J.
, vol.22
, pp. 6653-6664
-
-
Akiyama, T.1
-
69
-
-
0038482050
-
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein
-
Ley R., et al. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein. Bim. J. Biol. Chem. 278 (2003) 18811-18816
-
(2003)
Bim. J. Biol. Chem.
, vol.278
, pp. 18811-18816
-
-
Ley, R.1
-
70
-
-
35148870200
-
c-Cbl is not required for ERK1/2-dependent degradation of BimEL
-
Wiggins C.M., et al. c-Cbl is not required for ERK1/2-dependent degradation of BimEL. Cell. Signal. 19 (2007) 2605-2611
-
(2007)
Cell. Signal.
, vol.19
, pp. 2605-2611
-
-
Wiggins, C.M.1
-
71
-
-
38049059937
-
Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment
-
Tait S.W., et al. Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J. Cell Biol. 179 (2007) 1453-1466
-
(2007)
J. Cell Biol.
, vol.179
, pp. 1453-1466
-
-
Tait, S.W.1
-
72
-
-
21744433861
-
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase
-
Cadwell K., and Coscoy L. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Science 309 (2005) 127-130
-
(2005)
Science
, vol.309
, pp. 127-130
-
-
Cadwell, K.1
Coscoy, L.2
-
73
-
-
34249042608
-
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
-
Wang X., et al. Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J. Cell Biol. 177 (2007) 613-624
-
(2007)
J. Cell Biol.
, vol.177
, pp. 613-624
-
-
Wang, X.1
-
74
-
-
13944274500
-
Mcl-1 regulation and its role in multiple myeloma
-
Le Gouill S., et al. Mcl-1 regulation and its role in multiple myeloma. Cell Cycle 3 (2004) 1259-1262
-
(2004)
Cell Cycle
, vol.3
, pp. 1259-1262
-
-
Le Gouill, S.1
-
75
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
-
Zhong Q., et al. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. Cell 121 (2005) 1085-1095
-
(2005)
Cell
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
-
76
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
Chen D., et al. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 121 (2005) 1071-1083
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
-
77
-
-
28344456279
-
A genomic and functional inventory of deubiquitinating enzymes
-
Nijman S.M., et al. A genomic and functional inventory of deubiquitinating enzymes. Cell 123 (2005) 773-786
-
(2005)
Cell
, vol.123
, pp. 773-786
-
-
Nijman, S.M.1
-
78
-
-
46249124976
-
Deubiquitylation and regulation of the immune response
-
Sun S.C. Deubiquitylation and regulation of the immune response. Nat. Rev. Immunol. 8 (2008) 501-511
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 501-511
-
-
Sun, S.C.1
-
79
-
-
0042467558
-
CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
-
Trompouki E., et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424 (2003) 793-796
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
-
80
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
-
Wertz I.E., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 430 (2004) 694-699
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
-
81
-
-
43749122598
-
NF-κB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
-
Enesa K., et al. NF-κB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J. Biol. Chem. 283 (2008) 7036-7045
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7036-7045
-
-
Enesa, K.1
-
82
-
-
39449083378
-
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
-
Shembade N., et al. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat. Immunol. 9 (2008) 254-262
-
(2008)
Nat. Immunol.
, vol.9
, pp. 254-262
-
-
Shembade, N.1
-
83
-
-
32044447161
-
The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover
-
Chang L., et al. The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell 124 (2006) 601-613
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
-
84
-
-
0036300083
-
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
-
Ryoo H.D., et al. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat. Cell Biol. 4 (2002) 432-438
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 432-438
-
-
Ryoo, H.D.1
-
85
-
-
0036300215
-
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
-
Wing J.P., et al. Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat. Cell Biol. 4 (2002) 451-456
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 451-456
-
-
Wing, J.P.1
-
86
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
Hunter A.M., et al. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12 (2007) 1543-1568
-
(2007)
Apoptosis
, vol.12
, pp. 1543-1568
-
-
Hunter, A.M.1
-
87
-
-
0036307854
-
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
-
Hays R., et al. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1. Nat. Cell Biol. 4 (2002) 425-431
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 425-431
-
-
Hays, R.1
-
88
-
-
33746570157
-
Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs
-
Kuranaga E., et al. Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell 126 (2006) 583-596
-
(2006)
Cell
, vol.126
, pp. 583-596
-
-
Kuranaga, E.1
-
89
-
-
32444437676
-
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change
-
Gallagher E., et al. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 1717-1722
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 1717-1722
-
-
Gallagher, E.1
-
90
-
-
1842457755
-
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis
-
Qiu X.B., et al. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 23 (2004) 800-810
-
(2004)
EMBO J.
