Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 534-544

  Wang, Xue Ding ^a   Li, Jia Li ^a   Lu, Yan ^a   Chen, Xiao ^b   Huang, Min ^a   Chowbay, Balram ^c   Zhou, Shu Feng ^d  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Dehydronifedipine; Liquid chromatography tandem mass spectrometry; Nifedipine; Pharmacokinetics; St. John's wort

Indexed keywords

IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); SOLVENT EXTRACTION;

DEHYDRONIFEDIPINE; HERBAL ANTIDEPRESSANT; NIFEDIPINE;

DRUG PRODUCTS;

CYTOCHROME P450 3A4; DEHYDRONIFEDIPINE; HERBACEOUS AGENT; NIFEDIPINE;

ACCURACY; ADULT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG METABOLISM; DRUG STRUCTURE; ELECTROSPRAY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDITY;

CALCIUM CHANNEL BLOCKERS; DRUG INTERACTIONS; HUMANS; HYPERICUM; NIFEDIPINE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 34249704588     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.02.026     Document Type: Article

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