, vol.23
, pp. 800-810
-
-
Qiu, X.B.1
-
91
-
-
15444364186
-
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
-
Sekine K., et al. HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. Biochem. Biophys. Res. Commun. 330 (2005) 279-285
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 279-285
-
-
Sekine, K.1
-
92
-
-
0033051322
-
MDM2 interacts with MDMX through their RING finger domains
-
Tanimura S., et al. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett. 447 (1999) 5-9
-
(1999)
FEBS Lett.
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
-
93
-
-
57649120782
-
Structures of the cIAP2 RING domain reveal conformational changes associated with Ubiquitin-conjugating Enzyme (E2) recruitment
-
Mace P.D., et al. Structures of the cIAP2 RING domain reveal conformational changes associated with Ubiquitin-conjugating Enzyme (E2) recruitment. J. Biol. Chem. 283 (2008) 31633-31640
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31633-31640
-
-
Mace, P.D.1
-
94
-
-
33846239416
-
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity
-
Poyurovsky M.V., et al. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J. 26 (2007) 90-101
-
(2007)
EMBO J.
, vol.26
, pp. 90-101
-
-
Poyurovsky, M.V.1
-
95
-
-
28044469866
-
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
-
Silke J., et al. Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16182-16187
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 16182-16187
-
-
Silke, J.1
-
96
-
-
16244377737
-
Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo
-
Conze D.B., et al. Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol. Cell. Biol. 25 (2005) 3348-3356
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 3348-3356
-
-
Conze, D.B.1
-
97
-
-
38849112545
-
The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously
-
Lee T.V., et al. The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development 135 (2008) 43-52
-
(2008)
Development
, vol.135
, pp. 43-52
-
-
Lee, T.V.1
-
98
-
-
33749346301
-
Modification of proteins by ubiquitin and ubiquitin-like proteins
-
Kerscher O., et al. Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu. Rev. Cell Dev. Biol. 22 (2006) 159-180
-
(2006)
Annu. Rev. Cell Dev. Biol.
, vol.22
, pp. 159-180
-
-
Kerscher, O.1
-
99
-
-
0034651987
-
The Drosophila caspase DRONC is regulated by DIAP1
-
Meier P., et al. The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 19 (2000) 598-611
-
(2000)
EMBO J.
, vol.19
, pp. 598-611
-
-
Meier, P.1
-
100
-
-
0034296394
-
Basic Medical Research Award. The ubiquitin system
-
Hershko A., et al. Basic Medical Research Award. The ubiquitin system. Nat. Med. 6 (2000) 1073-1081
-
(2000)
Nat. Med.
, vol.6
, pp. 1073-1081
-
-
Hershko, A.1
-
101
-
-
33748991453
-
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
-
Hoeller D., et al. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis. Nat. Rev. Cancer 6 (2006) 776-788
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 776-788
-
-
Hoeller, D.1
-
102
-
-
0038362292
-
When ubiquitin meets ubiquitin receptors: a signalling connection
-
Di Fiore P.P., et al. When ubiquitin meets ubiquitin receptors: a signalling connection. Nat. Rev. Mol. Cell Biol. 4 (2003) 491-497
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 491-497
-
-
Di Fiore, P.P.1
-
103
-
-
44349116590
-
Proteasome subunit Rpn13 is a novel ubiquitin receptor
-
Husnjak K., et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453 (2008) 481-488
-
(2008)
Nature
, vol.453
, pp. 481-488
-
-
Husnjak, K.1
-
104
-
-
44749093460
-
Ubiquitin-mediated regulation of TNFR1 signaling
-
Wertz I.E., and Dixit V.M. Ubiquitin-mediated regulation of TNFR1 signaling. Cytokine Growth Factor Rev. 19 (2008) 313-324
-
(2008)
Cytokine Growth Factor Rev.
, vol.19
, pp. 313-324
-
-
Wertz, I.E.1
Dixit, V.M.2
-
105
-
-
0036009115
-
NF-κB at the crossroads of life and death
-
Karin M., and Lin A. NF-κB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
-
(2002)
Nat. Immunol.
, vol.3
, pp. 221-227
-
-
Karin, M.1
Lin, A.2
|